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- Creators: Barrett, The Honors College
Description
Rasopathies are a family of developmental syndromes that exhibit craniofacial abnormalities, cognitive disabilities, developmental delay and increased risk of cancer. However, little is known about the pathogenesis of developmental defects in the nervous system. Frequently, gain-of-function mutations in the Ras/Raf/MEK/ERK cascade (aka ERK/MAPK) are associated with the observed pathogenesis. My research focuses on defining the relationship between increased ERK/MAPK signaling and its effects on the nervous system, specifically in the context of motor learning. Motor function depends on several neuroanatomically distinct regions, especially the spinal cord, cerebellum, striatum, and cerebral cortex. We tested whether hyperactivation of ERK/MAPK specifically in the cortex was sufficient to drive changes in motor function. We used a series of genetically modified mouse models and cre-lox technology to hyperactivate ERK/MAPK in the cerebral cortex. Nex:Cre/NeuroD6:Cre was employed to express a constitutively active MEK mutation throughout all layers of the cerebral cortex from an early stage of development. RBP4:Cre, caMEK only exhibited hyper activation in cortical glutamatergic neurons responsible for cortical output (neurons in layer V of the cerebral cortex). First, the two mouse strains were tested in an open field paradigm to assess global locomotor abilities and overall fitness for fine motor tasks. Next, a skilled motor reaching task was used to evaluate motor learning capabilities. The results show that Nex:Cre/NeuroD6:Cre, caMEK mutants do not learn the motor reaching task, although they performed normally on the open field task. Preliminary results suggest RBP4:Cre, caMEK mutants exhibit normal locomotor capabilities and a partial lack of learning. The difference in motor learning capabilities might be explained by the extent of altered connectivity in different regions of the corticospinal tract. Once we have identified the neuropathological effects of various layers in the cortex we will be able to determine whether therapeutic interventions are sufficient to reverse these learning defects.
ContributorsRoose, Cassandra Ann (Author) / Newbern, Jason M. (Thesis director) / Olive, Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The NBA operates under a unique system with both forms of the salary cap. The league has a team salary cap that sets a limit that teams can spend on their entire roster. The NBA has a soft cap and a luxury tax system, meaning if teams spend over a determined amount, they are taxed for the salaries in excess. The league also has a player salary cap. The 1999 NBA collective bargaining agreement first introduced the individual player salary cap in the league. This cap sets a limit on what the best players can earn, otherwise known as the maximum contract. In an economic system with a soft team cap, the introduction of the player salary cap has important implications. The stated outcome of such a salary cap is to improve competitive balance and better distribute star players throughout the league. This study evaluated the 1990-2015 regular seasons to measure the impact of the player salary cap on competitive balance, the distribution of team payrolls, and the dispersion of star players. In accordance with the Rottenberg's invariance hypothesis, the player salary cap has hurt the players and benefited the owners by redistributing income from one party to the other, without impacting the distribution of talent in the league. The rule change has not affected competitive balance, while team payrolls have converged and star players have become more dispersed throughout the league. These changes hurt the league overall, preventing the maximization of revenues. Despite this inefficiency, the chance of the league moving to eliminate the player salary cap is low.
ContributorsWelu, Brian Andrew (Author) / Marburger, Daniel (Thesis director) / Goegan, Brian (Committee member) / Sandra Day O'Connor College of Law (Contributor) / Department of Economics (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
This paper analyzes modern day Cuba and draws conclusions about the most likely future political and economic events that will take place. Because of Cuba's troubled economy, leadership change and the world's continued shift towards democratization, Cuba is in a position where drastic changes in its government and economic structure may occur. This paper investigates Cuba's history, politics, economy, and the general quality of life of its citizens, which are used to help predict what may happen to the Cuban government in the near future. The paper also analyzes options for foreign nations' policy towards Cuba and summarizes what actions they may take to increase the likelihood of an economic and political transition. Cuba's economic structure needs drastic reform, the reluctant privatization only increases wealth disparity, trust in the government continues to get weaker as more information and its human rights violations are causes of huge concern. There are four possible outcomes for Cuba's future: stagnation, adopting the mixed economic model, a peaceful transition to a democratic model, and rebellion. There is evidence that Cuba will not make drastic policy changes in favor of liberalization in the immediate future, however, if the economic conditions are not improved and an economic crisis ensues, this paper asserts that another revolution or coup will likely occur. The resulting government may be a new autocratic leader that fills the vacuum of leadership, or a democratic regime depending on the nature of the rebellion. The exact future of Cuba is uncertain, but one thing is clear, change is on the horizon.
ContributorsBeem, Christian D. (Author) / Anthony, Charles (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Economics (Contributor) / W.P. Carey School of Business (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The Medicaid expansion policy that was introduced during the Obama administration has been a political point of controversy. The expansion aimed to increase health insurance coverage for those who are unable to afford health insurance for themselves.
This analysis aimed to determine the economic effect of the Medicaid expansion on real GDP per capita. The expansion is believed to result in greater worker productivity and increases in healthcare service consumption and consumption of other goods. As health insurance coverage may increase real GDP per capita due to healthier workers being more productive, an analysis was first done on the effect of the expansion on health insurance coverage, then the effect of the health insurance coverage on real GDP per capita. The data used was in the time frame of 1999 to 2016 and organized by state, and gathered from the Bureau of Economic Analysis, the U.S Census Bureau, the Kaiser Family Foundation, Bureau of Labor Statistics, and the Federal Reserve Bank of St. Louis. The analysis was structured as a 2-stage multivariable linear regression. These regressions were modeled as a fixed-effects regression so states may be compared to itself over time. The first regression was of health insurance coverage on proportions of industry output from the agriculture, resources, manufacturing, and finance sector, median income, employment rate, poverty rate, Medicaid expansion status, and year. The predicted values of this regression were then used as an instrumental variable in the second regression. The second regression was of real GDP per capita on proportions of industry output from the agriculture, resources, manufacturing, and finance sector, median income, employment rate, poverty rate, the instrumental variable, and year. Regressions were also done on the expansion’s effect on per capita personal consumption expenditures and healthcare consumption expenditures using the instrumental variable.
The results of the regressions show that the expansion had a positive effect on health insurance coverage and real GDP per capita. It also increased personal expenditures per capita and healthcare expenditures per capita, suggesting that the lower price of healthcare results in increased overall consumption. The data was constrained by time, as the expansion was only implemented recently, and some states are still deciding whether or not to. Thus, the results of support expectations, but more time would need to pass to more accurately estimate the effects of the expansion on these states.
This analysis aimed to determine the economic effect of the Medicaid expansion on real GDP per capita. The expansion is believed to result in greater worker productivity and increases in healthcare service consumption and consumption of other goods. As health insurance coverage may increase real GDP per capita due to healthier workers being more productive, an analysis was first done on the effect of the expansion on health insurance coverage, then the effect of the health insurance coverage on real GDP per capita. The data used was in the time frame of 1999 to 2016 and organized by state, and gathered from the Bureau of Economic Analysis, the U.S Census Bureau, the Kaiser Family Foundation, Bureau of Labor Statistics, and the Federal Reserve Bank of St. Louis. The analysis was structured as a 2-stage multivariable linear regression. These regressions were modeled as a fixed-effects regression so states may be compared to itself over time. The first regression was of health insurance coverage on proportions of industry output from the agriculture, resources, manufacturing, and finance sector, median income, employment rate, poverty rate, Medicaid expansion status, and year. The predicted values of this regression were then used as an instrumental variable in the second regression. The second regression was of real GDP per capita on proportions of industry output from the agriculture, resources, manufacturing, and finance sector, median income, employment rate, poverty rate, the instrumental variable, and year. Regressions were also done on the expansion’s effect on per capita personal consumption expenditures and healthcare consumption expenditures using the instrumental variable.
The results of the regressions show that the expansion had a positive effect on health insurance coverage and real GDP per capita. It also increased personal expenditures per capita and healthcare expenditures per capita, suggesting that the lower price of healthcare results in increased overall consumption. The data was constrained by time, as the expansion was only implemented recently, and some states are still deciding whether or not to. Thus, the results of support expectations, but more time would need to pass to more accurately estimate the effects of the expansion on these states.
ContributorsSmoudi, Senan (Author) / Silverman, Daniel (Thesis director) / Baldwin, Marjorie (Committee member) / Department of Finance (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
A global trend towards cashlessness following the increase in technological advances in financial transactions lends way to a discussion of its various impacts on society. As part of this discussion, it is important to consider how this trend influences crime rates. The purpose of this project is to specifically investigate the relationship between a cashless society and the robbery rate. Using data collected from the World Bank’s Global Financial Inclusions Index and the United Nations Office of Drugs and Crime, we implemented a multilinear regression to observe this relationship across countries (n = 29). We aimed to do this by regressing the robbery rate on cashlessness and controlling for other related variables, such as gross domestic product and corruption. We found that as a country becomes more cashless, the robbery rate decreases (β = -677.8379, p = 0.071), thus providing an incentive for countries to join this global trend. We also conducted tests for heteroscedasticity and multicollinearity. Overall, our results indicate that a reduction in the amount of cash circulating within a country negatively impacts robbery rates.
ContributorsChoksi, Aashini S (Co-author) / Elliott, Keeley (Co-author) / Goegan, Brian (Thesis director) / McDaniel, Cara (Committee member) / School of International Letters and Cultures (Contributor) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
This study examines the economic impact of the opioid crisis in the United States. Primarily testing the years 2007-2018, I gathered data from the Census Bureau, Centers for Disease Control, and Kaiser Family Foundation in order to examine the relative impact of a one dollar increase in GDP per Capita on the death rates caused by opioids. By implementing a fixed-effects panel data design, I regressed deaths on GDP per Capita while holding the following constant: population, U.S. retail opioid prescriptions per 100 people, annual average unemployment rate, percent of the population that is Caucasian, and percent of the population that is male. I found that GDP per Capita and opioid related deaths are negatively correlated, meaning that with every additional person dying from opioids, GDP per capita decreases. The finding of this research is important because opioid overdose is harmful to society, as U.S. life expectancy is consistently dropping as opioid death rates rise. Increasing awareness on this topic can help prevent misuse and the overall reduction in opioid related deaths.
ContributorsRavi, Ritika Lisa (Author) / Goegan, Brian (Thesis director) / Hill, John (Committee member) / Department of Economics (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Existing research into the health benefits of insurance fall into two major categories \u2014 observational and experimental. Observational studies have centered on data sets from before 2000 and focus on the mortality differences between the privately insured and the uninsured. Experimental studies began with Massachusetts' 2006 health reform and continued after the passage of the Affordable Care Act. These studies measure the effects of public insurance among the coverage expansion populations. These two bodies of literature come to ambiguous and contradictory conclusions to the mortality effects and health value of insurance. This study extends the observational methodologies to the publicly insured in samples from the National Health and Nutrition Examination Survey in both the 1988-1994 survey and the 2001-2002 survey. Using the Cox Proportional Hazard model, this study estimates the hazard ratios faced by the privately and publicly insured compared to the uninsured. This study finds the publicly insured face hazards 1.5 times those of the uninsured (p<.001), while the privately insured do not face hazards significantly different from those of the uninsured. Literature suggests that some unobserved characteristic of the publicly insured are influencing their mortality. Interacting with participants health reveals that these differences across groups shrink as health declines. Experimental literature suggests that public insurance lowers the uninsured risk from "healthcare amenable" conditions. Treatment of these conditions may explain the hazard reductions among the uninsured in non-excellent health. The high risk of the publicly insured in excellent health defies explanation.
ContributorsMorita, Aidan James Donnelly (Author) / Veramendi, Gregory (Thesis director) / Zafar, Basit (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor) / School of Sustainability (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This paper examines the behavior of international lending networks a currency crisis, specifically focusing on connectivity as a differentiating factor between financial networks. The model consists of economies that borrow and lend capital in nominal units of the creditor's currency. A shock then leads to the depreciation of the currency of a single economy which causes exchange rate fluctuations throughout the financial network. This alters the nominal value of debts that economies are required to repay, potentially putting them at risk of default. The results show that the architecture of a financial network is an important factor in minimizing the number of defaults and maximizing total social welfare. An increase in connectivity among economies leads to both greater stability and greater total social welfare of a network, since diversification of liabilities decreases fluctuations in exchange rates.
ContributorsVon Beringe, Konstantin (Author) / Leiva Bertran, Fernando (Thesis director) / Schenone, Pablo (Committee member) / School of Mathematical and Statistical Sciences (Contributor, Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The RAS/MAPK (RAS/Mitogen Activated Protein Kinase) pathway is a highly conserved, canonical signaling cascade that is highly involved in cellular growth and proliferation as well as cell migration. As such, it plays an important role in development, specifically in development of the nervous system. Activation of ERK is indispensable for the differentiation of Embryonic Stem Cells (ESC) into neuronal precursors (Li z et al, 2006). ERK signaling has also shown to mediate Schwann cell myelination of the peripheral nervous system (PNS) as well as oligodendrocyte proliferation (Newbern et al, 2011). The class of developmental disorders that result in the dysregulation of RAS signaling are known as RASopathies. The molecular and cell-specific consequences of these various pathway mutations remain to be elucidated. While there is evidence for altered DNA transcription in RASopathies, there is little work examining the effects of the RASopathy-linked mutations on protein translation and post-translational modifications in vivo. RASopathies have phenotypic and molecular similarities to other disorders such as Fragile X Syndrome (FXS) and Tuberous Sclerosis (TSC) that show evidence of aberrant protein synthesis and affect related pathways. There are also well-defined downstream RAS pathway elements involved in translation. Additionally, aberrant corticospinal axon outgrowth has been observed in disease models of RASopathies (Xing et al, 2016). For these reasons, this present study examines a subset of proteins involved in translation and translational regulation in the context of RASopathy disease states. Results indicate that in both of the tested RASopathy model systems, there is altered mTOR expression. Additionally the loss of function model showed a decrease in rps6 activation. This data supports a role for the selective dysregulation of translational control elements in RASopathy models. This data also indicates that the primary candidate mechanism for control of altered translation in these modes is through the altered expression of mTOR.
ContributorsHilbert, Alexander Robert (Author) / Newbern, Jason (Thesis director) / Olive, M. Foster (Committee member) / Bjorklund, Reed (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The FIFA World Cup is one of the most anticipated, inspiring, and intense sporting events in the world. Soccer has integrated itself not only in sports circles, but also in politics, commerce, and society as a whole. The sport has about two hundred million active players and is still growing, especially in areas such as North America and Asia. As of mid-2007, FIFA’s membership included 208-member associations, making it not only one of the largest and most powerful sports governing bodies, but also one of the most popular in the world.
Since 1930—with the exception of the break for World War II—every four years, the world’s best national teams face off in a soccer tournament. The last two tournaments hosted by South Africa in 2010 and Brazil in 2014 will be the emphasis of this paper. Each tournament featured the thirty-two countries and captured a television audience of over three billion people throughout the month-long tournament, one billion of which tuned in for the final. For comparison, the Super Bowl XLIX where the New England Patriots defeated the Seattle Seahawks 28 to 24 was the most watched event in United States’ history with a viewership of 114.4 million people.
Countries spend years planning and preparing to win a bid to host one of these mega events. Bids are often times awarded eight to twelve years in advance. There has been a recent trend of developing countries hosting the FIFA World Cups and the future bids already awarded follow that trend. Many people ask the question of whether all the money spent on infrastructure, construction, and tourism to host this tournament and gain international exposure are really worth it? Simply put, the 2010 FIFA World Cup was valuable to South Africa while the 2014 FIFA World Cup was not worth the costs to Brazil.
Since 1930—with the exception of the break for World War II—every four years, the world’s best national teams face off in a soccer tournament. The last two tournaments hosted by South Africa in 2010 and Brazil in 2014 will be the emphasis of this paper. Each tournament featured the thirty-two countries and captured a television audience of over three billion people throughout the month-long tournament, one billion of which tuned in for the final. For comparison, the Super Bowl XLIX where the New England Patriots defeated the Seattle Seahawks 28 to 24 was the most watched event in United States’ history with a viewership of 114.4 million people.
Countries spend years planning and preparing to win a bid to host one of these mega events. Bids are often times awarded eight to twelve years in advance. There has been a recent trend of developing countries hosting the FIFA World Cups and the future bids already awarded follow that trend. Many people ask the question of whether all the money spent on infrastructure, construction, and tourism to host this tournament and gain international exposure are really worth it? Simply put, the 2010 FIFA World Cup was valuable to South Africa while the 2014 FIFA World Cup was not worth the costs to Brazil.
ContributorsLooney, Andrew (Author) / Goegan, Brian (Thesis director) / Eaton, John (Committee member) / Department of Economics (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05