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- Creators: Barrett, The Honors College
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Description
In a dormant state, cancer cells survive chemotherapy leaving the opportunity for cancer cell relapse and metastasis ultimately leading to patient death. A novel aminoglycoside-based hydrogel ‘Amikagel’ developed in Dr. Rege’s lab serves as a platform for a 3D tumor microenvironment (3DTM) mimicking cancer cell dormancy and relapse. Six Amikagels of varying mechanical stiffness and adhesivities were synthesized and evaluated as platforms for 3DTM formation through cell viability and cell cycle arrest analyses. The impact of fetal bovine serum concentration and bovine serum albumin concentration in the media were studied for their impact on 3DTM formation. These experiments allow us to identify the best possible Amikagel formulation for 3DTM.
ContributorsGjertsen, Haley Nicole (Author) / Rege, Kaushal (Thesis director) / Grandhi, Taraka Sai Pavan (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of this thesis is to convince readers of the benefits of cross-functional collaboration and innovation within the W. P. Carey School of Business. Specifically, cross-functional collaboration is the "innovation" that is being discussed and will be presented. Written from the perspective of a current business student, this thesis incorporates secondary research as well as personal experience to explain why this would benefit the business school at Arizona State University. The research conducted stems from online resources such as the Harvard Business Review, Kai Nexus, Forbes and other websites and explains why the author decided to pursue this topic. Cross-functional collaboration is seen in the everyday workings of the business world and are a utilized by a multitude of successful companies \u2014 Dell, Intel, Amazon, Apple and other similar companies. Therefore, it should be taken advantage of within undergraduate education in order to better prepare students for what they may experience afterwards. In addition, a majority of the paper is dedicated to recommendations for how exactly cross-functional collaboration could be incorporated, as well as examples of successful cross-functional courses and teams. These recommendations will be beneficial to business and general faculty members and can contribute to positive organizational change at the university.
ContributorsThompson, Trevor N (Author) / Trujillo, Rhett (Thesis director) / Peck, Sidnee (Committee member) / Department of Supply Chain Management (Contributor) / Department of Marketing (Contributor) / Department of Information Systems (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
This thesis will analyze the operations of two nonprofit organizations located in different parts of the world. One local and one international nonprofit organization was chosen for this thesis/creative project because of the diverse culture, customs and regulations in each setting. The paper will discuss the operations of St. Vincent de Paul, the Chandler Conference of St. Vincent de Paul, and Sri Sai Darshan Trust (SSDT). The paper begins with a brief history of nonprofit organizations followed by a detailed background on both organizations. The management (organizational structure), finances, marketing, and legalities will be discussed of each nonprofit. The paper will then examine the specialized projects of each organization throughout the year. A PEST, SWOT, value chain, Kraljic, spend, and demand analysis were conducted based off of the research on each nonprofit. The paper will then discuss the problems each organization exhibits and the potential solutions the nonprofits can implement into their daily operations in order to resolve them. This section analyzes the similarities and differences within each business area of the nonprofit organization. Short-term solutions to current business problems and long-term solutions to organizational problems will be discussed in this section. The conclusion is the final element of the thesis. In this section, a balanced scorecard will be created for each nonprofit organization. In addition, the authors will discuss what they learned throughout the entire process. The goal of this thesis/creative project was to integrate the knowledge and concepts from business (marketing, finance, management, accounting, supply chain management, and computer information systems), and find an application for each within nonprofit organizations around the world.
ContributorsPatel, Nisha (Co-author) / Sivakumar, Akila (Co-author) / Maltz, Arnold (Thesis director) / LePine, Marcie (Committee member) / W. P. Carey School of Business (Contributor) / Department of Supply Chain Management (Contributor) / School of Accountancy (Contributor) / Division of Teacher Preparation (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The story of Moneyball is an informative tale. It is the true story of the Oakland Athletics baseball team in the 2002 season who managed to not only compete with teams who had nearly three times the payroll size and all the star players, but also won an American League record 20 games in a row. Their manager, Billy Beane, was able to achieve this by using sabermetrics, a newly invented term that describes the advanced statistics and metrics used to judge a player's contribution to the success of the team over traditional statistics and gut feeling, to draft and trade for undervalued players to create a competitive team under his small-market budget. This story is well known as a best-selling novel by Michael Lewis and later a film by the same name. Clearly it was successful in the field of baseball, but can it be used in other business industries? The idea of sabermetrics, or finding more information to predict the future of a player is very similar to the ideas of Information Measurement Theory (IMT) as theorized by Dr. Dean Kashiwagi, a professor at Arizona State University. The goal of this paper is to use Moneyball as a narrative to show how applying the concepts of IMT to businesses could allow them to better predict their performance and the future of their industry. Moreover, these same ideas can predict if the leadership of the company will be successful by analyzing their personal characteristics. This paper will act as a guide for businesses to start following the concepts of IMT and to better analyze themselves and their industry to increase performance and reduce stressful decision-making.
ContributorsKent, Austin (Author) / Kashiwagi, Dean (Thesis director) / Kashiwagi, Jacob (Committee member) / Barrett, The Honors College (Contributor)
Created2016-05
Description
"EP \u2014 Kyan Palmer" is a compilation of three songs, "Hit List," "Queen Cobra," and "Burn Mona Lisa" all written and recorded by Barrett student, Kyan Palmer. The project explores the process involved in creating recorded music and exposes the vulnerability and self-reflection in writing a song. The following depicts the thought process that came about in the creation of each song from the lyrics, to the vocals, to the production. This paper depicts a journal-like writing style outlining the various events that took place while creating EP \u2014 Kyan Palmer. The bulk of this Thesis/Creative Project was the written, produced, and recorded music attached in the appendix. With that said, the following document is intended to be reflective rather than scholarly and acts as an accompaniment to the audio recordings and video entries.
ContributorsPalmer, Kyan (Author) / Swoboda, Deanna (Thesis director) / Tobias, Evan (Committee member) / W. P. Carey School of Business (Contributor) / School of Music (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Background: High risk types of human papillomavirus (HPV) are known to cause cancer, including cervical (99%) and oropharyngeal cancer (70%). HPV type 16 is the most common subtype. Three antigens that are critical for integration or tumor progression are E2, E6 and E7. In this study, we developed a systematic approach to identify naturally-processed HPV16-derived HLA class I epitopes for immunotherapy development. Methods: K562 cells, which lack HLA expression, were transduced with each HPV16 antigen using lentivirus and supertransfected with HLA-A2 by nucleofection. Stable cell lines expressing each antigen were selected for and maintained throughout the investigation. In order to establish a Gateway-compatible vector for robust transient gene expression, a Gateway recombination expression cloning cassette was inserted into the commercial Lonza pMAX GFP backbone, which has been experimentally shown to display high transfection expression efficiency. GFP was cloned into the vector and plain K562 cells were transfected with the plasmid by nucleofection. Results: Expression of K562-A2 was tested at various time points by flow cytometry and A2 expression was confirmed. Protein expression was shown for the transduced K562 E7 by Western blot analysis. High transfection efficiency of the pMAX_GFP_Dest vector (up to 97% GFP+ cells) was obtained 48 hours post transfection, comparable to the commercial GFP-plasmid. Conclusion: We have established a rapid system for target viral antigen co-expression with single HLA molecules for analysis of antigen presentation. Using HPV as a model system, our goal is to identify specific antigenic peptide sequences to develop immunotherapeutic treatments for HPV-associated cancers.
ContributorsVarda, Bianca Marie (Author) / Anderson, Karen (Thesis director) / Borges, Chad (Committee member) / Krishna, Sri (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Current studies in Multiple Myeloma suggest that patient tumors and cell lines cluster separately based on gene expression profiles. Hyperdiploid patients are also extremely underrepresented in established human myeloma cell lines (HMCLs). This suggests that the average HMCL model system does not accurately represent the average myeloma patient. To investigate this question we performed a combined CNA and SNV evolutionary comparison between four myeloma tumors and their established HMCLs (JMW-1, VP-6, KAS-6/1-KAS-6/2 and KP-6). We identified copy number changes shared between the tumors and their cell lines (mean of 74 events - 59%), those unique to patients (mean of 21.25 events - 17%), and those only in the cell lines (mean of 30.75 events \u2014 24%). A relapse sample from the JMW-1 patient showed 58% similarity to the primary diagnostic tumor. These data suggest that, on the level of copy number abnormalities, HMCLs show equal levels of evolutionary divergence as that observed within patients. By exome sequencing, patient tumors were 71% similar to their representative HMCLs, with ~12.5% and ~16.5% of SNVs unique to the tumors and HMCLs respectively. The HMCLs studied appear highly representative of the patient from which they were derived, with most differences associated with an enrichment of sub-populations present in the primary tumor. Additionally, our analysis of the KP-6 aCGH data showed that the patient's hyperdiploid karyotype was maintained in its respective HMCL. This discovery confirms the establishment and validation of a novel and potentially clinically relevant hyperdiploid HMCL that could provide a major advance in our ability to understand the pathogenesis and progression of this prominent patient population.
ContributorsBenard, Brooks Avery (Author) / Keats, Jonathan (Thesis director) / Anderson, Karen (Committee member) / Jelinek, Diane (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The key to success is hard work and determination. Achieving success is always under construction. This project began as a simple analysis of the firm's progress, as at the time it was in desperate need of new clients and a marketing strategy to strengthen its visibility on campus.Through this evaluation, our team found that the firm was in an abysmal state and the previously noted problems were not the only issues of concern. From our research we found that in order for the firm to grow and become a successful student run consulting firm, there are several interorganizational issues that need to be understood and addressed. The intention of New Venture Group and the Consulting Scholars academic program is to provide students the opportunity to garner practical learning experiences. These potential opportunities are not taken full advantage of because of the afflicting problems that exist. The purpose of this thesis is to understand what problems exist within the firm and the next steps that should be taken to resolve them.
ContributorsBaskin, Connor (Co-author) / Farr, Austin (Co-author) / Chou, Alexandra (Co-author) / Laub, Jeffrey (Thesis director) / Taylor, Todd (Committee member) / Department of Supply Chain Management (Contributor) / Department of Economics (Contributor) / Department of Marketing (Contributor) / Department of Finance (Contributor) / School of International Letters and Cultures (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Department of Information Systems (Contributor) / W. P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of this thesis is to examine how companies can most effectively attract and retain millennial workers. Millennials are the future of the corporate world, and their retention in the workforce is important. Research for this study was gathered through the use of two surveys administered to Arizona State University students and corporate recruiters. The student survey focuses on what students' value in future employers, while also concentrating on challenges and opportunities job seekers presently face. The corporate survey asks questions related to the efforts used to attract and retain future employees, and the challenges and opportunities of the millennial worker. The findings reveal the millennial generation and the employers of today find alignment and disagreement within the topics of job dedication, culture, generational perceptions, and perceptions of the millennial. This study has a number of practical implications for employers seeking to understand how to integrate millennial workers into their corporate environment. Students will also find practical implications from this study, as they can better understand how to successfully get hired and be a part of a corporate environment. Recommendations for change on the students and employers respective behalf are based on survey findings and secondary source research.
ContributorsSt. Marie-Lloyd, Honi (Author) / LePine, Marcie (Thesis director) / Hill, Sarah (Committee member) / Department of Supply Chain Management (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12
Description
The thesis titled "Exploring Undergraduate Admissions through the Development of Shadowing Programs" is an organizational study and analysis of a shadowing program developed by Krista Moller, Ryan Johnson, and Kean Thomas. It resulted in the creation of a 25+ person student organization in the W.P. Carey School of Business called "Explore". The organization received backing and support from the admissions department in W.P. Carey, notably Dean of Admissions, Timothy Desch. The organization's members (titled "ambassadors") host a high school student interested in the business school for a day of class. High school students are matched with an ambassador based on majors they might be interested in, and ideally the result of the day of shadowing is the high school student having a better understanding of the opportunities available at W.P. Carey. The organization began in the fall of 2013, and was intended to be used as a thesis project from its inception. As a result, the founder's experiences were carefully documented and this allowed for a detailed analysis to take place. The analysis delves into the difficulties faced by the organization's members and executive board as a result of internal and external influences. The successes and experiences they were fortunate enough to have are also detailed, and plans for the organization's future are included as well. In addition, the Explore program is analyzed in comparison to other programs around the country and even in Canada, with the goal being to see where we could potentially strengthen our program. The founders of the Explore program (and authors of this thesis) hope other students might learn from it so that more programs such as Explore can be created, benefiting the local community and ASU itself.
ContributorsMoller, Krista (Co-author) / Johnson, Ryan (Co-author) / Thomas, Kean (Co-author) / Suk, Mina (Thesis director) / Desch, Timothy (Committee member) / School of Accountancy (Contributor) / W. P. Carey School of Business (Contributor) / WPC Graduate Programs (Contributor) / Department of Supply Chain Management (Contributor) / Department of Finance (Contributor) / Barrett, The Honors College (Contributor)
Created2015-12