Filtering by
- All Subjects: Cancer
- All Subjects: Science
- Creators: Foy, Joseph
- Creators: Blattman, Joseph
Adaptive therapy utilizes competitive interactions between resistant and sensitive cells by keeping some sensitive cells to control tumor burden with the aim of increasing overall survival and time to progression. The use of adaptive therapy to treat breast cancer, ovarian cancer, and pancreatic cancer in preclinical models has shown significant results in controlling tumor growth. The purpose of this thesis is to draft a protocol to study adaptive therapy in a preclinical model of breast cancer on MCF7, estrogen receptor-positive, cells that have evolved resistance to fulvestrant and palbociclib (MCF7 R). In this study, we used two protocols: drug dose adjustment and intermittent therapy. The MCF7 R cell lines were injected into the mammary fat pads of 11-month-old NOD/SCID gamma (NSG) mice (18 mice) which were then treated with gemcitabine.<br/>The results of this experiment did not provide complete information because of the short-term treatments. In addition, we saw an increase in the tumor size of a few of the treated mice, which could be due to the metabolism of the drug at that age, or because of the difference in injection times. Therefore, these adaptive therapy protocols on hormone-refractory breast cancer cell lines will be repeated on young, 6-week old mice by injecting the cell lines at the same time for all mice, which helps the results to be more consistent and accurate.
This paper analyzes the history and impact of the double-slit experiment on the world of physics. The experiment was initially created by Thomas Young in the early nineteenth century to prove that light behaved as a wave, and the experiment’s findings ended up being foundational to the classical wave theory of light. Decades later, the experiment was replicated once more with electrons instead of light and shockingly demonstrated that electrons possessed a dual nature of behavior in that they acted in some instances as particles and in others as waves. Despite numerous modifications and replications, the dual behavior of electrons has never been definitively explained. Numerous interpretations of quantum mechanics all offer their own explanations of the double-slit experiment’s results. Notably, the Copenhagen Interpretation states that an observer measuring a quantum system, such as the double-slit experiment, causes the electrons to behave classically (i.e. as a particle.) The Many Worlds Interpretation offers that multiple branching worlds come into existence to represent the physical occurrence of all probable outcomes of the double-slit experiment. In these and other interpretations, explanations of the double-slit experiment are key to proving their respective dogmas. The double-slit experiment has historically been very important to the worlds of both classical and quantum physics and is still being modified and replicated to this day. It is clear that it will continue to remain relevant even in the future of physics.