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Optometry is an important field in medicine as it allows people a chance to have their vision corrected and it serves as a health screening opportunity for those who receive a dilated eye examination. One of the largest barriers to receiving a dilated eye exam is insurance coverage. Most health

Optometry is an important field in medicine as it allows people a chance to have their vision corrected and it serves as a health screening opportunity for those who receive a dilated eye examination. One of the largest barriers to receiving a dilated eye exam is insurance coverage. Most health insurance policies have limited optometric coverage. By expanding health insurance plans to be more inclusive of optometric care, people who use these health insurance plans will have a better access of care.

ContributorsFurey, Colleen (Author) / Ruth, Alissa (Thesis director) / Mullen, Tyler (Committee member) / School of Life Sciences (Contributor) / Department of Physics (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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There is a lot of variation in health outcomes when it comes to individual states in America. Some states, such as Hawaii, have the life expectancy equivalent to that of developed countries, whereas states like Mississippi have the life expectancy equivalent to that of third world countries. This raised the

There is a lot of variation in health outcomes when it comes to individual states in America. Some states, such as Hawaii, have the life expectancy equivalent to that of developed countries, whereas states like Mississippi have the life expectancy equivalent to that of third world countries. This raised the questions of which states are doing well in health and why, and if their health has to do with their performance in the primary, secondary, tertiary, and/or quaternary prevention levels. The purpose of this research was to investigate if there is a correlation between performance in any of the prevention levels and the overall health status of a state, and if there is, which prevention level would be most beneficial for states to prioritize. The hypothesis of this research was: states that prioritized primary and secondary levels of prevention would have better health than states that prioritized tertiary and quaternary levels of prevention, since basic health measures contribute more to health outcomes than advanced medicine. To investigate this question, indicators were chosen to derive the ranking of each state in health and each of the four prevention levels. Six states were then chosen to represent the high, average, and low health statuses respectively. The six states were ranked for all indicators, and the data was analyzed and compared to determine a potential relationship between the prevention level rankings and the overarching health ranking. It was found that there is a correlation between performance in the primary and secondary prevention levels and a state’s overall health status, whereas there was no such correlation for the tertiary and quaternary levels. A model for health was proposed for states looking to improve their health status, which was to invest in primary prevention, followed by secondary, tertiary, then quaternary prevention and only moving to the next prevention level once the previous level reached a satisfactory threshold.

ContributorsTeo, Ruthanne (Author) / Cortese, Denis (Thesis director) / Landman, Natalie (Committee member) / Hurlbut, Ben (Committee member) / School of Life Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The purpose of this cookbook and ingredient index is to simplify the reasoning behind eating a plant based diet--including how it can be beneficial to your health, and what benefits each ingredient provides. These recipes have been cultivated and modified over time to provide nutritious meals that are also tasty.

The purpose of this cookbook and ingredient index is to simplify the reasoning behind eating a plant based diet--including how it can be beneficial to your health, and what benefits each ingredient provides. These recipes have been cultivated and modified over time to provide nutritious meals that are also tasty. I was introduced to healthy eating at a young age, and have been fascinated by it ever since. The recipes and information conveyed about a plant based diet have come from the many books read and research I have done on the subject. This paper will walk you through how I started this journey, and go on to show a basic overview of what makes up the foods we consume and why we need them. The cookbook portion of my Thesis contains recipes for breakfast, lunch, dinner, snacks, sauces, and dessert. Following the cookbook is an ingredient index that goes through the majority of ingredients used in my recipes, and what health benefits they provide. I hope that by reading this, others will be inspired to use more plant-based whole foods in their diet, and realize the healing that can come from them.

ContributorsMartin, Ashley (Author) / Barth, Christina (Thesis director) / McMullen, Mary (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

A significant amount of prior research has been conducted to investigate type 2 diabetes, the most prevalent form afflicting over 90% of diabetic individuals [6]. Yet, gestational diabetes is an understudied form of diabetes that is thought to share various attributes with type 2 diabetes. It was the aim of

A significant amount of prior research has been conducted to investigate type 2 diabetes, the most prevalent form afflicting over 90% of diabetic individuals [6]. Yet, gestational diabetes is an understudied form of diabetes that is thought to share various attributes with type 2 diabetes. It was the aim of this project to investigate a proposed mechanism of the disease, the contra-insulin effect, through a cell-culture experiment. To address the question of whether glycemic and hormonal conditions of cell-culture media affect Hs 795.Pl morphology, cellular growth, and glucose uptake, immunocytochemistry (ICC) and a glucose uptake assay was performed. It was hypothesized that higher the presence of hormones, specifically lactogen, in cell culture media will exacerbate the contra-insulin effect, decreasing the glucose uptake of the Hs 795.Pl cells and inducing abhorrent cell morphology. Qualitatively, estradiol and cortisol had a severe impact on cellular morphology indicative of stress and death. As for glucose uptake, it was decreased when the hormones were isolated compared to all together with estradiol thought to be majorly inhibitory to insulin’s proper functioning. It was concluded that cell morphology, growth, and glucose uptake were detrimentally impacted by the gestational hormones, especially those of cortisol and estrogen.

ContributorsPickett, Sydney (Author) / Gilchrist, Alex (Co-author) / Holechek, Susan (Thesis director) / Clarke, Richard (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-05
Description

This project explores modern healthcare related disparities in Phoenix, Arizona, as well as the overarching historical structures that have influenced public health within the city. Historical and systemic racism, harmful housing policies, barriers preventing upwards economic mobility, and purposeful measures put in place by business leaders and city officials are

This project explores modern healthcare related disparities in Phoenix, Arizona, as well as the overarching historical structures that have influenced public health within the city. Historical and systemic racism, harmful housing policies, barriers preventing upwards economic mobility, and purposeful measures put in place by business leaders and city officials are all explored as factors impacting current disparities in access to care. In order to fully analyze the gaps in care, different areas, both high and low-income, are analyzed throughout history in order to understand shifting demographics and policies. The project concludes with an in-depth look at current public health efforts within Maricopa County, as well as with future policy recommendations.

ContributorsReiland, Sofia (Author) / Don, Rachael (Thesis director) / Schermerhorn, Calvin (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor) / School of Life Sciences (Contributor)
Created2023-05
Description
Exercise is widely recognized for its myriad of health benefits, particularly in the realm of chronic disease prevention and treatment. Despite this knowledge, exercise remains significantly underutilized in the United States, with only a quarter of the population meeting the recommended physical activity guidelines set by the Department of Health

Exercise is widely recognized for its myriad of health benefits, particularly in the realm of chronic disease prevention and treatment. Despite this knowledge, exercise remains significantly underutilized in the United States, with only a quarter of the population meeting the recommended physical activity guidelines set by the Department of Health and Human Services (Piercy et al., 2018). Recent research has spotlighted specific regions known as Blue Zones, where natural movement is incorporated into daily lives and populations are characterized by increased longevity and improved health outcomes, including lower rates of chronic diseases. This study aimed to explore and compare exercise behaviors between the United States and the Ikaria Blue Zone in Greece, investigating their potential implications for a longer lifespan and enhanced health. Employing ethnographic methods, including immersive observation, semi-structured, qualitative interviews with locals, and the distribution of validated International Physical Activity Questionnaire (IPAQ) surveys, comprehensive data on exercise habits within the Ikarian population was collected in November 2023. The findings from this study shed light on alternative forms of physical activity that have proven successful in populations with increased longevity. By identifying and understanding these practices, there is an opportunity to implement them in the United States, potentially contributing to improved exercise adherence and the prevention and treatment of chronic diseases. This research underscores the significance of cross-cultural insights in developing effective strategies to promote healthier lifestyles and enhance overall well-being.
ContributorsUnderhill, Jackson (Author) / Hrncir, Shawn (Thesis director) / Siegler, Jason (Committee member) / Barth, Christina (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
The Refugee Education and Clinic Team (REACT) is a local organization led by students at Arizona State University and the Mayo Clinic Alix School of Medicine with the purpose of improving the health of refugees and asylees. One way in which REACT aims to improve the health of refugees and

The Refugee Education and Clinic Team (REACT) is a local organization led by students at Arizona State University and the Mayo Clinic Alix School of Medicine with the purpose of improving the health of refugees and asylees. One way in which REACT aims to improve the health of refugees and asylees is through health education workshops, which inform refugees about health conditions and management options. The purpose of this project was to analyze how REACT’s health education workshop about obesity impacted refugees’ understanding of healthy living. This project implemented a pre- and post-presentation survey at REACT’s obesity workshop to measure refugees’ understanding of healthy living. Overall, a pre-existing understanding of the importance of healthy eating and daily exercise was measured and an improvement in their understanding of the symptoms associated with obesity was recorded.
ContributorsPatel, Reeti (Author) / DiVito, Brittany (Thesis director) / Kenny, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / School of Politics and Global Studies (Contributor)
Created2024-05
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Description
Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections (STI), affecting over 267 million women worldwide. HSV-2 causes a chronic, latent infection that increases the risk for acquisition with other STI, including HIV. Currently, there is no vaccine against HSV-2 and novel anti-viral treatments are

Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections (STI), affecting over 267 million women worldwide. HSV-2 causes a chronic, latent infection that increases the risk for acquisition with other STI, including HIV. Currently, there is no vaccine against HSV-2 and novel anti-viral treatments are needed. IL-36γ is a newly characterized cytokine that has been shown to play a role in inflammation and be upregulated in response to microbial infection and tissue damage. We have shown that IL-36γ is expressed in the female reproductive tract (FRT) and is upregulated by HSV-2 infection in vitro and in vivo. IL-36γ in turn induces production of proinflammatory cytokines and chemokines in human vaginal epithelial cells (VEC) that can aid in immune cell recruitment. We hypothesize that IL-36γ is a key regulator of mucosal inflammation in the FRT and functions to limit HSV-2 infection. We have demonstrated that IL-36γ treatment prior to infection protects against HSV-2 replication, disease severity, and promotes survival in a lethal mouse model. Thus, the objective of this study is to understand the mechanisms whereby IL-36γ inhibits HSV-2 replication. To understand the impact of IL-36γ on the HSV-2 lifecycle, we pretreated VEC with IL-36γ and evaluated viral titer during virus attachment and entry, replication, and cell-to-cell spread by plaque assay. Pretreatment with IL-36γ 4h prior to infection did not significantly reduce viral titers in VEC monolayers relative to untreated groups. This suggesting that IL-36γ may play a more significant role in immune cell recruitment during HSV-2 infection. To test this, FRT tissue samples from HSV-2 infected IL-36γ -/- and WT mice were analyzed by histochemistry to characterize immune cell recruitment. No clear pattern was determined for tissue samples in which cell clusters were observed and cell type within recruited clusters was unable to be identified at the current magnification. As these projects continue, the data will aid in elucidating the mechanism and level to which IL-36γ impacts HSV-2 infection in human VEC and FRT models.
ContributorsAlexander, Thessaly E (Author) / Herbst-Kralovetz, Melissa (Thesis director) / Capco, David (Committee member) / Hogue, Ian (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Homeless populations are often disproportionately impacted by several diseases due to factors such as overcrowding, unsanitary conditions, lack of access to healthcare and most importantly lack of education. The purpose of this project was to decrease a part of this health gap by spreading awareness of certain illnesses impacting Arizona’s

Homeless populations are often disproportionately impacted by several diseases due to factors such as overcrowding, unsanitary conditions, lack of access to healthcare and most importantly lack of education. The purpose of this project was to decrease a part of this health gap by spreading awareness of certain illnesses impacting Arizona’s homeless population and to increase the use plausible prevention methods. This was done through the creation of three simplified brochures that contained information regarding influenza, hepatitis, and schizophrenia. Two surveys were distributed to a local homeless population; the first survey was given prior to handing out the brochures and the second survey was given a week later after the participants had some time to read the information from the brochures. The data from the surveys supported the goal of the project by showing an increase in overall awareness of the diseases as well as an increase in behavioral changes that would lead to the increase of plausible prevention methods.
ContributorsBanuelos, Jason (Author) / Quaranta, Kimberly (Thesis director) / Szeli, Eva (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.

The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.
ContributorsDebray, Hannah Zara (Co-author) / Debray, Hannah (Co-author) / Blattman, Joseph (Thesis director) / Jurutka, Peter (Committee member) / Manhas, Kavita (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05