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- Creators: Barrett, The Honors College
- Creators: MacKinnon, David
Description
Variability in subjective response to alcohol has been shown to predict drinking behavior as well as the development of alcohol use disorders. The current study examined the extent to which individual differences in alcohol pharmacokinetics impact subjective response and drinking behavior during a single session alcohol administration paradigm. Participants (N = 98) completed measures of subjective response at two time points following alcohol consumption. Pharmacokinetic properties (rate of absorption and metabolism) were inferred using multiple BAC readings to calculate the area under the curve during the ascending limb for absorption and descending limb for metabolism. Following the completion of the subjective response measures, an ad-libitum taste rating task was implemented in which participants were permitted to consume additional alcoholic beverages. The amount consumed during the taste rating task served as the primary outcome variable. Results of the study indicated that participants who metabolized alcohol more quickly maintained a greater level of subjective stimulation as blood alcohol levels declined and reported greater reductions in subjective sedation. Although metabolism did not have a direct influence on within session alcohol consumption, a faster metabolism did relate to increased ad-libitum consumption indirectly through greater acute tolerance to sedative effects and greater maintenance of stimulant effects. Rate of absorption did not significantly predict subjective response or within session drinking. The results of the study add clarity to theories of subjective response to alcohol, and suggest that those at highest risk for alcohol problems experience a more rapid reduction in sedation following alcohol consumption while simultaneously experiencing heightened levels of stimulation. Variability in pharmacokinetics, namely how quickly one metabolizes alcohol, may be an identifiable biomarker of subjective response and may be used to infer risk for alcohol problems.
ContributorsBoyd, Stephen (Author) / Corbin, William R. (Thesis advisor) / Chassin, Laurie (Committee member) / MacKinnon, David (Committee member) / Olive, Michael Foster (Committee member) / Arizona State University (Publisher)
Created2014
Description
This thesis, entitled "A Community Perspective on Alcohol Education," was conducted over a ten month period during the Spring 2014 and Fall 2014 semesters, composed by Christopher Stuller and Nicholas Schmitzer. The research involved interviewing twelve professionals from Arizona State University and the City of Tempe to gather a holistic view on alcohol education and alcohol safety as it involves the students at ASU. Upon completion of the interviews, recommendations were made regarding areas of improvement for alcohol education and alcohol safety at Arizona State University. These recommendations range from creating a mandatory alcohol education class to passing a Guardian Angel Law to creating a national network of alcohol education best practices. Through this thesis, the authors hope to prevent future alcohol related injuries, deaths, and tragedies. For the final display of this thesis a website was created. For the ease of reading, all information has been presented in text format.
ContributorsSchmitzer, Nicholas (Co-author) / Stuller, Christopher (Co-author) / Koretz, Lora (Thesis director) / Scott Lynch, Jacquelyn (Committee member) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / School of Accountancy (Contributor) / Department of Supply Chain Management (Contributor)
Created2014-12
Description
Introduction: Depression is one of the most prevalent mental illnesses in the United States, and is characterized by feeling sad or empty most of the day, nearly every day (American Psychiatric Association, 2013). The experience of childhood trauma is one of many factors that may lead to depression, while trauma can also yield other adverse life outcomes, such as alcohol-related consequences (Felitti et al., 2001; Neumann, 2017). One of the specific aims of this investigation was to examine the direct influences of childhood trauma on depression. We also examined selected direct and indirect influences of childhood trauma on drinking outcomes through the potential mediating mechanism of depression. We examined three distinct drinking outcomes, 1) impaired control over drinking (i.e. the inability to stop drinking when intended), 2) heavy episodic drinking (four or more drinks on one occasion for men, four or more for women), and 3) alcohol-related problems. Methods: A survey was administered to 940 (466 women, 474 men) university students. Structural equation modeling was used to examine the data. Potential two- and three-path mediated effects were examined with the bias corrected bootstrap technique in Mplus (MacKinnon, 2008). Results: Emotional abuse was found to be positively associated with depression. In contrast, having an emotionally supportive family was found to be negatively associated with depression. Congruent with the Self-Medication Hypothesis, depression was found to be positively associated with impaired control over drinking. Physical neglect was found to be positively associated with impaired control. Lastly, emotional abuse was found to be indirectly linked to increased heavy episodic drinking and alcohol-related problems through depression and impaired control.
ContributorsBobel, Emily Rebecca Leslie (Author) / Patock-Peckham, Julie (Thesis director) / Glenberg, Arthur (Committee member) / Karoly, Paul (Committee member) / Department of Psychology (Contributor) / School of Criminology and Criminal Justice (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Recent research on alcohol use among LGB young adults indicates that sexual minority youth are at increased risk relative to their heterosexual peers. One possible contributing factor is that religiosity fails to provide the significant protection for LGB youth that it has been demonstrated to provide in general population samples. Although recent studies provide some support for this hypothesis, there is little research seeking to understand the reasons that religiosity may fail to protect against heavy drinking among LGB youth. The current study attempted to address this gap by examining relations among religiosity, age of self-identification, and alcohol use in a sample of 103 young adults self identified as lesbian, gay, or bisexual. Using multiple regression, we found that religiosity had an indirect effect on alcohol use operating through age of identification as LGB. Higher religiosity was associated with a later age of self-identification, which in turn, predicted greater increases in alcohol use among LGB youth during the transition from high school through college. Exploratory analyses found that gender significantly moderated the influence of age of self-identification on alcohol use such that a later age of self-identification was a risk factor for increased drinking for women, but not for men. The findings have important implications for understanding complex relations between religiosity and alcohol use among LGB youth. In addition, the findings may inform the development of religious support groups for LGB youth that will allow them to experience the benefits of religious involvement that heterosexual youth experience.
ContributorsOng, Thai Quang (Author) / Corbin, William (Thesis director) / Glenberg, Arthur (Committee member) / Grzanka, Patrick (Committee member) / Barrett, The Honors College (Contributor) / T. Denny Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor)
Created2013-12
Description
Given the prominence of alcohol in the Korean adult's daily life, further investigation into the negative effects of harmful alcohol consumption and the treatment of and culture surrounding alcohol use disorders is needed. An investigation into the status and treatment of alcohol use disorders in South Korea was chosen due to the significant cultural differences from the United States with regards to alcohol consumption, mental health, and healthcare. The investigation used academic and grey literature, news reports, and current healthcare and public health policy to evaluate South Korea's weak areas in addressing alcohol use disorders. Greater investment into mental health research and healthcare delivery, as well as further development of the continuum of care to help patients transition from treatment of the acute symptoms of an alcohol use disorder to lifetime management are needed. Lastly, increased alcohol regulatory policies are recommended.
ContributorsFlowers, Taylor Nicole (Author) / Gaughan, Monica (Thesis director) / Shin, Hoon Cheol (Committee member) / School of International Letters and Cultures (Contributor) / School of Human Evolution and Social Change (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This study addresses a gap in the literature by examining interactions between parental monitoring and parental autonomy giving/personal autonomy in predicting changes in drinking behavior from high school to college. Using data from two unique studies (study 1 was 62.8% female, n = 425; study 2 was 59.9% female, n = 2245), we analyzed main effects of parental monitoring, parental autonomy-giving, and personal autonomy. We also analyzed interactions between parental monitoring and autonomy-giving, and between parental monitoring and personal autonomy. Analyses found significant main effects of parental monitoring on drinking, with high levels of parental monitoring protecting against heavy drinking. Personal autonomy was a protective factor in both high school and college, whereas parental autonomy-giving did not predict drinking behavior in either high school or during the transition to college. This calls into question the extent to which parental autonomy-giving is a primary influence on personal autonomy. Hypothesized interactions between parental monitoring and parental autonomy giving/personal autonomy were not statistically significant. In summary, parental monitoring seems to be protective in high school, and personal autonomy—but not parental autonomy-giving—is also protective. Whereas the latter finding is well established from previous studies, the protective effect of personal autonomy during the transition to college is a novel finding. This relationship suggests that efforts to identify sources of personal autonomy in early adulthood and methods for increasing autonomy may be warranted.
ContributorsStack, Jaclyn Elaine (Author) / Corbin, William (Thesis director) / Meier, Madeline (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Polysubstance abuse is far more common than single substance abuse. One of the most widely abused, yet greatly understudied combination of drugs is the simultaneous use of methamphetamine (meth) and alcohol. Because little research has been conducted on the co-abuse of meth and alcohol, it is important to study the behavioral and neural mechanisms underlying the use of both to combat addiction and come closer to finding an effective treatment of this form of drug abuse. This study uses a rodent model to attempt to identify the mechanisms underlying this co-abuse through the stimulation of the medial forebrain bundle (MFB) and thus the activation of the mesocorticolimbic pathway, the brain's pleasure circuit. First, self-stimulation thresholds (the lowest electrical current the rats are willing to respond for) were determined using a process called Discrete Trials Training. This threshold was later used as a baseline measure to reference when the rats were administered the drugs of abuse: meth and alcohol, both alone and in combination. Our overall results did not show any significant effects of combining alcohol and meth relative to the effects of either drug alone, although subject attrition may have resulted in sample sizes that were statistically underpowered. The results of this and future studies will help provide a clearer understanding of the neural mechanisms underlying the polyabuse of meth and alcohol and can potentially lead to more successfully combating and treating this addiction.
ContributorsDrafton, Kaitlyn Marie (Author) / Olive, Foster (Thesis director) / Glenberg, Arthur (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Positive alcohol outcome expectancies (AOEs) are consistent longitudinal predictors of later alcohol use; however, exclusion of solitary drinking contexts in the measurement of AOEs may have resulted in an underestimation of the importance of low arousal positive (LAP) effects. The current study aimed to clarify the literature on the association between AOEs and drinking outcomes by examining the role of drinking context in AOE measurement. Further, exclusion of contextual influences has also limited understanding of the unique effects of AOEs relative to subjective responses (SR) to alcohol. The present study addressed this important question by exploring relations between AOEs and SR when drinking context was held constant across parallel measures of these constructs. Understanding which of these factors drives relations between alcohol effects and drinking behavior has important implications for intervention. After conducting confirmatory factor analysis (CFA) and tests of measurement invariance for the AOE and SR measures, 4 aims collectively examined the role of context in reporting of AOEs (Aims 1 and 2), the extent to which context specific AOEs uniquely relate to drinking outcomes (Aim 3), and the importance of context effects on correspondence between AOEs and SR (Aim 4). Results of Aims 1 and 2 demonstrated that participants are imagining contexts when reporting on measures of AOEs that do not specify the context, and found significant mean differences in high and low arousal positive AOEs across contexts. Contrary to the hypotheses of Aim 3, context-specific AOEs were not significantly associated with drinking behavior. Results of Aim 4 indicated that while LAP AOEs for both unspecified and solitary contexts were associated with LAP SR in a solitary setting, unspecified context AOEs had a stronger relation than the solitary context AOEs. No significant relations between high arousal positive (HAP) AOEs and HAP SR emerged. The findings suggest that further investigation of the relation between context-specific AOEs and drinking outcomes/SR is warranted. Future studies of these hypotheses in samples with a wider range of drinking behavior, or at different stages of alcohol involvement, will elucidate whether mean level differences in context specific AOEs are important in understanding alcohol related outcomes.
ContributorsScott, Caitlin (Author) / Corbin, William (Thesis advisor) / MacKinnon, David (Committee member) / Barrera, Manuel (Committee member) / Chassin, Laurie (Committee member) / Arizona State University (Publisher)
Created2016
Description
The current study utilized data from two longitudinal samples to test mechanisms in the relation between a polygenic risk score indexing serotonin functioning and alcohol use in adolescence. Specifically, this study tested whether individuals with lower levels of serotonin functioning as indexed by a polygenic risk score were vulnerable to poorer self-regulation, and whether poorer self-regulation subsequently predicted the divergent outcomes of depressive symptoms and aggressive/antisocial behaviors. This study then examined whether depressive symptoms and aggressive/antisocial behaviors conferred risk for later alcohol use in adolescence, and whether polygenic risk and effortful control had direct effects on alcohol use that were not mediated through problem behaviors. Finally, the study examined the potential moderating role of gender in these pathways to alcohol use.
Structural equation modeling was used to test hypotheses. Results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create serotonin (5-HT) polygenic risk scores, wherein higher scores reflected lower levels of 5-HT functioning. Data from three time points were drawn from each sample, and all paths were prospective. Findings suggested that 5-HT polygenic risk did not predict self-regulatory constructs. However, 5-HT polygenic risk did predict the divergent outcomes of depression and aggression/antisociality, such that higher levels of 5-HT polygenic risk predicted greater levels of depression and aggression/antisociality. Results most clearly supported adolescents’ aggression/antisociality as a mechanism in the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. These pathways to alcohol use might be the most salient for boys with low levels of socioeconomic status.
Results are novel contributions to the literature. The previously observed association between serotonin functioning and alcohol use might be due, in part, to the fact that individuals with lower levels of serotonin functioning are predisposed towards developing earlier aggression/antisociality. Results did not support the hypothesis that serotonin functioning predisposes individuals to deficits in self-regulatory abilities. Findings extend previous research by suggesting that serotonin functioning and self-regulation might be transdiagnostic risk factors for many types of psychopathology.
Structural equation modeling was used to test hypotheses. Results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create serotonin (5-HT) polygenic risk scores, wherein higher scores reflected lower levels of 5-HT functioning. Data from three time points were drawn from each sample, and all paths were prospective. Findings suggested that 5-HT polygenic risk did not predict self-regulatory constructs. However, 5-HT polygenic risk did predict the divergent outcomes of depression and aggression/antisociality, such that higher levels of 5-HT polygenic risk predicted greater levels of depression and aggression/antisociality. Results most clearly supported adolescents’ aggression/antisociality as a mechanism in the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. These pathways to alcohol use might be the most salient for boys with low levels of socioeconomic status.
Results are novel contributions to the literature. The previously observed association between serotonin functioning and alcohol use might be due, in part, to the fact that individuals with lower levels of serotonin functioning are predisposed towards developing earlier aggression/antisociality. Results did not support the hypothesis that serotonin functioning predisposes individuals to deficits in self-regulatory abilities. Findings extend previous research by suggesting that serotonin functioning and self-regulation might be transdiagnostic risk factors for many types of psychopathology.
ContributorsWang, Frances Lynn (Author) / Chassin, Laurie (Thesis advisor) / Eisenberg, Nancy (Committee member) / Lemery-Chalfant, Kathryn (Committee member) / MacKinnon, David (Committee member) / Arizona State University (Publisher)
Created2017
Description
This project investigated how alcohol might affect rates of Intimate Partner Aggression (IPA) within Hispanic populations specifically. Hispanics have the highest rates of IPA broadly speaking in the U.S., and I decided that further insight could be gleaned on why this might be by looking into how alcohol consumption might affect these rates. Data were gathered from Project IDEA, the research fellowship which this thesis piggybacked off of. Project IDEA was a survey asking couples about their drinking habits and relationship dynamics for the purpose of collecting more data on the connection between alcohol and IPA. My thesis focused more specifically on the Hispanic members of the sample. Ultimately, I found that Hispanics tend to engage in more heavy episodic drinking (i.e., drinking more in one sitting) than non-Hispanics, that heavy episodic drinking was positively correlated with IPA, and that Hispanics engaged more in all forms of IPA except for psychological perpetration than non-Hispanics. This essentially tells me that heavy episodic drinking might have something to do with the higher rates of IPA in Hispanic populations, but there is no definite causal relationship, and more research has to be done in this area.
ContributorsAcosta Huerta, Marcos (Author) / Davis, Kelly (Thesis director) / Hammett, Julia (Committee member) / Barrett, The Honors College (Contributor) / School of Criminology and Criminal Justice (Contributor) / Department of Psychology (Contributor)
Created2023-05