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Description
This project aims to address the current protocol regarding the diagnosis and treatment of traumatic brain injury (TBI) in medical industries around the world. Although there are various methods used to qualitatively determine if TBI has occurred to a patient, this study attempts to aid in the creation of a system for quantitative measurement of TBI and its relative magnitude. Through a method of artificial evolution/selection called phage display, an antibody that binds highly specifically to a post-TBI upregulated brain chondroitin sulfate proteoglycan called neurocan has been identified. As TG1 Escheria Coli bacteria were infected with KM13 helper phage and M13 filamentous phage in conjunction, monovalent display of antibody fragments (ScFv) was performed. The ScFv bind directly to the neurocan and from screening, phage that produced ScFv's with higher affinity and specificity to neurocan were separated and purified. Future research aims to improve the ScFv characteristics through increased screening toward neurocan. The identification of a highly specific antibody could lead to improved targeting of neurocan post-TBI in-vivo, aiding researchers in quantitatively defining TBI by visualizing its magnitude.
ContributorsSeelig, Timothy Scott (Author) / Stabenfeldt, Sarah (Thesis director) / Ankeny, Casey (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2015-05
Description
This thesis project provides a thorough cost-benefit analysis of the golf industry in Arizona. We begin by examining the economic, environmental, and social costs that the industry requires. One of the largest costs of the industry is water consumption. Golf courses in Arizona are currently finding ways to reduce water consumption through various methods, such as turf reduction and increasing the usage of drip irrigation. However, even at current levels of consumption, golf only consumes 1.9% of water in Arizona, compared to the 69% consumed by agriculture. Of the water consumed by the golf industry, 26.3% is wastewater, otherwise known as effluent water. Since the population in Arizona is projected to grow significantly over the next decade, the amount of effluent water produced will also increase. Due to this, we recommend that the golf industry move towards using as much effluent water as possible to conserve clean water sources. Additionally, we examine land allocation and agricultural tradeoffs to the state. Most golf courses are built in urban areas that would not be suitable for agriculture. The same land could be used to build a public park, but this would not provide as many economic benefits to the state. Many courses also act as floodplains which protect the communities surrounding them from flooding. These floodplains have proven to be crucial to protect from occasional flash floods by diverting the excess water away from homes. We also discuss golf's primary social cost in terms of its perception as being a sport played exclusively by privileged and wealthy people. This is proven to be false due to many non-profit organizations centered around the game, as well as municipal courses that provide affordable options for all citizens who want to play. We provide an in-depth analysis of the benefits that the industry provides to the state and its citizens primarily through business and tax revenue, employment, and property values. Including multiplier effects, the golf industry contributed 42,000 full- and part-time jobs, $3.9 billion in sales, $1.5 billion in labor income, and $2.1 billion value added in 2014. An estimated $72 million in state and local taxes were generated from golf facilities alone, without including taxes from indirectly impacted businesses. This tax revenue provides a great benefit to the public sector and increases Arizona's GDP. Also, much of this economic contribution is from the golf tourism industry, which brings new revenue into the state that would otherwise not exist. Golf courses also increase the surrounding real estate prices anywhere from 4.8% to 28%, providing a positive externality to community members in addition to scenic views. Finally, we provide a case study of the Waste Management Phoenix Open (WMO) to illustrate the impact of Arizona's single largest golf event each year. In 2017, the event brought an estimated $389 million into Arizona's economy in one week alone. Also, it regularly hosts massive crowds with a record-breaking 719,179 people attending the event in 2018. The WMO has also taken a "Zero Waste Challenge" to promote eco-friendly and sustainable practices by diverting all of the waste and materials produced by the tournament from landfills. The WMO has been dubbed both the "Greatest Show On Grass" and the "Greenest Show On Grass" due to the entertainment value provided as well as its effort to improve the environment.
ContributorsShershenovich, Andrew (Co-author) / Wilhelm, Spencer (Co-author) / Goegan, Brian (Thesis director) / Van Poucke, Rory (Committee member) / Department of Finance (Contributor) / W.P. Carey School of Business (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
A chimeric, humanized monoclonal antibody that recognizes a highly conserved fusion loop found on flaviviruses was constructed with a geminiviral replicon and transiently expressed in Nicotiana benthamiana plants through Agrobacterium tumefaciens infiltration. Characterization and expression studies were then conducted to confirm correct assembly of the antibody. Once the antibody was purified, an ELISA was conducted to validate that the antibody was able to bind to the flavivirus fusion loop.
ContributorsPardhe, Mary (Author) / Mason, Hugh (Thesis director) / Chen, Qiang (Committee member) / Mor, Tsafrir (Committee member) / School of Life Sciences (Contributor) / Department of Information Systems (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Research on California water markets has historically made two inaccurate assumptions regarding water rights: that water is a one-dimensional commodity, and that every water rights holder is in the market to sell. In reality, water is a bundled good that comprises varying attributes, and the decision to become a seller often has more to do with politics than price. This thesis analyzes the heterogeneous dimensions of a water right to explain the evolution of supply, demand, and price in California water markets. A dataset of 712 short-term surface water transfers in California from the period of 1990 through 2016 is analyzed to explain market trends and model the price of water. The data comes from a proprietary dataset of water transfers provided by WestWater Research, LLC (WestWater). Transfer data is distinguished based on variables such as buyer and seller experience, perennial crop plantings, seasonal timing of sale, buyer and seller region, water-year type, and end use. A variety of figures present summary statistics of the data. Ordinary Least Squares (OLS) regression is used to identify variables that are statistically significant in estimating the unit price of water in dollars per acre-foot ($/AF). The regression shows that State Water Bank (SWB) purchases, Environmental Water Account (EWA) purchases, environmental end use, North of Delta (NOD) seller location, the San Joaquin Valley Water-Year Index (San Joaquin Index), total perennial crop acreage, and purchases made by South Coast buyers were statistically significant at the 95% or 99% confidence interval. These variables were included in the final econometric model to estimate price.
ContributorsArnao, Audrey Louise (Author) / Hanemann, Michael (Thesis director) / Payne, Matthew (Committee member) / W.P. Carey School of Business (Contributor) / Department of Economics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Streetwear is a category of fashion that has evolved from being a niche style of dress influenced by American counter cultures, into a formidable industry. Over time, Streetwear has become a culture in itself whose members are critical of inauthentic brands and commercialization. Streetwear brands have the need to be perceived as authentic, exclusive, and being connected to celebrity to survive in the industry long-term. Additionally, as the industry grows larger, the marketplace has become increasingly saturated. This can be attributed to how easy it is to create a fledgling streetwear brand due to advances in garment production technology and streetwear's roots in low-cost clothing. Streetwear brands need to differentiate themselves in an effective manner to stand out to consumers in the saturated streetwear market. Primary research conducted via a survey administered to streetwear consumers was done to learn more about the effectiveness of popular tactics and marketplace events streetwear brands use to differentiate themselves. Secondary research was done in literature on the topics of creativity and energized differentiation. Research by Gerzema and Lebar presented in their book The Brand Bubble on the topic of energized differentiation is reviewed and applied to streetwear brands. This thesis will discuss the key elements brands need to have to be successful in the streetwear industry. Along with this, it will also look at the effectiveness of specific tactics bands can execute to effectively differentiate themselves in the saturated industry and the important role creativity plays in their success.
ContributorsGriblin, Austin W. (Author) / Ostrom, Amy (Thesis director) / Samper, Adriana (Committee member) / Department of Marketing (Contributor) / Herberger Institute for Design and the Arts (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This paper analyzes modern day Cuba and draws conclusions about the most likely future political and economic events that will take place. Because of Cuba's troubled economy, leadership change and the world's continued shift towards democratization, Cuba is in a position where drastic changes in its government and economic structure may occur. This paper investigates Cuba's history, politics, economy, and the general quality of life of its citizens, which are used to help predict what may happen to the Cuban government in the near future. The paper also analyzes options for foreign nations' policy towards Cuba and summarizes what actions they may take to increase the likelihood of an economic and political transition. Cuba's economic structure needs drastic reform, the reluctant privatization only increases wealth disparity, trust in the government continues to get weaker as more information and its human rights violations are causes of huge concern. There are four possible outcomes for Cuba's future: stagnation, adopting the mixed economic model, a peaceful transition to a democratic model, and rebellion. There is evidence that Cuba will not make drastic policy changes in favor of liberalization in the immediate future, however, if the economic conditions are not improved and an economic crisis ensues, this paper asserts that another revolution or coup will likely occur. The resulting government may be a new autocratic leader that fills the vacuum of leadership, or a democratic regime depending on the nature of the rebellion. The exact future of Cuba is uncertain, but one thing is clear, change is on the horizon.
ContributorsBeem, Christian D. (Author) / Anthony, Charles (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Economics (Contributor) / W.P. Carey School of Business (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Monoclonal antibody therapy focuses on engineering immune cells to target specific peptide sequences indicative of disease. An impediment in the continued advancement of this market is the lack of an efficient, inexpensive means of characterization that can be broadly applied to any antibody while still providing high-density data. Many characterization methods address an antibody's affinity for its cognate sequence but overlook other important aspects of binding behavior such as off-target binding interactions. The purpose of this study is to demonstrate how the binding intensity between an antibody and a library of random-sequence peptides, otherwise known as an immunosignature, can be evaluated to determine antibody specificity and polyreactivity. A total of 24 commercially available monoclonal antibodies were assayed on 125K and 330K peptide microarrays and analyzed using a motif clustering program to predict candidate epitopes within each antigen sequence. The results support the further development of immunosignaturing as an antibody characterization tool that is relevant to both therapeutic and non-therapeutic antibodies.
ContributorsDai, Jennifer T. (Author) / Stafford, Phillip (Thesis director) / Diehnelt, Chris (Committee member) / School of Life Sciences (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The following report addresses sustainable supply chain management (SSCM) and its application in the fashion industry. The purpose is to draw conclusions on why companies implement sustainability into their processes, and how these sustainable monitoring practices contribute to operational, competitive and financial advantages. This report contains various methods of analysis. Research derived from numerous scholarly articles on measurement methods, theories and governance structures will be discussed to develop a background on the current status of SSCM in the fashion industry, including the notable strengths and weaknesses. To understand the depth of practices involved in managing a sustainable supply chain, four leading companies within the industry will be analyzed using their annual sustainability reports. Based on this analysis, it can be concluded that sustainable practices are abundantly present in today's leading fashion companies, each having different mindsets motivating their sustainable actions. With this conclusion, it's also important to acknowledge that there's far more progress to be made in terms of sustainable development on a company and industry level, in order to make a lasting impact.
ContributorsRezzonico, Jordan Nicole (Author) / Dooley, Kevin (Thesis director) / Wiedmer, Robert (Committee member) / W.P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The FIFA World Cup is one of the most anticipated, inspiring, and intense sporting events in the world. Soccer has integrated itself not only in sports circles, but also in politics, commerce, and society as a whole. The sport has about two hundred million active players and is still growing, especially in areas such as North America and Asia. As of mid-2007, FIFA’s membership included 208-member associations, making it not only one of the largest and most powerful sports governing bodies, but also one of the most popular in the world.
Since 1930—with the exception of the break for World War II—every four years, the world’s best national teams face off in a soccer tournament. The last two tournaments hosted by South Africa in 2010 and Brazil in 2014 will be the emphasis of this paper. Each tournament featured the thirty-two countries and captured a television audience of over three billion people throughout the month-long tournament, one billion of which tuned in for the final. For comparison, the Super Bowl XLIX where the New England Patriots defeated the Seattle Seahawks 28 to 24 was the most watched event in United States’ history with a viewership of 114.4 million people.
Countries spend years planning and preparing to win a bid to host one of these mega events. Bids are often times awarded eight to twelve years in advance. There has been a recent trend of developing countries hosting the FIFA World Cups and the future bids already awarded follow that trend. Many people ask the question of whether all the money spent on infrastructure, construction, and tourism to host this tournament and gain international exposure are really worth it? Simply put, the 2010 FIFA World Cup was valuable to South Africa while the 2014 FIFA World Cup was not worth the costs to Brazil.
Since 1930—with the exception of the break for World War II—every four years, the world’s best national teams face off in a soccer tournament. The last two tournaments hosted by South Africa in 2010 and Brazil in 2014 will be the emphasis of this paper. Each tournament featured the thirty-two countries and captured a television audience of over three billion people throughout the month-long tournament, one billion of which tuned in for the final. For comparison, the Super Bowl XLIX where the New England Patriots defeated the Seattle Seahawks 28 to 24 was the most watched event in United States’ history with a viewership of 114.4 million people.
Countries spend years planning and preparing to win a bid to host one of these mega events. Bids are often times awarded eight to twelve years in advance. There has been a recent trend of developing countries hosting the FIFA World Cups and the future bids already awarded follow that trend. Many people ask the question of whether all the money spent on infrastructure, construction, and tourism to host this tournament and gain international exposure are really worth it? Simply put, the 2010 FIFA World Cup was valuable to South Africa while the 2014 FIFA World Cup was not worth the costs to Brazil.
ContributorsLooney, Andrew (Author) / Goegan, Brian (Thesis director) / Eaton, John (Committee member) / Department of Economics (Contributor) / W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05