As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020, this virus's deadly nature has required clinical testing to meet 2020's demands of higher throughput, higher accuracy and higher efficiency. Information technology has allowed institutions, like Arizona State University (ASU), to make strategic and operational changes to combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL) among business, communications, management/training, law, and clinical analysis. The first chapter of this manuscript covers the background of clinical laboratory automation and details the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The second chapter discusses the usability and efficiency of key information technology systems of the ABCTL. The third chapter explains the role of quality control and data management within ABCTL’s use of information technology. The fourth chapter highlights the importance of data modeling and 10 best practices when responding to future public health emergencies.

Developing a vaccine during the midst of a pandemic requires a careful balance between <br/>speed, safety, and efficacy. For the COVID-19 pandemic, the U.S. implemented Operation Warp Speed to accelerate the timeline for vaccine development. The FDA also imposed specific guidelines for granting Emergency Use Authorization (EUA). As of April 1st, 2021, Operation Warp Speed resulted in three different vaccines receiving EUA, all of which are currently being administered to the public. However, the rapid production and changes in the approval process intensified public scrutiny on the safety and efficacy of the vaccine. This thesis analyzes the differences in fast-tracking a vaccine, which consolidated the authorization process into months rather than years, and delineates the main concerns of the public regarding the COVID-19 vaccine through a media analysis. Although the EUA raised questions about the safety of the vaccine, polls indicate that most Americans would still be willing to receive the vaccine.

The objective of this thesis is to further understand the obstacles that impoverished families face, which may include: meeting nutritional needs, an earlier introduction to violence, or struggles with family planning. It is crucial to illustrate the effects of poverty on the physical, mental, and emotional health of both children and caregivers. Additionally, the family dynamics and educational challenges for children will also be explored as supplemental research. This study will draw upon psychological theories with an emphasis on maternal and child health. The goal is to empower families to make informed family planning decisions. This project will be focused on supporting families in low-income areas, particularly in Arizona

The study investigated unconscious biases in physicians regarding conflicts in developing care plans for patients related to religious restrictions in medicine. Fourteen physicians were interviewed to discuss their experiences with these patients and find patterns and factors that could lead to more negative attitudes from the physicians in the patient’s care. It was found that the gender, religious background, and location of residency had various impacts on the attitude of the physician regarding a religious concern; however, there was no outstanding demographic that led to a comparatively negative attitude. Additionally, the type of reasoning a patient used related to a religious concern had an impact on the attitude of the physician, and this was due to the logic and duration of the concern as well as the attitude of the patient. These factors and patient cases were thoroughly analyzed and discussed throughout the paper to shed light on possible factors that could negatively affect the patient’s care.

The purpose of this study was to evaluate the pandemic’s effect on the psychosocial and physical quality of life of children with and without classic galactosemia and their parents in the Babble Boot Camp. The Babble Boot Camp within ASU’s Speech and Hearing Genetics Lab provides early intervention speech therapy for children with classic galactosemia (CG), evaluating their speech progress as well as other metrics related to stress and quality of life. In this study, the Quality of Life questionnaire (Varni, 1998) was used to measure how three pandemic stages (pre-pandemic, intense-pandemic, post intense-pandemic) affected the entire participant population, those with CG children compared to typically developing, and each family member (father vs. mother vs. child). These factors were combined within an integrated regression model to see driving factors and correlations within responses. The main results were that the pandemic itself did not have a significant effect, but there was quite a significant impact on psychosocial health when comparing affected vs unaffected groups. Evaluating an integrated regression model with the consideration of all three pandemic phases, the results show that the factor driving group differences over time was the affectation of the participant for psychosocial health and family member for physical health. When looking at just pre-pandemic and intense pandemic phase, both models in their entirety were significant, showing that all predictors (affectation, pandemic phase, and family member) drove health differences. Lastly, the findings of the study show that there were significant correlations between the health scores of fathers, mothers, and children throughout the different stages of the pandemic.

Studies during and following the height of the Coronavirus pandemic show that psychological and physical health levels decrease, due to factors such as reduced human contact and anxiety. However, there is little to no research on how quality of life levels would change over the course of the pandemic for families who have the added stress of having a child with a developmental complication. To answer this question, this study utilized longitudinal data from the Babble Boot Camp, a project under the ASU Speech Language Genetics Lab, to analyze quality of life measures in families who have children with Classic Galactosemia (CG). CG is an inborn metabolic disorder that causes an intolerance to galactose, a sugar in dairy, the effects of which can be deadly. These children often show signs of developmental delays in multiple areas within the first few years of life. Studying quality of life surveys before, during, and after the most intense phase of the pandemic, this study investigates the difference between these families and those with typical children.

During the year 2020, the world saw unprecedented social change with the beginning of the COVID-19 pandemic, including increased risk of sexual assault. Limited information has been released regarding the pandemic and sexual assault; however, two prior studies reveal decreased utilization of rape kits and fewer emergency department exams for sexual assault during 2020 when compared to values before the pandemic. In Maricopa County, a group of forensic nurse examiners under HonorHealth performed screening exams on patients who reported sexual assault from the years 2015 to 2021. Using the prevalence of screening exams per year in Maricopa County, this study evaluated whether there was significant change in the number of exams performed during 2020 compared to pre-pandemic values. The year 2020 had the greatest percent discrepancy between predicted and observed quantities of exams when compared to the years 2015 to 2019.