Filtering by
- All Subjects: Cancer
- Creators: School of Mathematical and Statistical Sciences
1. Spirituality and faith are increasingly recognized as important aspects in a personʼs life. National research shows that 66% of people feel counseling should include spirituality. Research with ASU students found that students reflect this statistic, as they feel spirituality is an important part of counseling. Students also feel spirituality is appropriate to include as part of counseling services offered by centers referred to by ASU.
2. There is a need for counseling at ASU. Nationally,approximately1,100 college students commit suicide each year. At ASU, almost one-third of students reported feeling so depressed that it is difficult to function, and 0.9% report having attempted suicide within the past year.
3. Surveys of ASU students indicate that students who describe themselves as being religious are more desirous that counseling include a spiritual dimension. Surveys of campus pastors indicate that over 80% believe there is a need for faith-based counseling and would refer students to a local center.
4. Price is an issue. Indeed, a survey of campus pastors indicated that they believed cost of counseling to be one of the primary deterrents to students seeking help. One way to control costs is to use a mixture of residents and licensed counselors. As in medicine, students must complete coursework along with a period of residency or internship to obtain licensing. Both religious and secular masters programs in counseling exist in the greater Phoenix area. Thus, there is a potential supply of students who could work as residents, permitting RLCC to offer counseling services at reasonable prices.
The primary research question is, “How does involvement in Christian ministries at ASU relate to the wellness of students?” The study will examine multiple dimensions of wellness: occupational, physical, social, intellectual, spiritual, and emotional. Each component is essential to understanding the health and well-being of an individual, which is why this study will measure wellness levels in each dimension among samples of students at ASU.
The methodology chosen was a short, anonymous survey that 148 ASU students participated in—73 involved in Christian ministries at ASU and 75 not involved. The quantitative component included a wellness assessment using questions from The National Wellness Institute. These wellness scale questions were broken up into 5 randomized sections, each with one question per dimension, for 30 questions total. Each question response was assigned a rating on a 1 to 5 scale, 1 associated with low wellness and 5 high wellness. The qualitative component, comprised of short answer questions, only applied to students who were involved in a Christian ministry. This portion allowed respondents to explain if and how the ministry impacts each dimension of wellness uniquely.
The quantitative results showed some evident differences between students involved in Christian ministries and students not involved. The social and spiritual dimensions concluded much higher levels of wellness for involved students, both statistically significant with p-values of 0.028 and 0.004. Although some of the wellness differences between involved and not involved participants were not statistically significant, there is also notable variation among questions within each dimension. For the qualitative data, most students in Christian ministries said they believe their involvement increases their wellness in all six dimensions. For each dimension, over 75% of participants said that the ministry impacted their well-being. For the social, spiritual, and emotional dimensions, at least 97% of respondents said their ministry involvement impacted their wellness.
In examining the conclusions of the study, one recommendations is to strengthen the partnership between the greater ASU community and Christian ministries by collaborating and combining resources for programming that relates to their common goals and shared values. Additionally, other faith-based organizations at ASU may benefit from replicating this study to observe their unique wellness impact.
Over time, tumor treatment resistance inadvertently develops when androgen de-privation therapy (ADT) is applied to metastasized prostate cancer (PCa). To combat tumor resistance, while reducing the harsh side effects of hormone therapy, the clinician may opt to cyclically alternates the patient’s treatment on and off. This method,known as intermittent ADT, is an alternative to continuous ADT that improves the patient’s quality of life while testosterone levels recover between cycles. In this paper,we explore the response of intermittent ADT to metastasized prostate cancer by employing a previously clinical data validated mathematical model to new clinical data from patients undergoing Abiraterone therapy. This cell quota model, a system of ordinary differential equations constructed using Droop’s nutrient limiting theory, assumes the tumor comprises of castration-sensitive (CS) and castration-resistant (CR)cancer sub-populations. The two sub-populations rely on varying levels of intracellular androgen for growth, death and transformation. Due to the complexity of the model,we carry out sensitivity analyses to study the effect of certain parameters on their outputs, and to increase the identifiability of each patient’s unique parameter set. The model’s forecasting results show consistent accuracy for patients with sufficient data,which means the model could give useful information in practice, especially to decide whether an additional round of treatment would be effective.
Cancer rates vary between people, between cultures, and between tissue types, driven by clinically relevant distinctions in the risk factors that lead to different cancer types. Despite the importance of cancer location in human health, little is known about tissue-specific cancers in non-human animals. We can gain significant insight into how evolutionary history has shaped mechanisms of cancer suppression by examining how life history traits impact cancer susceptibility across species. Here, we perform multi-level analysis to test how species-level life history strategies are associated with differences in neoplasia prevalence, and apply this to mammary neoplasia within mammals. We propose that the same patterns of cancer prevalence that have been reported across species will be maintained at the tissue-specific level. We used a combination of factor analysis and phylogenetic regression on 13 life history traits across 90 mammalian species to determine the correlation between a life history trait and how it relates to mammary neoplasia prevalence. The factor analysis presented ways to calculate quantifiable underlying factors that contribute to covariance of entangled life history variables. A greater risk of mammary neoplasia was found to be correlated most significantly with shorter gestation length. With this analysis, a framework is provided for how different life history modalities can influence cancer vulnerability. Additionally, statistical methods developed for this project present a framework for future comparative oncology studies and have the potential for many diverse applications.
Cancer treatments such as chemotherapy and radiation are expensive, painful, and often ineffective, as they compromise the patient’s immune system. Genetically-modified Salmonella Typhimurium (GMS) strains, however, have been proven to target tumors and suppress tumor growth. The GMS then undergo programmed lysis, optimally leaving no trace of Salmonella in the body. Additionally, constant culturing of S. Typhimurium changes the pH of the culture medium. The objective of this research is to investigate using Salmonella to induce changes in the typically acidic tumor microenvironment (TME) pH, ideally hindering tumor growth. Future studies involve utilizing Salmonella to treat a multitude of cancers.