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The Potential of Virus-Like Particles (VLPs) as an Effective Vaccine Candidate for the COVID-19 Vaccine: Review

Description

Virus-like particles (VLPs) are optimum candidates for creating vaccines, as they are highly flexible, adaptable, safe, and similar to the structural proteins of the target cells. The COVID 19 pandemic has increased the need to create effective and safe vaccines that can be mass produced to stop the spread of…

Virus-like particles (VLPs) are optimum candidates for creating vaccines, as they are highly flexible, adaptable, safe, and similar to the structural proteins of the target cells. The COVID 19 pandemic has increased the need to create effective and safe vaccines that can be mass produced to stop the spread of COVID-19. Till now, various types of vaccine platforms have been utilized to create COVID-19 vaccines, each with unique characteristics and techniques. It is essential to use robust vaccine platforms that can deliver optimum results in a short period of time, with minimal risks. The structural proteins found in SARS-CoV-2, such as Spike (S) protein have been widely targeted to induce antibody response, also called a humoral response, which is a part of acquired immunity. The other structural proteins such as M (membrane) and E (envelope) can also be used as targets for antibodies. The S2 and glycoprotein (S full) can be used to induce an efficient IgG response. Therefore, the incorporation of structural proteins into VLPs can prove to be useful. Furthermore, double mosaic VLPs employs double epitopes, which can effectively cover the distances between the S proteins, thus optimizing the B cell activation process. This review describes the various developments that have taken place in the field of VLPs and more specifically, with regards to developing VLP vaccines against the SARS-CoV-2 virus.
ContributorsSharma, Anjali (Author) / Hogue, Brenda (Thesis director) / Li, Yize (Committee member) / Barrett, The Honors College (Contributor) / College of Health Solutions (Contributor)
Created2022-05
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The Influence of Tik Tok on the Music Industry During the Covid-19 Pandemic

Description
Social media and digital marketing has become a gateway for musicians and artists to share creative content virtually changing cultural practices, and evolving musical exposure and development. In the year 2020, during the Covid-19 pandemic, the social media platform TikTok revolutionized the world becoming the most influential application for music…

Social media and digital marketing has become a gateway for musicians and artists to share creative content virtually changing cultural practices, and evolving musical exposure and development. In the year 2020, during the Covid-19 pandemic, the social media platform TikTok revolutionized the world becoming the most influential application for music curation, social engagement, and digital marketing. This social platform has new demand for consumer-artist digital relationships and acts as a promotional vehicle for rising artists. Case studies analyzing TikTok influencers such as Dixie D’Amelio, Loren Gray, Bella Poarch, and Jxdn show how they used their vast social media following and the limiting factors of the Covid-19 pandemic to shift their social media presence, transitioning from influencers to prominent musicians signed to record labels.
ContributorsWhitmore, Adriana (Author) / Libman, Jeffrey (Thesis director) / Carrasco, Clare (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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The Psychosocial Effects on Minority Nursing Staff Due to COVID-19 Related Racial Discrimination

Description

The goal of the descriptive, cross-sectional study was to collect and analyze data among minority nursing staff including 1) the relationships between quality of life, social support, discrimination, and coping during the COVID-19 pandemic, and 2) the differences between quality of life, social support, discrimination, and coping among different racial/ethnic…

The goal of the descriptive, cross-sectional study was to collect and analyze data among minority nursing staff including 1) the relationships between quality of life, social support, discrimination, and coping during the COVID-19 pandemic, and 2) the differences between quality of life, social support, discrimination, and coping among different racial/ethnic groups during the COVID-19 pandemic. This paper is based on a secondary data analysis of the T1 data from a longitudinal study mentioned above and was performed by myself, while mentored by my committee, for completion of my thesis.
ContributorsBush, Tiffany (Author) / Chia-Chen Chen, Angela (Thesis director) / Li, Wei (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / Edson College of Nursing and Health Innovation (Contributor)
Created2022-05

The Vitality of Clean Air in Ulaanbaatar, Mongolia: A Health Analysis of Koyash, a Novel, Off Grid Air Purification System

Description
Ulaanbaatar, Mongolia is one of the world’s coldest capital cities with roughly 1.5 million residents. About fifty percent of the city’s residents are off the electrical grid and millions continue to live nomadic lifestyles, raising livestock for food. Problematically, residents often turn to raw coal - Mongolia’s largest export -…

Ulaanbaatar, Mongolia is one of the world’s coldest capital cities with roughly 1.5 million residents. About fifty percent of the city’s residents are off the electrical grid and millions continue to live nomadic lifestyles, raising livestock for food. Problematically, residents often turn to raw coal - Mongolia’s largest export - as a means to cook food and stay warm. Project Koyash is a philanthropic engineering initiative that was founded in the Arizona State University Program Engineering Projects in Community Service (EPICS) to combat the air quality crisis plaguing the ger districts of Ulaanbaatar. Koyash has already deployed 13 fully functional and autonomous units consisting of a solar powered air filtration system in Ulaanbaatar. Koyash innovated a solution of solar panels, air filters, batteries, inverters, PCB Arduinos, and other necessary components for providing crucial humanitarian services. The team is working to send more units and develop a local supply chain for the systems. This thesis project explores the development of Koyash, assesses the human health implications of air pollution, and reflects on the entire process.
ContributorsYavari, Bryan (Author) / Hartwell, Leland (Thesis director) / Schoepf, Jared (Thesis director) / Diddle, Julianna (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2024-05

Schildgen Miller Engerholm Engineering Company (SMEECo)

Description
Our Idea: As a team of engineers, two in the engineering field and one in computer science and software development, we wanted to find a way to put these skills to use in our company. As we did not have a revolutionary idea to build our own product, we wanted to base our…

Our Idea: As a team of engineers, two in the engineering field and one in computer science and software development, we wanted to find a way to put these skills to use in our company. As we did not have a revolutionary idea to build our own product, we wanted to base our company on the assumption that people have great ideas and lack the ability to execute on these ideas. Our mission is to enable these people and companies to make their ideas a reality, and allow them to go to market with a clean and user friendly product. We are using our skills and experience in hardware and device prototyping and testing, as well as software design and development to make this happen. Implementation: To this point, we have been working with a client building a human diagnostic and enhancement AI device. We have been consulting on mostly the design and creation of their first proof of concept, working on hardware and sensor interaction as well as developing the software allowing their platform to come to life. We have been working closely with the leaders of the company, who have the ideas and business knowledge, while we focus on the technology side. As for the scalability and market potential of our business, we believe that the potential market is not the limiting factor. Instead, the limiting factor to the growth of our business is the time we have to devote. We are currently only working with one client, and not looking to expand into new clients. We believe this would require the addition of new team members, but instead we are happy with the progress we are making at the moment. We believe we are not only building equity in business we believe in, but also building a product that could help the safety and wellness of our users.
ContributorsMiller, Kyle (Author) / Engerholm, Liam (Co-author) / Schildgen, Nathan (Co-author) / Byrne, Jared (Thesis director) / Lee, Christopher (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor)
Created2024-05

Examining Vaccine Supply and Demand: A Study of COVID-19 Vaccination in Israel

Description
Was Israel’s early successful vaccine rollout enough to get their population vaccinated in a timely and sufficient manner? This paper will dive into this question by approaching it from the lens of supply and demand. Factors that enabled their successful supply chain management of vaccines will be contrasted against demand…

Was Israel’s early successful vaccine rollout enough to get their population vaccinated in a timely and sufficient manner? This paper will dive into this question by approaching it from the lens of supply and demand. Factors that enabled their successful supply chain management of vaccines will be contrasted against demand constraints to illustrate that while Israel was successful in obtaining vaccines for their population, they ultimately, similarly to other countries, faced issues with vaccine hesitancy and reaching full coverage.
ContributorsMcCartan, Megan (Author) / Don, Rachael (Thesis director) / Moodley Naidoo, Roshini (Committee member) / Barrett, The Honors College (Contributor) / School of Human Evolution & Social Change (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05