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Functional or dynamic responses are prevalent in experiments in the fields of engineering, medicine, and the sciences, but proposals for optimal designs are still sparse for this type of response. Experiments with dynamic responses result in multiple responses taken over a spectrum variable, so the design matrix for a dynamic

Functional or dynamic responses are prevalent in experiments in the fields of engineering, medicine, and the sciences, but proposals for optimal designs are still sparse for this type of response. Experiments with dynamic responses result in multiple responses taken over a spectrum variable, so the design matrix for a dynamic response have more complicated structures. In the literature, the optimal design problem for some functional responses has been solved using genetic algorithm (GA) and approximate design methods. The goal of this dissertation is to develop fast computer algorithms for calculating exact D-optimal designs.



First, we demonstrated how the traditional exchange methods could be improved to generate a computationally efficient algorithm for finding G-optimal designs. The proposed two-stage algorithm, which is called the cCEA, uses a clustering-based approach to restrict the set of possible candidates for PEA, and then improves the G-efficiency using CEA.



The second major contribution of this dissertation is the development of fast algorithms for constructing D-optimal designs that determine the optimal sequence of stimuli in fMRI studies. The update formula for the determinant of the information matrix was improved by exploiting the sparseness of the information matrix, leading to faster computation times. The proposed algorithm outperforms genetic algorithm with respect to computational efficiency and D-efficiency.



The third contribution is a study of optimal experimental designs for more general functional response models. First, the B-spline system is proposed to be used as the non-parametric smoother of response function and an algorithm is developed to determine D-optimal sampling points of a spectrum variable. Second, we proposed a two-step algorithm for finding the optimal design for both sampling points and experimental settings. In the first step, the matrix of experimental settings is held fixed while the algorithm optimizes the determinant of the information matrix for a mixed effects model to find the optimal sampling times. In the second step, the optimal sampling times obtained from the first step is held fixed while the algorithm iterates on the information matrix to find the optimal experimental settings. The designs constructed by this approach yield superior performance over other designs found in literature.
ContributorsSaleh, Moein (Author) / Pan, Rong (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Runger, George C. (Committee member) / Kao, Ming-Hung (Committee member) / Arizona State University (Publisher)
Created2015
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Description
Mixture experiments are useful when the interest is in determining how changes in the proportion of an experimental component affects the response. This research focuses on the modeling and design of mixture experiments when the response is categorical namely, binary and ordinal. Data from mixture experiments is characterized by

Mixture experiments are useful when the interest is in determining how changes in the proportion of an experimental component affects the response. This research focuses on the modeling and design of mixture experiments when the response is categorical namely, binary and ordinal. Data from mixture experiments is characterized by the perfect collinearity of the experimental components, resulting in model matrices that are singular and inestimable under likelihood estimation procedures. To alleviate problems with estimation, this research proposes the reparameterization of two nonlinear models for ordinal data -- the proportional-odds model with a logistic link and the stereotype model. A study involving subjective ordinal responses from a mixture experiment demonstrates that the stereotype model reveals useful information about the relationship between mixture components and the ordinality of the response, which the proportional-odds fails to detect.

The second half of this research deals with the construction of exact D-optimal designs for binary and ordinal responses. For both types, the base models fall under the class of Generalized Linear Models (GLMs) with a logistic link. First, the properties of the exact D-optimal mixture designs for binary responses are investigated. It will be shown that standard mixture designs and designs proposed for normal-theory responses are poor surrogates for the true D-optimal designs. In contrast with the D-optimal designs for normal-theory responses which locate support points at the boundaries of the mixture region, exact D-optimal designs for GLMs tend to locate support points at regions of uncertainties. Alternate D-optimal designs for binary responses with high D-efficiencies are proposed by utilizing information about these regions.

The Mixture Exchange Algorithm (MEA), a search heuristic tailored to the construction of efficient mixture designs with GLM-type responses, is proposed. MEA introduces a new and efficient updating formula that lessens the computational expense of calculating the D-criterion for multi-categorical response systems, such as ordinal response models. MEA computationally outperforms comparable search heuristics by several orders of magnitude. Further, its computational expense increases at a slower rate of growth with increasing problem size. Finally, local and robust D-optimal designs for ordinal-response mixture systems are constructed using MEA, investigated, and shown to have high D-efficiency performance.
ContributorsMancenido, Michelle V (Author) / Montgomery, Douglas C. (Thesis advisor) / Pan, Rong (Thesis advisor) / Borror, Connie M. (Committee member) / Shunk, Dan L. (Committee member) / Arizona State University (Publisher)
Created2016
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Description
The majority of research in experimental design has, to date, been focused on designs when there is only one type of response variable under consideration. In a decision-making process, however, relying on only one objective or criterion can lead to oversimplified, sub-optimal decisions that ignore important considerations. Incorporating multiple, and

The majority of research in experimental design has, to date, been focused on designs when there is only one type of response variable under consideration. In a decision-making process, however, relying on only one objective or criterion can lead to oversimplified, sub-optimal decisions that ignore important considerations. Incorporating multiple, and likely competing, objectives is critical during the decision-making process in order to balance the tradeoffs of all potential solutions. Consequently, the problem of constructing a design for an experiment when multiple types of responses are of interest does not have a clear answer, particularly when the response variables have different distributions. Responses with different distributions have different requirements of the design.

Computer-generated optimal designs are popular design choices for less standard scenarios where classical designs are not ideal. This work presents a new approach to experimental designs for dual-response systems. The normal, binomial, and Poisson distributions are considered for the potential responses. Using the D-criterion for the linear model and the Bayesian D-criterion for the nonlinear models, a weighted criterion is implemented in a coordinate-exchange algorithm. The designs are evaluated and compared across different weights. The sensitivity of the designs to the priors supplied in the Bayesian D-criterion is explored in the third chapter of this work.

The final section of this work presents a method for a decision-making process involving multiple objectives. There are situations where a decision-maker is interested in several optimal solutions, not just one. These types of decision processes fall into one of two scenarios: 1) wanting to identify the best N solutions to accomplish a goal or specific task, or 2) evaluating a decision based on several primary quantitative objectives along with secondary qualitative priorities. Design of experiment selection often involves the second scenario where the goal is to identify several contending solutions using the primary quantitative objectives, and then use the secondary qualitative objectives to guide the final decision. Layered Pareto Fronts can help identify a richer class of contenders to examine more closely. The method is illustrated with a supersaturated screening design example.
ContributorsBurke, Sarah Ellen (Author) / Montgomery, Douglas C. (Thesis advisor) / Borror, Connie M. (Thesis advisor) / Anderson-Cook, Christine M. (Committee member) / Pan, Rong (Committee member) / Silvestrini, Rachel (Committee member) / Arizona State University (Publisher)
Created2016
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Description
Technological advances have enabled the generation and collection of various data from complex systems, thus, creating ample opportunity to integrate knowledge in many decision making applications. This dissertation introduces holistic learning as the integration of a comprehensive set of relationships that are used towards the learning objective. The holistic view

Technological advances have enabled the generation and collection of various data from complex systems, thus, creating ample opportunity to integrate knowledge in many decision making applications. This dissertation introduces holistic learning as the integration of a comprehensive set of relationships that are used towards the learning objective. The holistic view of the problem allows for richer learning from data and, thereby, improves decision making.

The first topic of this dissertation is the prediction of several target attributes using a common set of predictor attributes. In a holistic learning approach, the relationships between target attributes are embedded into the learning algorithm created in this dissertation. Specifically, a novel tree based ensemble that leverages the relationships between target attributes towards constructing a diverse, yet strong, model is proposed. The method is justified through its connection to existing methods and experimental evaluations on synthetic and real data.

The second topic pertains to monitoring complex systems that are modeled as networks. Such systems present a rich set of attributes and relationships for which holistic learning is important. In social networks, for example, in addition to friendship ties, various attributes concerning the users' gender, age, topic of messages, time of messages, etc. are collected. A restricted form of monitoring fails to take the relationships of multiple attributes into account, whereas the holistic view embeds such relationships in the monitoring methods. The focus is on the difficult task to detect a change that might only impact a small subset of the network and only occur in a sub-region of the high-dimensional space of the network attributes. One contribution is a monitoring algorithm based on a network statistical model. Another contribution is a transactional model that transforms the task into an expedient structure for machine learning, along with a generalizable algorithm to monitor the attributed network. A learning step in this algorithm adapts to changes that may only be local to sub-regions (with a broader potential for other learning tasks). Diagnostic tools to interpret the change are provided. This robust, generalizable, holistic monitoring method is elaborated on synthetic and real networks.
ContributorsAzarnoush, Bahareh (Author) / Runger, George C. (Thesis advisor) / Bekki, Jennifer (Thesis advisor) / Pan, Rong (Committee member) / Saghafian, Soroush (Committee member) / Arizona State University (Publisher)
Created2014
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Description
This thesis presents a meta-analysis of lead-free solder reliability. The qualitative analyses of the failure modes of lead- free solder under different stress tests including drop test, bend test, thermal test and vibration test are discussed. The main cause of failure of lead- free solder is fatigue crack, and the

This thesis presents a meta-analysis of lead-free solder reliability. The qualitative analyses of the failure modes of lead- free solder under different stress tests including drop test, bend test, thermal test and vibration test are discussed. The main cause of failure of lead- free solder is fatigue crack, and the speed of propagation of the initial crack could differ from different test conditions and different solder materials. A quantitative analysis about the fatigue behavior of SAC lead-free solder under thermal preconditioning process is conducted. This thesis presents a method of making prediction of failure life of solder alloy by building a Weibull regression model. The failure life of solder on circuit board is assumed Weibull distributed. Different materials and test conditions could affect the distribution by changing the shape and scale parameters of Weibull distribution. The method is to model the regression of parameters with different test conditions as predictors based on Bayesian inference concepts. In the process of building regression models, prior distributions are generated according to the previous studies, and Markov Chain Monte Carlo (MCMC) is used under WinBUGS environment.
ContributorsXu, Xinyue (Author) / Pan, Rong (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2014
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Description
In this era of fast computational machines and new optimization algorithms, there have been great advances in Experimental Designs. We focus our research on design issues in generalized linear models (GLMs) and functional magnetic resonance imaging(fMRI). The first part of our research is on tackling the challenging problem of constructing

exact

In this era of fast computational machines and new optimization algorithms, there have been great advances in Experimental Designs. We focus our research on design issues in generalized linear models (GLMs) and functional magnetic resonance imaging(fMRI). The first part of our research is on tackling the challenging problem of constructing

exact designs for GLMs, that are robust against parameter, link and model

uncertainties by improving an existing algorithm and providing a new one, based on using a continuous particle swarm optimization (PSO) and spectral clustering. The proposed algorithm is sufficiently versatile to accomodate most popular design selection criteria, and we concentrate on providing robust designs for GLMs, using the D and A optimality criterion. The second part of our research is on providing an algorithm

that is a faster alternative to a recently proposed genetic algorithm (GA) to construct optimal designs for fMRI studies. Our algorithm is built upon a discrete version of the PSO.
ContributorsTemkit, M'Hamed (Author) / Kao, Jason (Thesis advisor) / Reiser, Mark R. (Committee member) / Barber, Jarrett (Committee member) / Montgomery, Douglas C. (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2014
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Description
The main objective of this research is to develop an approach to PV module lifetime prediction. In doing so, the aim is to move from empirical generalizations to a formal predictive science based on data-driven case studies of the crystalline silicon PV systems. The evaluation of PV systems aged 5

The main objective of this research is to develop an approach to PV module lifetime prediction. In doing so, the aim is to move from empirical generalizations to a formal predictive science based on data-driven case studies of the crystalline silicon PV systems. The evaluation of PV systems aged 5 to 30 years old that results in systematic predictive capability that is absent today. The warranty period provided by the manufacturers typically range from 20 to 25 years for crystalline silicon modules. The end of lifetime (for example, the time-to-degrade by 20% from rated power) of PV modules is usually calculated using a simple linear extrapolation based on the annual field degradation rate (say, 0.8% drop in power output per year). It has been 26 years since systematic studies on solar PV module lifetime prediction were undertaken as part of the 11-year flat-plate solar array (FSA) project of the Jet Propulsion Laboratory (JPL) funded by DOE. Since then, PV modules have gone through significant changes in construction materials and design; making most of the field data obsolete, though the effect field stressors on the old designs/materials is valuable to be understood. Efforts have been made to adapt some of the techniques developed to the current technologies, but they are too often limited in scope and too reliant on empirical generalizations of previous results. Some systematic approaches have been proposed based on accelerated testing, but no or little experimental studies have followed. Consequently, the industry does not exactly know today how to test modules for a 20 - 30 years lifetime.

This research study focuses on the behavior of crystalline silicon PV module technology in the dry and hot climatic condition of Tempe/Phoenix, Arizona. A three-phase approach was developed: (1) A quantitative failure modes, effects, and criticality analysis (FMECA) was developed for prioritizing failure modes or mechanisms in a given environment; (2) A time-series approach was used to model environmental stress variables involved and prioritize their effect on the power output drop; and (3) A procedure for developing a prediction model was proposed for the climatic specific condition based on accelerated degradation testing
ContributorsKuitche, Joseph Mathurin (Author) / Pan, Rong (Thesis advisor) / Tamizhmani, Govindasamy (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2014
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Description
Healthcare operations have enjoyed reduced costs, improved patient safety, and

innovation in healthcare policy over a huge variety of applications by tackling prob-

lems via the creation and optimization of descriptive mathematical models to guide

decision-making. Despite these accomplishments, models are stylized representations

of real-world applications, reliant on accurate estimations from historical data to

Healthcare operations have enjoyed reduced costs, improved patient safety, and

innovation in healthcare policy over a huge variety of applications by tackling prob-

lems via the creation and optimization of descriptive mathematical models to guide

decision-making. Despite these accomplishments, models are stylized representations

of real-world applications, reliant on accurate estimations from historical data to jus-

tify their underlying assumptions. To protect against unreliable estimations which

can adversely affect the decisions generated from applications dependent on fully-

realized models, techniques that are robust against misspecications are utilized while

still making use of incoming data for learning. Hence, new robust techniques are ap-

plied that (1) allow for the decision-maker to express a spectrum of pessimism against

model uncertainties while (2) still utilizing incoming data for learning. Two main ap-

plications are investigated with respect to these goals, the first being a percentile

optimization technique with respect to a multi-class queueing system for application

in hospital Emergency Departments. The second studies the use of robust forecasting

techniques in improving developing countries’ vaccine supply chains via (1) an inno-

vative outside of cold chain policy and (2) a district-managed approach to inventory

control. Both of these research application areas utilize data-driven approaches that

feature learning and pessimism-controlled robustness.
ContributorsBren, Austin (Author) / Saghafian, Soroush (Thesis advisor) / Mirchandani, Pitu (Thesis advisor) / Wu, Teresa (Committee member) / Pan, Rong (Committee member) / Arizona State University (Publisher)
Created2018
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Description
In accelerated life tests (ALTs), complete randomization is hardly achievable because of economic and engineering constraints. Typical experimental protocols such as subsampling or random blocks in ALTs result in a grouped structure, which leads to correlated lifetime observations. In this dissertation, generalized linear mixed model (GLMM) approach is proposed to

In accelerated life tests (ALTs), complete randomization is hardly achievable because of economic and engineering constraints. Typical experimental protocols such as subsampling or random blocks in ALTs result in a grouped structure, which leads to correlated lifetime observations. In this dissertation, generalized linear mixed model (GLMM) approach is proposed to analyze ALT data and find the optimal ALT design with the consideration of heterogeneous group effects.

Two types of ALTs are demonstrated for data analysis. First, constant-stress ALT (CSALT) data with Weibull failure time distribution is modeled by GLMM. The marginal likelihood of observations is approximated by the quadrature rule; and the maximum likelihood (ML) estimation method is applied in iterative fashion to estimate unknown parameters including the variance component of random effect. Secondly, step-stress ALT (SSALT) data with random group effects is analyzed in similar manner but with an assumption of exponentially distributed failure time in each stress step. Two parameter estimation methods, from the frequentist’s and Bayesian points of view, are applied; and they are compared with other traditional models through simulation study and real example of the heterogeneous SSALT data. The proposed random effect model shows superiority in terms of reducing bias and variance in the estimation of life-stress relationship.

The GLMM approach is particularly useful for the optimal experimental design of ALT while taking the random group effects into account. In specific, planning ALTs under nested design structure with random test chamber effects are studied. A greedy two-phased approach shows that different test chamber assignments to stress conditions substantially impact on the estimation of unknown parameters. Then, the D-optimal test plan with two test chambers is constructed by applying the quasi-likelihood approach. Lastly, the optimal ALT planning is expanded for the case of multiple sources of random effects so that the crossed design structure is also considered, along with the nested structure.
ContributorsSeo, Kangwon (Author) / Pan, Rong (Thesis advisor) / Montgomery, Douglas C. (Committee member) / Villalobos, J. Rene (Committee member) / Rigdon, Steven E (Committee member) / Arizona State University (Publisher)
Created2017
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Description
Distributed Renewable energy generators are now contributing a significant amount of energy into the energy grid. Consequently, reliability adequacy of such energy generators will depend on making accurate forecasts of energy produced by them. Power outputs of Solar PV systems depend on the stochastic variation of environmental factors (solar irradiance,

Distributed Renewable energy generators are now contributing a significant amount of energy into the energy grid. Consequently, reliability adequacy of such energy generators will depend on making accurate forecasts of energy produced by them. Power outputs of Solar PV systems depend on the stochastic variation of environmental factors (solar irradiance, ambient temperature & wind speed) and random mechanical failures/repairs. Monte Carlo Simulation which is typically used to model such problems becomes too computationally intensive leading to simplifying state-space assumptions. Multi-state models for power system reliability offer a higher flexibility in providing a description of system state evolution and an accurate representation of probability. In this study, Universal Generating Functions (UGF) were used to solve such combinatorial problems. 8 grid connected Solar PV systems were analyzed with a combined capacity of about 5MW located in a hot-dry climate (Arizona) and accuracy of 98% was achieved when validated with real-time data. An analytics framework is provided to grid operators and utilities to effectively forecast energy produced by distributed energy assets and in turn, develop strategies for effective Demand Response in times of increased share of renewable distributed energy assets in the grid. Second part of this thesis extends the environmental modelling approach to develop an aging test to be run in conjunction with an accelerated test of Solar PV modules. Accelerated Lifetime Testing procedures in the industry are used to determine the dominant failure modes which the product undergoes in the field, as well as predict the lifetime of the product. UV stressor is one of the ten stressors which a PV module undergoes in the field. UV exposure causes browning of modules leading to drop in Short Circuit Current. This thesis presents an environmental modelling approach for the hot-dry climate and extends it to develop an aging test methodology. This along with the accelerated tests would help achieve the goal of correlating field failures with accelerated tests and obtain acceleration factor. This knowledge would help predict PV module degradation in the field within 30% of the actual value and help in knowing the PV module lifetime accurately.
ContributorsKadloor, Nikhil (Author) / Kuitche, Joseph (Thesis advisor) / Pan, Rong (Thesis advisor) / Wu, Teresa (Committee member) / Arizona State University (Publisher)
Created2017