Matching Items (579)
Filtering by
- All Subjects: Creative Project
- Creators: Barrett, The Honors College
Description
Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue, and currently plagues today’s world. Carcinomas are cancers derived from epithelial cells and include breast and prostate cancer. Breast cancer is a type of carcinoma that forms in breast tissue cells. The tumor cells can be further categorized after testing the cells for the presence of certain molecules. Hormone receptor positive breast cancer includes the tumor cells with receptors that respond to the steroid hormones, estrogen and progesterone, or the peptide hormone, HER2. These forms of cancer respond well to chemotherapy and endocrine therapy. On the other hand, triple negative breast cancer (TNBC) is characterized by the lack of hormone receptor expression and tends to have a worse prognosis in women. Prostate cancer forms in the cells of the prostate gland and has been attributed to mutations in androgen receptor ligand specificity. In a subset of triple negative breast cancer, genetic expression profiling has found a luminal androgen receptor that is dependent on androgen signaling. TNBC has also been found to respond well to enzalutamide, a an androgen receptor inhibitor. As the gene of the androgen receptor, AR, is located on the X chromosome and expressed in a variety of tissues, the responsiveness of TNBC to androgen receptor inhibition could be due to the differential usage of isoforms - different gene mRNA transcripts that produce different proteins. Thus, this study analyzed differential gene expression and differential isoform usage between TNBC cancers – that do and do not express the androgen receptor – and prostate cancer in order to better understand the underlying mechanism behind the effectiveness of androgen receptor inhibition in TNBC. Through the analysis of differential gene expression between the TNBC AR+ and AR- conditions, it was found that seven genes are significantly differentially expressed between the two types of tissues. Genes of significance are AR and EN1, which was found to be a potential prognostic marker in a subtype of TNBC. While some genes are differentially expressed between the TNBC AR+ and AR- tissues, the differences in isoform expression between the two tissues do not reflect the difference in gene expression. We discovered 11 genes that exhibited significant isoform switching between AR+ and AR- TNBC and have been found to contribute to cancer characteristics. The genes CLIC1 and RGS5 have been found to help the rapid, uncontrolled growth of cancer cells. HSD11B2, IRAK1, and COL1Al have been found to contribute to general cancer characteristics and metastasis in breast cancer. PSMA7 has been found to play a role in androgen receptor activation. Finally, SIDT1 and GLYATL1 are both associated with breast and prostate cancers. Overall, through the analysis of differential isoform usage between AR+ and AR- samples, we uncovered differences that were not detected by a gene level differential expression analysis. Thus, future work will focus on analyzing differential gene and isoform expression across all types of breast cancer and prostate cancer to better understand the responsiveness of TNBC to androgen receptor inhibition.
ContributorsDeshpande, Anagha J (Author) / Wilson-Sayres, Melissa (Thesis director) / Buetow, Kenneth (Committee member) / Natri, Heini (Committee member) / School of Human Evolution & Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell line.
ContributorsGhorayeb, Antoine (Author) / Neisewander, Janet (Thesis director) / Diehnelt, Chris (Committee member) / Moussallem, Suzan (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
A creative project detailing the representation of Asian Americans in Sports Media. I interviewed 6 Asian American sports journalists across the US talking about their journey into the media world. They also talked about the representation of AAPI's in their market and how that affects them and their community as a whole.
ContributorsOza, Rishi (Author) / Woods, Shemar (Thesis director) / Hawken, Denise (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor) / Department of Marketing (Contributor)
Created2024-05
DescriptionThis is a reflection on Michael Frayn's Copenhagen, a theatrical experiment. It explores how directing affects the audience's experience of the text. It metaphorically correlates quantum theory and theatre in the round.
ContributorsBen Ezer, Shy-Lee (Author) / Partlan, William (Thesis director) / Chamberlin, Ralph (Committee member) / Gharavi, Lance (Committee member) / Barrett, The Honors College (Contributor) / Department of English (Contributor) / Computer Science and Engineering Program (Contributor) / School of Music, Dance and Theatre (Contributor)
Created2024-05
Description
Creative thesis written in conjunction with my Media Arts and Sciences capstone project, Relatables. Relatables are a series of collectible cards and pins that feature four fictional characters representing a diverse range of backgrounds and personalities. These characters serve as catalysts for open and insightful discussions, encouraging children to explore and reflect upon the beginnings of complex aspects of human experiences in a comprehensible manner. A QR code on each of the cards direct users to an interactive website that acts as a hub for exploration and discussion where users can access more detailed profiles of each character and resources for parents.
ContributorsBustamante, McKenna (Author) / Kautz, Luke (Thesis director) / Kirtz, Jaime (Committee member) / Barrett, The Honors College (Contributor) / Walter Cronkite School of Journalism and Mass Comm (Contributor) / Arts, Media and Engineering Sch T (Contributor)
Created2024-05
Description
This creative project is about the investigation conducted by Detectives Madison Fox and Mia Katz into the series of murders orchestrated by Professor Grimm at ChemScholars Institute. Professor Grimm uses his botany expertise to locate toxic plants all over the college campus, which he uses to kill the students who mock him, creating a reign of terror. The detectives use toxicology, forensic science, crime scene reports, and autopsy reports to solve the puzzle. An essential part of the investigation is toxicological analysis, which is used to detect toxic substances in the bodies of the victims and link their deaths to Professor Grimm's botanical knowledge. Forensic examination of the crime scenes provides evidence of the traces of poisonous plants found at the murder scene as well as the traces of toxins, and this helps in the reconstruction of how the crime occurred. Fox and Katz combine the various disciplines of forensic science to solve the case, bringing the professor to justice in the end. The interdisciplinary cooperation they demonstrated shows the importance of working together to pursue truth and justice, providing closure for the families of the victims.
ContributorsLevy, Madeleine (Author) / Moore, Amelia (Co-author) / Sweat, Ken (Thesis director) / Sartorio, Adriana (Committee member) / Barrett, The Honors College (Contributor) / School of Interdisciplinary Forensics (Contributor)
Created2024-05
Description
Japanese puzzle boxes are exquisite wooden creations that combine artistry, craftsmanship, and the thrill of solving intricate puzzles. Originating in Hakone, Japan, over 100 years ago, these boxes are called "himitsu-bako," which translates to "Personal Secret Box" due to their meticulously designed hidden compartments and complex locking mechanisms. Unlocking these boxes involves a precise sequence of movements, twists, and rotations, turning the process into an interactive and engaging challenge. The goal of this project is to create a puzzle box from scratch while incorporating some of the mechanics from the traditional Japanese puzzle boxes.
ContributorsChallaram, Greeshma (Author) / Beiner, Susan (Thesis director) / Ang-Wanek, Nicole (Committee member) / Barrett, The Honors College (Contributor) / School of Art (Contributor) / Computer Science and Engineering Program (Contributor)
Created2024-05
Description
This case study explores the intricate relationship between Glioblastoma Multiforme (GBM) and Type II Diabetes Mellitus (T2DM) in a long-term survivor. A 51-year-old male with a medical history of type II diabetes presented with black out episodes. Neuroimaging revealed a large right frontal lesion suggestive of GBM. Following gross total resection, the tumor was identified as IDH-wildtype, MGMT methylated glioblastoma. The patient underwent Stupp protocol chemotherapy with Temozolomide and radiation, followed by adjuvant therapy. Management also included adjustments to diabetic medications. The patient experienced mild abulia and decreased executive function post-chemotherapy but responded well to subsequent treatments, including Avastin. Medication adjustments for diabetes were made based on A1C and glucose levels. Imaging studies revealed changes indicative of treatment response and disease progression. Correlation analyses revealed negative associations between resection cavity and affected brain tissue volume and glucose/A1C levels. The study underscores the importance of exploring the impact of antidiabetic medications on GBM outcomes and highlights the need for further research in this area. Lessons learned include the potential role of metabolic biomarkers in predicting treatment response and disease progression, guiding personalized therapeutic interventions for patients with comorbid GBM and T2DM.
ContributorsHuman, Hannah (Author) / Maley, Carlo (Thesis director) / Swanson, Kristin (Committee member) / Lee Kim, Peter (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of International Letters and Cultures (Contributor)
Created2024-05
Description
Cancer is a disease that occurs when the cells in the body grow and replicate uncontrollably while spreading throughout the body. Apart from the pre-existing treatments, bacteria based treatments maybe used as an alternative. The main system used to deliver antigens to host tissues was Salmonella. In order to use Salmonella as an anti-cancer platform, there are three major steps which must be followed: cell lysis, tumor navigation, and Salmonella tumor persistence.
ContributorsBharath, Shreya (Author) / Kong, Wei (Thesis director) / Fu, Lingchen (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05