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Description
The Way Home is a full-length young adult novel. The story is split between the perspectives of Theo and Ella, best friends from high school who are starting their freshman year in college. Neither is extremely excited about the start of the new phase of their lives; Theo struggles with severe anxiety and is just hoping to survive the four years; and dark memories in Ella's past don't seem to want to let her start over. A series of murders happening in town don't help their nerves at all, making it hard to focus on the "college experience." They were supposed to be there for each other... But then Ella goes missing, and Theo is left without a clue of where she went. While he searches for her desperately, she wakes up miles away from home, surrounded by strangers. In their efforts to find one another again, they instead find themselves presented with opportunities to study the impossible: magic. Things become stranger and stranger as murders, magic, police investigations, and ever-looming final exams begin to challenge Theo and Ella in ways they never expected. In writing this novel, I hoped to depict the transition from high school to college and the worries and wonders that come with it. The story is almost split directly in half, beginning with normal school life and shifting into the world of magic. The conflicts presented to the characters during the first half, such as grades, majors, and socializing, persist throughout the second half, but are also metaphorized once the characters begin studying magic. I chose to include a protagonist with an anxiety disorder because I believe mental disabilities are not represented enough in YA literature, though it is something that many high school and college students deal with. I wanted to create a character that could inform others and that students with similar mental disorders could relate to. Additional themes I deal with include newfound independence, individuality, growth, and friendship.
ContributorsWoner, Catherine Flynn (Author) / Blasingame, James (Thesis director) / Irish, Jennifer (Committee member) / Department of English (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
The purpose of this project is to explore the benefit of using prodrugs in chemotherapy, as well as to explain the concept of angiogenesis and the importance of this process to tumor development. Angiogenesis is the formation of new blood capillaries that are necessary for the survival of a tumor, as a tumor cannot grow larger than 1-2 mm3 without developing its own blood supply. Vascular disrupting agents, such as iodocombstatin, a derivative of combretastatin, can be used to effectively cut off the blood supply to a growing neoplasm, effectively inhibiting the supply of oxygen and nutrients needed for cell division Thus, VDAs have a very important implication in terms of the future of chemotherapy. A prodrug, defined as an agent that is inactive in the body until metabolized to yield the drug itself, was synthesized by combining iodocombstatin with a β-glucuronide linker. The prodrug is theoretically hydrolyzed in the body to afford the active drug by β-glucuronidase, an enzyme that is produced five times as much by cancer cells as by normal cells. This effectively creates a “magic-bullet” form of chemotherapy, known as Direct Enzyme Prodrug Therapy (DEPT).
ContributorsClark, Caroline Marie (Author) / Pettit, George Robert (Thesis director) / Melody, Noeleen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2015-05
Description
Despite the 40-year war on cancer, very limited progress has been made in developing a cure for the disease. This failure has prompted the reevaluation of the causes and development of cancer. One resulting model, coined the atavistic model of cancer, posits that cancer is a default phenotype of the cells of multicellular organisms which arises when the cell is subjected to an unusual amount of stress. Since this default phenotype is similar across cell types and even organisms, it seems it must be an evolutionarily ancestral phenotype. We take a phylostratigraphical approach, but systematically add species divergence time data to estimate gene ages numerically and use these ages to investigate the ages of genes involved in cancer. We find that ancient disease-recessive cancer genes are significantly enriched for DNA repair and SOS activity, which seems to imply that a core component of cancer development is not the regulation of growth, but the regulation of mutation. Verification of this finding could drastically improve cancer treatment and prevention.
ContributorsOrr, Adam James (Author) / Davies, Paul (Thesis director) / Bussey, Kimberly (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Life Sciences (Contributor)
Created2015-05
DescriptionA short, fantasy novel using essential characters, themes, and events as depicted in the Bible.
ContributorsMcDonald, Joshua Dave Mallrich (Author) / Facinelli, Diane (Thesis director) / Bruhn, Karen (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / School of Mathematical and Statistical Sciences (Contributor)
Created2014-05
Description
A coincidence reporter construct, consisting of the p21-promoter and two luciferase genes (Firefly and Renilla), was constructed for the screening of drugs that might inhibit Olig2's tumorigenic role in glioblastoma. The reporter construct was tested using an Olig2 inhibitor, HSP990, as well as short hairpin RNA targeting Olig2. Further confirmatory analysis is needed before the reporter cell line is ready for high-throughput screening at the NIH and lead compound selection.
ContributorsCusimano, Joseph Michael (Author) / LaBaer, Joshua (Thesis director) / Mangone, Marco (Committee member) / Mehta, Shwetal (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor)
Created2014-05
Description
Erosion: A Collection of Poems consists of ten prose poems that explore the processing of trauma through a single lens. We follow the work’s main character as she navigates recovery following a medical trauma in Peru from which she ought to have died. The pieces challenge the readers to immerse themselves within her narrative to understand the isolation that trauma ushers in, as she struggles to know her own newfound aloneness.
While the poems illustrate the complexity of one’s experience with both PTSD and its stages of recovery (e.g., emergency, numbness, intrusive/repetitive, integration), they are anchored in the sensory, the concrete. Amidst the terror of the symptoms at the most basic, raw level, she attempts to reclaim selfhood, which involves wrestling with philosophical suicide, reconciling realities, numbness and the widening of a barrier, stunning intimacies, the craving to feel, and both the desire and the need to connect authentically without being able to satiate such inclinations.
Influenced by the works of Frank Bidart, Claudia Rankine, James Longenbach, and Carolyn Forché, the pieces rely heavily upon rhythm and spacing, imagery, and associative linkages throughout the work to craft a sense of physical, intellectual, and emotional movement within the space.
The collection focuses upon the narrative of one survivor of trauma, and though traumas may be experienced differently, and while PTSD may manifest itself in profoundly diverse ways, the pieces aim to capture the shared foundation of the experience — the isolation and the pure, unadulterated pain — in order to cast a universal veil onto the exploration, providing the audience with insight into one of trauma’s most important facets.
While the poems illustrate the complexity of one’s experience with both PTSD and its stages of recovery (e.g., emergency, numbness, intrusive/repetitive, integration), they are anchored in the sensory, the concrete. Amidst the terror of the symptoms at the most basic, raw level, she attempts to reclaim selfhood, which involves wrestling with philosophical suicide, reconciling realities, numbness and the widening of a barrier, stunning intimacies, the craving to feel, and both the desire and the need to connect authentically without being able to satiate such inclinations.
Influenced by the works of Frank Bidart, Claudia Rankine, James Longenbach, and Carolyn Forché, the pieces rely heavily upon rhythm and spacing, imagery, and associative linkages throughout the work to craft a sense of physical, intellectual, and emotional movement within the space.
The collection focuses upon the narrative of one survivor of trauma, and though traumas may be experienced differently, and while PTSD may manifest itself in profoundly diverse ways, the pieces aim to capture the shared foundation of the experience — the isolation and the pure, unadulterated pain — in order to cast a universal veil onto the exploration, providing the audience with insight into one of trauma’s most important facets.
ContributorsBacon, Lauren Whitney (Author) / Ball, Sally (Thesis director) / Irish, Jennifer (Committee member) / Department of English (Contributor, Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
DescriptionAcademic interests combined into a speculative science fiction novel. Concepts from American Sign Language, mechanical engineering, and journalism studies were all utilized during development of the novel.
ContributorsGraziano, River (Author) / Irish, Jennifer (Thesis director) / Bell, Matt (Committee member) / Barrett, The Honors College (Contributor) / Mechanical and Aerospace Engineering Program (Contributor) / Department of English (Contributor)
Created2024-05
Description
This work of creative nonfiction explores the life of the writer's great-grandmother, Madge Richardson, and her sister Annie Richardson Johnson, as daughters of polygamist families and members of the Church of Jesus Christ of Latter-Day Saints in the religious colony of Colonia Díaz, Chihuahua, Mexico. The piece depicts several highs and lows in the late 19th to early 20th century pioneer town, with an emphasis on the mass exodus and devastation that occurred during the Mexican Revolution.
ContributorsGadberry, Emily (Author) / Ison, Tara (Thesis director) / Irish, Jennifer (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / Department of English (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05