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How Does Technology Development Influence the Assessment of Parkinson’s Disease? A Systematic Review
Description
Parkinson’s disease (PD) is a neurological disorder with complicated and disabling motor and non-motor symptoms. The pathology for PD is difficult and expensive. Furthermore, it depends on patient diaries and the neurologist’s subjective assessment of clinical scales. Objective, accurate, and continuous patient monitoring have become possible with the advancement in mobile and portable equipment. Consequently, a significant amount of work has been done to explore new cost-effective and subjective assessment methods or PD symptoms. For example, smart technologies, such as wearable sensors and optical motion capturing systems, have been used to analyze the symptoms of a PD patient to assess their disease progression and even to detect signs in their nascent stage for early diagnosis of PD.
This review focuses on the use of modern equipment for PD applications that were developed in the last decade. Four significant fields of research were identified: Assistance diagnosis, Prognosis or Monitoring of Symptoms and their Severity, Predicting Response to Treatment, and Assistance to Therapy or Rehabilitation. This study reviews the papers published between January 2008 and December 2018 in the following four databases: Pubmed Central, Science Direct, IEEE Xplore and MDPI. After removing unrelated articles, ones published in languages other than English, duplicate entries and other articles that did not fulfill the selection criteria, 778 papers were manually investigated and included in this review. A general overview of PD applications, devices used and aspects monitored for PD management is provided in this systematic review.
This review focuses on the use of modern equipment for PD applications that were developed in the last decade. Four significant fields of research were identified: Assistance diagnosis, Prognosis or Monitoring of Symptoms and their Severity, Predicting Response to Treatment, and Assistance to Therapy or Rehabilitation. This study reviews the papers published between January 2008 and December 2018 in the following four databases: Pubmed Central, Science Direct, IEEE Xplore and MDPI. After removing unrelated articles, ones published in languages other than English, duplicate entries and other articles that did not fulfill the selection criteria, 778 papers were manually investigated and included in this review. A general overview of PD applications, devices used and aspects monitored for PD management is provided in this systematic review.
ContributorsDeb, Ranadeep (Author) / Ogras, Umit Y. (Thesis advisor) / Shill, Holly (Committee member) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2019
Description
This thesis presents a power harvesting system combining energy from sub-cells of
multi-junction photovoltaic (MJ-PV) cells. A dual-input, inductor time-sharing boost
converter in continuous conduction mode (CCM) is proposed. A hysteresis inductor current
regulation in designed to reduce cross regulation caused by inductor-sharing in CCM. A
modified hill-climbing algorithm is implemented to achieve maximum power point
tracking (MPPT). A dual-path architecture is implemented to provide a regulated 1.8V
output. A proposed lossless current sensor monitors transient inductor current and a time-based power monitor is proposed to monitor PV power. The PV input provides power of
65mW. Measured results show that the peak efficiency achieved is around 85%. The
power switches and control circuits are implemented in standard 0.18um CMOS process.
multi-junction photovoltaic (MJ-PV) cells. A dual-input, inductor time-sharing boost
converter in continuous conduction mode (CCM) is proposed. A hysteresis inductor current
regulation in designed to reduce cross regulation caused by inductor-sharing in CCM. A
modified hill-climbing algorithm is implemented to achieve maximum power point
tracking (MPPT). A dual-path architecture is implemented to provide a regulated 1.8V
output. A proposed lossless current sensor monitors transient inductor current and a time-based power monitor is proposed to monitor PV power. The PV input provides power of
65mW. Measured results show that the peak efficiency achieved is around 85%. The
power switches and control circuits are implemented in standard 0.18um CMOS process.
ContributorsPeng, Qirong (Author) / Kiaei, Sayfe (Thesis advisor) / Bakkaloglu, Bertan (Committee member) / Ogras, Umit Y. (Committee member) / Arizona State University (Publisher)
Created2017
Description
The manufacturing process for electronic systems involves many players, from chip/board design and fabrication to firmware design and installation.
In today's global supply chain, any of these steps are prone to interference from rogue players, creating a security risk.
Manufactured devices need to be verified to perform only their intended operations since it is not economically feasible to control the supply chain and use only trusted facilities.
It is becoming increasingly necessary to trust but verify the received devices both at production and in the field.
Unauthorized hardware or firmware modifications, known as Trojans,
can steal information, drain the battery, or damage battery-driven embedded systems and lightweight Internet of Things (IoT) devices.
Since Trojans may be triggered in the field at an unknown instance,
it is essential to detect their presence at run-time.
However, it isn't easy to run sophisticated detection algorithms on these devices
due to limited computational power and energy, and in some cases, lack of accessibility.
Since finding a trusted sample is infeasible in general, the proposed technique is based on self-referencing to remove any effect of environmental or device-to-device variations in the frequency domain.
In particular, the self-referencing is achieved by exploiting the band-limited nature of Trojan activity using signal detection theory.
When the device enters the test mode, a predefined test application is run on the device
repetitively for a known period. The periodicity ensures that the spectral electromagnetic power of the test application concentrates at known frequencies, leaving the remaining frequencies within the operating bandwidth at the noise level. Any deviations from the noise level for these unoccupied frequency locations indicate the presence of unknown (unauthorized) activity. Hence, the malicious activity can differentiate without using a golden reference or any knowledge of the Trojan activity attributes.
The proposed technique's effectiveness is demonstrated through experiments with collecting and processing side-channel signals, such as involuntarily electromagnetic emissions and power consumption, of a wearable electronics prototype and commercial system-on-chip under a variety of practical scenarios.
In today's global supply chain, any of these steps are prone to interference from rogue players, creating a security risk.
Manufactured devices need to be verified to perform only their intended operations since it is not economically feasible to control the supply chain and use only trusted facilities.
It is becoming increasingly necessary to trust but verify the received devices both at production and in the field.
Unauthorized hardware or firmware modifications, known as Trojans,
can steal information, drain the battery, or damage battery-driven embedded systems and lightweight Internet of Things (IoT) devices.
Since Trojans may be triggered in the field at an unknown instance,
it is essential to detect their presence at run-time.
However, it isn't easy to run sophisticated detection algorithms on these devices
due to limited computational power and energy, and in some cases, lack of accessibility.
Since finding a trusted sample is infeasible in general, the proposed technique is based on self-referencing to remove any effect of environmental or device-to-device variations in the frequency domain.
In particular, the self-referencing is achieved by exploiting the band-limited nature of Trojan activity using signal detection theory.
When the device enters the test mode, a predefined test application is run on the device
repetitively for a known period. The periodicity ensures that the spectral electromagnetic power of the test application concentrates at known frequencies, leaving the remaining frequencies within the operating bandwidth at the noise level. Any deviations from the noise level for these unoccupied frequency locations indicate the presence of unknown (unauthorized) activity. Hence, the malicious activity can differentiate without using a golden reference or any knowledge of the Trojan activity attributes.
The proposed technique's effectiveness is demonstrated through experiments with collecting and processing side-channel signals, such as involuntarily electromagnetic emissions and power consumption, of a wearable electronics prototype and commercial system-on-chip under a variety of practical scenarios.
ContributorsKarabacak, Fatih (Author) / Ozev, Sule (Thesis advisor) / Ogras, Umit Y. (Thesis advisor) / Christen, Jennifer Blain (Committee member) / Kitchen, Jennifer (Committee member) / Arizona State University (Publisher)
Created2020