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- All Subjects: Health
- Creators: School of Life Sciences
Description
The Refugee Education and Clinic Team (REACT) is a local organization led by students at Arizona State University and the Mayo Clinic Alix School of Medicine with the purpose of improving the health of refugees and asylees. One way in which REACT aims to improve the health of refugees and asylees is through health education workshops, which inform refugees about health conditions and management options. The purpose of this project was to analyze how REACT’s health education workshop about obesity impacted refugees’ understanding of healthy living. This project implemented a pre- and post-presentation survey at REACT’s obesity workshop to measure refugees’ understanding of healthy living. Overall, a pre-existing understanding of the importance of healthy eating and daily exercise was measured and an improvement in their understanding of the symptoms associated with obesity was recorded.
ContributorsPatel, Reeti (Author) / DiVito, Brittany (Thesis director) / Kenny, Katherine (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / School of Politics and Global Studies (Contributor)
Created2024-05
Description
Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections (STI), affecting over 267 million women worldwide. HSV-2 causes a chronic, latent infection that increases the risk for acquisition with other STI, including HIV. Currently, there is no vaccine against HSV-2 and novel anti-viral treatments are needed. IL-36γ is a newly characterized cytokine that has been shown to play a role in inflammation and be upregulated in response to microbial infection and tissue damage. We have shown that IL-36γ is expressed in the female reproductive tract (FRT) and is upregulated by HSV-2 infection in vitro and in vivo. IL-36γ in turn induces production of proinflammatory cytokines and chemokines in human vaginal epithelial cells (VEC) that can aid in immune cell recruitment. We hypothesize that IL-36γ is a key regulator of mucosal inflammation in the FRT and functions to limit HSV-2 infection. We have demonstrated that IL-36γ treatment prior to infection protects against HSV-2 replication, disease severity, and promotes survival in a lethal mouse model. Thus, the objective of this study is to understand the mechanisms whereby IL-36γ inhibits HSV-2 replication. To understand the impact of IL-36γ on the HSV-2 lifecycle, we pretreated VEC with IL-36γ and evaluated viral titer during virus attachment and entry, replication, and cell-to-cell spread by plaque assay. Pretreatment with IL-36γ 4h prior to infection did not significantly reduce viral titers in VEC monolayers relative to untreated groups. This suggesting that IL-36γ may play a more significant role in immune cell recruitment during HSV-2 infection. To test this, FRT tissue samples from HSV-2 infected IL-36γ -/- and WT mice were analyzed by histochemistry to characterize immune cell recruitment. No clear pattern was determined for tissue samples in which cell clusters were observed and cell type within recruited clusters was unable to be identified at the current magnification. As these projects continue, the data will aid in elucidating the mechanism and level to which IL-36γ impacts HSV-2 infection in human VEC and FRT models.
ContributorsAlexander, Thessaly E (Author) / Herbst-Kralovetz, Melissa (Thesis director) / Capco, David (Committee member) / Hogue, Ian (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Homeless populations are often disproportionately impacted by several diseases due to factors such as overcrowding, unsanitary conditions, lack of access to healthcare and most importantly lack of education. The purpose of this project was to decrease a part of this health gap by spreading awareness of certain illnesses impacting Arizona’s homeless population and to increase the use plausible prevention methods. This was done through the creation of three simplified brochures that contained information regarding influenza, hepatitis, and schizophrenia. Two surveys were distributed to a local homeless population; the first survey was given prior to handing out the brochures and the second survey was given a week later after the participants had some time to read the information from the brochures. The data from the surveys supported the goal of the project by showing an increase in overall awareness of the diseases as well as an increase in behavioral changes that would lead to the increase of plausible prevention methods.
ContributorsBanuelos, Jason (Author) / Quaranta, Kimberly (Thesis director) / Szeli, Eva (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The retinoid-X receptor (RXR) can form heterodimers with both the retinoic-acid
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.
receptor (RAR) and vitamin D receptor (VDR). The RXR/RAR dimer is activated by ligand all
trans retinoic acid (ATRA), which culminates in gut-specific effector T cell migration. Similarly,
the VDR/RXR dimer binds 1,25(OH)2D3 to cause skin-specific effector T cell migration.
Targeted migration is a potent addition to current vaccines, as it would induce activated T cell
trafficking to appropriate areas of the immune system and ensure optimal stimulation (40).
ATRA, while in use clinically, is limited by toxicity and chemical instability. Rexinoids
are stable, synthetically developed ligands specific for the RXR. We have previously shown that
select rexinoids can enhance upregulation of gut tropic CCR9 receptors on effector T cells.
However, it is important to establish whether these cells can actually migrate, to show the
potential of rexinoids as vaccine adjuvants that can cause gut specific T cell migration.
Additionally, since the RXR is a major contributor to VDR-mediated transcription and
epidermotropism (15), it is worth investigating whether these compounds can also function as
adjuvants that promote migration by increasing expression of skin tropic CCR10 receptors on T
cells.
Prior experiments have demonstrated that select rexinoids can induce gut tropic migration
of CD8+ T cells in an in vitro assay and are comparable in effectiveness to ATRA (7). The effect
of rexinoids on CD4+ T cells is unknown however, so the aim of this project was to determine if
rexinoids can cause gut tropic migration in CD4+ T cells to a similar extent. A secondary aim
was to investigate whether varying concentrations in 1,25-Dihydroxyvitamin D3 can be linked to
increasing CCR10 upregulation on Jurkat CD4+ T cells, with the future aim to combine 1,25
Dihydroxyvitamin D3 with rexinoids.
These hypotheses were tested using murine splenocytes for the migration experiment, and
human Jurkat CD4+ T cells for the vitamin D experiment. Migration was assessed using a
Transwell chemotaxis assay. Our findings support the potential of rexinoids as compounds
capable of causing gut-tropic migration in murine CD4+ T cells in vitro, like ATRA. We did not
observe conclusive evidence that vitamin D3 causes upregulated CCR10 expression, but this
experiment must be repeated with a human primary T cell line.
ContributorsDebray, Hannah Zara (Co-author) / Debray, Hannah (Co-author) / Blattman, Joseph (Thesis director) / Jurutka, Peter (Committee member) / Manhas, Kavita (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Thousands of human lives are lost every day due to chronic diseases, some more preventable than others. For years, the gold standard for diagnosing and monitoring these diseases has been through traditional methods such as individualized doctor-patient clinical evaluations, usually involving laboratory tests. These methods, though effective, can be costly, time-consuming, and fail to encompass an overarching perspective of the health profile of the larger population. Wastewater-based epidemiology (WBE) has successfully been employed for decades as a population-level data source informing on the consumption of licit and illicit substance use. It also is showing promise for its use as a community-wide diagnostic tool for broader public health measurements. This literature review constitutes a theoretical evaluation of the potential use of WBE for monitoring the top two deadly diseases in the United States; cardiovascular disease (CVD) and cancer. Literature-reported metabolites indicative of these diseases were evaluated to determine if they were capable of being identified and monitored in wastewater. Potential analytes include cardiac-specific troponin, α-fenotroin, and inositol. Results obtained within suggest WBE could be used as a viable and economical tool to track and monitor the top deadly diseases in human populations. This methodology could be implemented in tandem with current practices in order to provide a more holistic understanding of prevalence and risk for CVD and cancer.
ContributorsAmin, Vivek (Author) / Halden, Rolf (Thesis director) / Niebuhr, Robert (Committee member) / Bowes, Devin (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Regenerative medicine is a relatively new area of interest among researchers and physicians alike and has truly come to light within the last twenty years. Its purpose is to “regenerate” cells in our body to return tissue and organs systems to their normal functions by utilizing innate cell mechanisms. Uses have ranged from growing completely new body tissue in labs, to promoting the repair of damaged neurons. More recently, the use of regenerative medicine techniques such as stem cell and platelet rich plasma therapy has seen significant growth throughout high level and professional sports. Beginning in the early 2000s, treatments quickly gained popularity as professional athletes began using them as an alternative to surgery, but this came before any concrete scientific support. This thesis paper will analyze the current statistical data supporting the use of platelet rich plasma and stem cell therapy and associated regulations to describe the connection between regenerative medicine and sports.
ContributorsFritzke, Jack Teodor (Author) / Washo-Krupps, Delon (Thesis director) / Foster, William (Committee member) / Levinson, Simin (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This study uses a survey-based approach to study the perception of water quality and sanitation habits in Cusibamba and Totora, Peru. The survey covered important aspects such as how the water tastes, looks, smells, where it comes from, how it is purified (boiled or chlorinated), and if the respondent is satisfied with their water. Participants reported that the water is of good quality overall and usually available (although scarcity may be an issue). They also reported good hygiene practices overall, and that they boil the water prior to using it for cooking, cleaning, or drinking. Educational information about ensuring water quality and sanitation would have been distributed in addition to in-person lessons on how to purify water if the COVID pandemic did not occur. These activities could not have been performed without risk to the communities and risk to those traveling to Peru.
ContributorsWriter, Carl (Author) / Lynch, John (Thesis director) / Huerta, Mark (Thesis director) / Cuya-Gavilano, Lorena (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor)
Created2022-05
Description
The purpose of this project was to garner a greater understanding of the form, function, and uses of school as well as community gardens. Worldwide, school and community gardens are used to promote health, nutrition, and some aspects of education. I wished to extend my knowledge of these gardens to greater lengths by building and incorporating a school garden in a community that was underderserving. Along the way I also sought to better my understanding of how to help communities through the knowledge and aid of experts and other community members. By doing this, I would hopefully both improve that community as well as understand the difficulties and problems that stand in the way of greater school garden incorporation.
ContributorsMitrius, Jake (Author) / Adamson, Joni (Thesis director) / Aggarwal, Rhimjim (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
Description
Upon analyzing the literature that is available on refugee populations in conjunction with our personal experiences with these populations, we ultimately decided to develop a mobile app that targeted the source of the numerous disparities we saw. These disparities ranged from increased prevalence of chronic diseases to difficulty in going to doctor's appointments due to transportation challenges. We focused on the three areas of government assistance, clinical health, and general well-being through our mobile app, Refugee Aid Initiative. This mobile app is designed to provide refugee populations with the resources necessary to build healthier, happier, and more independent lives for themselves and their families. Here, we focus on not only highlighting resources that are available but also adding supplementary information that helps refugee populations fully take advantage of the resources that are available to them.
ContributorsElsabbagh, Zaid (Author) / Bcharah, George (Co-author) / Sellner, Erin (Thesis director) / Jakubczak, Laura (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor)
Created2022-05
Description
The Founders lab is a year-long program that gives its students an opportunity to participate in a unique team-based, experiential Barrett honors thesis project to design and apply marketing and sales strategies, as well as business and financial models to create and launch a new business. Initially, our team focused on creating a product that would provide those who have received basic genetic testing from services such as 23andMe with nutrition, exercise, and health/wellness educational resources. Over time, we transitioned our focus to creating a community forum that would also provide those resources to people who had not received basic genetic testing, but were still interested in accessing educational resources about the specific conditions that basic genetic testing services provide reports for. To accomplish this, we have produced a website that allows users to post content and interact with each other.
ContributorsChapman, Isabelle (Author) / Umana Fleck, David (Co-author) / Niu, Hardy (Co-author) / Byrne, Jared (Thesis director) / Lee, Christopher (Committee member) / Balven, Rachel (Committee member) / Barrett, The Honors College (Contributor) / Division of Teacher Preparation (Contributor) / School of Life Sciences (Contributor)
Created2022-05