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Description
Language and music are fundamentally entwined within human culture. The two domains share similar properties including rhythm, acoustic complexity, and hierarchical structure. Although language and music have commonalities, abilities in these two domains have been found to dissociate after brain damage, leaving unanswered questions about their interconnectedness, including can one domain support the other when damage occurs? Evidence supporting this question exists for speech production. Musical pitch and rhythm are employed in Melodic Intonation Therapy to improve expressive language recovery, but little is known about the effects of music on the recovery of speech perception and receptive language. This research is one of the first to address the effects of music on speech perception. Two groups of participants, an older adult group (n=24; M = 71.63 yrs) and a younger adult group (n=50; M = 21.88 yrs) took part in the study. A native female speaker of Standard American English created four different types of stimuli including pseudoword sentences of normal speech, simultaneous music-speech, rhythmic speech, and music-primed speech. The stimuli were presented binaurally and participants were instructed to repeat what they heard following a 15 second time delay. Results were analyzed using standard parametric techniques. It was found that musical priming of speech, but not simultaneous synchronized music and speech, facilitated speech perception in both the younger adult and older adult groups. This effect may be driven by rhythmic information. The younger adults outperformed the older adults in all conditions. The speech perception task relied heavily on working memory, and there is a known working memory decline associated with aging. Thus, participants completed a working memory task to be used as a covariate in analyses of differences across stimulus types and age groups. Working memory ability was found to correlate with speech perception performance, but that the age-related performance differences are still significant once working memory differences are taken into account. These results provide new avenues for facilitating speech perception in stroke patients and sheds light upon the underlying mechanisms of Melodic Intonation Therapy for speech production.
ContributorsLaCroix, Arianna (Author) / Rogalsky, Corianne (Thesis advisor) / Gray, Shelley (Committee member) / Liss, Julie (Committee member) / Arizona State University (Publisher)
Created2015
Description
Exome sequencing was used to identify novel variants linked to amyotrophic lateral sclerosis (ALS), in a family without mutations in genes previously linked to ALS. A F115C mutation in the gene MATR3 was identified, and further examination of other ALS kindreds identified an additional three mutations in MATR3; S85C, P154S and T622A. Matrin 3 is an RNA/DNA binding protein as well as part of the nuclear matrix. Matrin 3 interacts with TDP-43, a protein that is both mutated in some forms of ALS, and found in pathological inclusions in most ALS patients. Matrin 3 pathology, including mislocalization and rare cytoplasmic inclusions, was identified in spinal cord tissue from a patient carrying a mutation in Matrin 3, as well as sporadic ALS patients. In an effort to determine the mechanism of Matrin 3 linked ALS, the protein interactome of wild-type and ALS-linked MATR3 mutations was examined. Immunoprecipitation followed by mass spectrometry experiments were performed using NSC-34 cells expressing human wild-type or mutant Matrin 3. Gene ontology analysis identified a novel role for Matrin 3 in mRNA transport centered on proteins in the TRanscription and EXport (TREX) complex, known to function in mRNA biogenesis and nuclear export. ALS-linked mutations in Matrin 3 led to its re-distribution within the nucleus, decreased co-localization with endogenous Matrin 3 and increased co-localization with specific TREX components. Expression of disease-causing Matrin 3 mutations led to nuclear mRNA export defects of both global mRNA and more specifically the mRNA of TDP-43 and FUS. Our findings identify ALS-causing mutations in the gene MATR3, as well as a potential pathogenic mechanism attributable to MATR3 mutations and further link cellular transport defects to ALS.
ContributorsBoehringer, Ashley (Author) / Bowser, Robert (Thesis advisor) / Liss, Julie (Committee member) / Jensen, Kendall (Committee member) / Ladha, Shafeeq (Committee member) / Arizona State University (Publisher)
Created2018
Description
The activation of the primary motor cortex (M1) is common in speech perception tasks that involve difficult listening conditions. Although the challenge of recognizing and discriminating non-native speech sounds appears to be an instantiation of listening under difficult circumstances, it is still unknown if M1 recruitment is facilitatory of second language speech perception. The purpose of this study was to investigate the role of M1 associated with speech motor centers in processing acoustic inputs in the native (L1) and second language (L2), using repetitive Transcranial Magnetic Stimulation (rTMS) to selectively alter neural activity in M1. Thirty-six healthy English/Spanish bilingual subjects participated in the experiment. The performance on a listening word-to-picture matching task was measured before and after real- and sham-rTMS to the orbicularis oris (lip muscle) associated M1. Vowel Space Area (VSA) obtained from recordings of participants reading a passage in L2 before and after real-rTMS, was calculated to determine its utility as an rTMS aftereffect measure. There was high variability in the aftereffect of the rTMS protocol to the lip muscle among the participants. Approximately 50% of participants showed an inhibitory effect of rTMS, evidenced by smaller motor evoked potentials (MEPs) area, whereas the other 50% had a facilitatory effect, with larger MEPs. This suggests that rTMS has a complex influence on M1 excitability, and relying on grand-average results can obscure important individual differences in rTMS physiological and functional outcomes. Evidence of motor support to word recognition in the L2 was found. Participants showing an inhibitory aftereffect of rTMS on M1 produced slower and less accurate responses in the L2 task, whereas those showing a facilitatory aftereffect of rTMS on M1 produced more accurate responses in L2. In contrast, no effect of rTMS was found on the L1, where accuracy and speed were very similar after sham- and real-rTMS. The L2 VSA measure was indicative of the aftereffect of rTMS to M1 associated with speech production, supporting its utility as an rTMS aftereffect measure. This result revealed an interesting and novel relation between cerebral motor cortex activation and speech measures.
ContributorsBarragan, Beatriz (Author) / Liss, Julie (Thesis advisor) / Berisha, Visar (Committee member) / Rogalsky, Corianne (Committee member) / Restrepo, Adelaida (Committee member) / Arizona State University (Publisher)
Created2018
Description
Previous studies have found that the detection of near-threshold stimuli is decreased immediately before movement and throughout movement production. This has been suggested to occur through the use of the internal forward model processing an efferent copy of the motor command and creating a prediction that is used to cancel out the resulting sensory feedback. Currently, there are no published accounts of the perception of tactile signals for motor tasks and contexts related to the lips during both speech planning and production. In this study, we measured the responsiveness of the somatosensory system during speech planning using light electrical stimulation below the lower lip by comparing perception during mixed speaking and silent reading conditions. Participants were asked to judge whether a constant near-threshold electrical stimulation (subject-specific intensity, 85% detected at rest) was present during different time points relative to an initial visual cue. In the speaking condition, participants overtly produced target words shown on a computer monitor. In the reading condition, participants read the same target words silently to themselves without any movement or sound. We found that detection of the stimulus was attenuated during speaking conditions while remaining at a constant level close to the perceptual threshold throughout the silent reading condition. Perceptual modulation was most intense during speech production and showed some attenuation just prior to speech production during the planning period of speech. This demonstrates that there is a significant decrease in the responsiveness of the somatosensory system during speech production as well as milliseconds before speech is even produced which has implications for speech disorders such as stuttering and schizophrenia with pronounced deficits in the somatosensory system.
ContributorsMcguffin, Brianna Jean (Author) / Daliri, Ayoub (Thesis director) / Liss, Julie (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Previous research has shown that a loud acoustic stimulus can trigger an individual's prepared movement plan. This movement response is referred to as a startle-evoked movement (SEM). SEM has been observed in the stroke survivor population where results have shown that SEM enhances single joint movements that are usually performed with difficulty. While the presence of SEM in the stroke survivor population advances scientific understanding of movement capabilities following a stroke, published studies using the SEM phenomenon only examined one joint. The ability of SEM to generate multi-jointed movements is understudied and consequently limits SEM as a potential therapy tool. In order to apply SEM as a therapy tool however, the biomechanics of the arm in multi-jointed movement planning and execution must be better understood. Thus, the objective of our study was to evaluate if SEM could elicit multi-joint reaching movements that were accurate in an unrestrained, two-dimensional workspace. Data was collected from ten subjects with no previous neck, arm, or brain injury. Each subject performed a reaching task to five Targets that were equally spaced in a semi-circle to create a two-dimensional workspace. The subject reached to each Target following a sequence of two non-startling acoustic stimuli cues: "Get Ready" and "Go". A loud acoustic stimuli was randomly substituted for the "Go" cue. We hypothesized that SEM is accessible and accurate for unrestricted multi-jointed reaching tasks in a functional workspace and is therefore independent of movement direction. Our results found that SEM is possible in all five Target directions. The probability of evoking SEM and the movement kinematics (i.e. total movement time, linear deviation, average velocity) to each Target are not statistically different. Thus, we conclude that SEM is possible in a functional workspace and is not dependent on where arm stability is maximized. Moreover, coordinated preparation and storage of a multi-jointed movement is indeed possible.
ContributorsOssanna, Meilin Ryan (Author) / Honeycutt, Claire (Thesis director) / Schaefer, Sydney (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Studies in Second Language Acquisition and Neurolinguistics have argued that adult learners when dealing with certain phonological features of L2, such as segmental and suprasegmental ones, face problems of articulatory placement (Esling, 2006; Abercrombie, 1967) and somatosensory stimulation (Guenther, Ghosh, & Tourville, 2006; Waldron, 2010). These studies have argued that adult phonological acquisition is a complex matter that needs to be informed by a specialized sensorimotor theory of speech acquisition. They further suggested that traditional pronunciation pedagogy needs to be enhanced by an approach to learning offering learners fundamental and practical sensorimotor tools to advance the quality of L2 speech acquisition.
This foundational study designs a sensorimotor approach to pronunciation pedagogy and tests its effect on the L2 speech of five adult (late) learners of American English. Throughout an eight week classroom experiment, participants from different first language backgrounds received instruction on Articulatory Settings (Honickman, 1964) and the sensorimotor mechanism of speech acquisition (Waldron 2010; Guenther et al., 2006). In addition, they attended five adapted lessons of the Feldenkrais technique (Feldenkrais, 1972) designed to develop sensorimotor awareness of the vocal apparatus and improve the quality of L2 speech movement. I hypothesize that such sensorimotor learning triggers overall positive changes in the way L2 learners deal with speech articulators for L2 and that over time they develop better pronunciation.
After approximately eight hours of intervention, analysis of results shows participants’ improvement in speech rate, degree of accentedness, and speaking confidence, but mixed changes in word intelligibility and vowel space area. Albeit not statistically significant (p >.05), these results suggest that such a sensorimotor approach to L2 phonological acquisition warrants further consideration and investigation for use in the L2 classroom.
This foundational study designs a sensorimotor approach to pronunciation pedagogy and tests its effect on the L2 speech of five adult (late) learners of American English. Throughout an eight week classroom experiment, participants from different first language backgrounds received instruction on Articulatory Settings (Honickman, 1964) and the sensorimotor mechanism of speech acquisition (Waldron 2010; Guenther et al., 2006). In addition, they attended five adapted lessons of the Feldenkrais technique (Feldenkrais, 1972) designed to develop sensorimotor awareness of the vocal apparatus and improve the quality of L2 speech movement. I hypothesize that such sensorimotor learning triggers overall positive changes in the way L2 learners deal with speech articulators for L2 and that over time they develop better pronunciation.
After approximately eight hours of intervention, analysis of results shows participants’ improvement in speech rate, degree of accentedness, and speaking confidence, but mixed changes in word intelligibility and vowel space area. Albeit not statistically significant (p >.05), these results suggest that such a sensorimotor approach to L2 phonological acquisition warrants further consideration and investigation for use in the L2 classroom.
ContributorsLima, J. Alberto S., Jr (Author) / Pruitt, Kathryn (Thesis advisor) / Gelderen, Elly van (Thesis advisor) / Liss, Julie (Committee member) / James, Mark (Committee member) / Arizona State University (Publisher)
Created2015
Description
Audiovisual (AV) integration is a fundamental component of face-to-face communication. Visual cues generally aid auditory comprehension of communicative intent through our innate ability to “fuse” auditory and visual information. However, our ability for multisensory integration can be affected by damage to the brain. Previous neuroimaging studies have indicated the superior temporal sulcus (STS) as the center for AV integration, while others suggest inferior frontal and motor regions. However, few studies have analyzed the effect of stroke or other brain damage on multisensory integration in humans. The present study examines the effect of lesion location on auditory and AV speech perception through behavioral and structural imaging methodologies in 41 left-hemisphere participants with chronic focal cerebral damage. Participants completed two behavioral tasks of speech perception: an auditory speech perception task and a classic McGurk paradigm measuring congruent (auditory and visual stimuli match) and incongruent (auditory and visual stimuli do not match, creating a “fused” percept of a novel stimulus) AV speech perception. Overall, participants performed well above chance on both tasks. Voxel-based lesion symptom mapping (VLSM) across all 41 participants identified several regions as critical for speech perception depending on trial type. Heschl’s gyrus and the supramarginal gyrus were identified as critical for auditory speech perception, the basal ganglia was critical for speech perception in AV congruent trials, and the middle temporal gyrus/STS were critical in AV incongruent trials. VLSM analyses of the AV incongruent trials were used to further clarify the origin of “errors”, i.e. lack of fusion. Auditory capture (auditory stimulus) responses were attributed to visual processing deficits caused by lesions in the posterior temporal lobe, whereas visual capture (visual stimulus) responses were attributed to lesions in the anterior temporal cortex, including the temporal pole, which is widely considered to be an amodal semantic hub. The implication of anterior temporal regions in AV integration is novel and warrants further study. The behavioral and VLSM results are discussed in relation to previous neuroimaging and case-study evidence; broadly, our findings coincide with previous work indicating that multisensory superior temporal cortex, not frontal motor circuits, are critical for AV integration.
ContributorsCai, Julia (Author) / Rogalsky, Corianne (Thesis advisor) / Azuma, Tamiko (Committee member) / Liss, Julie (Committee member) / Arizona State University (Publisher)
Created2017
Description
The distinctions between the neural resources supporting speech and music comprehension have long been studied using contexts like aphasia and amusia, and neuroimaging in control subjects. While many models have emerged to describe the different networks uniquely recruited in response to speech and music stimuli, there are still many questions, especially regarding left-hemispheric strokes that disrupt typical speech-processing brain networks, and how musical training might affect the brain networks recruited for speech after a stroke. Thus, our study aims to explore some questions related to the above topics. We collected task-based functional MRI data from 12 subjects who previously experienced a left-hemispheric stroke. Subjects listened to blocks of spoken sentences and novel piano melodies during scanning to examine the differences in brain activations in response to speech and music. We hypothesized that speech stimuli would activate right frontal regions, and music stimuli would activate the right superior temporal regions more than speech (both findings not seen in previous studies of control subjects), as a result of functional changes in the brain, following the left-hemispheric stroke and particularly the loss of functionality in the left temporal lobe. We also hypothesized that the music stimuli would cause a stronger activation in right temporal cortex for participants who have had musical training than those who have not. Our results indicate that speech stimuli compared to rest activated the anterior superior temporal gyrus bilaterally and activated the right inferior frontal lobe. Music stimuli compared to rest did not activate the brain bilaterally, but rather only activated the right middle temporal gyrus. When the group analysis was performed with music experience as a covariate, we found that musical training did not affect activations to music stimuli specifically, but there was greater right hemisphere activation in several regions in response to speech stimuli as a function of more years of musical training. The results of the study agree with our hypotheses regarding the functional changes in the brain, but they conflict with our hypothesis about musical expertise. Overall, the study has generated interesting starting points for further explorations of how musical neural resources may be recruited for speech processing after damage to typical language networks.
ContributorsKarthigeyan, Vishnu R (Author) / Rogalsky, Corianne (Thesis director) / Daliri, Ayoub (Committee member) / Harrington Bioengineering Program (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
More than a century of research has investigated the etiology of dyslexia, coalescing around ‘phonological awareness’ – the ability to recognize and manipulate phonemes – as a trait typically deficient in reading disorders. Meanwhile, the last few decades of research in neuroscience have highlighted the brain as a predictive organ, which subliminally calibrates sensory expectations according to experience. Do the brains of adults with dyslexia respond differently than those of matched controls to expected tones and unexpected omissions? While auditory oddball paradigms have previously been used to study dyslexia, these studies often interpret group differences to indicate deficit auditory discrimination rather than deficit auditory prediction. The current study takes a step toward fusing theories of predictive coding and dyslexia, finding that event-related potentials related to auditory prediction are attenuated in adults with dyslexia compared with typical controls. It further suggests that understanding dyslexia, and perhaps other psychiatric disorders, in terms of contributory neural systems will elucidate shared and distinct etiologies.
ContributorsBennett, Augustin (Author) / Peter, Beate (Thesis advisor) / Daliri, Ayoub (Committee member) / Goldinger, Stephen (Committee member) / Arizona State University (Publisher)
Created2023
Description
Studies using transcranial direct current stimulation (tDCS) to enhance motor training areoften irreproducible. This may be partly due to differences in stimulation parameters across
studies, but it is also plausible that uncontrolled placebo effects may interact with the true
‘treatment’ effect of tDCS. Thus, the purpose of this study was to test whether there was a
placebo effect of tDCS on motor training and to identify possible mechanisms of such an effect.
Fifty-one participants (age: 22.2 ± 4.16; 26 F) were randomly assigned to one of three groups:
active anodal tDCS (n=18), sham tDCS (n=18), or no stimulation control (n=15). Participant
expectations about how much tDCS could enhance motor function and their general suggestibility
were assessed. Participants then completed 30 trials of functional upper extremity motor training
with or without online tDCS. Stimulation (20-min, 2mA) was applied to the right primary motor
cortex (C4) in a double-blind, sham-controlled fashion, while the control group was unblinded and
not exposed to any stimulation. Following motor training, expectations about how much tDCS
could enhance motor function were assessed again for participants in the sham and active tDCS
groups only. Results showed no effect of active tDCS on motor training (p=.67). However, there
was a significant placebo effect, such that the collapsed sham and active tDCS groups improved
more during motor training than the control group (p=.02). This placebo effect was significantly
influenced by post-training expectations about tDCS (p=.0004). Thus, this exploratory study
showed that there is a measurable placebo effect of tDCS on motor training, likely driven by
participants’ perceptions of whether they received stimulation. Future studies should consider
placebo effects of tDCS and identify their underlying mechanisms in order to leverage them in
clinical care.
ContributorsHAIKALIS, NICOLE (Author) / Schaefer, Sydney Y (Thesis advisor) / Honeycutt, Claire (Committee member) / Daliri, Ayoub (Committee member) / Arizona State University (Publisher)
Created2022