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- Creators: Barrett, The Honors College
Description
British Neuroscientist Adrian Owen documents in his book Into the Grey Zone difficult cases of patients between a state of brain death and consciousness. His team collected evidence that sug- gested patients—presumed to be brain dead—were partially or, in some cases, fully conscious. The two culturally dominant metaphysical accounts of consciousness, Cartesian dualism and eliminative physicalism, are unable to explain the presence of consciousness in Owen’s cases. To better understand the consciousness present in Owen’s cases I argue we should look to Ned Block’s distinction between phenomenal and access consciousness.
ContributorsQuint, Elana (Author) / Karen, Taliaferro (Thesis director) / Jeff, Watson (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Civic & Economic Thought and Leadership (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
In the study of the human brain’s ability to multitask, there are two perspectives: concurrent multitasking (performing multiple tasks simultaneously) and sequential multitasking (switching between tasks). The goal of this study is to investigate the human brain’s ability to “multitask” with multiple demanding stimuli of approximately equal concentration, from an electrophysiological perspective different than that of stimuli which don’t require full attention or exhibit impulsive multitasking responses. This study investigates the P3 component which has been experimentally proven to be associated with mental workload through information processing and cognitive function in visual and auditory tasks, where in the multitasking domain the greater attention elicited, the larger P3 waves are produced. This experiment compares the amplitude of the P3 component of individual stimulus presentation to that of multitasking trials, taking note of the brain workload. This study questions if the average wave amplitude in a multitasking ERP experiment will be the same as the grand average when performing the two tasks individually with respect to the P3 component. The hypothesis is that the P3 amplitude will be smaller in the multitasking trial than in the individual stimulus presentation, indicating that the brain is not actually concentrating on both tasks at once (sequential multitasking instead of concurrent) and that the brain is not focusing on each stimulus to the same degree when it was presented individually. Twenty undergraduate students at Barrett, the Honors College at Arizona State University (10 males and 10 females, with a mean age of 18.75 years, SD= 1.517) right handed, with normal or corrected visual acuity, English as first language, and no evidence of neurological compromise participated in the study. The experiment results revealed that one- hundred percent of participants undergo sequential multitasking in the presence of two demanding stimuli in the electrophysiological data, behavioral data, and subjective data. In this particular study, these findings indicate that the presence of additional demanding stimuli causes the workload of the brain to decrease as attention deviates in a bottleneck process to the multiple requisitions for focus, indicated by a reduced P3 voltage amplitude with the multitasking stimuli when compared to the independent. This study illustrates the feasible replication of P3 cognitive workload results for demanding stimuli, not only impulsive-response experiments, to suggest the brain’s tendency to undergo sequential multitasking when faced with multiple demanding stimuli. In brief, this study demonstrates that when higher cognitive processing is required to interpret and respond to the stimuli, the human brain results to sequential multitasking (task- switching, not concurrent multitasking) in the face of more challenging problems with each stimulus requiring a higher level of focus, workload, and attention.
ContributorsNeill, Ryan (Author) / Brewer, Gene (Thesis director) / Peter, Beate (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Whistleblowing in Biomedical Research and Medicine: An Analysis of Ethical Expectations and Dilemmas
Description
In biomedical research institutions and medical institutions alike, whistleblowing, or the reporting of misconduct, has been severely retaliated against. Whistleblowers report misconduct by adhering to institutional whistleblowing policies, and do so in order to maintain ethical practice within their institution; it is important to note that by taking this ethical action, whistleblowers are aiming to protect the future of biomedical research and medicine. Despite these intentions, whistleblowing has developed a negative stigma due to the misconception that whistleblowers have self-proclaimed authority and are unable to function as part of a team. The retaliation against whistleblowers has been connected to psychological and professional fallout for the whistleblower, and it has been found that many whistleblowers suffer as a direct result of a lack of institutional support. The problems with whistleblowing culture demonstrate issues surrounding how ethics are maintained in institutions, who ethics policies apply to, and who has authority. The retaliation seen against whistleblowers outlines inherent institutional failures, and highlights the need for institutional change in order to both promote ethical practice and protect the whistleblowers who adhere to ethics policies. This thesis discusses such failures in detail, and outlines several broad solutions in order to combat this issue.
ContributorsTaylor, Kylee Anne (Author) / Robert, Jason (Thesis director) / Ellison, Karin (Committee member) / Johnson, Nate (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Previous research has showed that auditory modulation may be affected by pure tone
stimuli played prior to the onset of speech production. In this experiment, we are examining the
specificity of the auditory stimulus by implementing congruent and incongruent speech sounds in
addition to non-speech sound. Electroencephalography (EEG) data was recorded for eleven adult
subjects in both speaking (speech planning) and silent reading (no speech planning) conditions.
Data analysis was accomplished manually as well as via generation of a MATLAB code to
combine data sets and calculate auditory modulation (suppression). Results of the P200
modulation showed that modulation was larger for incongruent stimuli than congruent stimuli.
However, this was not the case for the N100 modulation. The data for pure tone could not be
analyzed because the intensity of this stimulus was substantially lower than that of the speech
stimuli. Overall, the results indicated that the P200 component plays a significant role in
processing stimuli and determining the relevance of stimuli; this result is consistent with role of
P200 component in high-level analysis of speech and perceptual processing. This experiment is
ongoing, and we hope to obtain data from more subjects to support the current findings.
stimuli played prior to the onset of speech production. In this experiment, we are examining the
specificity of the auditory stimulus by implementing congruent and incongruent speech sounds in
addition to non-speech sound. Electroencephalography (EEG) data was recorded for eleven adult
subjects in both speaking (speech planning) and silent reading (no speech planning) conditions.
Data analysis was accomplished manually as well as via generation of a MATLAB code to
combine data sets and calculate auditory modulation (suppression). Results of the P200
modulation showed that modulation was larger for incongruent stimuli than congruent stimuli.
However, this was not the case for the N100 modulation. The data for pure tone could not be
analyzed because the intensity of this stimulus was substantially lower than that of the speech
stimuli. Overall, the results indicated that the P200 component plays a significant role in
processing stimuli and determining the relevance of stimuli; this result is consistent with role of
P200 component in high-level analysis of speech and perceptual processing. This experiment is
ongoing, and we hope to obtain data from more subjects to support the current findings.
ContributorsTaylor, Megan Kathleen (Author) / Daliri, Ayoub (Thesis director) / Liss, Julie (Committee member) / School of Life Sciences (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Serotonin 2A receptor (5-HT2AR) levels are decreased in the brains of schizophrenia patients. This phenomenon is modeled in mice that lack the transcription factor Egr3. The head-twitch response (HTR) is a behavioral assay used to assess the physiological function of 5-HT2ARs. However, current quantification methods are time consuming and prone to inter-rater variability. Here, we demonstrate the validity and reliability of an automated head-twitch system to quantify HTRs of Egr3-/- mice.
ContributorsOzols, Annika Biruta (Author) / Lisenbee, Cayle S. (Thesis director) / Gallitano, Amelia L. (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This paper explores the benefits reading and writing medical poetry can benefit preprofessional/medical students, physicians, and patients as a means to share the experiences they
encounter in the medical world. The concept for this paper originates from the idea of narrative
medicine as a way to foster relationships between physicians and patients through the sharing of
stories, or narratives, between the two parties. In efforts to help teach this skill, universities and
medical schools have begun to offer courses in the medical humanities. The goal of these courses
is to teach students how to develop the skills they need to empathize and learn from their
patients’ experiences. Paired with the traditional rigor of a science-based curriculum, the medical
humanities have become part of medical schools’ efforts to “train the whole physician.”
Medical poetry is an example of the types of humanities courses that can benefit students
interested in medicine. The history of medical poetry spans across decades of literary history.
Beginning with the early references of medicine from the ancient world to the contemporary
work of the present, poets of different backgrounds and histories are discussed. Research to
support the efficacy of medical poetry include studies done on how medical poetry has impacted
students, readers, and patients. Finally, the author’s experiences as both a pre-professional
student and patient are shared to further explore the benefits that reading, and writing can bring.
encounter in the medical world. The concept for this paper originates from the idea of narrative
medicine as a way to foster relationships between physicians and patients through the sharing of
stories, or narratives, between the two parties. In efforts to help teach this skill, universities and
medical schools have begun to offer courses in the medical humanities. The goal of these courses
is to teach students how to develop the skills they need to empathize and learn from their
patients’ experiences. Paired with the traditional rigor of a science-based curriculum, the medical
humanities have become part of medical schools’ efforts to “train the whole physician.”
Medical poetry is an example of the types of humanities courses that can benefit students
interested in medicine. The history of medical poetry spans across decades of literary history.
Beginning with the early references of medicine from the ancient world to the contemporary
work of the present, poets of different backgrounds and histories are discussed. Research to
support the efficacy of medical poetry include studies done on how medical poetry has impacted
students, readers, and patients. Finally, the author’s experiences as both a pre-professional
student and patient are shared to further explore the benefits that reading, and writing can bring.
ContributorsVilla, Rosario Alicia (Author) / Dombroski, Rosemarie (Thesis director) / Hanlon, Christopher (Committee member) / College of Health Solutions (Contributor) / Department of English (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Multiple sclerosis is currently deemed the most common autoimmune disease. By definition, multiple sclerosis, known more commonly as MS, involves an immune-mediated process in which an abnormal response of the body’s immune system is directed against the central nervous system (“Definition of MS,” n.d.). Common treatment protocols call for daily, monthly, or yearly disease-modifying medications. These drugs are taken indefinitely to stop the spread and appearance of new lesions, improve symptoms, and offer relief to the afflicted individuals. The necessity for patients to take these basic medical treatments is paramount, however, it should not be overlooked to make lifestyle changes as well. The purpose of this paper is to give a detailed understanding of multiple sclerosis, its etiology evolution, and medical advancements, while emphasizing the necessary transitions which must be made from a nutritional and lifestyle management standpoint. A brief focus will be placed on sleep, exercise, and stress management, with an emphasis on nutrition.
ContributorsDeets, Breanna L (Author) / Levinson, Simin (Thesis director) / Grant, Shauna (Committee member) / Department of Management and Entrepreneurship (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Homeless populations are often disproportionately impacted by several diseases due to factors such as overcrowding, unsanitary conditions, lack of access to healthcare and most importantly lack of education. The purpose of this project was to decrease a part of this health gap by spreading awareness of certain illnesses impacting Arizona’s homeless population and to increase the use plausible prevention methods. This was done through the creation of three simplified brochures that contained information regarding influenza, hepatitis, and schizophrenia. Two surveys were distributed to a local homeless population; the first survey was given prior to handing out the brochures and the second survey was given a week later after the participants had some time to read the information from the brochures. The data from the surveys supported the goal of the project by showing an increase in overall awareness of the diseases as well as an increase in behavioral changes that would lead to the increase of plausible prevention methods.
ContributorsBanuelos, Jason (Author) / Quaranta, Kimberly (Thesis director) / Szeli, Eva (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Transcranial Current Stimulation (TCS) is a long-established method of modulating neuronal activity in the brain. One type of this stimulation, transcranial alternating current stimulation (tACS), is able to entrain endogenous oscillations and result in behavioral change. In the present study, we used five stimulation conditions: tACS at three different frequencies (6Hz, 12Hz, and 22Hz), transcranial random noise stimulation (tRNS), and a no-stimulation sham condition. In all stimulation conditions, we recorded electroencephalographic data to investigate the link between different frequencies of tACS and their effects on brain oscillations. We recruited 12 healthy participants. Each participant completed 30 trials of the stimulation conditions. In a given trial, we recorded brain activity for 10 seconds, stimulated for 12 seconds, and recorded an additional 10 seconds of brain activity. The difference between the average oscillation power before and after a stimulation condition indicated change in oscillation amplitude due to the stimulation. Our results showed the stimulation conditions entrained brain activity of a sub-group of participants.
ContributorsChernicky, Jacob Garrett (Author) / Daliri, Ayoub (Thesis director) / Liss, Julie (Committee member) / School of Life Sciences (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The culture surrounding death in America is one of science and silence. When possible, death is hidden away from the public view. When exposure to death is unavoidable, it is sensationalized, made into a spectacle. Our dying are put into hospice care, nursing homes, and other hidden spaces, or else they are plastered over the news and internet. So, we get one of two views of death: the sterile, silent death that happens in the presence of medical professionals or the bloody, tragic deaths that are constantly reported across news outlets and social media or sensationalized on entertainment platforms such as movies and video games. Entire genres of television and movies are created on the foundation of bloody deaths and we are exposed to the concept of death constantly.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
Despite the consistent coverage of death on a large scale, the average person is not often exposed to death on a personal level in this day and age. The deaths we see on television or in the movies are not typically connected to people with whom we are attached and so we are not required to work through our emotional response and experience. We are afforded the space to be a casual observer in most of the deaths that we see—we do not need the emotional and mental tools to cope with death on a personal level. While this distance from death may be true of the American whole, it is not entirely generalizable. Professionals in select fields are required to deal with death on a much more regular basis than the average person, including, but not limited to, healthcare and forensic professionals. In these professions, death is a fundamental aspect of the job—either as an expected risk or a necessary precursor. These professionals deal intimately with death, its causes, and its effects on a regular basis because of their chose line of work and, in doing so, are regularly exposed to death and other trauma which has the potential to affect them on both a professional and personal level. In doing so, these professionals are required to, as scientists, analyze and record these experiences with death through the lens of objectivity. These professionals are expected to maintain a professional distance while also being required to give an empathetic response to other’s trauma. The potential effect of this secondary trauma on these professionals is only sharpened by the culture of machismo in these science-based fields that prevents many professionals from expressing emotions regarding their job and getting the social support they need from others within their community.
ContributorsSandoval, Alicia Rose (Author) / Kobojek, Kimberly (Thesis director) / Watrous, Lisa (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12