The COVID-19 pandemic caused uncertainty and changing public health recommendations across the world as our understanding of the SARS-CoV-2 virus changed. Following a preliminary assessment by the World Health Organization, non-steroidal anti-inflammatory drugs were said to worsen symptoms and should be avoided before the recommendation was subsequently revoked. There also was pain associated with infection, leading to the hypothesis that use of over-the-counter pain medication increases may correlate with increases of SARS-CoV-2 infections. Wastewater samples were collected from two communities in Tempe, AZ from December 2019 to July 2020 (n = 35) and were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) to identify levels of acetaminophen, ibuprofen and their metabolites, acetaminophen sulfate and carboxy-ibuprofen. Results showed 100% detection frequency of all analytes in all samples across the duration of the study. Mass loadings of acetaminophen (918.4 g day-1 +/- 354.8 g day-1) were higher than ibuprofen (182.9 g day-1 +/- 49.8 g day-1), potentially driven by flushing behaviors rather than consumption activities. However, ibuprofen was more heavily consumed than acetaminophen across all days of the study period. Comparisons to COVID-19 clinical cases data showed increased use in ibuprofen with increases in clinical cases loads, while acetaminophen showed no change, suggesting ibuprofen was the over the counter (OTC) medication of choice during the first wave of the pandemic.

This thesis is a retrospective study analyzing data from patient implanted cardiac devices in other to determine the effect of SARS-CoV-2 on cardiac arrhythmias. This study is also the first, to the knowledge of the researchers, in which a cohort of undifferentiated hospitalized and non-hospitalized COVID patients were studied using data from cardiac implanted devices. The results from this study has shown that SARS-CoV-2 leads to statistically significant increases in arrhythmic burden, in particular increased overall arrhythmic episodes, increased VT episodes, increased AT Burden percent, and increased SVT Average Ventricular Rate, and a statistically significant decrease in VT Average Ventricular Rate.

This study investigates the impact of the COVID-19 pandemic on telemedicine-prescribed controlled substances by discussing the opinions of pharmacists holding an Arizona pharmacy license. To accommodate the rapid changes during the COVID-19 pandemic, the federal government adapted pharmacy laws to better support the healthcare community. The use of remote healthcare services such as telemedicine visits and online pharmacy services dramatically increased during the pandemic, so regulators waived tele-health restrictions like the Ryan Haight Act. This study involved structured interviews with 3 participants. The interviews revealed a positive outlook on the future of telehealth and the possibilities of modernizing healthcare and pharmacy. The study suggests that the waiving of the Ryan Haight Act was perceived somewhat positively by pharmacists, although they still had concerns regarding abandoning parts of the Act from a patient safety standpoint. The study concludes that certain pharmacy and telemedicine regulations are outdated given the positive and negative outcomes of these laws during the global pandemic. While this study offers insights on bringing various healthcare and law arguments together, the small sample size results in limited scope. The study still provides points of discussion to offer recommendations for implementation of the Ryan Haight Act and other similar tele-health and online-pharmacy regulations.