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Description
Magnetic Resonance Imaging using spiral trajectories has many advantages in speed, efficiency in data-acquistion and robustness to motion and flow related artifacts. The increase in sampling speed, however, requires high performance of the gradient system. Hardware inaccuracies from system delays and eddy currents can cause spatial and temporal distortions in the encoding gradient waveforms. This causes sampling discrepancies between the actual and the ideal k-space trajectory. Reconstruction assuming an ideal trajectory can result in shading and blurring artifacts in spiral images. Current methods to estimate such hardware errors require many modifications to the pulse sequence, phantom measurements or specialized hardware. This work presents a new method to estimate time-varying system delays for spiral-based trajectories. It requires a minor modification of a conventional stack-of-spirals sequence and analyzes data collected on three orthogonal cylinders. The method is fast, robust to off-resonance effects, requires no phantom measurements or specialized hardware and estimate variable system delays for the three gradient channels over the data-sampling period. The initial results are presented for acquired phantom and in-vivo data, which show a substantial reduction in the artifacts and improvement in the image quality.
ContributorsBhavsar, Payal (Author) / Pipe, James G (Thesis advisor) / Frakes, David (Committee member) / Kodibagkar, Vikram (Committee member) / Arizona State University (Publisher)
Created2013
Description
Cigarette smoking remains a major global public health issue. This is partially due to the chronic and relapsing nature of tobacco use, which contributes to the approximately 90% quit attempt failure rate. The recent rise in mobile technologies has led to an increased ability to frequently measure smoking behaviors and related constructs over time, i.e., obtain intensive longitudinal data (ILD). Dynamical systems modeling and system identification methods from engineering offer a means to leverage ILD in order to better model dynamic smoking behaviors. In this dissertation, two sets of dynamical systems models are estimated using ILD from a smoking cessation clinical trial: one set describes cessation as a craving-mediated process; a second set was reverse-engineered and describes a psychological self-regulation process in which smoking activity regulates craving levels. The estimated expressions suggest that self-regulation more accurately describes cessation behavior change, and that the psychological self-regulator resembles a proportional-with-filter controller. In contrast to current clinical practice, adaptive smoking cessation interventions seek to personalize cessation treatment over time. An intervention of this nature generally reflects a control system with feedback and feedforward components, suggesting its design could benefit from a control systems engineering perspective. An adaptive intervention is designed in this dissertation in the form of a Hybrid Model Predictive Control (HMPC) decision algorithm. This algorithm assigns counseling, bupropion, and nicotine lozenges each day to promote tracking of target smoking and craving levels. Demonstrated through a diverse series of simulations, this HMPC-based intervention can aid a successful cessation attempt. Objective function weights and three-degree-of-freedom tuning parameters can be sensibly selected to achieve intervention performance goals despite strict clinical and operational constraints. Such tuning largely affects the rate at which peak bupropion and lozenge dosages are assigned; total post-quit smoking levels, craving offset, and other performance metrics are consequently affected. Overall, the interconnected nature of the smoking and craving controlled variables facilitate the controller's robust decision-making capabilities, even despite the presence of noise or plant-model mismatch. Altogether, this dissertation lays the conceptual and computational groundwork for future efforts to utilize engineering concepts to further study smoking behaviors and to optimize smoking cessation interventions.
ContributorsTimms, Kevin Patrick (Author) / Rivera, Daniel E (Thesis advisor) / Frakes, David (Committee member) / Nielsen, David R (Committee member) / Arizona State University (Publisher)
Created2014
Description
Single cell phenotypic heterogeneity studies reveal more information about the pathogenesis process than conventional bulk methods. Furthermore, investigation of the individual cellular response mechanism during rapid environmental changes can only be achieved at single cell level. By enabling the study of cellular morphology, a single cell three-dimensional (3D) imaging system can be used to diagnose fatal diseases, such as cancer, at an early stage. One proven method, CellCT, accomplishes 3D imaging by rotating a single cell around a fixed axis. However, some existing cell rotating mechanisms require either intricate microfabrication, and some fail to provide a suitable environment for living cells. This thesis develops a microvorterx chamber that allows living cells to be rotated by hydrodynamic alone while facilitating imaging access. In this thesis work, 1) the new chamber design was developed through numerical simulation. Simulations revealed that in order to form a microvortex in the side chamber, the ratio of the chamber opening to the channel width must be smaller than one. After comparing different chamber designs, the trapezoidal side chamber was selected because it demonstrated controllable circulation and met the imaging requirements. Microvortex properties were not sensitive to the chambers with interface angles ranging from 0.32 to 0.64. A similar trend was observed when chamber heights were larger than chamber opening. 2) Micro-particle image velocimetry was used to characterize microvortices and validate simulation results. Agreement between experimentation and simulation confirmed that numerical simulation was an effective method for chamber design. 3) Finally, cell rotation experiments were performed in the trapezoidal side chamber. The experimental results demonstrated cell rotational rates ranging from 12 to 29 rpm for regular cells. With a volumetric flow rate of 0.5 µL/s, an irregular cell rotated at a mean rate of 97 ± 3 rpm. Rotational rates can be changed by altering inlet flow rates.
ContributorsZhang, Wenjie (Author) / Frakes, David (Thesis advisor) / Meldrum, Deirdre (Thesis advisor) / Chao, Shih-hui (Committee member) / Wang, Xiao (Committee member) / Arizona State University (Publisher)
Created2011
Description
Image segmentation is of great importance and value in many applications. In computer vision, image segmentation is the tool and process of locating objects and boundaries within images. The segmentation result may provide more meaningful image data. Generally, there are two fundamental image segmentation algorithms: discontinuity and similarity. The idea behind discontinuity is locating the abrupt changes in intensity of images, as are often seen in edges or boundaries. Similarity subdivides an image into regions that fit the pre-defined criteria. The algorithm utilized in this thesis is the second category.
This study addresses the problem of particle image segmentation by measuring the similarity between a sampled region and an adjacent region, based on Bhattacharyya distance and an image feature extraction technique that uses distribution of local binary patterns and pattern contrasts. A boundary smoothing process is developed to improve the accuracy of the segmentation. The novel particle image segmentation algorithm is tested using four different cases of particle image velocimetry (PIV) images. The obtained experimental results of segmentations provide partitioning of the objects within 10 percent error rate. Ground-truth segmentation data, which are manually segmented image from each case, are used to calculate the error rate of the segmentations.
This study addresses the problem of particle image segmentation by measuring the similarity between a sampled region and an adjacent region, based on Bhattacharyya distance and an image feature extraction technique that uses distribution of local binary patterns and pattern contrasts. A boundary smoothing process is developed to improve the accuracy of the segmentation. The novel particle image segmentation algorithm is tested using four different cases of particle image velocimetry (PIV) images. The obtained experimental results of segmentations provide partitioning of the objects within 10 percent error rate. Ground-truth segmentation data, which are manually segmented image from each case, are used to calculate the error rate of the segmentations.
ContributorsHan, Dongmin (Author) / Frakes, David (Thesis advisor) / Adrian, Ronald (Committee member) / Turaga, Pavan (Committee member) / Arizona State University (Publisher)
Created2015
Description
With the advent of GPGPU, many applications are being accelerated by using CUDA programing paradigm. We are able to achieve around 10x -100x speedups by simply porting the application on to the GPU and running the parallel chunk of code on its multi cored SIMT (Single instruction multiple thread) architecture. But for optimal performance it is necessary to make sure that all the GPU resources are efficiently used, and the latencies in the application are minimized. For this, it is essential to monitor the Hardware usage of the algorithm and thus diagnose the compute and memory bottlenecks in the implementation. In the following thesis, we will be analyzing the mapping of CUDA implementation of BLIINDS-II algorithm on the underlying GPU hardware, and come up with a Kepler architecture specific solution of using shuffle instruction via CUB library to tackle the two major bottlenecks in the algorithm. Experiments were conducted to convey the advantage of using shuffle instru3ction in algorithm over only using shared memory as a buffer to global memory. With the new implementation of BLIINDS-II algorithm using CUB library, a speedup of around 13.7% was achieved.
ContributorsWadekar, Ameya (Author) / Sohoni, Sohum (Thesis advisor) / Aukes, Daniel (Committee member) / Redkar, Sangram (Committee member) / Arizona State University (Publisher)
Created2017
Description
In nature, some animals have an exoskeleton that provides protection, strength, and stability to the organism, but in engineering, an exoskeleton refers to a device that augments or aids human ability. However, the method of controlling these devices has been a challenge historically. Depending on the objective, control systems for exoskeletons have ranged from devices as simple spring-loaded systems to using sensors such as electromyography (EMG). Despite EMGs being very common, force sensing resistors (FSRs) can be used instead. There are multiple types of exoskeletons that target different areas of the human body, and the targeted area depends on the need of the device. Usually, the devices are developed for either medical or military usage; for this project, the focus is on medical development of an automated elbow joint to assist in rehabilitation. This thesis is a continuation of my ASU Barrett honors thesis, Upper-Extremity Exoskeleton. While working on my honors thesis, I helped develop a design for an upper extremity exoskeleton based on the Wilmer orthosis design for Mayo Clinic. Building upon the design of an orthosis, for the master’s thesis, I developed an FSR control system that is designed using a Wheatstone bridge circuit that can provide a clean reliable signal as compared to the current EMG setup.
ContributorsCarlton, Bryan (Author) / Sugar, Thomas (Thesis advisor) / Aukes, Daniel (Committee member) / Hollander, Kevin (Committee member) / Arizona State University (Publisher)
Created2023
Description
In this paper, we discuss the methods and requirements to simulate a soft bodied beam using traditional rigid body kinematics to produce motion inspired by eels. Eels produce a form of undulatory locomotion called anguilliform locomotion that propagates waves throughout the entire body. The system that we are analyzing is a flexible 3D printed beam being actively driven by a servo motor. Using the simulation, we also analyze different parameters for these spines to maximize the linear speed of the system.
ContributorsKwan, Anson (Author) / Aukes, Daniel (Thesis director) / Marvi, Hamidreza (Committee member) / Barrett, The Honors College (Contributor) / Engineering Programs (Contributor)
Created2022-05
Description
This dissertation studies the methods to enhance the performance of foldable robots manufactured by laminated techniques. This class of robots are unique in their manufacturing process, which involves cutting and staking up thin layers of different materials with various stiffness. While inheriting the advantages of soft robots -- low weight, affordable manufacturing cost and a fast prototyping process -- a wider range of actuators is available to these mechanisms, while modeling their behavior requires less computational cost.The fundamental question this dissertation strives to answer is how to decode and leverage the effect of material stiffness in these robots. These robots' stiffness is relatively limited due to their slender design, specifically at larger scales. While compliant robots may have inherent advantages such as being safer to work around, this low rigidity makes modeling more complex. This complexity is mostly contained in material deformation since the conventional actuators such as servo motors can be easily leveraged in these robots. As a result, when introduced to real-world environments, efficient modeling and control of these robots are more achievable than conventional soft robots.
Various approaches have been taken to design, model, and control a variety of laminate robot platforms by investigating the effect of material deformation in prototypes while they interact with their working environments. The results obtained show that data-driven approaches such as experimental identification and machine learning techniques are more reliable in modeling and control of these mechanisms. Also, machine learning techniques for training robots in non-ideal experimental setups that encounter the uncertainties of real-world environments can be leveraged to find effective gaits with high performance. Our studies on the effect of stiffness of thin, curved sheets of materials has evolved into introducing a new class of soft elements which we call Soft, Curved, Reconfigurable, Anisotropic Mechanisms (SCRAMs). Like bio-mechanical systems, SCRAMs are capable of re-configuring the stiffness of curved surfaces to enhance their performance and adaptability. Finally, the findings of this thesis show promising opportunities for foldable robots to become an alternative for conventional soft robots since they still offer similar advantages in a fraction of computational expense.
ContributorsSharifzadeh, Mohammad (Author) / Aukes, Daniel (Thesis advisor) / Sugar, Thomas (Committee member) / Zhang, Wenlong (Committee member) / Arizona State University (Publisher)
Created2021
Description
This thesis presents a kit of materials intended to present students with a glimpse of what engineering entails by guiding them through building engineering projects similar to what is in the real world. The objective of this project is to pique the interest of children by introducing them to lesser known engineering related topics, and increasing their literacy of terms and methods engineers use to solve problems. The effectiveness of the kit’s content and teaching methods was tested in a classroom of 6th graders and was measured using the responses from surveys handed out. I found that kit did in fact positively lead to a change in the way the students perceived engineering, and it taught students about new engineering related topics. Students were capable of completing difficult tasks of wiring and coding successfully through the use of detailed instruction. However, the instructions were seen in two opposing views of either being too overwhelming or more guidance was necessary.
ContributorsQuezada, Hebellyn Arleth (Author) / Aukes, Daniel (Thesis director) / Kellam, Nadia (Committee member) / Engineering Programs (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
ContributorsKwan, Anson (Author) / Aukes, Daniel (Thesis director) / Marvi, Hamidreza (Committee member) / Barrett, The Honors College (Contributor) / Engineering Programs (Contributor)
Created2022-05