The purpose of this study was to evaluate how COVID-19 has affected college athletes physically and mentally. A survey with 36 questions encompassing gender, sport, COVID-19 symptom severity, type and duration, return to play factors, perceived social isolation, depression and anxiety was distributed to all student athletes at Arizona State University. A total of 26 athletes (84.6% female, 15.4% male) who previously contracted the COVID-19 virus participated in the survey, representing a variety of 12 different sports. The study concluded that as student athletes symptom severity increased, symptom duration increased as well. Between one day to 10 months of continued symptoms after returning to sport play was reported by one-third of participating student athletes; however, there was no indication that vaccination status, obtaining a negative COVID-19 test, or obtaining medical clearance prior to returning to sport play after contracting COVID-19 affected if symptoms persisted or not after returning to play. Most (92.3%) athletes reported higher levels of perceived isolation, and as social isolation scores increased, depression scores increased. Abnormal anxiety symptoms were reported by 30.8% of student athletes, and as depression scores increased, anxiety scores increased as well. Study results and further research can be utilized to improve and refine gradual return to play protocols, enhance methods of communication and integration during mass social isolation, and greater assess depression and anxiety prevalence in student athletes.

Virus-like particles (VLPs) are optimum candidates for creating vaccines, as they are highly flexible, adaptable, safe, and similar to the structural proteins of the target cells. The COVID 19 pandemic has increased the need to create effective and safe vaccines that can be mass produced to stop the spread of COVID-19. Till now, various types of vaccine platforms have been utilized to create COVID-19 vaccines, each with unique characteristics and techniques. It is essential to use robust vaccine platforms that can deliver optimum results in a short period of time, with minimal risks. The structural proteins found in SARS-CoV-2, such as Spike (S) protein have been widely targeted to induce antibody response, also called a humoral response, which is a part of acquired immunity. The other structural proteins such as M (membrane) and E (envelope) can also be used as targets for antibodies. The S2 and glycoprotein (S full) can be used to induce an efficient IgG response. Therefore, the incorporation of structural proteins into VLPs can prove to be useful. Furthermore, double mosaic VLPs employs double epitopes, which can effectively cover the distances between the S proteins, thus optimizing the B cell activation process. This review describes the various developments that have taken place in the field of VLPs and more specifically, with regards to developing VLP vaccines against the SARS-CoV-2 virus.

The goal of the descriptive, cross-sectional study was to collect and analyze data among minority nursing staff including 1) the relationships between quality of life, social support, discrimination, and coping during the COVID-19 pandemic, and 2) the differences between quality of life, social support, discrimination, and coping among different racial/ethnic groups during the COVID-19 pandemic. This paper is based on a secondary data analysis of the T1 data from a longitudinal study mentioned above and was performed by myself, while mentored by my committee, for completion of my thesis.