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- Creators: Arizona State University
- Creators: Buetow, Kenneth
- Creators: Sanford School of Social and Family Dynamics
Description
Parenting approaches that are firm yet warm (i.e., authoritative parenting) have been found to be robustly beneficial for mainstream White Americans youths, but do not demonstrate similarly consistent effects among Chinese Americans (CA) adolescents. Evidence suggests that CA adolescents interpret and experience parenting differently than their mainstream counterparts given differences in parenting values and child-rearing norms between traditional Chinese and mainstream American cultures. The current study tests the theory that prospective effects of parenting on psychological and academic functioning depends on adolescents' cultural frameworks for interpreting and understanding parenting. CA adolescents with values and expectations of parenting that are more consistent with mainstream American parenting norms were predicted to experience parenting similar to their White American counterparts (i.e., benefiting from a combination of parental strictness and warmth). In contrast, CA adolescents with parenting values and expectations more consistent with traditional Chinese parenting norms were predicted to experience parenting and its effects on academic and psychological outcomes differently than patterns documented in the mainstream literature. This study was conducted with a sample of Chinese American 9th graders (N = 500) from the Multicultural Family Adolescent Study. Latent Class Analysis (LCA), a person-centered approach to modeling CA adolescents' cultural frameworks for interpreting parenting, was employed using a combination of demographic variables (e.g., nativity, language use at home, mother's length of stay in the U.S.) and measures of parenting values and expectations (e.g., parental respect, ideal strictness & laxness). The study then examined whether prospective effects of parenting behaviors (strict control, warmth, and their interaction effect) on adolescent adjustment (internalizing and externalizing symptoms, substance use, and GPA) were moderated by latent class membership. The optimal LCA solution identified five distinct cultural frameworks for understanding parenting. Findings generally supported the idea that effects of parenting on CA adolescent adjustment depend on adolescents' cultural framework for parenting. The classic authoritative parenting effect (high strictness and warmth leads to positive outcomes) was found for the two most acculturated groups of adolescents. However, only one of these groups overtly endorsed mainstream American parenting values.
ContributorsLiu, Freda Fangfang (Author) / Gonzales, Nancy A. (Thesis advisor) / Tein, Jenn-Yun (Committee member) / Yoo, Hyung Chol (Committee member) / Barrera, Manuel (Committee member) / Arizona State University (Publisher)
Created2011
Description
In recent years, the field of nanomedicine has progressed at an astonishing rate, particularly with respect to applications in cancer treatment and molecular imaging. Although organic systems have been the frontrunners, inorganic systems have also begun to show promise, especially those based upon silica and magnetic nanoparticles (NPs). Many of these systems are being designed for simultaneous therapeutic and diagnostic capabilities, thus coining the term, theranostics. A unique class of inorganic systems that shows great promise as theranostics is that of layered double hydroxides (LDH). By synthesis of a core/shell structures, e.g. a gold nanoparticle (NP) core and LDH shell, the multifunctional theranostic may be developed without a drastic increase in the structural complexity. To demonstrate initial proof-of-concept of a potential (inorganic) theranostic platform, a Au-core/LDH-shell nanovector has been synthesized and characterized. The LDH shell was heterogeneously nucleated and grown on the surface of silica coated gold NPs via a coprecipitation method. Polyethylene glycol (PEG) was introduced in the initial synthesis steps to improve crystallinity and colloidal stability. Additionally, during synthesis, fluorescein isothiocyanate (FITC) was intercalated into the interlayer spacing of the LDH. In contrast to the PEG stabilization, a post synthesis citric acid treatment was used as a method to control the size and short-term stability. The heterogeneous core-shell system was characterized with scanning electron microscopy (SEM), energy dispersive x-ray spectroscopy (EDX), dynamic light scattering (DLS), and powder x-ray diffraction (PXRD). A preliminary in vitro study carried out with the assistance of Dr. Kaushal Rege's group at Arizona State University was to demonstrate the endocytosis capability of homogeneously-grown LDH NPs. The DLS measurements of the core-shell NPs indicated an average particle size of 212nm. The PXRD analysis showed that PEG greatly improved the crystallinity of the system while simultaneously preventing aggregation of the NPs. The preliminary in vitro fluorescence microscopy revealed a moderate uptake of homogeneous LDH NPs into the cells.
ContributorsRearick, Colton (Author) / Dey, Sandwip K (Thesis advisor) / Krause, Stephen (Committee member) / Ramakrishna, B (Committee member) / Arizona State University (Publisher)
Created2011
Description
Native American communities face an ongoing challenge of effectively addressing cancer health disparities, as well as environmental racism issues that may compound these inequities. This dissertation identified the shared cultural knowledge and beliefs about cancer in a southwest American Indian community utilizing a cultural consensus method, an approach that combines qualitative and quantitative data. A community-based participatory research (CBPR) approach was applied at all stages of the study. The three phases of research that were undertaken included: 1) ethnographic interviews - to identifying the themes or the content of the participants' cultural model, 2A) ranking of themes - to provide an understanding of the relative importance of the content of the cultural model, 2B) pile sorts - identify the organization of items within specific domains, and 3) a community survey - access whether the model is shared in the greater community. The cultural consensus method has not been utilized to date in identifying the collective cultural beliefs about cancer prevention, treatment or survivorship in a Native American community. Its use represents a methodological step forward in two areas: 1) the traditional ethnographic inferences used in identifying and defining cultural meaning as it relates to health can be tested more rigorously than in the past, and 2) it addresses the challenge of providing reliable results based on a small number of community informants. This is especially significant when working with smaller tribal/cultural groups where the small sample size has led to questions concerning the reliability and validity of health-related research. Results showed that the key consultants shared strong agreement or consensus on a cultural model regarding the importance of environmental and lifestyle causes of cancer. However, there was no consensus found among the key consultants on the prevention and treatment of cancer. The results of the community survey indicated agreement or consensus in the sub-domains of descriptions of cancer, risk/cause, prevention, treatment, remission/cure and living with cancer. Identifying cultural beliefs and models regarding cancer could contribute to the effective development of culturally responsive cancer prevention education and treatment programs.
ContributorsClaus, Cynthia (Author) / Koss, Joan (Thesis advisor) / Brandt, Elizabeth, (Thesis advisor) / Joe, Jennie (Committee member) / Maupin, Jonathan (Committee member) / Arizona State University (Publisher)
Created2011
Description
This study examines the possibility of using social and historical contexts, image analysis, and personal themes to engage adolescent photography students in the craft of photography. This new curriculum was designed around large themes that correspond to the developmental stage of adolescence. Issues such as self-identity, teenage stereotypes, school, family, and community were explored through examining historical documents and photographs, comparing popular culture perspectives, and learning basic semiotics. The students then worked within these ideas by creating their own photographs and reflecting upon their art making choices. The new approach was implemented in an analog film class in which basic 35mm camera and film techniques are taught. It is argued that meaning making motivates the adolescent photographer rather than the achievement of strong technical skills. This qualitative study was conducted using an action research approach, in which the author was both the classroom teacher and the researcher. The study incorporates data collected from student-created photographs, student written responses, interviews of students, interviews of photography teachers, and the researcher's field notes. Major themes were discovered over time by applying a grounded theory approach to understanding the data. The curriculum brought a new level of student engagement, both in participation in the course and in the complexity of their image making. By incorporating the chosen topics, students' images were rich with personal meaning. Students retained concepts of historical and social uses for photography and demonstrated a base understanding of semiotic theory. Furthermore, the data points to a stronger sense of community and teacher-student relationships within the classroom. The researcher argues that this deeper rapport is due to the concentration on personal themes within the practice of photography. Setbacks within the study included censorship by the school of mature subjects, a limited amount of equipment, and a limited amount of time with the students. This study demonstrates the need for art curriculum to provide connections between visual art, interdisciplinary associations, students' level of development, and students' personal interests. The research provides a possible approach to redesigning curriculum for photography courses for the twenty-first century student.
ContributorsOverby, Alexandra (Author) / Young, Bernard (Thesis advisor) / Margolis, Eric (Committee member) / Erickson, Mary (Committee member) / Stokrocki, Mary (Committee member) / Arizona State University (Publisher)
Created2011
Description
Growing concern about obesity prevalence among youth has prompted the examination of socio-environmental influences that shape the development of eating and activity behaviors believed to regulate weight. Given the presumed significance of close friendships during adolescence, the present investigation assessed longitudinal relations between friends' physical activity, sedentary activity, and healthy eating behaviors and explored whether friends' obesity-promoting behaviors are linked to heightened obesity risk among adolescents. This prospective study utilized two Waves of data from 862 reciprocal and 1908 nonreciprocal same-sex friend dyads participating in the National Longitudinal Study of Adolescent Health. To account for nonindependence tied to membership in a particular friendship dyad, multi-level models were estimated for indistinguishable (i.e., reciprocal) and distinguishable (i.e., nonreciprocal) friend pairs using the Actor Partner Interdependence Model. Adolescents' self-reported physical activity and healthy eating were significantly associated with their own and their friends' physical activity and healthy eating one year later; the strength of socialization across friend dyads did not vary with the frequency of interaction between friends or the stability of friendships over time. Limited support was found for a cumulative risk model of obesity-promoting behaviors as a predictor of increased obesity risk; heightened risk for weight gain was found only for adolescents whose reciprocal same-sex friends reported a higher number of obesity-promoting eating and activity behaviors. Overall, study findings highlight the role of close friends for adolescents' obesity risk and obesity-related behaviors. Stronger evidence of socialization resulted for adolescents that perceived their friends to be salient social models, as reflected by their acknowledgement of an existing friendship with such peers (i.e., reciprocal friends and nominators within nonreciprocal friend dyads).
ContributorsSlutzky, Carly Beth (Author) / Updegraff, Kimberly A (Thesis advisor) / Simpkins, Sandra D (Committee member) / Gance-Cleveland, Bonnie (Committee member) / Schaefer, David R (Committee member) / Iida, Masumi (Committee member) / Arizona State University (Publisher)
Created2011
Description
This paper outlines the three research projects that I performed between 2009-present: Slow Movement Training (SMT) lab, Self-education Through Embodied Movement (STEM), and the Athletic Movement Program (AMP). It first evaluates the major issues that spawned each research project, and then provides a framework for understanding the shift in the student-centered physical and mental movement practices that I developed in response to the need for reform. The content will address the personal and professional paradigmatic shift that I experienced through the lens of a practitioner and educator. It will focus heavily on the transitions between each of the projects and finally the emergence of the Athletic Movement Program. The focal point becomes one of community needs, alternate resources and hybrid-online classroom support. The paper concludes with an overview and content comparison between the one-size-fits-all model used within public movement education and Athletic Movement Programs' strengths and challenges.
ContributorsCroitoru, Michael (Author) / Mitchell, John D. (Thesis advisor) / Fitzgerald, Mary (Committee member) / Coleman, Grisha (Committee member) / Arizona State University (Publisher)
Created2011
Description
This study explores the relationship between restrictive language policies and dropout influences for language minority students. It furthers understanding of factors related to school attachment and restrictive language policies through an analysis of student's attitudes towards their imposed curriculum. Few studies to date have addressed English language learners' (ELLs') attitudes toward school, especially when schools enforce highly restrictive language policies, and the implications of these student perceptions as related to students' level of attachment to school in general. This study addresses this gap. It investigated middle and high school ELLs' and reclassified (RC) students' attitudes toward school, their aspirations for the future, and the language program in which they are or were recently enrolled within the state of Arizona. Using Erickson's analytic induction method and employing descriptive statistics, t tests, and hierarchical multiple regression, 2,264 students were polled from urban school districts in Arizona. The 85-question survey was comprised of demographic questions and attitude items as measured on a 5-point Likert scale. Results indicate some students are not satisfied with the four-hour block and that many students are aware of the negative implications involvement in the four-hour block can incur. Findings also show that language minority students are not receiving an equal education in regards to their curriculum. More importantly, considering policies and practices of schools as a factor, especially those which are restrictive language policies, is important in better understanding ELL and RC students' attachment to school and the potential impact of these policies on the likelihood of language minority students dropping out of school in the future. Policy implications are discussed.
ContributorsLillie, Karen Elizabeth Capullo (Author) / Arias, M Beatriz (Thesis advisor) / Wiley, Terrence G. (Thesis advisor) / Ovando, Carlos J (Committee member) / Arizona State University (Publisher)
Created2011
Description
Given the process of tumorigenesis, biological signaling pathways have become of interest in the field of oncology. Many of the regulatory mechanisms that are altered in cancer are directly related to signal transduction and cellular communication. Thus, identifying signaling pathways that have become deregulated may provide useful information to better understanding altered regulatory mechanisms within cancer. Many methods that have been created to measure the distinct activity of signaling pathways have relied strictly upon transcription profiles. With advancements in comparative genomic hybridization techniques, copy number data has become extremely useful in providing valuable information pertaining to the genomic landscape of cancer. The purpose of this thesis is to develop a methodology that incorporates both gene expression and copy number data to identify signaling pathways that have become deregulated in cancer. The central idea is that copy number data may significantly assist in identifying signaling pathway deregulation by justifying the aberrant activity being measured in gene expression profiles. This method was then applied to four different subtypes of breast cancer resulting in the identification of signaling pathways associated with distinct functionalities for each of the breast cancer subtypes.
ContributorsTrevino, Robert (Author) / Kim, Seungchan (Thesis advisor) / Ringner, Markus (Committee member) / Liu, Huan (Committee member) / Arizona State University (Publisher)
Created2011
Description
Obesity in Hispanic youth has reached alarmingly high levels, increasing the risk of type 2 diabetes, hyperlipidemia, hypertension, and cardiovascular disease. In Mexican American children ages 6-11 years, 41.7% are overweight and obese, 24.7% are obese and 19.6% have a Body Mass Index (BMI) greater than the 97th percentile. While personal, behavioral, and environmental factors contribute to these high rates, emerging literature suggests acculturation, self-efficacy and social support are key influences. The one-group, pre- and post-test, quasi-experimental design used a community-based participatory research (CBPR) method to test the feasibility, acceptability, and preliminary efficacy of the 8-week intervention. Social Cognitive Theory (SCT) was used to guide the design. Measurements included an analysis of recruitment, retention, participant satisfaction, observation of intervention sessions, paired t-tests, effect sizes, and bivariate correlations between study variables (acculturation, nutrition and physical activity [PA] knowledge, attitude and behaviors, perceived confidence and social support) and outcome variables (BMI z-score, waist circumference and BP percentile) Findings showed the SSLN program was feasible and acceptable. Participants (n = 16) reported that the curriculum was fun and they learned about nutrition and PA. The retention rate was 94%. The preliminary effects on adolescent nutrition and PA behaviors showed mixed results with small-to-medium effect sizes for nutrition knowledge and attitude, PA and sedentary behavior. Correlation analysis among acculturation and study variables was not significant. Positive associations were found between perceived confidence in eating and nutrition attitude (r = .61, p < .05) and nutrition behavior (r = .62, p < .05), perceived confidence in exercise and nutrition behavior (r = .66, p < .05), social support from family for exercise and PA behavior (r = .67, p < .01) and social support from friends for exercise and PA behavior (r = .56, p < .05). These findings suggest a culturally specific healthy eating and activity program for adolescents was feasible and acceptable and warrants further investigation, since it may fill a gap in existing obesity programs designed for Hispanic youth. The positive correlations suggest further testing of the theoretical model.
ContributorsStevens, Carol (Author) / Gance-Cleveland, Bonnie (Thesis advisor) / Komnenich, Pauline (Committee member) / Shaibi, Gabriel (Committee member) / Arcoleo, Kimberly (Committee member) / Arizona State University (Publisher)
Created2011
Description
The bleomycins are a family of glycopeptide-derived antibiotics isolated from various Streptomyces species and have been the subject of much attention from the scientific community as a consequence of their antitumor activity. Bleomycin clinically and is an integral part of a number of combination chemotherapy regimens. It has previously been shown that bleomycin has the ability to selectively target tumor cells over their non-malignant counterparts. Pyrimidoblamic acid, the N-terminal metal ion binding domain of bleomycin is known to be the moiety that is responsible for O2 activation and the subsequent chemistry leading to DNA strand scission and overall antitumor activity. Chapter 1 describes bleomycin and related DNA targeting antitumor agents as well as the specific structural domains of bleomycin. Various structural analogues of pyrimidoblamic acid were synthesized and subsequently incorporated into their corresponding full deglycoBLM A6 derivatives by utilizing a solid support. Their activity was measured using a pSP64 DNA plasmid relaxation assay and is summarized in Chapter 2. The specifics of bleomycin—DNA interaction and kinetics were studied via surface plasmon resonance and are presented in Chapter 3. By utilizing carefully selected 64-nucleotide DNA hairpins with variable 16-mer regions whose sequences showed strong binding in past selection studies, a kinetic profile was obtained for several BLMs for the first time since bleomycin was discovered in 1966. The disaccharide moiety of bleomycin has been previously shown to be a specific tumor cell targeting element comprised of L-gulose-D-mannose, especially between MCF-7 (breast cancer cells) and MCF-10A ("normal" breast cells). This phenomenon was further investigated via fluorescence microscopy using multiple cancerous cell lines with matched "normal" counterparts and is fully described in Chapter 4.
ContributorsBozeman, Trevor C (Author) / Hecht, Sidney M. (Thesis advisor) / Chaput, John (Committee member) / Gould, Ian (Committee member) / Arizona State University (Publisher)
Created2013