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panCanSYGNAL is a web-application designed to allow cancer researchers to search the relationships between somatic mutations, regulators, and biclusters corresponding to many cancers using a Google-like searchable database.

ContributorsWatson, Jacob (Author) / Plaisier, Christopher (Thesis director) / Clough, Michael (Committee member) / Barrett, The Honors College (Contributor) / Computer Science and Engineering Program (Contributor)
Created2022-05
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Countries such as Haiti—where corruption, violence, and extreme poverty hinder economic growth and recovery— require multifaceted, interdisciplinary solutions. The United States, along with much of the western world, has a flawed understanding of foreign aid. Though current humanitarian efforts have effectively improved the lives of millions of Haitians, they fail

Countries such as Haiti—where corruption, violence, and extreme poverty hinder economic growth and recovery— require multifaceted, interdisciplinary solutions. The United States, along with much of the western world, has a flawed understanding of foreign aid. Though current humanitarian efforts have effectively improved the lives of millions of Haitians, they fail to address the systemic roots of Haiti’s issues. Likewise, some efforts have been counterproductive or even harmful. If the US wishes to assist Haiti (and similar developing countries for that matter) in its journey to restoring the rule of law, reducing corruption, and empowering its citizens, it must collaborate with Haitian leaders and prioritize socioeconomic policy programs.

ContributorsSteiner, Bennett (Author) / O'Donnell, Edward (Thesis director) / Datta, Manjira (Thesis director) / Barrett, The Honors College (Contributor) / Department of Information Systems (Contributor) / Economics Program in CLAS (Contributor)
Created2022-05
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A growing body of research suggests that there is more to course assessment than homework scores and test performance. This paper contributes to the empirical literature in economics and education by evaluating the impact of racial and gender congruency on the performance of ASU students. Expanding on previous research which

A growing body of research suggests that there is more to course assessment than homework scores and test performance. This paper contributes to the empirical literature in economics and education by evaluating the impact of racial and gender congruency on the performance of ASU students. Expanding on previous research which only covered elementary and high school, we are able to draw conclusions and policy recommendations to solve the racial achievement gap in the USA.
ContributorsAlmeida, Alexander (Author) / Aucejo, Esteban (Thesis director) / Larroucau, Tomas (Committee member) / Barrett, The Honors College (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Economics Program in CLAS (Contributor)
Created2022-05
Description
The Patient Guidance Project was created by a team of research assistants in the Arizona Cancer Evolution Center as a source of supplemental education and support for recently diagnosed cancer patients. Extensive background research in the form of literature reviews highlighted disparities between the information patients want and are receiving,

The Patient Guidance Project was created by a team of research assistants in the Arizona Cancer Evolution Center as a source of supplemental education and support for recently diagnosed cancer patients. Extensive background research in the form of literature reviews highlighted disparities between the information patients want and are receiving, as well as between average literacy levels of patients and the literacy levels at which cancer information is commonly provided. The Patient Guidance Project has published comprehensive guides for specific types of cancer, which so far include metastatic melanoma, glioblastoma, prostate cancer, oral cancer, kidney cancer, breast cancer, and colorectal cancer. The content of the guides is intended to bridge the gaps in information for patients with an emphasis on treatment options, treatment side effects, and psychological support resources, which surveys have identified as the topics patients want information on most. Written at a sixth-grade literacy level, which over half of adults in the U.S. read at, the guides are meant to be of benefit to as many people as possible. In the future, the team hopes to expand the Patient Guidance Project to include more cancer types, guides in different languages, and multimodal features to increase their effectiveness.
ContributorsWilliams, Erica (Author) / Maley, Carlo (Thesis director) / Baciu, Cristina (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-12
Description
Cancer is an ever-relevant disease with many genetic, social, environmental, and behavioral risk factors. One factor which has been garnering interest is the impact of nutrition on cancer. As a disease process, cancer is primarily driven by an accumulation of genetic aberrations. Recent epidemiological, pre-clinical, and clinical studies have demonstrated

Cancer is an ever-relevant disease with many genetic, social, environmental, and behavioral risk factors. One factor which has been garnering interest is the impact of nutrition on cancer. As a disease process, cancer is primarily driven by an accumulation of genetic aberrations. Recent epidemiological, pre-clinical, and clinical studies have demonstrated various impacts of bioactive food molecules on the promotion or prevention of these oncogenic mutations. This work explores several of these molecules and their relation to cancer prevention and provides a sample meal plan, which highlights many additional molecules that are currently being studied.
ContributorsCurtin, Elise (Author) / Don, Rachael (Thesis director) / Compton, Carolyn (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2022-05
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Description

Obesity increases the risk for colorectal cancer. In mice, a pro-obesity high-fat-diet (HFD) leads to an intestinal phenotype characterized by enhanced proliferation, numbers, function and tumor-initiating capacity of stem cells, the cell-of-origin for many intestinal cancers. This phenotype is driven by a lipid metabolism program facilitated by an intrinsic Peroxisome

Obesity increases the risk for colorectal cancer. In mice, a pro-obesity high-fat-diet (HFD) leads to an intestinal phenotype characterized by enhanced proliferation, numbers, function and tumor-initiating capacity of stem cells, the cell-of-origin for many intestinal cancers. This phenotype is driven by a lipid metabolism program facilitated by an intrinsic Peroxisome Proliferator-Activated Receptor/Fatty Acid Oxidation (PPAR/FAO) axis that senses and utilizes cellular lipids. However, the microbiome is a known regulator of lipid metabolism in the gut, but little is understood about how the gut commensals affect access to the lipids and alter stem cell function. Here, we use the long term HFD-fed mouse model to analyze the phenotypic changes in the intestinal stem cells (ISCs) after depletion of the gut microbiota. We find that the loss of the gut microbiome after four weeks of antibiotic treatment imposes significant changes in ISC function leading to reduced HFD ISC regenerative potential. These results indicate that the gut microbiome plays a crucial role in the lipid metabolic process which regulates and maintains the HFD ISC phenotype, and further suggests that the gut microbiome may augment the diet-induced tumor initiating capacity by altering the stem cell function.

ContributorsSantos Molina, Pablo (Author) / Mana, Miyeko (Thesis director) / Whisner, Corrie (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
Description

This paper examines the physics behind cancer treatment and more specifically radiation therapy. A phenomenon known as Compton scattering has played a substantial role in the treatment of breast cancer and improvement of lives of women around the world. Through Compton scattering, radiation therapy has been tremendously improved and has

This paper examines the physics behind cancer treatment and more specifically radiation therapy. A phenomenon known as Compton scattering has played a substantial role in the treatment of breast cancer and improvement of lives of women around the world. Through Compton scattering, radiation therapy has been tremendously improved and has allowed for the most accurate and effective treatment in breast cancer patients today.

ContributorsRombaoa, Matthew Bryce (Author) / Foy, Joseph (Thesis director) / Hines, Taylor (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / Department of Psychology (Contributor)
Created2023-05
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Description

Over the past twenty years, the United States has experienced what Dr. Thomas Philippon calls "The Great Reversal," or a slow drift away from the free market competition which defined the American economy for the last century, towards an increasingly oligopolistic consolidation of market power. What does this mean? For

Over the past twenty years, the United States has experienced what Dr. Thomas Philippon calls "The Great Reversal," or a slow drift away from the free market competition which defined the American economy for the last century, towards an increasingly oligopolistic consolidation of market power. What does this mean? For the average American, prices have increased, wages remain stagnant, quality has declined, and the variety of goods has diminished. The reason? The growing political power of incumbent firms, who use their established economic power to influence the political process in their favor, towards high barriers to entry and decreased antitrust scrutiny, through lobbying and the financing of campaigns. Or have they? "The Great Reversal," and hypotheses like it, are far from a consensus... This Thesis is a meta study of the literature surrounding domestic competition in the United States and the impact that the lobbying activity of industry leaders has on said competition. Analyzing over 20 papers covering economics, political science, and political economy, this Thesis argues that domestic competition in the United States has indeed declined over the past two decades and that the growing political power of firms, rather than "unique" technological or structural changes in the economy, has caused this drift away from free markets. Using this analysis, this Thesis further suggests a few solutions to "The Great Reversal" and restoring competition in the American economy.

ContributorsJohnson, Logan (Author) / Hill, Alexander (Thesis director) / Schatzman, Christina (Committee member) / Barrett, The Honors College (Contributor) / School of Politics and Global Studies (Contributor)
Created2021-12
Description
This paper examines the decreasing affordability of single-family residential homes across the United States, with a special emphasis on Maricopa and Pinal County, Arizona. A historical analysis was conducted on the single-family residential property sector utilizing Federal Reserve and local government data. An affordability model is developed to demonstrate income

This paper examines the decreasing affordability of single-family residential homes across the United States, with a special emphasis on Maricopa and Pinal County, Arizona. A historical analysis was conducted on the single-family residential property sector utilizing Federal Reserve and local government data. An affordability model is developed to demonstrate income thresholds needed to afford a median priced home in Maricopa and Pinal County, while a factor model is developed to predict the economic shifts needed to rectify this issue. My findings suggest that single-family homes have reached peak prices and are not affordable for the average American, based on median income. This housing crisis is the result of many economic factors, including but not limited to: below-average homebuilding, the lock-in effect, excessively cheap monetary policy, mortgages rates, and housing inflation. This is an unprecedented time in our nation’s history, placing tremendous pressure on the Federal Open Market Committee (FOMC) and Congress to tackle this issue. A closing recommendation will discuss the outlook for the single family residential sector.
ContributorsNunez, Christian (Author) / Koblenz, Blair (Thesis director) / Stapp, Mark (Committee member) / Barrett, The Honors College (Contributor) / Department of Finance (Contributor)
Created2024-05
Description
Modified Salmonella strains and recombinant DNA in a plasmid are used to construct a Salmonella strain that is dependent on the experimentally inserted plasmid. This construction will be done via lab techniques such as polymerase chain reactions (PCR), transformation, and other means to create this construction. With future successful construction, the inhibition

Modified Salmonella strains and recombinant DNA in a plasmid are used to construct a Salmonella strain that is dependent on the experimentally inserted plasmid. This construction will be done via lab techniques such as polymerase chain reactions (PCR), transformation, and other means to create this construction. With future successful construction, the inhibition of flagella assembly, within the tumor environment, and increased synthesis of flagellin will be possible. In the case that only assembly is prevented, then, the reliance on the lysis system to release flagellin into the tumor microenvironment will be used as a means to induce immune response. With the success of the self-lysis ability, these strains could be used to target these tumor cells to deliver anticancer material as a vaccine delivery system.
ContributorsShagi, Agnel (Author) / Kong, Wei (Thesis director) / Fu, Lingchen (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2024-05