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As life expectancy increases worldwide, age related diseases are becoming greater health concerns. One of the most prevalent age-related diseases in the United States is dementia, with Alzheimer’s disease (AD) being the most common form, accounting for 60-80% of cases. Genetics plays a large role in a person’s risk of developing AD. Familial AD, which makes up less than 1% of all AD cases, is caused by autosomal dominant gene mutations and has almost 100% penetrance. Genetic risk factors are believed to make up about 49%-79% of the risk in sporadic cases. Many different genetic risk factors for both familial and sporadic AD have been identified, but there is still much work to be done in the field of AD, especially in non-Caucasian populations. This review summarizes the three major genes responsible for familial AD, namely APP, PSEN1 and PSEN2. Also discussed are seven identified genetic risk factors for sporadic AD, single nucleotide polymorphisms in the APOE, ABCA7, NEDD9, CASS4, PTK2B, CLU, and PICALM genes. An overview of the main function of the proteins associated with the genes is given, along with the supposed connection to AD pathology.
Each chapter of this thesis closely studies a different object of a different medium to trace relationships between Constructivist objects and Soviet community. El Lissitzky’s PROUN Manifesto illuminates the creation of an artistic community. Alexander Rodchenko’s print Propaganda communicates between a state and its people. Varvara Stepanova’s Sportswear designs facilitate a society of workers. Alexandra Exter’s Marionettes combine common everyday objects and children’s theater. Vladimir Tatlin’s Monument to the Third International, envisions the ideal Soviet society as place in which socialists could convene. And Liubov Popova’s Painterly Architectonics relates the functional and aesthetic goals of Constructivism from Russia to the international art world. Benedict Anderson’s Imagined Communities, Bruno Latour’s Reassembling the Social, and Pierre Bourdieu’s Distinction each provide the framework for discussing the intersections of art objects and community. Anderson explores nationhood through the lens of language and print media, Latour studies how social interaction on an individual basis might rely upon the physical objects around them, whereas Bourdieu addresses hierarchies in distinguishing objects of art in class-based societies by outlining the conflicts between cultural capital and tastemaking in the analysis of objects.
Through the exploration of each Constructivist object, this thesis explores individual, national, and international communities while considering their changing political, social contexts.
Activist burnout theory has produced minimal but meaningful literature and research that explores the dynamics of burnout culture, movement in-fighting, marginalized identities, and dimensions of burnout symptoms. Black feminist visionaries and writers such as Audre Lorde and bell hooks have developed theories of love, self-care and community as central to resistance that have informed my research approach. Thus, my study aims to investigate activist burnout from a perspective that marries popular activist burnout theory with these frameworks of self-care and community. I conducted a survey of Arizona State University student organizers and activists (N=34) to address the following research questions: What are the causes and symptoms of burnout for Arizona State University activists and organizers? How have self-care and community played a role in their work and countered burnout? Can working conceptions of self-care and community serve as resistance in ways that feel meaningful to activists? The survey was broken into three dimensions: “Demographics and Experience,” “Burnout,” and “Self-Care and Community.” The results reinforced prior findings on established toxic cultures and burnout symptoms but introduced complications to working theories, such as the connections between cycles of burnout and the cyclical nature of electoral politics along with the roles of chronic and mental illness. Respondents largely demonstrated conceptions of self-care and community as resistance but also demonstrated personal and professional barriers to putting these conceptions into practice.
"FIJI's Shave to Save" took place in Fall 2021 when 47 members of Phi Gamma Delta (FIJI) at Arizona State University got their heads shaved as a public demonstration of the fraternity's commitment to the mission of the Translational Genomics Research Institute (TGen) and their Center for Rare Childhood Disorders (the Center). Through tremendous community support, the majority of which came from members' families, FIJI alumni, and participating member sororities of Arizona State University's Panhellenic Council, we collectively raised $63,640 for the Center. These funds are directed towards the Center's groundbreaking research and efforts to improve the lives of children with rare disorders through genomic sequencing. Aside from the lives impacted by the fundraiser, this news was highlighted in publications from multiple media outlets and exhibited the positive impact that Greek Life is capable of. Months prior to this initiative, Taylor Dintzner (2021 Chapter President) and Cameron Chew (2021 Philanthropy Chairman) were lost and did not know how to approach the execution of a successful fundraiser. In December 2021, they met with Rob Caudill, Executive Director at the International Headquarters of Phi Gamma Delta (FIJI), to discuss international publicity for the initiative. The verdict was that other FIJI Chapters may benefit from a "toolkit" that details how FIJI at Arizona State University was able to raise $63,500 for TGen. "FIJI's Shave to Save: A Toolkit for Successful Fundraising by Charitable Organizations" is intended to be a resource that encourages FIJI Chapters internationally to execute their own "FIJI's Shave to Save" initiative, giving them all of the tools necessary to follow a similar format and raise funds for TGen's Center for Rare Childhood Disorders. Media Highlighting FIJI at Arizona State University's Community Impact: https://linktr.ee/fijigraduatechapter
Food is one of the most universal and uniting human experiences. It is a powerful tool to bring communities together and it is a simple way to bring joy to an individual. This project is an exercise in marketing and entrepreneurship that was inspired by these ideas, which culminated in a fundraiser bake sale to benefit Creighton Community Foundation, a local nonprofit.
The current study investigated emotional language use in middle aged and older adults in interviews in which they were asked questions relating to Alzheimer's disease and related dementias. Participants were split into two groups, one that attended Memory Clinic to have their cognition assessed, representing information seekers, and those who did not attend. These interviews were then transcribed and run through LIWC2015 software to determine linguistic differences between the two groups. Results did not indicate statistically significant differences between language use in those who attended Memory Clinic compared with those who did not. Further study with a sample that has higher levels of anxiety related to Alzheimer's disease and related dementias may produce statistically significant results.