Matching Items (8)
Description

The Founders lab is a year-long program that gives its students an opportunity to participate in a unique team-based, experiential Barrett honors thesis project to design and apply marketing and sales strategies, as well as business and financial models to start up and launch a new business. This honors thesis

The Founders lab is a year-long program that gives its students an opportunity to participate in a unique team-based, experiential Barrett honors thesis project to design and apply marketing and sales strategies, as well as business and financial models to start up and launch a new business. This honors thesis project focuses on increasing the rate of vaccination outcomes in a country where people are increasingly busy (less time) and unwilling to get a needle through a new business venture that provides a service that brings vaccinations straight to businesses, making them available for their employees. Through our work with the Founders Lab, our team was able to create this pitch deck.

ContributorsHanzlick, Emily Anastasia (Co-author) / Zatonskiy, Albert (Co-author) / Gomez, Isaias (Co-author) / Byrne, Jared (Thesis director) / Hall, Rick (Committee member) / Silverstein, Taylor (Committee member) / Harrington Bioengineering Program (Contributor) / Department of Information Systems (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Transient Receptor Potential (TRP) channels are a diverse class of ion channels notable as polymodal sensors. TRPM8 is a TRP channel implicated in cold sensation, nociception, and a variety of human diseases, including obesity and cancer. Despite sustained interest in TRPM8 since its discovery in 2001, many of the molecular

Transient Receptor Potential (TRP) channels are a diverse class of ion channels notable as polymodal sensors. TRPM8 is a TRP channel implicated in cold sensation, nociception, and a variety of human diseases, including obesity and cancer. Despite sustained interest in TRPM8 since its discovery in 2001, many of the molecular mechanisms that underlie function are not yet clear. Knowledge of these properties could have implications for medicine and physiological understanding of sensation and signaling. Structures of TRP channels have proven challenging to solve, but recent Cryoelectron microscopy (Cryo-EM) structures of TRPV1 provide a basis for homology-based modeling of TRP channel structures and interactions. I present an ensemble of 11,000 Rosetta computational homology models of TRPM8 based on the recent Cryo-EM apo structure of TRPV1 (PDB code:3J5P). Site-directed mutagenesis has provided clues about which residues are most essential for modulatory ligands to bind, so the models presented provide a platform to investigate the structural basis of TRPM8 ligand modulation complementary to existing functional and structural information. Menthol and icilin appear to interact with interfacial residues in the sensor domain (S1-S4). One consensus feature of these sites is the presence of local contacts to the S4 helix, suggesting this helix may be mechanistically involved with the opening of the pore. Phosphatidylinositol 4,5-bisphosphate (PIP2)has long been known to interact with the C-terminus of TRPM8, and some of the homology models contain plausible binding pockets where PIP2 can come into contact with charged residues known to be essential for PIP2 modulation. Future in silico binding experiments could provide testable hypothesis for in vitro structural studies, and experimental data (e.g. distance constraints from electron paramagnetic resonance spectroscopy [EPR]) could further refine the models.
ContributorsHelsell, Cole Vincent Maher (Author) / Van Horn, Wade (Thesis director) / Wang, Xu (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
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Description

Our Founders Lab group created a pop-up thrift store on campus using donated clothing. We generated over $1000 in profits from our clothing sales to donate to a local charity, making our team the highest earning Founders Lab team. Our shop, Devils Rack, tabled twice on the Tempe ASU campus

Our Founders Lab group created a pop-up thrift store on campus using donated clothing. We generated over $1000 in profits from our clothing sales to donate to a local charity, making our team the highest earning Founders Lab team. Our shop, Devils Rack, tabled twice on the Tempe ASU campus in order to generate our revenue.

ContributorsHaffner, Amanda (Author) / Walsh, Elizabeth (Co-author) / Soble, Lena (Co-author) / Burton, Tanner (Co-author) / Steffes, Keelyn (Co-author) / Byrne, Jared (Thesis director) / Lee, Christopher (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Human Evolution & Social Change (Contributor) / Department of Information Systems (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2023-05
Description

Students for Success is a consulting firm designed to connect undergraduate ASU students with those applying to ASU. Our counselors are well versed in scholarships, housing, programs, clubs, and deadline information. This firm provides flexible work for undergraduate students, while giving applicants a custom experience from a student who truly

Students for Success is a consulting firm designed to connect undergraduate ASU students with those applying to ASU. Our counselors are well versed in scholarships, housing, programs, clubs, and deadline information. This firm provides flexible work for undergraduate students, while giving applicants a custom experience from a student who truly understands the most recent application process.

ContributorsBerryman, Hannah (Author) / Meier, Brooke (Co-author) / Gabaldon, Gabriella (Co-author) / Deniger, Leah (Co-author) / O'Brien, Selam (Co-author) / Byrne, Jared (Thesis director) / Lawson, Brennan (Committee member) / Kneer, Danny (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Politics and Global Studies (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2023-05
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Description

The Founders Lab is a team-focused, exploratory Barrett Thesis project that allows students the opportunity to discover and utilize their “inner entrepreneur”. This project empowers teams of students to come up with a business idea; create a strategic business model; conduct research on a target market; generate a brand style,

The Founders Lab is a team-focused, exploratory Barrett Thesis project that allows students the opportunity to discover and utilize their “inner entrepreneur”. This project empowers teams of students to come up with a business idea; create a strategic business model; conduct research on a target market; generate a brand style, logo, and other marketing-related materials; meet with business professionals as a way to receive feedback; and finalize a business plan with tangible deliverables. This project in particular focuses on the creation of an app that allows users to connect with others in competitive esports tournaments and participate in tutoring sessions for financial incentives. Throughout our experience participating in the Founders Lab, we were able to construct this business pitch.

ContributorsSmith, Garrison (Author) / Wandzilak, Olivia (Co-author) / Tefft, Austin (Co-author) / Byrne, Jared (Thesis director) / Pierce, John (Committee member) / Balven, Rachel (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2022-05
Description
With uses in fields such as medicine, agriculture, and biotechnology, halogenases are useful enzymes in nature which add or substitute halogens onto other molecules. By doing so, they become necessary for biosynthesis and cross-coupling reactions. Halogenases can be classified by three main types of mechanisms: nucleophilic, radical, and electrophilic. From

With uses in fields such as medicine, agriculture, and biotechnology, halogenases are useful enzymes in nature which add or substitute halogens onto other molecules. By doing so, they become necessary for biosynthesis and cross-coupling reactions. Halogenases can be classified by three main types of mechanisms: nucleophilic, radical, and electrophilic. From there, they can be further broken down by the halogen involved, the substrate needed, other proteins used, or molecules generated. A notable example is PrnA which is a tryptophan-7 halogenase that falls under the flavin-dependent definition with an electrophilic mechanism. Historically, research on these enzymes was slow until the use of bioinformatics rapidly accelerated discoveries to the point where halogenases like VirX1 can be identified from viruses. By reviewing the literature available on halogenase since their first analysis, a better understanding of their functions can be obtained. Also, with the application of bioinformatics, a phylogenetic analysis on the halogenases present in cyanobacteria can be conducted and compared.
ContributorsUsmani, Hibah (Author) / Zhu, Qiyun (Thesis director) / Neilan, Brett (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / School of Life Sciences (Contributor)
Created2024-05
Description

“Social Sports is an application which facilitates the environment fans need to support their teams, in doing so our application aids hospitality businesses market their events and brings business during their downtime. Social Sports allows businesses to market their sports screening events to fans and supporters. Fans and supporters using

“Social Sports is an application which facilitates the environment fans need to support their teams, in doing so our application aids hospitality businesses market their events and brings business during their downtime. Social Sports allows businesses to market their sports screening events to fans and supporters. Fans and supporters using Social Sports are able to see the percentage of supporters/fans on each side and decide which bar or restaurant to go watch the game. Social Sport’s mission is to connect sports fans with other like minded passionate fans and enable community formation and allow sports fans around the world to socialize with much ease.”

ContributorsWood, Alexander (Author) / Rodin, Dawson (Co-author) / Bhargana, Akshat (Co-author) / Cheshire, Ashley (Co-author) / Fuller, Sarah (Co-author) / Byrne, Jared (Thesis director) / Thomasson, Anna (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2023-05
Description

This paper serves as an analysis of the current operational conditions of a real-world company – referred to as “Company X” – with respect to the IC substrate industry. The cost of substrates, a crucial component in the production of Company X’s product, has recently diverged from Company X’s predictions

This paper serves as an analysis of the current operational conditions of a real-world company – referred to as “Company X” – with respect to the IC substrate industry. The cost of substrates, a crucial component in the production of Company X’s product, has recently diverged from Company X’s predictions and is contributing to declining profitability. This analysis aims to discover the underlying cause for price divergence and recommend potential resolutions to improve the forecast of substrate costs and profitability. The paper is organized as follows: Chapter 1 is an introduction to IC substrates and the industry as a whole, Chapter 2 is a breakdown of the specific factors responsible for substrate prices, and Chapter 3 delivers a final recommendation to Company X and concludes the paper.

ContributorsO'Loughlin, Connor (Author) / Fares, Ari (Co-author) / Aggarwal, Bianca (Co-author) / King, Camden (Co-author) / Guillaume, Riley (Co-author) / Simonson, Mark (Thesis director) / Hertzel, Mike (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2023-05