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Description
In the search for chemical biosensors designed for patient-based physiological applications, non-invasive diagnostic approaches continue to have value. The work described in this thesis builds upon previous breath analysis studies. In particular, it seeks to assess the adsorptive mechanisms active in both acetone and ethanol biosensors designed for breath analysis. The thermoelectric biosensors under investigation were constructed using a thermopile for transduction and four different materials for biorecognition. The analytes, acetone and ethanol, were evaluated under dry-air and humidified-air conditions. The biosensor response to acetone concentration was found to be both repeatable and linear, while the sensor response to ethanol presence was also found to be repeatable. The different biorecognition materials produced discernible thermoelectric responses that were characteristic for each analyte. The sensor output data is presented in this report. Additionally, the results were evaluated against a mathematical model for further analysis. Ultimately, a thermoelectric biosensor based upon adsorption chemistry was developed and characterized. Additional work is needed to characterize the physicochemical action mechanism.
ContributorsWilson, Kimberly (Author) / Guilbeau, Eric (Thesis advisor) / Pizziconi, Vincent (Thesis advisor) / LaBelle, Jeffrey (Committee member) / Arizona State University (Publisher)
Created2011
Description
Volume depletion can lead to migraines, dizziness, and significant decreases in a subject's ability to physically perform. A major cause of volume depletion is dehydration, or loss in fluids due to an imbalance in fluid intake to fluid excretion. Because proper levels of hydration are necessary in order to maintain both short and long term health, the ability to monitor hydration levels is growing in clinical demand. Although devices capable of monitoring hydration level exist, these devices are expensive, invasive, or inaccurate and do not offer a continuous mode of measurement. The ideal hydration monitor for consumer use needs to be characterized by its portability, affordability, and accuracy. Also, this device would need to be noninvasive and offer continuous hydration monitoring in order to accurately assess fluctuations in hydration data throughout a specified time period. One particular method for hydration monitoring that fits the majority of these criteria is known as bioelectric impedance analysis (BIA). Although current devices using BIA do not provide acceptable levels of accuracy, portability, or continuity in data collection, BIA could potentially be modified to fit many, if not all, desired customer specifications. The analysis presented here assesses the viability of using BIA as a new standard in hydration level measurement. The analysis uses data collected from 22 subjects using an existing device that employs BIA. A regression derived for estimating TBW based on the parameters of age, weight, height, sex, and impedance is presented. Using impedance data collected for each subject, a regression was also derived for estimating impedance based on the factors of age, weight, height, and sex. The derived regression was then used to calculate a new impedance value for each subject, and these new impedance values were used to estimate TBW. Through a paired-t test between the TBW values derived by using the direct measurements versus the calculated measurements of impedance, the two samples were found to be comparable. Considerations for BIA as a noninvasive measurement of hydration are discussed.
ContributorsTenorio, Jorge Antonio (Author) / LaBelle, Jeffrey (Thesis director) / Pizziconi, Vincent (Committee member) / Spano, Mark (Committee member) / Barrett, The Honors College (Contributor) / W. P. Carey School of Business (Contributor) / Harrington Bioengineering Program (Contributor)
Created2013-05
Description
Modern intelligent transportation systems (ITS) make driving more efficient, easier, and safer. Knowledge of real-time traffic conditions is a critical input for operating ITS. Real-time freeway traffic state estimation approaches have been used to quantify traffic conditions given limited amount of data collected by traffic sensors. Currently, almost all real-time estimation methods have been developed for estimating laterally aggregated traffic conditions in a roadway segment using link-based models which assume homogeneous conditions across multiple lanes. However, with new advances and applications of ITS, knowledge of lane-based traffic conditions is becoming important, where the traffic condition differences among lanes are recognized. In addition, most of the current real-time freeway traffic estimators consider only data from loop detectors. This dissertation develops a bi-level data fusion approach using heterogeneous multi-sensor measurements to estimate real-time lane-based freeway traffic conditions, which integrates a link-level model-based estimator and a lane-level data-driven estimator.
Macroscopic traffic flow models describe the evolution of aggregated traffic characteristics over time and space, which are required by model-based traffic estimation approaches. Since current first-order Lagrangian macroscopic traffic flow model has some unrealistic implicit assumptions (e.g., infinite acceleration), a second-order Lagrangian macroscopic traffic flow model has been developed by incorporating drivers’ anticipation and reaction delay. A multi-sensor extended Kalman filter (MEKF) algorithm has been developed to combine heterogeneous measurements from multiple sources. A MEKF-based traffic estimator, explicitly using the developed second-order traffic flow model and measurements from loop detectors as well as GPS trajectories for given fractions of vehicles, has been proposed which gives real-time link-level traffic estimates in the bi-level estimation system.
The lane-level estimation in the bi-level data fusion system uses the link-level estimates as priors and adopts a data-driven approach to obtain lane-based estimates, where now heterogeneous multi-sensor measurements are combined using parallel spatial-temporal filters.
Experimental analysis shows that the second-order model can more realistically reproduce real world traffic flow patterns (e.g., stop-and-go waves). The MEKF-based link-level estimator exhibits more accurate results than the estimator that uses only a single data source. Evaluation of the lane-level estimator demonstrates that the proposed new bi-level multi-sensor data fusion system can provide very good estimates of real-time lane-based traffic conditions.
Macroscopic traffic flow models describe the evolution of aggregated traffic characteristics over time and space, which are required by model-based traffic estimation approaches. Since current first-order Lagrangian macroscopic traffic flow model has some unrealistic implicit assumptions (e.g., infinite acceleration), a second-order Lagrangian macroscopic traffic flow model has been developed by incorporating drivers’ anticipation and reaction delay. A multi-sensor extended Kalman filter (MEKF) algorithm has been developed to combine heterogeneous measurements from multiple sources. A MEKF-based traffic estimator, explicitly using the developed second-order traffic flow model and measurements from loop detectors as well as GPS trajectories for given fractions of vehicles, has been proposed which gives real-time link-level traffic estimates in the bi-level estimation system.
The lane-level estimation in the bi-level data fusion system uses the link-level estimates as priors and adopts a data-driven approach to obtain lane-based estimates, where now heterogeneous multi-sensor measurements are combined using parallel spatial-temporal filters.
Experimental analysis shows that the second-order model can more realistically reproduce real world traffic flow patterns (e.g., stop-and-go waves). The MEKF-based link-level estimator exhibits more accurate results than the estimator that uses only a single data source. Evaluation of the lane-level estimator demonstrates that the proposed new bi-level multi-sensor data fusion system can provide very good estimates of real-time lane-based traffic conditions.
ContributorsZhou, Zhuoyang (Author) / Mirchandani, Pitu (Thesis advisor) / Askin, Ronald (Committee member) / Runger, George C. (Committee member) / Zhou, Xuesong (Committee member) / Arizona State University (Publisher)
Created2015
Description
The American Diabetes Association reports that diabetes costs $322 billion annually and affects 29.1 million Americans. The high out-of-pocket cost of managing diabetes can lead to noncompliance causing serious and expensive complications. There is a large market potential for a more cost-effective alternative to the current market standard of screen-printed self-monitoring blood glucose (SMBG) strips. Additive manufacturing, specifically 3D printing, is a developing field that is growing in popularity and functionality. 3D printers are now being used in a variety of applications from consumer goods to medical devices. Healthcare delivery will change as the availability of 3D printers expands into patient homes, which will create alternative and more cost-effective methods of monitoring and managing diseases, such as diabetes. 3D printing technology could transform this expensive industry. A 3D printed sensor was designed to have similar dimensions and features to the SMBG strips to comply with current manufacturing standards. To make the sensor electrically active, various conductive filaments were tested and the conductive graphene filament was determined to be the best material for the sensor. Experiments were conducted to determine the optimal print settings for printing this filament onto a mylar substrate, the industry standard. The reagents used include a mixture of a ferricyanide redox mediator and flavin adenine dinucleotide dependent glucose dehydrogenase. With these materials, each sensor only costs $0.40 to print and use. Before testing the 3D printed sensor, a suitable design, voltage range, and redox probe concentration were determined. Experiments demonstrated that this novel 3D printed sensor can accurately correlate current output to glucose concentration. It was verified that the sensor can accurately detect glucose levels from 25 mg/dL to 400 mg/dL, with an R2 correlation value as high as 0.97, which was critical as it covered hypoglycemic to hyperglycemic levels. This demonstrated that a 3D-printed sensor was created that had characteristics that are suitable for clinical use. This will allow diabetics to print their own test strips at home at a much lower cost compared to SMBG strips, which will reduce noncompliance due to the high cost of testing. In the future, this technology could be applied to additional biomarkers to measure and monitor other diseases.
ContributorsAdams, Anngela (Author) / LaBelle, Jeffrey (Thesis advisor) / Pizziconi, Vincent (Committee member) / Abbas, James (Committee member) / Arizona State University (Publisher)
Created2017
Description
Recurring incidents between pedestrians, bicycles, and vehicles at the intersection of Rural Road and Spence Avenue led to a team of students conducting their own investigation into the current conditions and analyzing a handful of alternatives. An extension of an industry-standard technique was used to build a control case which alternatives would be compared to. Four alternatives were identified, and the two that could be modeled in simulation software were both found to be technically feasible in the preliminary analysis.
ContributorsFellows, Christopher Lee (Author) / Lou, Yingyan (Thesis director) / Zhou, Xuesong (Committee member) / Civil, Environmental and Sustainable Engineering Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis aims to incorporate exosomes into an electrospun scaffold for tissue engineering applications. The motivation for this work is to develop an implant to regenerate tissue for patients with laryngeal defects. It was determined that it is feasible to incorporate exosomes into an electrospun scaffold. This addition of exosomes does alter the scaffold properties, by decreasing the average fiber diameter by roughly a factor of three and increasing the average modulus by roughly a factor of two. Cells were cultured on a scaffold with exosomes incorporated and were found to proliferate more than on a scaffold alone. This research lays the groundwork for further developing and optimizing an electrospun scaffold with exosomes incorporated to elicit a tissue regenerative response.
ContributorsKennedy, Maeve (Author) / Pizziconi, Vincent (Thesis director) / McPhail, Michael (Committee member) / School of International Letters and Cultures (Contributor) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05