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- All Subjects: Biomedical Engineering
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Description
For my honors thesis, I developed a proof of concept alpha prototype of a biomedical device for detection of cerebrospinal fluid leaks during spinal surgery. Cerebrospinal fluid leaks are a consequence of tears in the dura mater of the spinal cord and can result in potentially life-threatening conditions and are overall a large burden not only on the patient but upon the clinical teams managing the patient postoperatively. What I created was an optical sensor that I programmed to be sensitive to detecting green wavelength light. The device would ideally be attached to surgical drain tubing and used in conjunction with fluorescein (a green fluorescent dye) infused lumbar punctures into the spinal canal of patients. As the dye circulates through the spinal cord, any tears in the dura mater would cause the fluorescein to leak out with cerebrospinal fluid into the incision site. This fluid may then be collected by the surgical drain where the sensor may detect the fluorescein, triggering a buzzer response that would notify the patient or the surgeons of an ongoing leak that requires repair. The time I spent on my thesis involved sensor validation to ensure it could differentiate between colors, testing the sensor's color sensitivity by performing a fluorescein aliquot, and running proof of concept testing that could show the sensor can detect fluorescein drain tubing and provide an adequate response. The sensor was able to differentiate between varying concentrations of fluorescein in solution and provided exceptional results in its proof-of-concept testing. Next steps will be to re-run the sensor validation study with different dyes as well as consolidating the device's electrical hardware onto a single circuit board as development of beta and gamma prototypes move forward.
ContributorsAlam, Framarz (Author) / Muthuswamy, Jitendran (Thesis director) / Bohl, Michael (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This thesis seeks to evaluate whether the benefits of spinal fusion surgeries are worth their increasing costs. The paper examines the trends that contribute to these surgeries' increasing prices and then evaluates the customer impact of these surgeries in order to make a conclusion on whether the surgeries are worth it. This paper discusses the main factors that contribute to the increase in prices of these surgeries and these include the aging population, the increase in diabetes rates, and the practice of purchasing physicians owned distributorships (PODs) devices in some hospitals. The paper concluded that there is a definite correlation between the increased rate of spinal surgeries performed as a result of an increase in diabetes rates in the US population. It was argued that diabetes can lead to multiple spinal diseases which increase the demand of spinal surgeries which in turn causes the prices of these surgeries to rise. The paper also argued that current technological advances have allowed us to live longer which in turn leads to an increase in spine surgeries simply due to old age and a deteriorating spine. Lastly, it was argued that the recent surge in the POD devices being used in spinal surgeries in some hospitals can be seen as a possible influence to the increase in the cost of these surgeries. This is because the hospitals that chose to purchase surgery devices from PODs are more likely to increase the cost to perform the surgery because they are paying a lot more for those devices. Looking at the customer impact, it was apparent that spinal fusion surgeries carry certain risks because they require decortication of bone and, often, placement of implants; along with extensive dissection and longer operative time. However, based on the research conducted, there was no conclusion to be made on whether spinal fusions carried more risks than all other spinal surgeries because the data used only compared the surgery to some that are arguably less complicated like discectomies.
ContributorsDisengi Nkunzi, Jossel (Author) / Allenby, Braden (Thesis director) / Bohl, Michael (Committee member) / Barrett, The Honors College (Contributor)
Created2017-12