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Description
Currently Java is making its way into the embedded systems and mobile devices like androids. The programs written in Java are compiled into machine independent binary class byte codes. A Java Virtual Machine (JVM) executes these classes. The Java platform additionally specifies the Java Native Interface (JNI). JNI allows Java

Currently Java is making its way into the embedded systems and mobile devices like androids. The programs written in Java are compiled into machine independent binary class byte codes. A Java Virtual Machine (JVM) executes these classes. The Java platform additionally specifies the Java Native Interface (JNI). JNI allows Java code that runs within a JVM to interoperate with applications or libraries that are written in other languages and compiled to the host CPU ISA. JNI plays an important role in embedded system as it provides a mechanism to interact with libraries specific to the platform. This thesis addresses the overhead incurred in the JNI due to reflection and serialization when objects are accessed on android based mobile devices. It provides techniques to reduce this overhead. It also provides an API to access objects through its reference through pinning its memory location. The Android emulator was used to evaluate the performance of these techniques and we observed that there was 5 - 10 % performance gain in the new Java Native Interface.
ContributorsChandrian, Preetham (Author) / Lee, Yann-Hang (Thesis advisor) / Davulcu, Hasan (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Reliable extraction of human pose features that are invariant to view angle and body shape changes is critical for advancing human movement analysis. In this dissertation, the multifactor analysis techniques, including the multilinear analysis and the multifactor Gaussian process methods, have been exploited to extract such invariant pose features from

Reliable extraction of human pose features that are invariant to view angle and body shape changes is critical for advancing human movement analysis. In this dissertation, the multifactor analysis techniques, including the multilinear analysis and the multifactor Gaussian process methods, have been exploited to extract such invariant pose features from video data by decomposing various key contributing factors, such as pose, view angle, and body shape, in the generation of the image observations. Experimental results have shown that the resulting pose features extracted using the proposed methods exhibit excellent invariance properties to changes in view angles and body shapes. Furthermore, using the proposed invariant multifactor pose features, a suite of simple while effective algorithms have been developed to solve the movement recognition and pose estimation problems. Using these proposed algorithms, excellent human movement analysis results have been obtained, and most of them are superior to those obtained from state-of-the-art algorithms on the same testing datasets. Moreover, a number of key movement analysis challenges, including robust online gesture spotting and multi-camera gesture recognition, have also been addressed in this research. To this end, an online gesture spotting framework has been developed to automatically detect and learn non-gesture movement patterns to improve gesture localization and recognition from continuous data streams using a hidden Markov network. In addition, the optimal data fusion scheme has been investigated for multicamera gesture recognition, and the decision-level camera fusion scheme using the product rule has been found to be optimal for gesture recognition using multiple uncalibrated cameras. Furthermore, the challenge of optimal camera selection in multi-camera gesture recognition has also been tackled. A measure to quantify the complementary strength across cameras has been proposed. Experimental results obtained from a real-life gesture recognition dataset have shown that the optimal camera combinations identified according to the proposed complementary measure always lead to the best gesture recognition results.
ContributorsPeng, Bo (Author) / Qian, Gang (Thesis advisor) / Ye, Jieping (Committee member) / Li, Baoxin (Committee member) / Spanias, Andreas (Committee member) / Arizona State University (Publisher)
Created2011
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Description
With the introduction of compressed sensing and sparse representation,many image processing and computer vision problems have been looked at in a new way. Recent trends indicate that many challenging computer vision and image processing problems are being solved using compressive sensing and sparse representation algorithms. This thesis assays some applications

With the introduction of compressed sensing and sparse representation,many image processing and computer vision problems have been looked at in a new way. Recent trends indicate that many challenging computer vision and image processing problems are being solved using compressive sensing and sparse representation algorithms. This thesis assays some applications of compressive sensing and sparse representation with regards to image enhancement, restoration and classication. The first application deals with image Super-Resolution through compressive sensing based sparse representation. A novel framework is developed for understanding and analyzing some of the implications of compressive sensing in reconstruction and recovery of an image through raw-sampled and trained dictionaries. Properties of the projection operator and the dictionary are examined and the corresponding results presented. In the second application a novel technique for representing image classes uniquely in a high-dimensional space for image classification is presented. In this method, design and implementation strategy of the image classification system through unique affine sparse codes is presented, which leads to state of the art results. This further leads to analysis of some of the properties attributed to these unique sparse codes. In addition to obtaining these codes, a strong classier is designed and implemented to boost the results obtained. Evaluation with publicly available datasets shows that the proposed method outperforms other state of the art results in image classication. The final part of the thesis deals with image denoising with a novel approach towards obtaining high quality denoised image patches using only a single image. A new technique is proposed to obtain highly correlated image patches through sparse representation, which are then subjected to matrix completion to obtain high quality image patches. Experiments suggest that there may exist a structure within a noisy image which can be exploited for denoising through a low-rank constraint.
ContributorsKulkarni, Naveen (Author) / Li, Baoxin (Thesis advisor) / Ye, Jieping (Committee member) / Sen, Arunabha (Committee member) / Arizona State University (Publisher)
Created2011
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Description

Glioblastoma (GB) is one of the deadliest cancers and the most common form of adult primary brain tumors. SGEF (ARHGEF26) has been previously shown to be overexpressed in GB tumors, play a role in cell invasion/migration, and increase temozolomide (TMZ) resistance.[3] It was hypothesized parental LN229 cell lines with SGEF

Glioblastoma (GB) is one of the deadliest cancers and the most common form of adult primary brain tumors. SGEF (ARHGEF26) has been previously shown to be overexpressed in GB tumors, play a role in cell invasion/migration, and increase temozolomide (TMZ) resistance.[3] It was hypothesized parental LN229 cell lines with SGEF knockdown (LN229-SGEFi) will show decreased metabolism in the MTS assay and decreased colony formation in a colony formation assay compared to parental LN229 cells after challenging the two cell lines with TMZ. For WB and co-immunoprecipitation (co-IP), parental LN229 cells with endogenous SGEF and BRCA were expected to interact and stain in the BRCA1:IP WB. LN229-SGEFi cells were expected to show very little SGEF precipitated due to shRNA targeted knockdown of SGEF. In conditions with mutations in the BRCA1 binding site (LN229-SGEFi + AdBRCAm/AdDM), SGEF expression was expected to decrease compared to parental LN229 or LN229-SGEFi cells reconstituted with WT SGEF (LN229-SGEFi + AdWT). LN229 infected with AdSGEF with a mutated nuclear localization signal (LN229-SGEFi + AdNLS12m) were expected to show BRCA and SGEF interaction since whole cell lysates were used for the co-IP. MTS data showed no significant differences in metabolism between the two cell lines at all three time points (3, 5, and 7 days). Western blot analysis was successful at imaging both SGEF and BRCA1 protein bands from whole cell lysate. The CFA showed no significant difference between cell lines after being challenged with 500uM TMZ. The co-IP immunoblot showed staining for BRCA1 and SGEF for all lysate samples, including unexpected lysates such as LN229-SGEFi, LN229-SGEFi + AdBRCAm, and LN229-SGEFi + AdDM. These results suggested either an indirect protein interaction between BRCA1 and SGEF, an additional BRCA binding site not included in the consensus, or possible detection of the translocated SGEF in knockdown cells lines since shRNA cannot enter the nucleus. Further optimization of CO-IP protocol, MTS assay, and CFA will be needed to characterize the SGEF/BRCA1 interaction and its role in cell survival.

ContributorsNabaty, Natalie Lana (Author) / Douglas, Lake (Thesis director) / Loftus, Joseph C. (Committee member) / School of Life Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Cancer rates vary between people, between cultures, and between tissue types, driven by clinically relevant distinctions in the risk factors that lead to different cancer types. Despite the importance of cancer location in human health, little is known about tissue-specific cancers in non-human animals. We can gain significant insight into

Cancer rates vary between people, between cultures, and between tissue types, driven by clinically relevant distinctions in the risk factors that lead to different cancer types. Despite the importance of cancer location in human health, little is known about tissue-specific cancers in non-human animals. We can gain significant insight into how evolutionary history has shaped mechanisms of cancer suppression by examining how life history traits impact cancer susceptibility across species. Here, we perform multi-level analysis to test how species-level life history strategies are associated with differences in neoplasia prevalence, and apply this to mammary neoplasia within mammals. We propose that the same patterns of cancer prevalence that have been reported across species will be maintained at the tissue-specific level. We used a combination of factor analysis and phylogenetic regression on 13 life history traits across 90 mammalian species to determine the correlation between a life history trait and how it relates to mammary neoplasia prevalence. The factor analysis presented ways to calculate quantifiable underlying factors that contribute to covariance of entangled life history variables. A greater risk of mammary neoplasia was found to be correlated most significantly with shorter gestation length. With this analysis, a framework is provided for how different life history modalities can influence cancer vulnerability. Additionally, statistical methods developed for this project present a framework for future comparative oncology studies and have the potential for many diverse applications.

ContributorsFox, Morgan Shane (Author) / Maley, Carlo C. (Thesis director) / Boddy, Amy (Committee member) / Compton, Zachary (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The goal of this project was to design and create a genetic construct that would allow for <br/>tumor growth to be induced in the center of the wing imaginal disc of Drosophila larvae, the <br/>R85E08 domain, using a heat shock. The resulting transgene would be combined with other <br/>transgenes in

The goal of this project was to design and create a genetic construct that would allow for <br/>tumor growth to be induced in the center of the wing imaginal disc of Drosophila larvae, the <br/>R85E08 domain, using a heat shock. The resulting transgene would be combined with other <br/>transgenes in a single fly that would allow for simultaneous expression of the oncogene and, in <br/>the surrounding cells, other genes of interest. This system would help establish Drosophila as a <br/>more versatile and reliable model organism for cancer research. Furthermore, pilot studies were <br/>performed, using elements of the final proposed system, to determine if tumor growth is possible <br/>in the center of the disc, which oncogene produces the best results, and if oncogene expression <br/>induced later in development causes tumor growth. Three different candidate genes were <br/>investigated: RasV12, PvrACT, and Avli.

ContributorsSt Peter, John Daniel (Author) / Harris, Rob (Thesis director) / Varsani, Arvind (Committee member) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Developed a business product with a team of CS students.

ContributorsPerri, Cole Thomas (Co-author) / Hernandez, Maximilliano (Co-author) / Schneider, Kaitlin (Co-author) / Call, Andy (Thesis director) / Hunt, Neil (Committee member) / School of Accountancy (Contributor) / Watts College of Public Service & Community Solut (Contributor) / WPC Graduate Programs (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
In many classication problems data samples cannot be collected easily, example in drug trials, biological experiments and study on cancer patients. In many situations the data set size is small and there are many outliers. When classifying such data, example cancer vs normal patients the consequences of mis-classication are probably

In many classication problems data samples cannot be collected easily, example in drug trials, biological experiments and study on cancer patients. In many situations the data set size is small and there are many outliers. When classifying such data, example cancer vs normal patients the consequences of mis-classication are probably more important than any other data type, because the data point could be a cancer patient or the classication decision could help determine what gene might be over expressed and perhaps a cause of cancer. These mis-classications are typically higher in the presence of outlier data points. The aim of this thesis is to develop a maximum margin classier that is suited to address the lack of robustness of discriminant based classiers (like the Support Vector Machine (SVM)) to noise and outliers. The underlying notion is to adopt and develop a natural loss function that is more robust to outliers and more representative of the true loss function of the data. It is demonstrated experimentally that SVM's are indeed susceptible to outliers and that the new classier developed, here coined as Robust-SVM (RSVM), is superior to all studied classier on the synthetic datasets. It is superior to the SVM in both the synthetic and experimental data from biomedical studies and is competent to a classier derived on similar lines when real life data examples are considered.
ContributorsGupta, Sidharth (Author) / Kim, Seungchan (Thesis advisor) / Welfert, Bruno (Committee member) / Li, Baoxin (Committee member) / Arizona State University (Publisher)
Created2011
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Description
Bridging semantic gap is one of the fundamental problems in multimedia computing and pattern recognition. The challenge of associating low-level signal with their high-level semantic interpretation is mainly due to the fact that semantics are often conveyed implicitly in a context, relying on interactions among multiple levels of concepts or

Bridging semantic gap is one of the fundamental problems in multimedia computing and pattern recognition. The challenge of associating low-level signal with their high-level semantic interpretation is mainly due to the fact that semantics are often conveyed implicitly in a context, relying on interactions among multiple levels of concepts or low-level data entities. Also, additional domain knowledge may often be indispensable for uncovering the underlying semantics, but in most cases such domain knowledge is not readily available from the acquired media streams. Thus, making use of various types of contextual information and leveraging corresponding domain knowledge are vital for effectively associating high-level semantics with low-level signals with higher accuracies in multimedia computing problems. In this work, novel computational methods are explored and developed for incorporating contextual information/domain knowledge in different forms for multimedia computing and pattern recognition problems. Specifically, a novel Bayesian approach with statistical-sampling-based inference is proposed for incorporating a special type of domain knowledge, spatial prior for the underlying shapes; cross-modality correlations via Kernel Canonical Correlation Analysis is explored and the learnt space is then used for associating multimedia contents in different forms; model contextual information as a graph is leveraged for regulating interactions among high-level semantic concepts (e.g., category labels), low-level input signal (e.g., spatial/temporal structure). Four real-world applications, including visual-to-tactile face conversion, photo tag recommendation, wild web video classification and unconstrained consumer video summarization, are selected to demonstrate the effectiveness of the approaches. These applications range from classic research challenges to emerging tasks in multimedia computing. Results from experiments on large-scale real-world data with comparisons to other state-of-the-art methods and subjective evaluations with end users confirmed that the developed approaches exhibit salient advantages, suggesting that they are promising for leveraging contextual information/domain knowledge for a wide range of multimedia computing and pattern recognition problems.
ContributorsWang, Zhesheng (Author) / Li, Baoxin (Thesis advisor) / Sundaram, Hari (Committee member) / Qian, Gang (Committee member) / Ye, Jieping (Committee member) / Arizona State University (Publisher)
Created2011
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Description
A statement appearing in social media provides a very significant challenge for determining the provenance of the statement. Provenance describes the origin, custody, and ownership of something. Most statements appearing in social media are not published with corresponding provenance data. However, the same characteristics that make the social media environment

A statement appearing in social media provides a very significant challenge for determining the provenance of the statement. Provenance describes the origin, custody, and ownership of something. Most statements appearing in social media are not published with corresponding provenance data. However, the same characteristics that make the social media environment challenging, including the massive amounts of data available, large numbers of users, and a highly dynamic environment, provide unique and untapped opportunities for solving the provenance problem for social media. Current approaches for tracking provenance data do not scale for online social media and consequently there is a gap in provenance methodologies and technologies providing exciting research opportunities. The guiding vision is the use of social media information itself to realize a useful amount of provenance data for information in social media. This departs from traditional approaches for data provenance which rely on a central store of provenance information. The contemporary online social media environment is an enormous and constantly updated "central store" that can be mined for provenance information that is not readily made available to the average social media user. This research introduces an approach and builds a foundation aimed at realizing a provenance data capability for social media users that is not accessible today.
ContributorsBarbier, Geoffrey P (Author) / Liu, Huan (Thesis advisor) / Bell, Herbert (Committee member) / Li, Baoxin (Committee member) / Sen, Arunabha (Committee member) / Arizona State University (Publisher)
Created2011