Matching Items (12)
Description

Consider Steven Cryos’ words, “When disaster strikes, the time to prepare has passed.” Witnessing domestic water insecurity in events such as Hurricane Katrina, the instability in Flint, Michigan, and most recently the winter storms affecting millions across Texas, we decided to take action. The period between a water supply’s disruption

Consider Steven Cryos’ words, “When disaster strikes, the time to prepare has passed.” Witnessing domestic water insecurity in events such as Hurricane Katrina, the instability in Flint, Michigan, and most recently the winter storms affecting millions across Texas, we decided to take action. The period between a water supply’s disruption and restoration is filled with anxiety, uncertainty, and distress -- particularly since there is no clear indication of when, exactly, restoration comes. It is for this reason that Water Works now exists. As a team of students from diverse backgrounds, what started as an honors project with the Founders Lab at Arizona State University became the seed that will continue to mature into an economically sustainable business model supporting the optimistic visions and tenants of humanitarianism. By having conversations with community members, conducting market research, competing for funding and fostering progress amid the COVID-19 pandemic, our team’s problem-solving traverses the disciplines. The purpose of this paper is to educate our readers about a unique solution to emerging issues of water insecurity that are nested across and within systems who could benefit from the introduction of a personal water reclamation system, showcase our team’s entrepreneurial journey, and propose future directions that will this once pedagogical exercise to continue fulfilling its mission: To heal, to hydrate and to help bring safe water to everyone.

ContributorsReitzel, Gage Alexander (Co-author) / Filipek, Marina (Co-author) / Sadiasa, Aira (Co-author) / Byrne, Jared (Thesis director) / Sebold, Brent (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Human Evolution & Social Change (Contributor, Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description
Dielectrophoresis is a separations strategy that has the potential to separate small amounts of different proteins from each other. The forces at play in the channel used for dielectrophoresis are electroosmotic flow (EOF), electrophoresis (EP), and dielectrophoresis (DEP). EOF is the force exerted on liquid from an applied potential (1).

Dielectrophoresis is a separations strategy that has the potential to separate small amounts of different proteins from each other. The forces at play in the channel used for dielectrophoresis are electroosmotic flow (EOF), electrophoresis (EP), and dielectrophoresis (DEP). EOF is the force exerted on liquid from an applied potential (1). EP is the force exerted on charged particles in a uniform electric field (2). DEP is the force exerted on particles (charged and uncharged) in a non-uniform electric field (3). This experiment was focused on the testing of a new microfluidic device to see if it could improve the focusing of proteins in dielectrophoresis. It was predicted that the addition of a salt bridge would improve focusing by preventing the ions created by the electrolysis of water around the electrodes from interacting with the proteins and causing aggregation, among other problems. Control trials using the old device showed that electrolysis was likely occurring and was the causal agent for poor outcomes. After applying the electric potential for some time a pH front traveled through the channel causing aggregation of proteins and the current in the channel decreased rapidly, even while the voltage was held constant. The resistance in the channels of the control trials also slightly decreased over time, until the pH shift occurred, at which time it increased rapidly. Experimental trials with a new device that included salt bridges eliminated this pH front and had a roughly linear increase of current in the channel with the voltage applied. This device can now be used in future research with protein dielectrophoresis, including in the potential differentiation of different proteins. References: 1) Electroosmosis. Oxford Dictionary of Biochemistry and Molecular Biology. 2. Oxford University Press: Oxford, England. 2006. 2) Electrophoresis. Oxford Dictionary of Biochemistry and Molecular Biology. 2. Oxford University Press: Oxford, England. 2006. 3) Dielectrophoresis. Oxford Dictionary of Biochemistry and Molecular Biology. 2. Oxford University Press: Oxford, England. 2006.
ContributorsHayes, Katelyn Donna (Author) / Hayes, Mark (Thesis director) / Borges, Chad (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description
Pantothenate kinase-associated neurodegeneration, PKAN, is a neurological disease that is caused by biallelic mutations in the PANK2 gene, which codes for a pantothenate kinase. Some PANK2 mutations that cause PKAN retain enzymatic activity. A possible explanation for the mutations that have residual activity but still cause the disease is that

Pantothenate kinase-associated neurodegeneration, PKAN, is a neurological disease that is caused by biallelic mutations in the PANK2 gene, which codes for a pantothenate kinase. Some PANK2 mutations that cause PKAN retain enzymatic activity. A possible explanation for the mutations that have residual activity but still cause the disease is that they do not have the correct cellular localization. The localization of PANK2 was studied through cellular fractionation. We found the precursor form of PANK2, pPANK2, appears to be anchored to the inner membrane of the mitochondria, and the mature form, mPANK2, is located in the inter-membrane space, IMS. However, the IMS of the PKAN causing mutants is completely devoid of mPANK2 which suggests some disease-causing mutations may be mislocalized. In addition, PANK2 catalyzes the first and rate limiting step in Coenzyme A biosynthesis, and in other studies, it has been shown that the CoA biosynthesis enzymes form a complex in yeast. Therefore, we also considered the possibility that PKAN-causing mutations that retain activity have altered interactions with the other CoA biosynthesis enzymes. Coimmunoprecipitation of the proteins in the pathway was done to determine if there were any interactions with PANK2. The results indicate that PANK2 does not directly interact with either PPCS or CoASY, the second and final enzymatic activities in the CoA biosynthesis pathway.
ContributorsHadziahmetovic, Una (Author) / Newbern, Jason (Thesis director) / Kruer, Michael (Thesis director) / Padilla-Lopez, Sergio (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
Predicting the binding sites of proteins has historically relied on the determination of protein structural data. However, the ability to utilize binding data obtained from a simple assay and computationally make the same predictions using only sequence information would be more efficient, both in time and resources. The purpose of

Predicting the binding sites of proteins has historically relied on the determination of protein structural data. However, the ability to utilize binding data obtained from a simple assay and computationally make the same predictions using only sequence information would be more efficient, both in time and resources. The purpose of this study was to evaluate the effectiveness of an algorithm developed to predict regions of high-binding on proteins as it applies to determining the regions of interaction between binding partners. This approach was applied to tumor necrosis factor alpha (TNFα), its receptor TNFR2, programmed cell death protein-1 (PD-1), and one of its ligand PD-L1. The algorithms applied accurately predicted the binding region between TNFα and TNFR2 in which the interacting residues are sequential on TNFα, however failed to predict discontinuous regions of binding as accurately. The interface of PD-1 and PD-L1 contained continuous residues interacting with each other, however this region was predicted to bind weaker than the regions on the external portions of the molecules. Limitations of this approach include use of a linear search window (resulting in inability to predict discontinuous binding residues), and the use of proteins with unnaturally exposed regions, in the case of PD-1 and PD-L1 (resulting in observed interactions which would not occur normally). However, this method was overall very effective in utilizing the available information to make accurate predictions. The use of the microarray to obtain binding information and a computer algorithm to analyze is a versatile tool capable of being adapted to refine accuracy.
ContributorsBrooks, Meilia Catherine (Author) / Woodbury, Neal (Thesis director) / Diehnelt, Chris (Committee member) / Ghirlanda, Giovanna (Committee member) / Department of Psychology (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
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Description
The p53 gene functions as a tumor suppressor that inhibits proliferation, regulates apoptosis, DNA repair, and normal cell cycle arrest. Mutation of the p53 gene is linked to be prevalent in 50% of all human cancers. In this paper, we are exploring triple negative breast cancer and the effects of

The p53 gene functions as a tumor suppressor that inhibits proliferation, regulates apoptosis, DNA repair, and normal cell cycle arrest. Mutation of the p53 gene is linked to be prevalent in 50% of all human cancers. In this paper, we are exploring triple negative breast cancer and the effects of simvastatin on tumor growth and survival. Simvastatin is a drug that is primarily used to treat high cholesterol and heart disease. Simvastatin is unique because it is able to inhibit protein prenylation through regulation of the mevalonate pathway. This makes it a potential targeted drug for therapy against p53 mutant cancer. The mechanism behind this is hypothesized to be correlated to aberrant activation of the Ras pathway. The Ras subfamily functions to transcriptionally regulate cell growth and survival, and will therefore allow for a tumor to thrive if the pathway is continually and abnormally activated. The Ras protein has to be prenylated in order for activation of this pathway to occur, making statin drug treatment a viable option as a cancer treatment. This is because it acts as a regulator of the mevalonate pathway which is upstream of protein prenylation. It is thus vital to understand these pathways at both the gene and protein level in different p53 mutants to further understand if simvastatin is indeed a drug with anti-cancer properties and can be used to target cancers with p53 mutation. The goal of this project is to study the biochemistry behind the mutation of p53's sensitivity to statin. With this information we can create a possible signature for those who could benefit from Simvastatin drug treatment as a possible targeted treatment for p53 mutant cancers.
ContributorsGrewal, Harneet (Co-author) / Loo, Yi Jia Valerie (Co-author) / Anderson, Karen (Thesis director) / Blattman, Joseph (Committee member) / Ferdosi, Shayesteh (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description

Volunteers at Hand is an inclusive platform that focuses on creating an interconnected community of volunteers while providing an efficient and effective system that categorizes volunteer/service opportunities based on individual interests. The primary focus of our platform is to foster a compassionate community of individuals who will inspire each other

Volunteers at Hand is an inclusive platform that focuses on creating an interconnected community of volunteers while providing an efficient and effective system that categorizes volunteer/service opportunities based on individual interests. The primary focus of our platform is to foster a compassionate community of individuals who will inspire each other as well as others, and provide hope through their contributions towards helping and healing people. The foundation of Volunteers at Hand will be established through development of an elaborate platform/website that would be equally and openly accessible to all individuals and organizations interested in contributing efforts towards volunteer/service experiences. The platform will implement a filtering system that would categorize service opportunities and events based on personal preferences and interests, thus enabling a more efficient and effective method of discovering various opportunities that an individual would be passionate in contributing their efforts towards. Our platform would also implement a community based aspect that fosters further communication and interactions amongst volunteers as well as organizations involved in volunteer/service experiences.

ContributorsMurshed, Faiyaj (Author) / Salahuddin, Ibtesam (Co-author) / Byrne, Jared (Thesis director) / Surmacz, Amaris (Committee member) / Young, Andrea (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Department of Psychology (Contributor)
Created2023-05
Description

Volunteers at Hand is an inclusive platform that focuses on creating an interconnected community of volunteers while providing an efficient and effective system that categorizes volunteer/service opportunities based on individual interests. The primary focus of our platform is to foster a compassionate community of individuals who will inspire each other

Volunteers at Hand is an inclusive platform that focuses on creating an interconnected community of volunteers while providing an efficient and effective system that categorizes volunteer/service opportunities based on individual interests. The primary focus of our platform is to foster a compassionate community of individuals who will inspire each other as well as others, and provide hope through their contributions towards helping and healing people. The foundation of Volunteers at Hand will be established through development of an elaborate platform/website that would be equally and openly accessible to all individuals and organizations interested in contributing efforts towards volunteer/service experiences. The platform will implement a filtering system that would categorize service opportunities and events based on personal preferences and interests, thus enabling a more efficient and effective method of discovering various opportunities that an individual would be passionate in contributing their efforts towards. Our platform would also implement a community based aspect that fosters further communication and interactions amongst volunteers as well as organizations involved in volunteer/service experiences.

ContributorsSalahuddin, Ibtesam (Author) / Murshed, Faiyaj (Co-author) / Byrne, Jared (Thesis director) / Surmacz, Amaris (Committee member) / Young, Andrea (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor)
Created2023-05
Description

Students for Success is a consulting firm designed to connect undergraduate ASU students with those applying to ASU. Our counselors are well versed in scholarships, housing, programs, clubs, and deadline information. This firm provides flexible work for undergraduate students, while giving applicants a custom experience from a student who truly

Students for Success is a consulting firm designed to connect undergraduate ASU students with those applying to ASU. Our counselors are well versed in scholarships, housing, programs, clubs, and deadline information. This firm provides flexible work for undergraduate students, while giving applicants a custom experience from a student who truly understands the most recent application process.

ContributorsBerryman, Hannah (Author) / Meier, Brooke (Co-author) / Gabaldon, Gabriella (Co-author) / Deniger, Leah (Co-author) / O'Brien, Selam (Co-author) / Byrne, Jared (Thesis director) / Lawson, Brennan (Committee member) / Kneer, Danny (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Politics and Global Studies (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2023-05
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Description

This thesis explore how current tracking technologies such as the 1D barcode, QR code, and RFID commercialized in the business world. After a comparison of the current technologies, a pitch is created for DENSEC ID and a subsequent business plan is created.

ContributorsZhao, Michelle (Author) / Reeves, James (Thesis director) / Trujillo, Rhett (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Department of Supply Chain Management (Contributor) / Department of Information Systems (Contributor) / Watts College of Public Service & Community Solut (Contributor)
Created2022-05
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Description

A Skunkworks project is the name given to a small team of individuals leading an innovative undertaking, and conducting research and development outside of the normal scope of an organization. With this concept in mind, our team of six individuals was tasked with finding and conceptualizing innovative solutions within varying

A Skunkworks project is the name given to a small team of individuals leading an innovative undertaking, and conducting research and development outside of the normal scope of an organization. With this concept in mind, our team of six individuals was tasked with finding and conceptualizing innovative solutions within varying business markets of interest. Our team started off with five markets that we identified issues in and were passionate about solving. These included Sports Engagement, Education, Student Debt, Digital Literacy, and Viral Health. From extensive research, trial and error, and endless conversations we settled on creating business models in two final areas: Student Debt and Viral Health. Our research in Student Debt led us to the discovery that the average Arizona State student, takes out $21,237 in loans for their four year degree and in the whole state of Arizona, a student takes out an average of $22,253. Our solution to this problem was to create a student financial app that served as an efficient debt tracker that provided important information about finances, investing, and student loan information. Additionally, our team also wanted the address the issue of sexually transmitted diseases, just a small scope of Viral Health, within Arizona State University. Our research led us to discover that 50% of people report not getting tested, and from this population most reported it was due to anxiety and financial issues. From our research the StayInformed app was created to provide students with better accessibility to both at-home and clinic testing services, and updated education on sexual health. With this project model we hope to increase the rate of students testing and allow students more agency over their sexual health. Although these two services are addressing very different markets, they both utilize forward thinking technology to create much needed solutions and better the lives of students.

ContributorsBurry, Grace (Author) / Ward, Hayley (Co-author) / Vanstrom, Zak (Co-author) / Hart, Karsten (Co-author) / Mundy, Jacqueline (Co-author) / Schwingendorf, Jordan (Co-author) / Byrne, Jared (Thesis director) / O'Keefe, Kelly (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05