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A point of care glucose sensor using electrochemical impedance spectroscopy (EIS) with a glutaraldehyde-linked enzyme shows promise as an effective biosensor platform. This report details the characterization of various factors on optimal binding frequency (OBF) and sensor performance to better prepare the sensor for future experimentation. Utilizing a screen printed

A point of care glucose sensor using electrochemical impedance spectroscopy (EIS) with a glutaraldehyde-linked enzyme shows promise as an effective biosensor platform. This report details the characterization of various factors on optimal binding frequency (OBF) and sensor performance to better prepare the sensor for future experimentation. Utilizing a screen printed carbon electrode, the necessary amount of glucose oxidase was determined to be 10 mg/mL. Binding time trials ranging from 1-3 minutes demonstrated that 1.5 minutes was the optimal binding time. This timeframe produced the strongest impedance response at each glucose concentration. Using this enzyme concentration and binding time, the native OBF of the biosensor was found to be 1.18 Hz using vector analysis. Temperature testing showed little change in OBF in sensors exposed to 4 \u00B0C through 43.3 \u00B0C. Only exposure to 60 \u00B0C resulted in rapid OBF change which was likely due to glucose oxidase becoming denatured. Humidity tests showed little change in OBF and sensor performance between sensors prepared at the humidities of 7.5%, 10.625% and 16.5% humidity. Alternatively, solutions containing common interference molecules such as uric acid, acetaminophen, and ascorbic acid resulted in a highly shifted OBF and drastically reduced signal.
ContributorsMatloff, Daniel (Co-author) / Khanwalker, Mukund (Co-author) / Johns, Jared (Co-author) / LaBelle, Jeffrey (Thesis director) / Pizziconi, Vincent (Committee member) / Lin, Chi (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
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Description

2D fetal echocardiography (ECHO) can be used for monitoring heart development in utero. This study’s purpose is to empirically model normal fetal heart growth and function changes during development by ECHO and compare these to fetuses diagnosed with and without cardiomyopathy with diabetic mothers. There are existing mathematical models describing

2D fetal echocardiography (ECHO) can be used for monitoring heart development in utero. This study’s purpose is to empirically model normal fetal heart growth and function changes during development by ECHO and compare these to fetuses diagnosed with and without cardiomyopathy with diabetic mothers. There are existing mathematical models describing fetal heart development but they warrant revalidation and adjustment. 377 normal fetuses with healthy mothers, 98 normal fetuses with diabetic mothers, and 37 fetuses with cardiomyopathy and diabetic mothers had their cardiac structural dimensions, cardiothoracic ratio, valve flow velocities, and heart rates measured by fetal ECHO in a retrospective chart review. Cardiac features were fitted to linear functions, with respect to gestational age, femur length, head circumference, and biparietal diameter and z-scores were created to model normal fetal growth for all parameters. These z-scores were used to assess what metrics had no difference in means between the normal fetuses of both healthy and diabetic mothers but differed from those diagnosed with cardiomyopathy. It was found that functional metrics like mitral and tricuspid E wave and pulmonary velocity could be important predictors for cardiomyopathy when fitted by gestational age, femur length, head circumference, and biparietal diameter. Additionally, aortic and tricuspid annulus diameters when fitted to estimated gestational age showed potential to be predictors for fetal cardiomyopathy. While the metrics overlapped over their full range, combining them together may have the potential for predicting cardiomyopathy in utero. Future directions of this study will explore creating a classifier model that can predict cardiomyopathy using the metrics assessed in this study.

ContributorsMishra, Shambhavi (Co-author) / Numani, Asfia (Co-author) / Sweazea, Karen (Thesis director) / Plasencia, Jonathan (Committee member) / Economics Program in CLAS (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

2D fetal echocardiography (ECHO) can be used for monitoring heart development in utero. This study’s purpose is to empirically model normal fetal heart growth and function changes during development by ECHO and compare these to fetuses diagnosed with and without cardiomyopathy with diabetic mothers. There are existing mathematical models describing

2D fetal echocardiography (ECHO) can be used for monitoring heart development in utero. This study’s purpose is to empirically model normal fetal heart growth and function changes during development by ECHO and compare these to fetuses diagnosed with and without cardiomyopathy with diabetic mothers. There are existing mathematical models describing fetal heart development but they warrant revalidation and adjustment. 377 normal fetuses with healthy mothers, 98 normal fetuses with diabetic mothers, and 37 fetuses with cardiomyopathy and diabetic mothers had their cardiac structural dimensions, cardiothoracic ratio, valve flow velocities, and heart rates measured by fetal ECHO in a retrospective chart review. Cardiac features were fitted to linear functions, with respect to gestational age, femur length, head circumference, and biparietal diameter and z-scores were created to model normal fetal growth for all parameters. These z-scores were used to assess what metrics had no difference in means between the normal fetuses of both healthy and diabetic mothers, but differed from those diagnosed with cardiomyopathy. It was found that functional metrics like mitral and tricuspid E wave and pulmonary velocity could be important predictors for cardiomyopathy when fitted by gestational age, femur length, head circumference, and biparietal diameter. Additionally, aortic and tricuspid annulus diameters when fitted to estimated gestational age showed potential to be predictors for fetal cardiomyopathy. While the metrics overlapped over their full range, combining them together may have the potential for predicting cardiomyopathy in utero. Future directions of this study will explore creating a classifier model that can predict cardiomyopathy using the metrics assessed in this study.

ContributorsNumani, Asfia (Co-author) / Mishra, Shambhavi (Co-author) / Sweazea, Karen (Thesis director) / Plasencia, Jon (Committee member) / School of Mathematical and Statistical Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The Green Gamers is a start-up concept revolving around incentivizing healthy eating in Arizonan adolescents through the use of reward-based participation campaigns (popularized by conglomerates like Mondelez and Coca-Cola)

ContributorsDavis, Benjamin (Co-author) / Wong, Brendan (Co-author) / Hwan, Kim (Thesis director) / McKearney, John (Committee member) / Department of Finance (Contributor, Contributor) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

The purpose of this cookbook and ingredient index is to simplify the reasoning behind eating a plant based diet--including how it can be beneficial to your health, and what benefits each ingredient provides. These recipes have been cultivated and modified over time to provide nutritious meals that are also tasty.

The purpose of this cookbook and ingredient index is to simplify the reasoning behind eating a plant based diet--including how it can be beneficial to your health, and what benefits each ingredient provides. These recipes have been cultivated and modified over time to provide nutritious meals that are also tasty. I was introduced to healthy eating at a young age, and have been fascinated by it ever since. The recipes and information conveyed about a plant based diet have come from the many books read and research I have done on the subject. This paper will walk you through how I started this journey, and go on to show a basic overview of what makes up the foods we consume and why we need them. The cookbook portion of my Thesis contains recipes for breakfast, lunch, dinner, snacks, sauces, and dessert. Following the cookbook is an ingredient index that goes through the majority of ingredients used in my recipes, and what health benefits they provide. I hope that by reading this, others will be inspired to use more plant-based whole foods in their diet, and realize the healing that can come from them.

ContributorsMartin, Ashley (Author) / Barth, Christina (Thesis director) / McMullen, Mary (Committee member) / School of Life Sciences (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Art (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

Habitual Health is a holistic health firm meant to provide the Arizona State University students with awareness of healthy practices. Our Founders Ava Bobbs, Mario DiVenere, and Jack Hammond have found that students have a severe lack of knowledge involving healthy practices including diet, fitness, and cooking. The combination of

Habitual Health is a holistic health firm meant to provide the Arizona State University students with awareness of healthy practices. Our Founders Ava Bobbs, Mario DiVenere, and Jack Hammond have found that students have a severe lack of knowledge involving healthy practices including diet, fitness, and cooking. The combination of our strengths and complements to weaknesses puts the firm in a strong position to garner market share and provide value to our company. Throughout on-campus research, the team found that the average Arizona State University student does not feel that they have the sufficient means to be healthy, which is a huge misalignment that prevents the average ASU student from living a healthy lifestyle. This is where Habitual Health comes in, we are going to bridge the gap between the lack of information about healthy initiatives and the implication that living a healthy lifestyle is too expensive, difficult, and time consuming. Habitual Health is a paid platform where ASU students can go to access fitness plans, recipes, topical discussions and analysis, and other health related resources. The product we have established is an interactive, user-friendly website that includes various healthy recipes, nutritional tips and habits, and physical exercise routines. Our data is based on running the website from 01/20/2023 - 03/01/2023. Our company's value proposition is that students’ health would benefit long-term from our platform's resources. We have targeted the ASU Greek Community, which includes roughly 6% of the ASU population.1 We tested our product within the Greek community because of the tight knit nature of the community, as well as the communal kitchen system in the Greek Leadership Village making it harder for those individuals to cook for themselves. We expect to see a revamped community within the GLV, causing a positive impact across the entire campus.

ContributorsDi Venere, Mario (Author) / Hammond, Jack (Co-author) / Bobbs, Ava (Co-author) / Byrne, Jared (Thesis director) / Larsen, Wiley (Committee member) / Boeh, Morgan (Committee member) / Pierce, John (Committee member) / Barrett, The Honors College (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Department of Finance (Contributor)
Created2023-05
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Description
The Solar Mamas Program, created by the Indian-based non-profit Barefoot College, brings illiterate and semi-literate older women from rural communities around the world to India for a six-month training on solar engineering and entrepreneurship. The Barefoot enterprise is unique in that it contrasts the typical flow of humanitarian aid and

The Solar Mamas Program, created by the Indian-based non-profit Barefoot College, brings illiterate and semi-literate older women from rural communities around the world to India for a six-month training on solar engineering and entrepreneurship. The Barefoot enterprise is unique in that it contrasts the typical flow of humanitarian aid and implements a South-South development dynamic. Belize is one country that Barefoot selects potential Solar Mamas from with help from its ground partner, Plenty Belize. This ethnographic study aims to identify and assess the direct and indirect impacts the solar project has created in traditional Mayan life in the Toledo District. Interviews were conducted in Santa Elena and Jalacte, which are two villages with and without solar electrification, respectively. The study observed positive impacts on various aspects of health, education, and economics, as well as gender relations. Although relatively successful in its mission, constructive feedback was provided to all actors in the solar project with the aim of enhancing the Solar Mamas’ experience and effectiveness as a “new class of leaders” in their communities, as well as to ensure the continued success that solar electrification has had in the Mayan communities.
ContributorsLaufer, Grant (Co-author) / Gonzalez, Olivia (Co-author) / Bascon, Glenn Ivan (Co-author) / Carrese, Susan (Thesis director) / Ellsworth, Kevin (Committee member) / Paris, Rodrigo (Committee member) / Department of Economics (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Civic & Economic Thought and Leadership (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
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Description
The purpose of this study on Cruise Lines & Health and Wellness Trends is to explain the significance of health and wellness trends within the tourism industry, specifically the cruise line industry, and recommend that cruise lines implement changes to their food and beverage offerings for a continued competitive edge.

The purpose of this study on Cruise Lines & Health and Wellness Trends is to explain the significance of health and wellness trends within the tourism industry, specifically the cruise line industry, and recommend that cruise lines implement changes to their food and beverage offerings for a continued competitive edge. Research was completed on the cruise line industry, today’s health and wellness trends, and how cruise lines are currently catering towards as many guests’ preferences as possible. Interviews were completed with a variety of crew members aboard a recently launched cruise ship. These four employees, to be kept anonymous, were asked questions regarding general demographics, their thoughts on guests’ dining preferences, and whether or not their company was successful in incorporating current health and wellness trends. This particular cruise line appeared to provide many tools to be healthier onboard; however, the crew members agreed that there is room for improvement and a need to focus on a younger demographic.
As mindsets on wellness change, dietary restrictions become more prevalent, and there is more food and beverage innovation, the general public desires more options in daily life. Holistic wellness trends and plant-based options are being welcomed into many personal routines. With substantial commitments and dietary restrictions, guests onboard cruises need additional food and beverage options. Values of Millennials and Generation Z will also need to be considered as they mature into adulthood and gain more buying power. Both generations value experiences over material items, holistic wellness, and inclusivity. Thus, minor additions of plant-based, allergy-friendly, and/or nutritional items onboard would be beneficial to ships within the rapidly growing cruise line industry. Many cruise lines have already begun to make slight changes to their menus and selections, such as plant-based juice bars and notations on menus for vegan or allergy-friendly items. While it is difficult to satisfy all, cruise lines must be more proactive in catering to the lifestyle changes being made by guests if they hope to remain competitive in the leisure travel market.
ContributorsKennett, Kyra Lynn (Co-author) / Kennett, Kyra (Co-author) / LaRosa, Julia (Thesis director) / Hoyt, Heather (Committee member) / Department of Management and Entrepreneurship (Contributor) / Dean, W.P. Carey School of Business (Contributor) / School of Community Resources and Development (Contributor) / Barrett, The Honors College (Contributor)
Created2019-12
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Description
Birds maintain resting plasma glucose concentrations (pGlu) nearly twice that of comparably sized mammals. Despite this, birds do not incur much of the oxidative tissue damage that might be expected from a high pGlu. Their ability to stave off oxidative damage allows birds to serve as a negative model of

Birds maintain resting plasma glucose concentrations (pGlu) nearly twice that of comparably sized mammals. Despite this, birds do not incur much of the oxidative tissue damage that might be expected from a high pGlu. Their ability to stave off oxidative damage allows birds to serve as a negative model of hyperglycemia-related complications, making them ideal for the development of new diabetes treatments with the potential for human application. Previous studies conducted by the Sweazea Lab at Arizona State University aimed to use diet as a means to raise blood glucose in mourning doves (Zenaida macroura) in order to better understand the mechanisms they utilize to stave off oxidative damage. These protocols used dietary interventions—a 60% high fat (HF) “chow” diet, and a high carbohydrate (HC) white bread diet—but were unsuccessful in inducing pathologies. Based on this research, we hypothesized that a model of an urban diet (high in fat, refined carbohydrates, and sodium) might impair vasodilation, as the effect of this diet on birds is currently unknown. We found that tibial vasodilation was significantly impaired in birds fed an urban diet compared to those fed a seed diet. Unexpectedly, vasodilation in the urban diet group was comparable to data of wild-caught birds from previous research, possibly indicating that the birds had already been eating a diet similar to this study’s urban diet before they were caught. This may constitute evidence that the seed diet improved vasodilation while the urban diet more closely mimicked the diet of the birds before the trial, suggesting that the model of the urban diet acted as the control diet in this context. This study is the first step in elucidating avian mechanisms for dealing with diabetogenic diets and has potential to aid in the development of treatments for humans with metabolic syndrome.
ContributorsRenner, Michael William (Author) / Sweazea, Karen (Thesis director) / Johnston, Carol (Committee member) / Basile, Anthony (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
Genistein, a compound found in soy that functions as a phytoestrogen, has been found to play a role in the body’s inflammatory response. By suppressing the expression of inflammatory genes and inhibiting tumor cell growth, genistein is thought to have both anti-inflammatory and cancer fighting properties. This study seeks to

Genistein, a compound found in soy that functions as a phytoestrogen, has been found to play a role in the body’s inflammatory response. By suppressing the expression of inflammatory genes and inhibiting tumor cell growth, genistein is thought to have both anti-inflammatory and cancer fighting properties. This study seeks to demonstrate genistein’s potential to mitigate the negative consequences of consuming a high fat diet specifically as it relates to increased inflammation and changes in the gut microbiome. Using an animal model, the study tested whether supplementing the mice’s diet with soy derived genistein would affect their serum IL-6 levels and the way in which their gut microbiomes responded to their high fat consumption. It was presumed that genistein supplementation would result in a less significant shift from the biomarkers tested in the control group and reduce the impact of the high fat diet. It was also hypothesized that consumption of the high fat diet would raise IL-6 levels and increase the presence of harmful bacteria in the test subjects.
ContributorsPettit, Gabrielle Sofia (Author) / Whisner, Dr. Corrie (Thesis director) / Al-Nakkash, Dr. Layla (Committee member) / Ortega Santos, Carmen (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05