The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in the event of an opioid overdose to provide recommendations for ASU. Data was collected by surveying first-year NPC and IFC students at ASU on their knowledge and behavior patterns regarding opioids and overdoses. Additionally, a series of interviews with large public universities in the United States were conducted to discuss resources available to students. It was found that the fraternity and sorority members surveyed have an inadequate amount of knowledge about opioids and overdoses, but have less experiences with opioids and/or overdoses compared to non-Greek affiliated students at ASU. It is believed that with proper education and access to resources, students will decrease their risk of experiencing an overdose. This research provided the basis to argue for educational programs and resources being provided to students at ASU.

This is a composition of information derived from the research conducted to produce each episode of Nefarious. As part of my final thesis project for my undergraduate degrees in criminal justice and forensic psychology, I created a podcast on the topic of true crime with an academic approach titled Nefarious. Each episode of Nefarious examines a particular case in relation to some academic theme learned throughout my educational career at Arizona State University. Episode one examines the life and crimes of Richard Ramirez and different criminological theories that could be used to explain his behavior. Episode two looks at the case of Brock Turner and Chanel Miller and focuses on the larger problem of rape culture in America and sexual assault on college campuses. In episode three the case of the Central Park Five is detailed in relation to false confessions and wrongful convictions within the legal system. Episode four is centered around Kyle Rittenhouse and the use of self-defense as a legal defense in the justice system as well as the political atmosphere surrounding this case. The fifth episode explores three cases of police brutality against racial minorities and the history of police in America. The final episode of Nefarious covers the life and crimes of Jeffrey Dahmer and analyzes such actions from a forensic psychology approach.

The opioid crisis is a dangerous public health issue on the rise among college students involved in Greek organizations. This study investigated what first-year students involved in National Panhellenic Conference (NPC) sororities and Interfraternity Council (IFC) fraternities at Arizona State University (ASU) know about opioids and how to react in the event of an opioid overdose to provide recommendations for ASU. Data was collected by surveying first-year NPC and IFC students at ASU on their knowledge and behavior patterns regarding opioids and overdoses. Additionally, a series of interviews with large public universities in the United States were conducted to discuss resources available to students. It was found that the fraternity and sorority members surveyed have an inadequate amount of knowledge about opioids and overdoses, but have less experiences with opioids and/or overdoses compared to non-Greek affiliated students at ASU. It is believed that with proper education and access to resources, students will decrease their risk of experiencing an overdose. This research provided the basis to argue for educational programs and resources being provided to students at ASU.

Background: Creation and reuse of reliable clinical code sets could accelerate the use of EHR data for research. To support that vision, there is an imperative need for methodologically. driven, transparent and automatic approaches to create error-free clinical code sets. Objectives: Propose and evaluate an automatic, generalizable, and knowledge-based approach that uses as starting point a correct and complete knowledge base of ingredients (e.g., the US Drug Enforcement Administration Controlled Substance repository list includes fentanyl as an opioid) to create medication code sets (e.g., Abstral is an opioid medication with fentanyl as ingredient). Methods: Algorithms were written to convert lists of ingredients into medication code sets, where all the medications are codified in the RxNorm terminology, are active medications and have at least one ingredient from the ingredient list. Generalizability and accuracy of the methods was demonstrated by applying them to the discovery of opioid and anti-depressant medications. Results: Errors (39 (1.73%) and 13 (6.28%)), obsolete drugs (172 (7.61%) and 0 (0%)) and missing medications (1,587 (41.26%) and 1,456 (87.55%)) were found in publicly available opioid and antidepressant medication code sets, respectively. Conclusion: The proposed knowledge-based algorithms to discover correct, complete, and up to date ingredient-based medication code sets proved to be accurate and reusable. The resulting algorithms and code sets have been made publicly available for others to use.

Our current understanding of the mitochondrial genome was revolutionized in 2015 with the discovery of short open reading frames (sORFs) that produced protein products called mitochondrial-derived peptides (MDPs). Interestingly, unlike other proteins produced by the organelle, these MDPs are not directly involved in the electron transport chain but rather serve the role of metabolic regulators. In particular, one of these peptides called MOTS-c has been shown to regulate glucose and fat metabolism in an AMPK-dependent manner. With its capacity to enter the mitochondria and impact gene expression, MOTS-c has also displayed the ability to increase aerobic exercise performance by triggering elevated synthesis of the HO-1 antioxidant. Overall these findings position MOTS-c as a promising treatment for metabolic diseases as well as a potential dietary supplement to boost ATP availability.