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Description
Human breath is a concoction of thousands of compounds having in it a breath-print of physiological processes in the body. Though breath provides a non-invasive and easy to handle biological fluid, its analysis for clinical diagnosis is not very common. Partly the reason for this absence is unavailability of cost effective and convenient tools for such analysis. Scientific literature is full of novel sensor ideas but it is challenging to develop a working device, which are few. These challenges include trace level detection, presence of hundreds of interfering compounds, excessive humidity, different sampling regulations and personal variability. To meet these challenges as well as deliver a low cost solution, optical sensors based on specific colorimetric chemical reactions on mesoporous membranes have been developed. Sensor hardware utilizing cost effective and ubiquitously available light source (LED) and detector (webcam/photo diodes) has been developed and optimized for sensitive detection. Sample conditioning mouthpiece suitable for portable sensors is developed and integrated. The sensors are capable of communication with mobile phones realizing the idea of m-health for easy personal health monitoring in free living conditions. Nitric oxide and Acetone are chosen as analytes of interest. Nitric oxide levels in the breath correlate with lung inflammation which makes it useful for asthma management. Acetone levels increase during ketosis resulting from fat metabolism in the body. Monitoring breath acetone thus provides useful information to people with type1 diabetes, epileptic children on ketogenic diets and people following fitness plans for weight loss.
ContributorsPrabhakar, Amlendu (Author) / Tao, Nongjian (Thesis advisor) / Forzani, Erica (Committee member) / Lindsay, Stuart (Committee member) / Arizona State University (Publisher)
Created2013
Description
Surface plasmon resonance (SPR) has emerged as a popular technique for elucidating subtle signals from biological events in a label-free, high throughput environment. The efficacy of conventional SPR sensors, whose signals are mass-sensitive, diminishes rapidly with the size of the observed target molecules. The following work advances the current SPR sensor paradigm for the purpose of small molecule detection. The detection limits of two orthogonal components of SPR measurement are targeted: speed and sensitivity. In the context of this report, speed refers to the dynamic range of measured kinetic rate constants, while sensitivity refers to the target molecule mass limitation of conventional SPR measurement. A simple device for high-speed microfluidic delivery of liquid samples to a sensor surface is presented to address the temporal limitations of conventional SPR measurement. The time scale of buffer/sample switching is on the order of milliseconds, thereby minimizing the opportunity for sample plug dispersion. The high rates of mass transport to and from the central microfluidic sensing region allow for SPR-based kinetic analysis of binding events with dissociation rate constants (kd) up to 130 s-1. The required sample volume is only 1 μL, allowing for minimal sample consumption during high-speed kinetic binding measurement. Charge-based detection of small molecules is demonstrated by plasmonic-based electrochemical impedance microscopy (P-EIM). The dependence of surface plasmon resonance (SPR) on surface charge density is used to detect small molecules (60-120 Da) printed on a dextran-modified sensor surface. The SPR response to an applied ac potential is a function of the surface charge density. This optical signal is comprised of a dc and an ac component, and is measured with high spatial resolution. The amplitude and phase of local surface impedance is provided by the ac component. The phase signal of the small molecules is a function of their charge status, which is manipulated by the pH of a solution. This technique is used to detect and distinguish small molecules based on their charge status, thereby circumventing the mass limitation (~100 Da) of conventional SPR measurement.
ContributorsMacGriff, Christopher Assiff (Author) / Tao, Nongjian (Thesis advisor) / Wang, Shaopeng (Committee member) / LaBaer, Joshua (Committee member) / Chae, Junseok (Committee member) / Arizona State University (Publisher)
Created2013
Description
This work demonstrates the integration of a wearable particulate detector and a wireless chemical sensor into a single portable system. The detection philosophy of the chemical sensor is based on highly selective and sensitive microfabricated quartz tuning fork arrays and the particle detector detects the particulate level in real-time using a nephelometric (light scattering) approach. The device integration is realized by carefully evaluating the needs of flow rate, power and data collection. Validation test has been carried out in both laboratory and in field trials such as parking structures and highway exits with high and low traffic emissions. The integrated single portable detection system is capable of reducing the burden for a child to carry multiple devices, simplifying the task of researchers to synchronize and analyze data from different sensors, and minimizing the overall weight, size, and cost of the sensor. It also has a cell phone for data analysis, storage, and transmission as a user-friendly interface. As the chemical and particulate levels present important exposure risks that are of high interests to epidemiologists, the integrated device will provide an easier, wearable and cost effective way to monitor it.
ContributorsGao, Tianle (Author) / Tao, Nongjian (Thesis advisor) / Chae, Junseok (Committee member) / Tsow, Tsing (Committee member) / Arizona State University (Publisher)
Created2012
Description
Air pollution is one of the biggest challenges people face today. It is closely related to people's health condition. The agencies set up standards to regulate the air pollution. However, many of the pollutants under the regulation level may still result in adverse health effect. On the other hand, it is not clear the exact mechanism of air pollutants and its health effect. So it is difficult for the health centers to advise people how to prevent the air pollutant related diseases. It is of vital importance for both the agencies and the health centers to have a better understanding of the air pollution. Based on these needs, it is crucial to establish mobile health sensors for personal exposure assessment. Here, two sensing principles are illustrated: the tuning fork platform and the colorimetric platform. Mobile devices based on these principles have been built. The detections of ozone, NOX, carbon monoxide and formaldehyde have been shown. An integrated device of nitrogen dioxide and carbon monoxide is introduced. Fan is used for sample delivery instead pump and valves to reduce the size, cost and power consumption. Finally, the future work is discussed.
ContributorsWang, Rui (Author) / Tao, Nongjian (Thesis advisor) / Forzani, Erica (Committee member) / Zhang, Yanchao (Committee member) / Karam, Lina (Committee member) / Arizona State University (Publisher)
Created2012
Description
The commercial semiconductor industry is gearing up for 5G communications in the 28GHz and higher band. In order to maintain the same relative receiver sensitivity, a larger number of antenna elements are required; the larger number of antenna elements is, in turn, driving semiconductor development. The purpose of this paper is to introduce a new method of dividing wireless communication protocols (such as the 802.11a/b/g
and cellular UMTS MAC protocols) across multiple unreliable communication links using a new link layer communication model in concert with a smart antenna aperture design referred to as Vector Antenna. A vector antenna is a ‘smart’ antenna system and as any smart antenna aperture, the design inherently requires unique microwave component performance as well as Digital Signal Processing (DSP) capabilities. This performance and these capabilities are further enhanced with a patented wireless protocol stack capability.
and cellular UMTS MAC protocols) across multiple unreliable communication links using a new link layer communication model in concert with a smart antenna aperture design referred to as Vector Antenna. A vector antenna is a ‘smart’ antenna system and as any smart antenna aperture, the design inherently requires unique microwave component performance as well as Digital Signal Processing (DSP) capabilities. This performance and these capabilities are further enhanced with a patented wireless protocol stack capability.
ContributorsJames, Frank Lee (Author) / Reisslein, Martin (Thesis advisor) / Seeling, Patrick (Thesis advisor) / McGarry, Michael (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2019
Description
Monitoring of air pollutants is critical for many applications and studies. In
order to access air pollutants with high spatial and temporal resolutions, it is
necessary to develop an affordable, small size and weight, low power, high
sensitivity and selectivity, and wireless enable device that can provide real time
monitoring of air pollutants. Three different kind of such devices are presented, they
are targeting environmental pollutants such as volatile organic components (VOCs),
nitrogen dioxide (NO2) and ozone. These devices employ innovative detection
methods, such as quartz crystal tuning fork coated with molecularly imprinted
polymer and chemical reaction induced color change colorimetric sensing. These
portable devices are validated using the gold standards in the laboratory, and their
functionality and capability are proved during the field tests, make them great tools
for various air quality monitoring applications.
order to access air pollutants with high spatial and temporal resolutions, it is
necessary to develop an affordable, small size and weight, low power, high
sensitivity and selectivity, and wireless enable device that can provide real time
monitoring of air pollutants. Three different kind of such devices are presented, they
are targeting environmental pollutants such as volatile organic components (VOCs),
nitrogen dioxide (NO2) and ozone. These devices employ innovative detection
methods, such as quartz crystal tuning fork coated with molecularly imprinted
polymer and chemical reaction induced color change colorimetric sensing. These
portable devices are validated using the gold standards in the laboratory, and their
functionality and capability are proved during the field tests, make them great tools
for various air quality monitoring applications.
ContributorsChen, Cheng, Ph.D (Author) / Tao, Nongjian (Thesis advisor) / Kiaei, Sayfe (Committee member) / Zhang, Yanchao (Committee member) / Tsow, Tsing (Committee member) / Arizona State University (Publisher)
Created2014
Description
Antibiotic resistant bacteria are a worldwide epidemic threatening human survival. Antimicrobial susceptibility tests (ASTs) are important for confirming susceptibility to empirical antibiotics and detecting resistance in bacterial isolates. Current ASTs are based on bacterial culturing, which take 2-14 days to complete depending on the microbial growth rate. Considering the high mortality and morbidity rates for most acute infections, such long time frames are clinically impractical and pose a huge risk to a patient's life. A faster AST will reduce morbidity and mortality rates, as well as help healthcare providers, administer narrow spectrum antibiotics at the earliest possible treatment stage.
In this dissertation, I developed a nonculture-based AST using an imaging and cell tracking technology. I track individual Escherichia coli O157:H7 (E. coli O157:H7) Uropathogenic Escherichia Coli (UPEC) cells, widely implicated in food-poisoning outbreaks and urinary tract infections respectively. Cells tethered to a surface are tracked on the nanometer scale, and phenotypic motion is correlated with bacterial metabolism. Antibiotic action significantly slows down motion of tethered bacterial cells, which is used to perform antibiotic susceptibility testing. Using this technology, the clinical minimum bactericidal concentration of an antibiotic against UPEC pathogens was calculated within 2 hours directly in urine samples as compared to 3 days using current gold standard tools.
Such technologies can make a tremendous impact to improve the efficacy and efficiency of infectious disease treatment. This has the potential to reduce the antibiotic mis-prescription steeply, which can drastically decrease the annual 2M+ hospitalizations and 23,000+ deaths caused due to antibiotic resistance bacteria along with saving billions of dollars to payers, patients, and hospitals.
In this dissertation, I developed a nonculture-based AST using an imaging and cell tracking technology. I track individual Escherichia coli O157:H7 (E. coli O157:H7) Uropathogenic Escherichia Coli (UPEC) cells, widely implicated in food-poisoning outbreaks and urinary tract infections respectively. Cells tethered to a surface are tracked on the nanometer scale, and phenotypic motion is correlated with bacterial metabolism. Antibiotic action significantly slows down motion of tethered bacterial cells, which is used to perform antibiotic susceptibility testing. Using this technology, the clinical minimum bactericidal concentration of an antibiotic against UPEC pathogens was calculated within 2 hours directly in urine samples as compared to 3 days using current gold standard tools.
Such technologies can make a tremendous impact to improve the efficacy and efficiency of infectious disease treatment. This has the potential to reduce the antibiotic mis-prescription steeply, which can drastically decrease the annual 2M+ hospitalizations and 23,000+ deaths caused due to antibiotic resistance bacteria along with saving billions of dollars to payers, patients, and hospitals.
ContributorsSyal, Karan (Author) / Tao, Nongjian (Thesis advisor) / Haydel, Shelley (Committee member) / Rege, Kaushal (Committee member) / Wang, Shaopeng (Committee member) / Haynes, Karmella (Committee member) / Arizona State University (Publisher)
Created2017
Description
Video capture, storage, and distribution in wireless video sensor networks
(WVSNs) critically depends on the resources of the nodes forming the sensor
networks. In the era of big data, Internet of Things (IoT), and distributed
demand and solutions, there is a need for multi-dimensional data to be part of
the Sensor Network data that is easily accessible and consumable by humanity as
well as machinery. Images and video are expected to become as ubiquitous as is
the scalar data in traditional sensor networks. The inception of video-streaming
over the Internet, heralded a relentless research for effective ways of
distributing video in a scalable and cost effective way. There has been novel
implementation attempts across several network layers. Due to the inherent
complications of backward compatibility and need for standardization across
network layers, there has been a refocused attention to address most of the
video distribution over the application layer. As a result, a few video
streaming solutions over the Hypertext Transfer Protocol (HTTP) have been
proposed. Most notable are Apple’s HTTP Live Streaming (HLS) and the Motion
Picture Experts Groups Dynamic Adaptive Streaming over HTTP (MPEG-DASH). These
frameworks, do not address the typical and future WVSN use cases. A highly
flexible Wireless Video Sensor Network Platform and compatible DASH (WVSNP-DASH)
are introduced. The platform's goal is to usher video as a data element that
can be integrated into traditional and non-Internet networks. A low cost,
scalable node is built from the ground up to be fully compatible with the
Internet of Things Machine to Machine (M2M) concept, as well as the ability to
be easily re-targeted to new applications in a short time. Flexi-WVSNP design
includes a multi-radio node, a middle-ware for sensor operation and
communication, a cross platform client facing data retriever/player framework,
scalable security as well as a cohesive but decoupled hardware and software
design.
(WVSNs) critically depends on the resources of the nodes forming the sensor
networks. In the era of big data, Internet of Things (IoT), and distributed
demand and solutions, there is a need for multi-dimensional data to be part of
the Sensor Network data that is easily accessible and consumable by humanity as
well as machinery. Images and video are expected to become as ubiquitous as is
the scalar data in traditional sensor networks. The inception of video-streaming
over the Internet, heralded a relentless research for effective ways of
distributing video in a scalable and cost effective way. There has been novel
implementation attempts across several network layers. Due to the inherent
complications of backward compatibility and need for standardization across
network layers, there has been a refocused attention to address most of the
video distribution over the application layer. As a result, a few video
streaming solutions over the Hypertext Transfer Protocol (HTTP) have been
proposed. Most notable are Apple’s HTTP Live Streaming (HLS) and the Motion
Picture Experts Groups Dynamic Adaptive Streaming over HTTP (MPEG-DASH). These
frameworks, do not address the typical and future WVSN use cases. A highly
flexible Wireless Video Sensor Network Platform and compatible DASH (WVSNP-DASH)
are introduced. The platform's goal is to usher video as a data element that
can be integrated into traditional and non-Internet networks. A low cost,
scalable node is built from the ground up to be fully compatible with the
Internet of Things Machine to Machine (M2M) concept, as well as the ability to
be easily re-targeted to new applications in a short time. Flexi-WVSNP design
includes a multi-radio node, a middle-ware for sensor operation and
communication, a cross platform client facing data retriever/player framework,
scalable security as well as a cohesive but decoupled hardware and software
design.
ContributorsSeema, Adolph (Author) / Reisslein, Martin (Thesis advisor) / Kitchen, Jennifer (Committee member) / Seeling, Patrick (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2017
Description
Collision-free path planning is also a major challenge in managing unmanned aerial vehicles (UAVs) fleets, especially in uncertain environments. The design of UAV routing policies using multi-agent reinforcement learning has been considered, and propose a Multi-resolution, Multi-agent, Mean-field reinforcement learning algorithm, named 3M-RL, for flight planning, where multiple vehicles need to avoid collisions with each other while moving towards their destinations. In this system, each UAV makes decisions based on local observations, and does not communicate with other UAVs. The algorithm trains a routing policy using an Actor-Critic neural network with multi-resolution observations, including detailed local information and aggregated global information based on mean-field. The algorithm tackles the curse-of-dimensionality problem in multi-agent reinforcement learning and provides a scalable solution. The proposed algorithm is tested in different complex scenarios in both 2D and 3D space and the simulation results show that 3M-RL result in good routing policies. Also as a compliment, dynamic data communications between UAVs and a control center has also been studied, where the control center needs to monitor the safety state of each UAV in the system in real time, where the transition of risk level is simply considered as a Markov process. Given limited communication bandwidth, it is impossible for the control center to communicate with all UAVs at the same time. A dynamic learning problem with limited communication bandwidth is also discussed in this paper where the objective is to minimize the total information entropy in real-time risk level tracking. The simulations also demonstrate that the algorithm outperforms policies such as a Round & Robin policy.
ContributorsWang, Weichang (Author) / Ying, Lei (Thesis advisor) / Liu, Yongming (Thesis advisor) / Zhang, Junshan (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2021