Virans is a book comprised of illustrations, hand-written text, and digital elements The book was conceived as an encapsulation of the broad social changes brought on by the COVID-19 pandemic. With a unique art style utilizing distorted human forms, complex line patterns, pointillism, and flat compositions, each of the book's 15 spreads represent an issue observed during the pandemic. These issues include isolation, political concerns, conspiracy theories, and the overall human toll of the pandemic.

Redox homeostasis is described as the net physiologic balance between inter-convertible oxidized and reduced equivalents within subcellular compartments that remain in a dynamic equilibrium. This equilibrium is impacted by reactive oxygen species (ROS), which are natural by-products of normal cellular activity. Studies have shown that cancer cells have high ROS levels and altered redox homeostasis due to increased basal metabolic activity, mitochondrial dysfunction, peroxisome activity, as well as the enhanced activity of NADPH oxidase, cyclooxygenases, and lipoxygenases. Glioblastoma (GBM) is the most prevalent primary brain tumor in adults with a median survival of 15 months. GBM is characterized by its extreme resistance to therapeutic interventions as well as an elevated metabolic rate that results in the exacerbated production of ROS. Therefore, many agents with either antioxidant or pro-oxidant mechanisms of action have been rigorously employed in preclinical as well as clinical settings for treating GBM by inducing oxidative stress within the tumor. Among those agents are well-known antioxidant vitamin C and small molecular weight SOD mimic BMX-001, both of which are presently in clinical trials on GBM patients. Despite the wealth of investigations, limited data is available on the response of normal brain vs glioblastoma tissue to these therapeutic interventions. Currently, a sensitive and rapid liquid chromatography tandem mass spectrometry (LC-MS/MS) method was established for the quantification of a panel of oxidative stress biomarkers: glutathione (GSH), cysteine (Cys), glutathione disulfide (GSSG), and cysteine disulfide in human-derived brain tumor and mouse brain samples; this method will be enriched with additional oxidative stress biomarkers homocysteine (Hcy), methionine (Met), and cystathionine (Cyst). Using this enriched method, we propose to evaluate the thiol homeostasis and the redox state of both normal brain and GBM in mice after exposure with redox-active therapeutics. Our results showed that, compared to normal brain (in intact mice), GBM tissue has significantly lower GSH/GSSG and Cys/CySS ratios indicating much higher oxidative stress levels. Contralateral “normal” brain tissue collected from the mice with intracranial GBM were also under significant oxidative stress compared to normal brains collected from the intact mice. Importantly, normal brain tissue in both studies retained the ability to restore redox homeostasis after treatment with a redox-active therapeutic within 24 hours while glioblastoma tissue does not. Ultimately, elucidating the differential redox response of normal vs tumor tissue will allow for the development of more redox-active agents with therapeutic benefit.

This business plan is centered around the creation of a digital marketplace that will promote small businesses and sustainable shopping habits throughout the community and beyond. Our business decisions will be guided by our vision which involves encouraging environmentally conscious shopping habits, supporting small artists, and raising money for charity without compromising quality. In addition to our focus on creating a social media-based digital marketplace, we aim to ultimately help local artists grow their businesses and further support the causes they care about.

From a young age I felt disconnected, and found art to be an effective means to connect with others. Guided by this I wanted to create an artistic piece to connect with the community that I have spent so much time living in. Utilizing an emerging opportunity near my apartment, I was able to secure a wall at a local venue to create a mural. I ran into my fair share of difficulties, taking a few lessons with me into future projects. The final design revolves around the university, being located right off campus, and the main pursuit of many of the residents here; graduation. I'm proud of the piece I've created and I'm happy to see the venue/community does as well.

Coelophysis (see-luh-fai-suhs) was an early theropod dinosaur that lived during the Triassic Period over 200 million years ago. Coelophysis has often been depicted as a creature that was scaly and lizard-like in appearance. However, recent paleontological evidence paints a different picture of this early dinosaur. This sculptural rendition of Coelophysis includes round pupils, feathered insulation, and even varied color patterns, all based on possibilities generated from current scientific findings. This hypothetical model was created to stretch popular assumptions about the appearance of early dinosaurs.