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The purpose of this study was to examine the validity of a modified Assisted Cycling Therapy bicycle for improving depression in children with Down Syndrome (DS). Seven participants completed 2x/week for 8 weeks, 30 minutes at a time of ACT, in which participants’ voluntary pedaling rates were augmented via the bicycle motor, ensuring that they were pedaling at a rate greater than their self-paced rate. Depression was measured using a modified version of the Children’s Depressive Inventory, called the CDI-2. Our study demonstrated that the scores from the CDI-2 decreased, demonstrating less depressive symptomatology after the conclusion of the 8 week intervention. Our results were interpreted via our model of the mechanisms involved in influencing the success of ACT. Future research would include a greater sample size, a more relevant measure of depressive scores, and a consistent data collection environment. However our initial pilot study showed promising results for improving mental health in children with DS.
Our current understanding of the mitochondrial genome was revolutionized in 2015 with the discovery of short open reading frames (sORFs) that produced protein products called mitochondrial-derived peptides (MDPs). Interestingly, unlike other proteins produced by the organelle, these MDPs are not directly involved in the electron transport chain but rather serve the role of metabolic regulators. In particular, one of these peptides called MOTS-c has been shown to regulate glucose and fat metabolism in an AMPK-dependent manner. With its capacity to enter the mitochondria and impact gene expression, MOTS-c has also displayed the ability to increase aerobic exercise performance by triggering elevated synthesis of the HO-1 antioxidant. Overall these findings position MOTS-c as a promising treatment for metabolic diseases as well as a potential dietary supplement to boost ATP availability.
This thesis explores the impact of physical activity--what I have chosen to call “moments of movement” -- inside the classroom throughout the elementary school day. Journal-based observations were made by a student teacher placed in a special education 4th-6th grade writing and reading resource classroom from August-December of 2018 and a fourth grade general education classroom from January-May of 2019. All observations were made at Adams Elementary School, a Title 1 school, in the Mesa, Arizona school district. At this K-6 grade school, many students live with the challenges of poverty, neglect, unstable family dynamics, and trauma. Because the teachers work tirelessly to cultivate a sense of home for the students, there is a strong emphasis on non-traditional teaching methods, including the AVID program and the Kagan, and Tribes strategies.
Ms. Norris (the special education teacher) and Ms. Foss (the fourth grade teacher) both have strong backgrounds in fitness and naturally incorporate physical activity in their classrooms, which is not something typically found at elementary schools. In this paper, physical activity strategies in classrooms of Ms. Norris and Ms. Foss are analyzed, as well as the benefits of implementing these strategies. The impact of these “moments of movement” on the whole class and individual students is discussed, and suggestions are made to help educators incorporate “moments of movement” into their own classrooms. Educators can use the strategies present at Adams Elementary School as a model for incorporating exercise in their own classrooms.