Matching Items (4)
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- All Subjects: Children's Literature
- All Subjects: medicine
- Creators: College of Liberal Arts and Sciences
Description
Children's literature is a comparatively new concept that has changed as the view of children and childhood has changed. The idea that books written for children are more than just amusement and that these books instill values and pride in one's culture has been approached very differently in the United States and Russia. While there are universal morals and common themes in children's literature, there are just as many culturally-dependent ideals that make children's literature and its translation an enlightening way to study the culture of a people or nation and ease the tensions between emerging global and traditional national lessons in children's literature.
ContributorsZubiate, Rachel (Author) / Moldabekova, Saule (Thesis director) / Hoogenboom, Hilde (Committee member) / Hogue, Cynthia (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
This study was conducted as part of an underlying initiative to elucidate the mechanism of action of natural antibacterial clay minerals for application as therapeutic agents for difficult-to-treat infections such as methicillin-resistant Staphylococcus aureus (MRSA)-derived skin lesions and Buruli ulcer. The goal of this investigation was to determine whether exposure to the leachate of an antibacterial clay mineral, designated as CB, produced DNA double-strand breaks (DSBs) in Escherichia coli. A neutral comet assay for bacterial cells was adapted to assess DSB levels upon exposure to soluble antimicrobial compounds. Challenges involved with the adaptation process included comet visualization and data collection. To appropriately account for antimicrobial-mediated strand fragmentation, suitable control reactions comprised of exposures to water, ethanol, kanamycin, and bleomycin were developed and optimized for the assay. Bacterial exposure to CB resulted in significantly longer comet lengths compared to negative control exposures, suggesting that CB killing activity involves the induction of DNA DSBs. The results of this investigation further characterize the antimicrobial mechanisms associated with a particular clay mineral mixture. The adapted comet assay protocol described herein functions as an effective tool to assess double-strand fragmentation resulting from exposure to soluble antimicrobial compounds and to visually compare results from experimental and control reactions.
ContributorsSolanky, Dipesh (Author) / Haydel, Shelley (Thesis director) / Stout, Valerie (Committee member) / Adusumilli, Sarojini (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
Glioblastoma multiforme (GBMs) is the most prevalent brain tumor type and causes approximately 40% of all non-metastic primary tumors in adult patients [1]. GBMs are malignant, grade-4 brain tumors, the most aggressive classication as established by the World Health Organization and are marked by their low survival rate; the median survival time is only twelve months from initial diagnosis: Patients who live more than three years are considered long-term survivors [2]. GBMs are highly invasive and their diffusive growth pattern makes it impossible to remove the tumors by surgery alone [3]. The purpose of this paper is to use individual patient data to parameterize a model of GBMs that allows for data on tumor growth and development to be captured on a clinically relevant time scale. Such an endeavor is the rst step to a clinically applicable predictions of GBMs. Previous research has yielded models that adequately represent the development of GBMs, but they have not attempted to follow specic patient cases through the entire tumor process. Using the model utilized by Kostelich et al. [4], I will attempt to redress this deciency. In doing so, I will improve upon a family of models that can be used to approximate the time of development and/or structure evolution in GBMs. The eventual goal is to incorporate Magnetic Resonance Imaging (MRI) data into a parameterized model of GBMs in such a way that it can be used clinically to predict tumor growth and behavior. Furthermore, I hope to come to a denitive conclusion as to the accuracy of the Koteslich et al. model throughout the development of GBMs tumors.
ContributorsManning, Miles (Author) / Kostelich, Eric (Thesis director) / Kuang, Yang (Committee member) / Preul, Mark (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
The front cover of Uncle What-Is-It is Coming to Visit, a 1993 children’s book by Michael-Willhoite, features two white children frightened by the hairy arm and upturned wrist of an unseen adult. The arm is clad in a frilly pink and orange sleeve, and gaudy bracelets hang from the wrist. The plot hinges on the children’s uncertainty about an uncle they have yet to meet; they know he is gay but are unsure of what it means. Before their mother can explain, she is distracted by a kitchen mishap and the siblings turn to other neighborhood children for answers. They encounter a host of descriptions that terrify them: one neighbor describes gay people as “fags [and] queers [who] really want to be women.” He shows the children a newspaper clipping photo of “a large man dressed in a frilly dress [with] a turban piled high with fruit on his head,” an implicitly racialized caricature reminiscent of Latina style icon Carmen Miranda. Another neighbor describes gay people as “dressed up in black leather. Zippers and chains all over...Dark glasses [and] chaps” (Willhoite, 1993). After having nightmares of men with sinister expressions in tropical-themed drag and leather, the children are overjoyed to discover that their uncle seems “normal.” Relative to depictions of other gay people in the book, Uncle Brett is normal because he is nonthreatening—he is white with short, straight, brown hair; he wears a plain, blue, collared shirt and brown dress pants; he carries a brown briefcase; and he enjoys and excels at activities appropriate for his gender, like catch. Although the book seems to have an affirming message about accepting queer people, it sends a clear message about which queer people are to be feared by children and which are nonthreatening. Nonthreatening queers are those who seem most like people mainstream western society considers normal: people who conform to expected gender roles, who have a vested interest parenting, and who are white and middle-upper class. These nonthreatening queers are by far the most represented in queer-themed literature for children. Based on a survey of 68 children’s books with queer characters, this paper argues that the representation of queer identities in children’s literature upholds more than challenges heteronormativity. I will first address ways many of the books perpetuate gender normativity by problematizing young male characters’ gender-transgressing behavior, portraying queer adults with less threatening gender presentations, and upholding gender binarism; next, I will address how the majority of the books promote repro-narrativity by focusing on monogamous couples’ strong desires and concerted efforts to have/raise children; I will then address race and class and the way white and upper-middle class queer characters are overrepresented while non-white and lower-class queer characters are underrepresented or not represented at all.
ContributorsLester, Jasmine (Author) / Danielson, Marivel (Thesis director) / Blasingame, James (Committee member) / Kuo, Karen (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12