The COVID-19 pandemic has resulted in preventative measures and has led to extensive changes in lifestyle for the vast majority of the American population. As the pandemic progresses, a growing amount of evidence shows that minority groups, such as the Deaf community, are often disproportionately and uniquely affected. Deaf people are directly affected in their ability to personally socialize and continue with daily routines. More specifically, this can constitute their ability to meet new people, connect with friends/family, and to perform in their work or learning environment. It also may result in further mental health changes and an increased reliance on technology. The impact of COVID-19 on the Deaf community in clinical settings must also be considered. This includes changes in policies for in-person interpreters and a rise in telehealth. Often, these effects can be representative of the pre-existing low health literacy, frequency of miscommunication, poor treatment, and the inconvenience felt by Deaf people when trying to access healthcare. Ultimately, these effects on the Deaf community must be taken into account when attempting to create a full picture of the societal shift caused by COVID-19.

Hundreds of thousands of people die annually from malaria; a protozoan of the genus Plasmodium is responsible for this mortality. The Plasmodium parasite undergoes several life stages within the mosquito vector, the transition between which require passage across the lumen of the mosquito midgut. It has been observed that in about 15% of parasites that develop ookinetes in the mosquito abdomen, sporozoites never develop in the salivary glands, indicating that passage across the midgut lumen is a significant barrier in parasite development (Gamage-Mendis et al., 1993). We aim to investigate a possible correlation between passage through the midgut lumen and drug-resistance trends in Plasmodium falciparum parasites. This study contains a total of 1024 Anopheles mosquitoes: 187 Anopheles gambiae and 837 Anopheles funestus samples collected in high malaria transmission areas of Mozambique between March and June of 2016. Sanger sequencing will be used to determine the prevalence of known resistance alleles for anti-malarial drugs: chloroquine resistance transporter (pfcrt), multidrug resistance (pfmdr1) gene, dihydropteroate synthase (pfdhps) and dihydrofolate reductase (pfdhfr). We compare prevalence of resistance between abdomen and head/thorax in order to determine whether drug resistant parasites are disproportionately hindered during their passage through the midgut lumen. A statistically significant difference between resistance alleles in the two studied body sections supports the efficacy of new anti-malarial gene surveillance strategies in areas of high malaria transmission.

As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

During the COVID-19 pandemic, increased burdens have been placed on the Arizona healthcare system, and its healthcare providers. Using a survey with a sample of N=308 prescribing providers and nurses in the Arizona healthcare system, the impact of COVID-19 on the wellbeing of healthcare providers was assessed. The survey used measures to evaluate for physical and emotional wellbeing, burnout, stressors associated with COVID-19, and work-life experiences, and found an overall negative impact on the wellbeing of healthcare workers during the COVID-19 pandemic with increased levels of reported stress and tiredness, concern for the health of family and loved ones, concern for the hardships of patients, lack of alignment between organizational priorities and personal values, and low levels of support and appreciation from socially and from leadership at work.

COVID-19 misinformation covers a wide range of topics such as fatality rate, mask effectiveness, potential cures, vaccine development, and the idea of a "plandemic". The spread of this misinformation happens at a rapid speed with the help of social media and powerful influencers, including major political figures. This thesis is a focused case study on hydroxychloroquine, and builds a timeline of the misinformation surrounding the drug. From poorly conducted studies to the use of false experts, this study reveals how politicized misinformation garners more public attention than the actual science.

The COVID-19 pandemic has renewed interest in the importance of indoor air quality for health. The spread of respiratory aerosols is the primary mechanism for COVID-19 transmission, making it crucial to understand the role of effective ventilation in managing the risk of disease transmission. The concentration of exhaled carbon dioxide (CO2) in indoor spaces can be used as a proxy measure of ventilation efficiency. Poor indoor air quality has been associated with a range of acute and chronic health problems, including respiratory issues, cardiovascular disease, and cancer. Poor air quality may also impair cognitive performance and productivity. Social and economic inequalities exacerbate the impact of indoor air quality issues, making it crucial to address these problems in an equitable manner. Public libraries have been identified as an effective intermediary for providing education and free air quality monitoring technology to communities, with the ultimate goal of promoting awareness and increasing access to tools to promote accountability for maintaining high indoor air quality standards. The primary objectives of this initiative are to: 1) develop a citizen science toolkit for assessing indoor air quality in public spaces and deploy the toolkit to public libraries in Arizona; and 2) to conduct a program evaluation to determine whether this kit can be effectively deployed through public libraries to promote citizen science efforts and engage community members in promoting healthier indoor air quality, identify areas where improvements can be made, and prepare the program to be scaled to a larger audience.

The occurrence of tragedies throughout history, whether it be natural disasters, pandemics, or wars, is inevitable. The way that humans have chosen to respond to destruction and disagreements has also changed. However, something that remains the same is that those with less monetary resources and political power are at a higher disadvantage whenever the world is under duress or hardship. This propensity (tendency) can be seen through the comparison of two very different yet very profound events in recent history, the COVID-19 pandemic and World War II. The two events are distinct in their time periods, the nature of the disaster that they caused, and the problems that were created by their existence. Although they are very dissimilar, those in the US who had less monetarily were still disadvantaged much more than those who were more affluent. This pattern of disparity is revealed through the use and failure of the supply chain during both events. A supply chain is the sequence of processes involved in the production and distribution of a commodity or service (Supply Chain Definition & Meaning, n.d.). Although the supply chains used in World War II were not as fine-tuned as the ones required to distribute goods around the world today, World War II was instrumental in the refinement and use of the supply chain due to the high demand for goods and personnel across the world. During COVID-19 the quick shift in demand for unprecedented goods and services exposed the inflexibility of the world's largest supply chains, which in turn caused shortages around the world. For the United States government or large global corporations to fix the problems caused by these events, they both turned to the people who bear the majority of the burden of working overtime to account for the loss of goods; those who are most susceptible to the shortages of goods and services: those in lower-income communities.

The occurrence of tragedies throughout history, whether it be natural disasters, pandemics, or wars, is inevitable. The way that humans have chosen to respond to destruction and disagreements has also changed. However, something that remains the same is that those with less monetary resources and political power are at a higher disadvantage whenever the world is under duress or hardship. This propensity (tendency) can be seen through the comparison of two very different yet very profound events in recent history, the COVID-19 pandemic and World War II. The two events are distinct in their time periods, the nature of the disaster that they caused, and the problems that were created by their existence. Although they are very dissimilar, those in the US who had less monetarily were still disadvantaged much more than those who were more affluent. This pattern of disparity is revealed through the use and failure of the supply chain during both events. A supply chain is the sequence of processes involved in the production and distribution of a commodity or service (Supply Chain Definition & Meaning, n.d.). Although the supply chains used in World War II were not as fine-tuned as the ones required to distribute goods around the world today, World War II was instrumental in the refinement and use of the supply chain due to the high demand for goods and personnel across the world. During COVID-19 the quick shift in demand for unprecedented goods and services exposed the inflexibility of the world's largest supply chains, which in turn caused shortages around the world. For the United States government or large global corporations to fix the problems caused by these events, they both turned to the people who bear the majority of the burden of working overtime to account for the loss of goods; those who are most susceptible to the shortages of goods and services: those in lower-income communities.

The purpose of this Honors Thesis was to first, understand the implications of social isolation and loneliness on an individuals’ physical and mental health and second, uncover successful strategies that individuals used to overcome social isolation and loneliness. This thesis used two primary data sets to draw conclusions about individuals’ subjective feelings of loneliness and isolation and to further understand what strategies were used to overcome these feelings. The results from this thesis demonstrated that individuals who successfully avoided feelings of social isolation and loneliness during the COVID-19 pandemic took up new activities, used strategies to facilitate communication, participated in community engagement, completed acts of service, practiced mindfulness and reflection, and made new connections.