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Description
Concussion, a subset of mild traumatic brain injury (mTBI), has recently been brought to the forefront of the media due to a large lawsuit filed against the National Football League. Concussion resulting from injury varies in severity, duration, and type, based on many characteristics about the individual that research does not presently understand. Chronic fatigue, poor working memory, impaired self-awareness, and lack of attention to task are symptoms commonly present post-concussion. Currently, there is not a standard method of assessing concussion, nor is there a way to track an individual's recovery, resulting in misguided treatment for better prognosis. The aim of the following study was to determine patient specific higher-order cognitive processing deficits for clinical diagnosis and prognosis of concussion. Six individuals (N=6) were seen during the acute phase of concussion, two of whom were seen subsequently when their symptoms were deemed clinically resolved. Subjective information was collected from both the patient and from neurology testing. Each individual completed a task, in which they were presented with degraded speech, taxing their higher-order cognitive processing. Patient specific behavioral patterns are noted, creating a unique paradigm for mapping subjective and objective data for each patient's strategy to compensate for deficits and understand speech in a difficult listening situation. Keywords: concussion, cognitive processing
ContributorsBerg, Dena (Author) / Liss, Julie M (Committee member) / Azuma, Tamiko (Committee member) / Caviness, John (Committee member) / Arizona State University (Publisher)
Created2013
Description
The recent spotlight on concussion has illuminated deficits in the current standard of care with regard to addressing acute and persistent cognitive signs and symptoms of mild brain injury. This stems, in part, from the diffuse nature of the injury, which tends not to produce focal cognitive or behavioral deficits that are easily identified or tracked. Indeed it has been shown that patients with enduring symptoms have difficulty describing their problems; therefore, there is an urgent need for a sensitive measure of brain activity that corresponds with higher order cognitive processing. The development of a neurophysiological metric that maps to clinical resolution would inform decisions about diagnosis and prognosis, including the need for clinical intervention to address cognitive deficits. The literature suggests the need for assessment of concussion under cognitively demanding tasks. Here, a joint behavioral- high-density electroencephalography (EEG) paradigm was employed. This allows for the examination of cortical activity patterns during speech comprehension at various levels of degradation in a sentence verification task, imposing the need for higher-order cognitive processes. Eight participants with concussion listened to true-false sentences produced with either moderately to highly intelligible noise-vocoders. Behavioral data were simultaneously collected. The analysis of cortical activation patterns included 1) the examination of event-related potentials, including latency and source localization, and 2) measures of frequency spectra and associated power. Individual performance patterns were assessed during acute injury and a return visit several months following injury. Results demonstrate a combination of task-related electrophysiology measures correspond to changes in task performance during the course of recovery. Further, a discriminant function analysis suggests EEG measures are more sensitive than behavioral measures in distinguishing between individuals with concussion and healthy controls at both injury and recovery, suggesting the robustness of neurophysiological measures during a cognitively demanding task to both injury and persisting pathophysiology.
ContributorsUtianski, Rene (Author) / Liss, Julie M (Thesis advisor) / Berisha, Visar (Committee member) / Caviness, John N (Committee member) / Dorman, Michael (Committee member) / Arizona State University (Publisher)
Created2014
Description
This work considers the problem of multiple detection and tracking in two complex time-varying environments, urban terrain and underwater. Tracking multiple radar targets in urban environments is rst investigated by exploiting multipath signal returns, wideband underwater acoustic (UWA) communications channels are estimated using adaptive learning methods, and multiple UWA communications users are detected by designing the transmit signal to match the environment. For the urban environment, a multi-target tracking algorithm is proposed that integrates multipath-to-measurement association and the probability hypothesis density method implemented using particle filtering. The algorithm is designed to track an unknown time-varying number of targets by extracting information from multiple measurements due to multipath returns in the urban terrain. The path likelihood probability is calculated by considering associations between measurements and multipath returns, and an adaptive clustering algorithm is used to estimate the number of target and their corresponding parameters. The performance of the proposed algorithm is demonstrated for different multiple target scenarios and evaluated using the optimal subpattern assignment metric. The underwater environment provides a very challenging communication channel due to its highly time-varying nature, resulting in large distortions due to multipath and Doppler-scaling, and frequency-dependent path loss. A model-based wideband UWA channel estimation algorithm is first proposed to estimate the channel support and the wideband spreading function coefficients. A nonlinear frequency modulated signaling scheme is proposed that is matched to the wideband characteristics of the underwater environment. Constraints on the signal parameters are derived to optimally reduce multiple access interference and the UWA channel effects. The signaling scheme is compared to a code division multiple access (CDMA) scheme to demonstrate its improved bit error rate performance. The overall multi-user communication system performance is finally analyzed by first estimating the UWA channel and then designing the signaling scheme for multiple communications users.
ContributorsZhou, Meng (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Tepedelenlioğlu, Cihan (Committee member) / Kovvali, Narayan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2014
Description
The ability to identify unoccupied resources in the radio spectrum is a key capability for opportunistic users in a cognitive radio environment. This paper draws upon and extends geometrically based ideas in statistical signal processing to develop estimators for the rank and the occupied subspace in a multi-user environment from multiple temporal samples of the signal received at a single antenna. These estimators enable identification of resources, such as the orthogonal complement of the occupied subspace, that may be exploitable by an opportunistic user. This concept is supported by simulations showing the estimation of the number of users in a simple CDMA system using a maximum a posteriori (MAP) estimate for the rank. It was found that with suitable parameters, such as high SNR, sufficient number of time epochs and codes of appropriate length, the number of users could be correctly estimated using the MAP estimator even when the noise variance is unknown. Additionally, the process of identifying the maximum likelihood estimate of the orthogonal projector onto the unoccupied subspace is discussed.
ContributorsBeaudet, Kaitlyn (Author) / Cochran, Douglas (Thesis advisor) / Turaga, Pavan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2014
Description
Information divergence functions, such as the Kullback-Leibler divergence or the Hellinger distance, play a critical role in statistical signal processing and information theory; however estimating them can be challenge. Most often, parametric assumptions are made about the two distributions to estimate the divergence of interest. In cases where no parametric model fits the data, non-parametric density estimation is used. In statistical signal processing applications, Gaussianity is usually assumed since closed-form expressions for common divergence measures have been derived for this family of distributions. Parametric assumptions are preferred when it is known that the data follows the model, however this is rarely the case in real-word scenarios. Non-parametric density estimators are characterized by a very large number of parameters that have to be tuned with costly cross-validation. In this dissertation we focus on a specific family of non-parametric estimators, called direct estimators, that bypass density estimation completely and directly estimate the quantity of interest from the data. We introduce a new divergence measure, the $D_p$-divergence, that can be estimated directly from samples without parametric assumptions on the distribution. We show that the $D_p$-divergence bounds the binary, cross-domain, and multi-class Bayes error rates and, in certain cases, provides provably tighter bounds than the Hellinger divergence. In addition, we also propose a new methodology that allows the experimenter to construct direct estimators for existing divergence measures or to construct new divergence measures with custom properties that are tailored to the application. To examine the practical efficacy of these new methods, we evaluate them in a statistical learning framework on a series of real-world data science problems involving speech-based monitoring of neuro-motor disorders.
ContributorsWisler, Alan (Author) / Berisha, Visar (Thesis advisor) / Spanias, Andreas (Thesis advisor) / Liss, Julie (Committee member) / Bliss, Daniel (Committee member) / Arizona State University (Publisher)
Created2017
Description
Dealing with relational data structures is central to a wide-range of applications including social networks, epidemic modeling, molecular chemistry, medicine, energy distribution, and transportation. Machine learning models that can exploit the inherent structural/relational bias in the graph structured data have gained prominence in recent times. A recurring idea that appears in all approaches is to encode the nodes in the graph (or the entire graph) as low-dimensional vectors also known as embeddings, prior to carrying out downstream task-specific learning. It is crucial to eliminate hand-crafted features and instead directly incorporate the structural inductive bias into the deep learning architectures.
In this dissertation, deep learning models that directly operate on graph structured data are proposed for effective representation learning. A literature review on existing graph representation learning is provided in the beginning of the dissertation. The primary focus of dissertation is on building novel graph neural network architectures that are robust against adversarial attacks. The proposed graph neural network models are extended to multiplex graphs (heterogeneous graphs). Finally, a relational neural network model is proposed to operate on a human structural connectome. For every research contribution of this dissertation, several empirical studies are conducted on benchmark datasets. The proposed graph neural network models, approaches, and architectures demonstrate significant performance improvements in comparison to the existing state-of-the-art graph embedding strategies.
ContributorsShanthamallu, Uday Shankar (Author) / Spanias, Andreas (Thesis advisor) / Thiagarajan, Jayaraman J (Committee member) / Tepedelenlioğlu, Cihan (Committee member) / Berisha, Visar (Committee member) / Arizona State University (Publisher)
Created2021
Description
Severe forms of mental illness, such as schizophrenia and bipolar disorder, are debilitating conditions that negatively impact an individual's quality of life. Additionally, they are often difficult and expensive to diagnose and manage, placing a large burden on society. Mental illness is typically diagnosed by the use of clinical interviews and a set of neuropsychiatric batteries; a key component of nearly all of these evaluations is some spoken language task. Clinicians have long used speech and language production as a proxy for neurological health, but most of these assessments are subjective in nature. Meanwhile, technological advancements in speech and natural language processing have grown exponentially over the past decade, increasing the capacity of computer models to assess particular aspects of speech and language. For this reason, many have seen an opportunity to leverage signal processing and machine learning applications to objectively assess clinical speech samples in order to automatically compute objective measures of neurological health. This document summarizes several contributions to expand upon this body of research. Mainly, there is still a large gap between the theoretical power of computational language models and their actual use in clinical applications. One of the largest concerns is the limited and inconsistent reliability of speech and language features used in models for assessing specific aspects of mental health; numerous methods may exist to measure the same or similar constructs and lead researchers to different conclusions in different studies. To address this, a novel measurement model based on a theoretical framework of speech production is used to motivate feature selection, while also performing a smoothing operation on features across several domains of interest. Then, these composite features are used to perform a much wider range of analyses than is typical of previous studies, looking at everything from diagnosis to functional competency assessments. Lastly, potential improvements to address practical implementation challenges associated with the use of speech and language technology in a real-world environment are investigated. The goal of this work is to demonstrate the ability of speech and language technology to aid clinical practitioners toward improvements in quality of life outcomes for their patients.
ContributorsVoleti, Rohit Nihar Uttam (Author) / Berisha, Visar (Thesis advisor) / Liss, Julie M (Thesis advisor) / Turaga, Pavan (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2022
Description
Spatial audio can be especially useful for directing human attention. However, delivering spatial audio through speakers, rather than headphones that deliver audio directly to the ears, produces the issue of crosstalk, where sounds from each of the two speakers reach the opposite ear, inhibiting the spatialized effect. A research team at Meteor Studio has developed an algorithm called Xblock that solves this issue using a crosstalk cancellation technique. This thesis project expands upon the existing Xblock IoT system by providing a way to test the accuracy of the directionality of sounds generated with spatial audio. More specifically, the objective is to determine whether the usage of Xblock with smart speakers can provide generalized audio localization, which refers to the ability to detect a general direction of where a sound might be coming from. This project also expands upon the existing Xblock technique to integrate voice commands, where users can verbalize the name of a lost item using the phrase, “Find [item]”, and the IoT system will use spatial audio to guide them to it.
ContributorsSong, Lucy (Author) / LiKamWa, Robert (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2022-05
Description
Spatial audio can be especially useful for directing human attention. However, delivering spatial audio through speakers, rather than headphones that deliver audio directly to the ears, produces the issue of crosstalk, where sounds from each of the two speakers reach the opposite ear, inhibiting the spatialized effect. A research team at Meteor Studio has developed an algorithm called Xblock that solves this issue using a crosstalk cancellation technique. This thesis project expands upon the existing Xblock IoT system by providing a way to test the accuracy of the directionality of sounds generated with spatial audio. More specifically, the objective is to determine whether the usage of Xblock with smart speakers can provide generalized audio localization, which refers to the ability to detect a general direction of where a sound might be coming from. This project also expands upon the existing Xblock technique to integrate voice commands, where users can verbalize the name of a lost item using the phrase, “Find [item]”, and the IoT system will use spatial audio to guide them to it.
ContributorsSong, Lucy (Author) / LiKamWa, Robert (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2022-05
Description
Spatial audio can be especially useful for directing human attention. However, delivering spatial audio through speakers, rather than headphones that deliver audio directly to the ears, produces the issue of crosstalk, where sounds from each of the two speakers reach the opposite ear, inhibiting the spatialized effect. A research team at Meteor Studio has developed an algorithm called Xblock that solves this issue using a crosstalk cancellation technique. This thesis project expands upon the existing Xblock IoT system by providing a way to test the accuracy of the directionality of sounds generated with spatial audio. More specifically, the objective is to determine whether the usage of Xblock with smart speakers can provide generalized audio localization, which refers to the ability to detect a general direction of where a sound might be coming from. This project also expands upon the existing Xblock technique to integrate voice commands, where users can verbalize the name of a lost item using the phrase, “Find [item]”, and the IoT system will use spatial audio to guide them to it.
ContributorsSong, Lucy (Author) / LiKamWa, Robert (Thesis director) / Berisha, Visar (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2022-05