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Description
Modern medicine is a wonderfully complex field of study, with several advances in both its theoretical and practical aspects being made everyday. In light of the pride modern physicians and scientists take in their vast knowledge, it is important to remember how far we have come throughout history. Many civilizations and cultures around the world have made essential contributions to medicine, both great and small, but no one can deny the impact both ancient Chinese and Islamic medical and alchemical practices have had on modern medicine. Qi was the central principle behind Chinese correlative thought, and it was believed to be the one thing that drove human life, as it occurred everywhere. Written texts took an increasingly more prominent role in the transmission of knowledge, and in no time at all, the educated yi ("physician") emerged. Other noteworthy contributions include an early conceptualization of the circulatory system, the development of pharmacies, the establishment of proper medical school systems, and the emergence of a set of standard hygienic practices that would allow people to take responsibility for their own health. The scholars of the Islamic Golden Age, for the most part, seemed to decry the mixing of the occult with science, and therefore sought to draw a clear distinction between alchemy (by limiting its application to the transmutation of metals) and what they deemed "real" science. Notable contributions of Arab-Islamic scientists include the pioneering of a hospital prototype, along with the development of the science of chemistry and the introduction of the experimental laboratory as the birthplace of new scientific knowledge. The important question that has yet to be answered is how extensive the connection was between the Chinese and Arab worlds. Trade was thriving during the medieval period, and so it is not wrong to assume that the exchange of goods would go hand-in-hand with the exchange of knowledge. We may never fully know exactly what happened, but further research on this topic may eventually bring an answer to light.
ContributorsRaban, Miranda Meriam (Author) / Bokenkamp, Stephen (Thesis director) / Ling, Xiaoqiao (Committee member) / Ali, Souad T. (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This study was conducted as part of an underlying initiative to elucidate the mechanism of action of natural antibacterial clay minerals for application as therapeutic agents for difficult-to-treat infections such as methicillin-resistant Staphylococcus aureus (MRSA)-derived skin lesions and Buruli ulcer. The goal of this investigation was to determine whether exposure to the leachate of an antibacterial clay mineral, designated as CB, produced DNA double-strand breaks (DSBs) in Escherichia coli. A neutral comet assay for bacterial cells was adapted to assess DSB levels upon exposure to soluble antimicrobial compounds. Challenges involved with the adaptation process included comet visualization and data collection. To appropriately account for antimicrobial-mediated strand fragmentation, suitable control reactions comprised of exposures to water, ethanol, kanamycin, and bleomycin were developed and optimized for the assay. Bacterial exposure to CB resulted in significantly longer comet lengths compared to negative control exposures, suggesting that CB killing activity involves the induction of DNA DSBs. The results of this investigation further characterize the antimicrobial mechanisms associated with a particular clay mineral mixture. The adapted comet assay protocol described herein functions as an effective tool to assess double-strand fragmentation resulting from exposure to soluble antimicrobial compounds and to visually compare results from experimental and control reactions.
ContributorsSolanky, Dipesh (Author) / Haydel, Shelley (Thesis director) / Stout, Valerie (Committee member) / Adusumilli, Sarojini (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Glioblastoma multiforme (GBMs) is the most prevalent brain tumor type and causes approximately 40% of all non-metastic primary tumors in adult patients [1]. GBMs are malignant, grade-4 brain tumors, the most aggressive classication as established by the World Health Organization and are marked by their low survival rate; the median survival time is only twelve months from initial diagnosis: Patients who live more than three years are considered long-term survivors [2]. GBMs are highly invasive and their diffusive growth pattern makes it impossible to remove the tumors by surgery alone [3]. The purpose of this paper is to use individual patient data to parameterize a model of GBMs that allows for data on tumor growth and development to be captured on a clinically relevant time scale. Such an endeavor is the rst step to a clinically applicable predictions of GBMs. Previous research has yielded models that adequately represent the development of GBMs, but they have not attempted to follow specic patient cases through the entire tumor process. Using the model utilized by Kostelich et al. [4], I will attempt to redress this deciency. In doing so, I will improve upon a family of models that can be used to approximate the time of development and/or structure evolution in GBMs. The eventual goal is to incorporate Magnetic Resonance Imaging (MRI) data into a parameterized model of GBMs in such a way that it can be used clinically to predict tumor growth and behavior. Furthermore, I hope to come to a denitive conclusion as to the accuracy of the Koteslich et al. model throughout the development of GBMs tumors.
ContributorsManning, Miles (Author) / Kostelich, Eric (Thesis director) / Kuang, Yang (Committee member) / Preul, Mark (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12