Matching Items (143)
Filtering by
- Creators: Barrett, The Honors College
- Creators: School of Historical, Philosophical and Religious Studies
- Member of: Barrett, The Honors College Thesis/Creative Project Collection
Description
Menopause is associated with a wide array of negative symptoms. As average lifespan increases due to advances in healthcare and technology, more women are spending a larger portion of their lives in a menopausal state low in estrogen and progesterone. Hormone therapies such as Conjugated Equine Estrogens (CEE) and the bioidentical estrogen, 17-estradiol (E2), are commonly prescribed to treat the negative symptoms of menopause. Our laboratory has previously shown that CEE has differential effects on cognitive ability depending on whether menopause is transitional (VCD) or surgical (ovariectomy, OVX). Further, the negative impact of CEE on cognitive function in a transitional ovary-intact model of menopause was associated with high levels of serum androstenedione; the primary hormone circulating in a follicle-deplete menopausal state. Here, we investigate the cognitive effects of these two common hormone therapies separately, and in conjunction with the hormone androstenedione, in a "blank-slate" OVX mouse model. We assessed cognitive ability using two behavioral tasks such at the Water Radial Arm Maze (WRAM, measuring spatial working and reference memory) and the Morris water maze (MM, measuring spatial reference memory). In the WRAM, every treatment group saw impaired performance compared to Vehicle but the combination group of E2 plus Androstenedione. In the MM, the combination group of E2 plus Androstenedione actually enhanced performance in the maze compared to every other comparable group. Translationally, these results suggest that CEE given in the presence of an androstenedione-dominant hormone milieu is impairing to cognition, E2 in this same manner is not. These results yield valuable insight into optimal hormone therapies for menopausal women.
ContributorsGranger, Steven Jay (Author) / Bimonte-Nelson, Heather (Thesis director) / Presson, Clark (Committee member) / Hiroi, Sheri (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Alexander the Great is one of the most well known figures in history, but while many of his battles and actions are documented, little is known about his personality. This is because very few documents survive from his contemporaries, and we have no way of knowing his own private thoughts. However, extensive research has been done to try to establish and understanding of the character of the man, and so, in an effort to create the most well-rounded and complete portrayal of Alexander the Great possible, I seek to examine and synthesize many of these testimonials into a comprehensive analysis of his personality. In this process, we must rely on the secondary historians of Alexander, namely Quintus Curtius Rufus and Lucius Flavius Arrianus. Curtius is important because he based much of his work off of Cleitarchus who actually was a contemporary of Alexander. I will also look to the work of more recent hisotrins and popular literature in order to form the most comprehensive picture of Alexander's personality.
ContributorsShoaf, John Taylor (Author) / Carroll, Kevin (Thesis director) / George, Lisa (Committee member) / Barrett, The Honors College (Contributor)
Created2002-05
Description
Abstract The Art of Memory: Public Memorials Scarlett Olson In ancient times, memorials were constructed to commemorate victories in battle or to pay homage to kings and gods. Now, however, memorials focus more on the events of war and those who died fighting for their country. They are spaces designed to create an atmosphere of quiet reflection to allow us to honor the dead and to serve as a reminder of the consequences of our actions. In this paper, I will analyze public memorials, specifically the Vietnam Veterans Memorial, using the concept of collective memory. The idea of collective memory was first formulated by Maurice Halbwachs in the early twentieth century, and it is at its core the belief that a group can share the same memories regarding specific events. The ideas and theories of collective memory, when applied to the analysis of memorial, can provide a new framework for exploring the form, content, effect, and affect of these structures. Collective memory can be manipulated by society and the creation of specific memorials is one very effective way to influence public opinion about certain historical events.
ContributorsOlson, Scarlett (Author) / Codell, Julie (Thesis director) / Hoffman, Daniel (Committee member) / Pedersen, Lindsey (Committee member) / Barrett, The Honors College (Contributor)
Created2005-05
Description
The aim of this thesis is to explore the relationship between architecture and history in Virginia from 1607 to the eve of the American Revolution to create a complete historical narrative. The interdependency of history and architecture creates culturally important pieces and projects the colonist's need to connect to the past as well as their innovations in their own cultural exploration. The thesis examines the living conditions of the colonists that formed Jamestown, and describes the architectural achievements and the historical events that were taking place at the time. After Jamestown, the paper moves on to the innovations of early Virginian architecture from Colonial architecture to Georgian architecture found in Williamsburg. Conclusively, the thesis presents a historical narrative on how architecture displays a collection of ideals from the Virginian colonists at the time. The external display of architecture parallels the events as well as the economic conditions of Virginia, creating a social dialogue between the gentry and the common class in the colony of Virginia.
ContributorsChang, Hosu (Author) / Gray, Susan (Thesis director) / O'Donnell, Catherine (Committee member) / Barrett, The Honors College (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Social Transformation (Contributor)
Created2015-05
Description
Drospirenone (DRSP) is a novel, pharmacologically unique synthetic progestin with properties more similar to the endogenous progestogen, progesterone, than any other progestin currently on the market. While a significant amount of research has been conducted on the risks associated with DRSP, the impact of DRSP on cognition, especially in reference to learning and memory, is not well understood. However, it is imperative to fully understand the cognitive effects of DRSP, both alone and in combination with EE (as taken in a combined oral contraceptive [COC]), so that women and their physicians can make a fully-informed decision when deciding to take a DRSP-containing COC. Study 1 examined the effects of three doses of DRSP in order to determine the optimal dose for combining with EE, and found that the medium dose of DRSP (30 µg/day) enhanced spatial working memory performance. In Study 2, the medium dose of DRSP from Study 1 was combined with low (0.125 µg/day) and high (0.3 µg/day) doses of EE to examine the effects of DRSP as taken with EE in a COC. The results from Study 2 indicated that when DRSP was combined with a low, but not high, dose of EE, spatial working memory impairments were seen at the highest working memory load. Anxiety-like behavior was evaluated using the OFT, and DRSP was shown to decrease measures of anxiety-like behavior. Additionally, while treatment with a high dose of EE decreased several measures of anxiety-like behavior, a low dose of EE did not, suggestive of a dose response. Taken together, the findings presented from both studies suggest that some of the cognitive effects of the combination of DRSP with EE are different than those of either hormone administered on its own. Further exploration in a preclinical, ovary-intact animal model is a next step to fully understand these effects in the translational context of a contraceptive, given that women taking an EE-DRSP combination are typically ovary-intact.
ContributorsPoisson, Mallori Louise (Author) / Bimonte-Nelson, Heather (Thesis director) / Doane, Leah (Committee member) / School of Nutrition and Health Promotion (Contributor) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Poland's early history defines the geo-political and religious aspects of Medieval Eastern Europe. This historiographical essay analyzes various scholars' input on what certain aspects of Polish history, regarding the Piast and Jagiellonian Dynasties, had the most impressive impact. By analyzing the importance of religion and conversion in the early Piast realm, we are able to interpret Poland's involvement in the Holy Wars and consequential wars against the Infidel. According to various scholars, Poland's involvement may have been purely political and scarce at most. It is also crucial to look at how each of the most influential Kings ran their kingdom. From politics, to expansion, to regulations on social estates each kind chose a different way to make their mark on the Kingdom of Poland. The Anjou and Jagiellonian Dynasties produced the first female king of Poland. Queen Jadwiga is just one impressive aspect of Polish history. Scholars analyze the important of language and dialects when assuming Polish "citizenship". This criterial is fluid and changes throughout history. Scholars can agree, however, that "Polishness" is one's loyalty and obedience to the King or local Duke and their ability to speak the native tongue. However, even this statement is controversial, as an established local tongue did not occur until much later in time. At this time, Latin, Polish, Lithuanian, Prussian, and other Polish dialects would form into what is now known as modern Polish. This historiographical essay provides insight to the past of what Poland was before it was "Poland". With this information in mind, we can begin to understand why and how history evolves over time.
ContributorsStewart, Lacy (Author) / Cichopek-Gajraj, Anna (Thesis director) / Krajdocha-Oginska, Miroslawa (Committee member) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The Norman invasion and conquest of England in 1066, led by Duke William "the Conqueror," is well-known in British history; less well-known is the fact that the conquest caused a group of Norman Jews to immigrate to England. These immigrants were the first significant population of Jews to ever reside in England, and by about 1100, distinct communities of Jews had established themselves in several cities throughout the country. However, Jewish life in England came to an abrupt end less than two-hundred and thirty years after its beginning when King Edward I expelled the entire Jewish population from England in 1290. The edict of expulsion was approved by the English parliament on June 18, 1290, and there are no surviving records of what happened in that meeting or why Edward decided to banish the Jews. Accordingly, there are a host of questions that need answering if one is to propose a explanation. For example, what could compel Edward I, who struggled financially and was deeply in debt for the duration of his reign, to expel the people who had been the crown's greatest asset for two centuries? Why did the king break the charter which specifically placed the Jews under the monarchy's protection? Why was the aristocracy so intent on getting rid of the Jews who, on several occasions, kept the baronies financially afloat through generous loans? My goal in writing this thesis is threefold: first, to provide a concise but clear account of this extraordinarily specific section of history; second, to present the information in such a way that those who read it might be convinced that the Expulsion was, in fact, primarily motivated by financial factors; and third, to identify several structural and institutional factors which were critical to the Jews' experiences in medieval England.
ContributorsMiller, Drew Beaupre (Author) / Tirosh-Samuelson, Hava (Thesis director) / Barth, Jonathan (Committee member) / School of Politics and Global Studies (Contributor) / School of Social Transformation (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Resistive Random Access Memory (RRAM) is an emerging type of non-volatile memory technology that seeks to replace FLASH memory. The RRAM crossbar array is advantageous in its relatively small cell area and faster read latency in comparison to NAND and NOR FLASH memory; however, the crossbar array faces design challenges of its own in sneak-path currents that prevent proper reading of memory stored in the RRAM cell. The Current Sensing Amplifier is one method of reading RRAM crossbar arrays. HSpice simulations are used to find the associated reading delays of the Current Sensing Amplifier with respect to various sizes of RRAM crossbar arrays, as well as the largest array size compatible for accurate reading. It is found that up to 1024x1024 arrays are achievable with a worst-case read delay of 815ps, and it is further likely 2048x2048 arrays are able to be read using the Current Sensing Amplifier. In comparing the Current Sensing Amplifier latency results with previously obtained latency results from the Voltage Sensing Amplifier, it is shown that the Voltage Sensing Amplifier reads arrays in sizes up to 256x256 faster while the Current Sensing Amplifier reads larger arrays faster.
ContributorsMoore, Jenna Barber (Author) / Yu, Shimeng (Thesis director) / Liu, Rui (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Books are constantly changing. For this project I looked at books and how they have changed over time. Starting with just before the Gutenberg Printing Press was invented and ending with the introduction of the Internet this project tracked those changes over time and looked at how they changed how people read, who read, and what this said about the people at the time. First, I looked at how books changed physically. At the time of the Gutenberg Printing Press vellum and parchment were being used for the pages of books and illuminated manuscripts made some volumes works of art. Now with the Internet greatly influencing books, that format is radically different. Different materials allowed for books to be made more cheaply and when this happened more people were able to afford them. I also looked at aspects of books like publishing and where the books were sold and how that made a difference in how and why people read. Through all of my research I kept a blog and this allowed me to be almost part of the history and research I was doing. This blog will eventually become an eBook. Books have not only shaped history and people but have been shaped by history. Books are a vital part of helping to spread information and while they will keep changing especially with the Internet, books will never disappear.
ContributorsAdams, Kennedy Rei (Author) / Tebeau, Mark (Thesis director) / Soares, Rebecca (Committee member) / School of Historical, Philosophical and Religious Studies (Contributor) / School of Social Transformation (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
The purpose of this essay is to determine how the narratives of veterans who served in combat roles during the Vietnam War have affected how historians have written about the war. First, this project will briefly cover the history of the general public’s view of the war and it’s veterans, looking at how feelings towards Vietnam War veterans have shifted over the past fifty years. Next, this project will analyze two books about the Vietnam War that focus primarily on the veteran experience, rather than on the internal politics of the United States and Vietnam or on the successes or failures of battle, and determine the extent to which these books contribute to public understanding of the war. This essay will then determine the role memory plays in crafting these narratives and how historians have an obligation to include or at least consider the complex perspectives of veterans and their families when they write on topics as controversial as warfare.
ContributorsArroyo, Jose Maria (Author) / Miller, Keith (Thesis director) / Thompson, Victoria (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05