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Description
Increasing interest in individualized treatment strategies for prevention and treatment of health disorders has created a new application domain for dynamic modeling and control. Standard population-level clinical trials, while useful, are not the most suitable vehicle for understanding the dynamics of dosage changes to patient response. A secondary analysis of intensive longitudinal data from a naltrexone intervention for fibromyalgia examined in this dissertation shows the promise of system identification and control. This includes datacentric identification methods such as Model-on-Demand, which are attractive techniques for estimating nonlinear dynamical systems from noisy data. These methods rely on generating a local function approximation using a database of regressors at the current operating point, with this process repeated at every new operating condition. This dissertation examines generating input signals for data-centric system identification by developing a novel framework of geometric distribution of regressors and time-indexed output points, in the finite dimensional space, to generate sufficient support for the estimator. The input signals are generated while imposing “patient-friendly” constraints on the design as a means to operationalize single-subject clinical trials. These optimization-based problem formulations are examined for linear time-invariant systems and block-structured Hammerstein systems, and the results are contrasted with alternative designs based on Weyl's criterion. Numerical solution to the resulting nonconvex optimization problems is proposed through semidefinite programming approaches for polynomial optimization and nonlinear programming methods. It is shown that useful bounds on the objective function can be calculated through relaxation procedures, and that the data-centric formulations are amenable to sparse polynomial optimization. In addition, input design formulations are formulated for achieving a desired output and specified input spectrum. Numerical examples illustrate the benefits of the input signal design formulations including an example of a hypothetical clinical trial using the drug gabapentin. In the final part of the dissertation, the mixed logical dynamical framework for hybrid model predictive control is extended to incorporate a switching time strategy, where decisions are made at some integer multiple of the sample time, and manipulation of only one input at a given sample time among multiple inputs. These are considerations important for clinical use of the algorithm.
ContributorsDeśapāṇḍe, Sunīla (Author) / Rivera, Daniel E. (Thesis advisor) / Peet, Matthew M. (Committee member) / Si, Jennie (Committee member) / Tsakalis, Konstantinos S. (Committee member) / Arizona State University (Publisher)
Created2014
Description
Toward the ambitious long-term goal of a fleet of cooperating Flexible Autonomous Machines operating in an uncertain Environment (FAME), this thesis addresses various control objectives for ground vehicles.
There are two main objectives within this thesis, first is the use of visual information to control a Differential-Drive Thunder Tumbler (DDTT) mobile robot and second is the solution to a minimum time optimal control problem for the robot around a racetrack.
One method to do the first objective is by using the Position Based Visual Servoing (PBVS) approach in which a camera looks at a target and the position of the target with respect to the camera is estimated; once this is done the robot can drive towards a desired position (x_ref, z_ref). Another method is called Image Based Visual Servoing (IBVS), in which the pixel coordinates (u,v) of markers/dots placed on an object are driven towards the desired pixel coordinates (u_ref, v_ref) of the corresponding markers.
By doing this, the mobile robot gets closer to a desired pose (x_ref, z_ref, theta_ref).
For the second objective, a camera-based and noncamera-based (v,theta) cruise-control systems are used for the solution of the minimum time problem. To set up the minimum time problem, optimal control theory is used. Then a direct method is implemented by discretizing states and controls of the system. Finally, the solution is obtained by modeling the problem in AMPL and submitting to the nonlinear optimization solver KNITRO. Simulation and experimental results are presented.
The DDTT-vehicle used within this thesis has different components as summarized below:
(1) magnetic wheel-encoders/IMU for inner-loop speed-control and outer-loop directional control,
(2) Arduino Uno microcontroller-board for encoder-based inner-loop speed-control and encoder-IMU-based outer-loop cruise-directional-control,
(3) Arduino motor-shield for inner-loop speed-control,
(4) Raspberry Pi II computer-board for outer-loop vision-based cruise-position-directional-control,
(5) Raspberry Pi 5MP camera for outer-loop cruise-position-directional control.
Hardware demonstrations shown in this thesis are summarized: (1) PBVS without pan camera, (2) PBVS with pan camera, (3) IBVS with 1 marker/dot, (4) IBVS with 2 markers, (5) IBVS with 3 markers, (6) camera and (7) noncamera-based (v,theta) cruise control system for the minimum time problem.
There are two main objectives within this thesis, first is the use of visual information to control a Differential-Drive Thunder Tumbler (DDTT) mobile robot and second is the solution to a minimum time optimal control problem for the robot around a racetrack.
One method to do the first objective is by using the Position Based Visual Servoing (PBVS) approach in which a camera looks at a target and the position of the target with respect to the camera is estimated; once this is done the robot can drive towards a desired position (x_ref, z_ref). Another method is called Image Based Visual Servoing (IBVS), in which the pixel coordinates (u,v) of markers/dots placed on an object are driven towards the desired pixel coordinates (u_ref, v_ref) of the corresponding markers.
By doing this, the mobile robot gets closer to a desired pose (x_ref, z_ref, theta_ref).
For the second objective, a camera-based and noncamera-based (v,theta) cruise-control systems are used for the solution of the minimum time problem. To set up the minimum time problem, optimal control theory is used. Then a direct method is implemented by discretizing states and controls of the system. Finally, the solution is obtained by modeling the problem in AMPL and submitting to the nonlinear optimization solver KNITRO. Simulation and experimental results are presented.
The DDTT-vehicle used within this thesis has different components as summarized below:
(1) magnetic wheel-encoders/IMU for inner-loop speed-control and outer-loop directional control,
(2) Arduino Uno microcontroller-board for encoder-based inner-loop speed-control and encoder-IMU-based outer-loop cruise-directional-control,
(3) Arduino motor-shield for inner-loop speed-control,
(4) Raspberry Pi II computer-board for outer-loop vision-based cruise-position-directional-control,
(5) Raspberry Pi 5MP camera for outer-loop cruise-position-directional control.
Hardware demonstrations shown in this thesis are summarized: (1) PBVS without pan camera, (2) PBVS with pan camera, (3) IBVS with 1 marker/dot, (4) IBVS with 2 markers, (5) IBVS with 3 markers, (6) camera and (7) noncamera-based (v,theta) cruise control system for the minimum time problem.
ContributorsAldaco Lopez, Jesus (Author) / Rodriguez, Armando A. (Thesis advisor) / Artemiadis, Panagiotis K. (Committee member) / Berman, Spring M. (Committee member) / Arizona State University (Publisher)
Created2016