As much as SARS-CoV-2 has altered the way humans live since the beginning of 2020,<br/>this virus's deadly nature has required clinical testing to meet 2020's demands of higher<br/>throughput, higher accuracy and higher efficiency. Information technology has allowed<br/>institutions, like Arizona State University (ASU), to make strategic and operational changes to<br/>combat the SARS-CoV-2 pandemic. At ASU, information technology was one of the six facets<br/>identified in the ongoing review of the ASU Biodesign Clinical Testing Laboratory (ABCTL)<br/>among business, communications, management/training, law, and clinical analysis. The first<br/>chapter of this manuscript covers the background of clinical laboratory automation and details<br/>the automated laboratory workflow to perform ABCTL’s COVID-19 diagnostic testing. The<br/>second chapter discusses the usability and efficiency of key information technology systems of<br/>the ABCTL. The third chapter explains the role of quality control and data management within<br/>ABCTL’s use of information technology. The fourth chapter highlights the importance of data<br/>modeling and 10 best practices when responding to future public health emergencies.

In the past year, considerable misinformation about the COVID-19 pandemic has circulated on social media platforms. Faced with this pervasive issue, it is important to identify the extent to which people are able to spot misinformation on social media and ways to improve people’s accuracy in spotting misinformation. Therefore, the current study aims to investigate people’s accuracy in spotting misinformation, the effectiveness of a game-based intervention, and the role of political affiliation in spotting misinformation. In this study, 235 participants played a misinformation game in which they evaluated COVID-19-related tweets and indicated whether or not they thought each of the tweets contained misinformation. Misinformation accuracy was measured using game scores, which were based on the correct identification of misinformation. Findings revealed that participants’ beliefs about how accurate they are at spotting misinformation about COVID-19 did not predict their actual accuracy. Participants’ accuracy improved after playing the game, but democrats were more likely to improve than republicans.

Early stages of the COVID-19 pandemic introduced a change in communication norms in regard to well-being. People traversed through different forms of communication to adapt to policies and regulations that limited in-person interactions to prevent the spread of the COVID-19 virus. Social interactions have been found to be an innate human need, important to one’s health and well-being. The study looked at the relationship between socializing and well-being during the state of the COVID-19 pandemic. Socializing variables consisted of remote and in-person socializing which in-person socializing was divided into two distinct categories. In-person socializing was divided into in-person safe socializing, indicating socializing that was safe from the risk of contracting the virus, and in-person unsafe socializing which indicates that socializing was at risk of contracting the virus. Additionally, the current study also investigated how age moderates this relationship between socializing and well-being. SEM analyses reported that in-person unsafe socializing has a significant positive association with well-being outcomes: anxiety and depression which indicate high levels of anxiety and depression with increased in-person unsafe socializing. The study also found remote socializing to have a significant positive association with the well-being outcome: positive affect, indicating increased levels of positive affect with increased remote socializing. Regression analyses looked at moderation by age, finding no significant interactions of age between socializing and well-being. Findings suggest the beneficial role of remote socializing and although remote socializing cannot replace in-person interactions, it serves as a supplemental resource during unpredictable events such as the COVID-19 pandemic.

Molecular pathology makes use of estimates of tumor content (tumor percentage) for pre-analytic and analytic purposes, such as molecular oncology testing, massive parallel sequencing, or next-generation sequencing (NGS), assessment of sample acceptability, accurate quantitation of variants, assessment of copy number changes (among other applications), determination of specimen viability for testing (since many assays require a minimum tumor content to report variants at the limit of detection) may all be improved with more accurate and reproducible estimates of tumor content. Currently, tumor percentages of samples submitted for molecular testing are estimated by visual examination of Hematoxylin and Eosin (H&E) stained tissue slides under the microscope by pathologists. These estimations can be automated, expedited, and rendered more accurate by applying machine learning methods on digital whole slide images (WSI).