Matching Items (8)
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- All Subjects: Parkinson's disease
- Creators: Electrical Engineering Program
Description
At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together with machine learning tools to automate the process of Parkinson’s disease classification and severity assessment. An automated, stable, and accurate method to evaluate Parkinson’s would be significant in streamlining diagnoses of patients and providing families more time for corrective measures. We propose a methodology which incorporates TDA into analyzing Parkinson’s disease postural shifts data through the representation of persistence images. Studying the topology of a system has proven to be invariant to small changes in data and has been shown to perform well in discrimination tasks. The contributions of the paper are twofold. We propose a method to 1) classify healthy patients from those afflicted by disease and 2) diagnose the severity of disease. We explore the use of the proposed method in an application involving a Parkinson’s disease dataset comprised of healthy-elderly, healthy-young and Parkinson’s disease patients.
ContributorsRahman, Farhan Nadir (Co-author) / Nawar, Afra (Co-author) / Turaga, Pavan (Thesis director) / Krishnamurthi, Narayanan (Committee member) / Electrical Engineering Program (Contributor) / Computer Science and Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The Lightning Audio capstone group, consisting of Brian Boerhinger, Rahul Nandan, Jaime Ramirez, and Niccolo Magnotto (myself), united in the effort to prove the feasibility of a consumer grade plasma arc speaker. This was achieved in group's prototype design, which demonstrates the potential for a refined product in its conventional interfacing, casing, size, safety, and aesthetics. If the potential for an excellent ionization-based loudspeaker product were realized, it would be highly profitable in its reasonable cost of production, novelty, and place in a large and fitting market.
ContributorsMagnotto, Niccolo John (Author) / Roedel, Ronald (Thesis director) / Huffman, James (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2014-05
Description
The artificial neural network is a form of machine learning that is highly effective at recognizing patterns in large, noise-filled datasets. Possessing these attributes uniquely qualifies the neural network as a mathematical basis for adaptability in personal biomedical devices. The purpose of this study was to determine the viability of neural networks in predicting Freezing of Gait (FoG), a symptom of Parkinson's disease in which the patient's legs are suddenly rendered unable to move. More specifically, a class of neural networks known as layered recurrent networks (LRNs) was applied to an open- source FoG experimental dataset donated to the Machine Learning Repository of the University of California at Irvine. The independent variables in this experiment \u2014 the subject being tested, neural network architecture, and sampling of the majority classes \u2014 were each varied and compared against the performance of the neural network in predicting future FoG events. It was determined that single-layered recurrent networks are a viable method of predicting FoG events given the volume of the training data available, though results varied significantly between different patients. For the three patients tested, shank acceleration data was used to train networks with peak precision/recall values of 41.88%/47.12%, 89.05%/29.60%, and 57.19%/27.39% respectively. These values were obtained for networks optimized using detection theory rather than optimized for desired values of precision and recall. Furthermore, due to the nature of the experiments performed in this study, these values are representative of the lower-bound performance of layered recurrent networks trained to detect gait freezing. As such, these values may be improved through a variety of measures.
ContributorsZia, Jonathan Sargon (Author) / Panchanathan, Sethuraman (Thesis director) / McDaniel, Troy (Committee member) / Adler, Charles (Committee member) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The use of conventional weather radar in vulcanology leads to two problems: the radars often use wavelengths which are too long to detect the fine ash particles, and they cannot be field–adjusted to fit the wide variety of eruptions. Thus, to better study these geologic processes, a new radar must be developed that is easily reconfigurable to allow for flexibility and can operate at sufficiently short wavelengths.
This thesis investigates how to design a radar using a field–programmable gate array board to generate the radar signal, and process the returned signal to determine the distance and concentration of objects (in this case, ash). The purpose of using such a board lies in its reconfigurability—a design can (relatively easily) be adjusted, recompiled, and reuploaded to the hardware with none of the cost or time overhead required of a standard weather radar.
The design operates on the principle of frequency–modulated continuous–waves, in which the output signal frequency changes as a function of time. The difference in transmit and echo frequencies determines the distance of an object, while the magnitude of a particular difference frequency corresponds to concentration. Thus, by viewing a spectrum of frequency differences, one is able to see both the concentration and distances of ash from the radar.
The transmit signal data was created in MATLAB®, while the radar was designed with MATLAB® Simulink® using hardware IP blocks and implemented on the ROACH2 signal processing hardware, which utilizes a Xilinx® Virtex®–6 chip. The output is read from a computer linked to the hardware through Ethernet, using a Python™ script. Testing revealed minor flaws due to the usage of lower–grade components in the prototype. However, the functionality of the proposed radar design was proven, making this approach to radar a promising path for modern vulcanology.
This thesis investigates how to design a radar using a field–programmable gate array board to generate the radar signal, and process the returned signal to determine the distance and concentration of objects (in this case, ash). The purpose of using such a board lies in its reconfigurability—a design can (relatively easily) be adjusted, recompiled, and reuploaded to the hardware with none of the cost or time overhead required of a standard weather radar.
The design operates on the principle of frequency–modulated continuous–waves, in which the output signal frequency changes as a function of time. The difference in transmit and echo frequencies determines the distance of an object, while the magnitude of a particular difference frequency corresponds to concentration. Thus, by viewing a spectrum of frequency differences, one is able to see both the concentration and distances of ash from the radar.
The transmit signal data was created in MATLAB®, while the radar was designed with MATLAB® Simulink® using hardware IP blocks and implemented on the ROACH2 signal processing hardware, which utilizes a Xilinx® Virtex®–6 chip. The output is read from a computer linked to the hardware through Ethernet, using a Python™ script. Testing revealed minor flaws due to the usage of lower–grade components in the prototype. However, the functionality of the proposed radar design was proven, making this approach to radar a promising path for modern vulcanology.
ContributorsLee, Byeong Mok (Co-author) / Xi, Andrew Jinchi (Co-author) / Groppi, Christopher (Thesis director) / Mauskopf, Philip (Committee member) / Baumann, Alicia (Committee member) / Cochran, Douglas (Committee member) / Electrical Engineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The use of conventional weather radar in vulcanology leads to two problems: the radars often use wavelengths which are too long to detect the fine ash particles, and they cannot be field–adjusted to fit the wide variety of eruptions. Thus, to better study these geologic processes, a new radar must be developed that is easily reconfigurable to allow for flexibility and can operate at sufficiently short wavelengths.
This thesis investigates how to design a radar using a field–programmable gate array board to generate the radar signal, and process the returned signal to determine the distance and concentration of objects (in this case, ash). The purpose of using such a board lies in its reconfigurability—a design can (relatively easily) be adjusted, recompiled, and reuploaded to the hardware with none of the cost or time overhead required of a standard weather radar.
The design operates on the principle of frequency–modulated continuous–waves, in which the output signal frequency changes as a function of time. The difference in transmit and echo frequencies determines the distance of an object, while the magnitude of a particular difference frequency corresponds to concentration. Thus, by viewing a spectrum of frequency differences, one is able to see both the concentration and distances of ash from the radar.
The transmit signal data was created in MATLAB®, while the radar was designed with MATLAB® Simulink® using hardware IP blocks and implemented on the ROACH2 signal processing hardware, which utilizes a Xilinx® Virtex®–6 chip. The output is read from a computer linked to the hardware through Ethernet, using a Python™ script. Testing revealed minor flaws due to the usage of lower–grade components in the prototype. However, the functionality of the proposed radar design was proven, making this approach to radar a promising path for modern vulcanology.
This thesis investigates how to design a radar using a field–programmable gate array board to generate the radar signal, and process the returned signal to determine the distance and concentration of objects (in this case, ash). The purpose of using such a board lies in its reconfigurability—a design can (relatively easily) be adjusted, recompiled, and reuploaded to the hardware with none of the cost or time overhead required of a standard weather radar.
The design operates on the principle of frequency–modulated continuous–waves, in which the output signal frequency changes as a function of time. The difference in transmit and echo frequencies determines the distance of an object, while the magnitude of a particular difference frequency corresponds to concentration. Thus, by viewing a spectrum of frequency differences, one is able to see both the concentration and distances of ash from the radar.
The transmit signal data was created in MATLAB®, while the radar was designed with MATLAB® Simulink® using hardware IP blocks and implemented on the ROACH2 signal processing hardware, which utilizes a Xilinx® Virtex®–6 chip. The output is read from a computer linked to the hardware through Ethernet, using a Python™ script. Testing revealed minor flaws due to the usage of lower–grade components in the prototype. However, the functionality of the proposed radar design was proven, making this approach to radar a promising path for modern vulcanology.
ContributorsXi, Andrew Jinchi (Co-author) / Lee, Matthew Byeongmok (Co-author) / Groppi, Christopher (Thesis director) / Mauskopf, Philip (Committee member) / Cochran, Douglas (Committee member) / Baumann, Alicia (Committee member) / Electrical Engineering Program (Contributor) / School of Mathematical and Statistical Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The purpose of this project is to analyze the MIT OpenCourseWare coffee can radar design and modify it to be better suited for drone based synthetic aperture radar (SAR) applications while maintaining the low-cost aspect of the original design. The MIT coffee can radar can function as a ranged radar, a Doppler radar, or as SAR. Through simulations and research, the suggestions for how to modify the radar resulted in swapping the coffee can monopole antennas for patch antenna arrays or helical ordinary end-fire antennas, adding an Arduino for automatic recording of output pulses, and switching from a breadboard construction to a PCB to shrink form factor and keep costs and construction time low.
ContributorsRivera, Danielle (Author) / Trichopoulos, Georgios (Thesis director) / Aberle, James (Committee member) / Department of Information Systems (Contributor) / Electrical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12
Description
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.
ContributorsGin, Taylor (Author) / McCarthy, Alexandra (Co-author) / Berisha, Visar (Thesis director) / Baumann, Alicia (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2022-05
Description
This paper serves to report the research performed towards detecting PD and the effects of medication through the use of machine learning and finger tapping data collected through mobile devices. The primary objective for this research is to prototype a PD classification model and a medication classification model that predict the following: the individual’s disease status and the medication intake time relative to performing the finger-tapping activity, respectively.
ContributorsMcCarthy, Alexandra (Author) / Gin, Taylor (Co-author) / Berisha, Visar (Thesis director) / Baumann, Alicia (Committee member) / Barrett, The Honors College (Contributor) / Electrical Engineering Program (Contributor)
Created2022-05