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- Creators: School of Life Sciences
- Creators: Department of Psychology
Description
This study examines the effect of exercise therapy on a stationary bike on cognitive function, specifically inhibition and set-switching, in adolescents with Down syndrome. 44 participants were randomly divided between the voluntary cycling therapy group (VCT) (i.e., self-selected cadence), assisted cycling therapy group (ACT) (i.e., 30% faster than self-selected cadence accomplished by a motor), and a control group (NC) in which the participants did not undergo any exercise therapy. Both cycling groups rode a stationary bicycle, for 30 minutes, three times a week, for eight-weeks. At the beginning (i.e., pretest) and end (i.e., posttest) of the eight-week session the participants completed tasks to evaluate their cognitive function. They completed three trials of the card sort test (i.e., set-switching) and three trials of the knock-tap test (i.e, inhibition) before and after eight-weeks of cycling therapy. The scores of these tests were analyzed using one-way ANOVA between groups and paired samples t-tests. The results showed that after eight-weeks of cycling therapy the participants in the VCT group performed worse in the knock-tap test, but improved in two trials of the card sort test. The results also showed that the participants in the ACT group performed worse after eight-weeks of exercise therapy in one trial of the card sort test. No significant changes were seen for the control group. Due to the fact that on average the participants in the VCT group cycled with a higher heart rate, our results suggest exercise that significantly elevates heart rate can improve cognitive function, specifically set-switching, in adolescents with Down syndrome.
ContributorsBenson, Alicia Meigh (Author) / Ringenbach, Shannon (Thesis director) / Amazeen, Eric (Committee member) / Maraj, Brian (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2015-05
Description
The purpose of the study was to examine the effectiveness of two modes of exercise on depression in adolescents with Down syndrome (DS). Twelve participants randomly completed one of two exercise interventions. The interventions were: 1) Voluntary Cycling (VC), in which participants cycled at their self-selected pedaling rate 2) Assisted Cycling (AC), in which the participants' voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpms. In each intervention, the participant completed three cycling sessions each week for a total of eight weeks. Depression scores did decrease or improved after both AC and VC, but not significantly. There was a greater mean improvement for participants in the AC group than VC when analyzing total score and t-score. Future research will include a greater sample size and control group to reach significant results as well as try and reveal the mechanisms involved in these mental health improvements found after an acute bout of assisted cycling in adolescents with DS.
ContributorsTeslevich, Jennifer Lynn (Author) / Ringenbach, Shannon (Thesis director) / Kulinna, Pamela (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / Department of Psychology (Contributor)
Created2013-12
Description
This study was conducted to examine the potential effects of exercise training on partial spinal cord injury on locomotor recovery in juvenile rats. Three groups were tested, where three female Long-Evans rats 10-12 weeks of age were studied for their locomotion. All animals underwent a T8-T9 laminectomy and two of the three in each group received a dorsal, partial spinal cord injury. Locomotion was then analyzed every week, over 8-10 weeks. One of the two injured animals was given open access to a wheel after 2 weeks for voluntary exercise training. The results of this study suggested that injured animals displayed more irregular stepping patterns, larger hindlimb bases of support, greater and more variable interpaw distances, slower hindlimb speed, and increased dependency of swing-phase duty cycle on hindlimb speed. Trained animals displayed quicker recovery of stepping patterns, stepping of the hindpaw in relation to the preceding ipsilateral forepaw, and higher swing-duty cycle dependency on hindlimb speed in comparison to injured animals that did not receive exercise training. Due to a small sample size, there was a large amount of variation between individual animals in most parameters. These results are considered to be potential effects that may be seen in further study with a larger sample size. The research team will continue the research project to examine changes in neural pathways in the spinal cord and the effects of exercise on recovery after injury.
ContributorsSleem, Tamara Hatem (Author) / Abbas, James (Thesis director) / Hamm, Thomas (Committee member) / School of Human Evolution and Social Change (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The anthracycline drug Doxorubicin (DOX) is a highly effective treatment for breast cancer, but its clinical utility is limited by dose-dependent cardiovascular toxicity. The toxic effects are partly attributed to DOX-induced generation of reactive oxygen species, which may impair nitric oxide-mediated vasodilation. Exercise training activates antioxidant defense mechanisms and is thus hypothesized to counteract oxidative stress when initiated prior to DOX administration. Adult 8-week old, ovariectomized female Sprague-Dawley rats were divided into 4 groups: sedentary + vehicle (Sed+Veh); Sed+DOX; exercise + veh (Ex+Veh); and Ex+DOX. Rats in the exercise groups were preconditioned with high intensity interval training consisting of 4x4 minute bouts of exercise at 85-95% of VO2peak separated by 2 minutes of active recovery performed 5 days per week. Exercise was implemented one week prior to the first injection and continued throughout the study. Animals received either DOX (4mg/kg) or veh (saline) intraperitoneal injections bi-weekly for a cumulative dose of 12 mg/kg per animal. Five days following the final injection, animals were anesthetized with isoflurane, decapitated and aortas and perivascular adipose tissue (PVAT) were removed for western blot analyses. No significant differences in aortic protein expression were detected for inducible nitric oxide synthase (iNOS) or the upstream activator of endothelial nitric oxide synthase (eNOS), Akt, across groups (p>0.05), whereas eNOS protein expression was significantly downregulated in Sed+DOX (p=0.003). In contrast, eNOS expression was not altered in Ex+DOX treated animals. Protein expression of iNOS in PVAT was upregulated with exercise in the DOX-treated groups (p=0.039). These findings suggest that exercise preconditioning may help mitigate vascular effects of DOX by preventing downregulation of eNOS in the aorta.
ContributorsO'Neill, Liam Martin (Author) / Sweazea, Karen (Thesis director) / Angadi, Siddhartha (Committee member) / Dickinson, Jared (Committee member) / School of Human Evolution and Social Change (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. It is primarily misdiagnosed or undiagnosed in women until adulthood is reached. There are multiple effective therapies available once a diagnosis of ADHD is made. These include, but are not limited to, stimulant prescription medications, complementary and alternative medicine therapies (CAM) and gut health. Complementary and alternative medicine therapies can include meditation/spiritual health, Cognitive Behavioral Therapy (CBT), holistic/herbal medicine, exercise/yoga, and diet and dietary supplements. More research on gender differences in ADHD could decrease the misdiagnosis of women who have ADHD and offer more treatment options once a diagnosis is made.
ContributorsMarch, Christina (Author) / Arce, Alma (Thesis director) / Hoffner, Kristin (Committee member) / O'Keefe, Kelly (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor)
Created2023-12
Description
Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about in modern forms of media. Finally, we apply the research to college students. At the end of the paper, you will find a brochure we made specifically for the college student struggling with anxiety or depression.
ContributorsCristante, Lilia (Author) / Ritter, Hailey (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
Description
Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about in modern forms of media. Finally, we apply the research to college students. At the end of the paper, you will find a brochure we made specifically for the college student struggling with anxiety or depression.
ContributorsRitter, Hailey (Author) / Cristante, Lilia (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor)
Created2022-05
Description
Exercise is widely recognized for its myriad of health benefits, particularly in the realm of chronic disease prevention and treatment. Despite this knowledge, exercise remains significantly underutilized in the United States, with only a quarter of the population meeting the recommended physical activity guidelines set by the Department of Health and Human Services (Piercy et al., 2018). Recent research has spotlighted specific regions known as Blue Zones, where natural movement is incorporated into daily lives and populations are characterized by increased longevity and improved health outcomes, including lower rates of chronic diseases.
This study aimed to explore and compare exercise behaviors between the United States and the Ikaria Blue Zone in Greece, investigating their potential implications for a longer lifespan and enhanced health. Employing ethnographic methods, including immersive observation, semi-structured, qualitative interviews with locals, and the distribution of validated International Physical Activity Questionnaire (IPAQ) surveys, comprehensive data on exercise habits within the Ikarian population was collected in November 2023.
The findings from this study shed light on alternative forms of physical activity that have proven successful in populations with increased longevity. By identifying and understanding these practices, there is an opportunity to implement them in the United States, potentially contributing to improved exercise adherence and the prevention and treatment of chronic diseases. This research underscores the significance of cross-cultural insights in developing effective strategies to promote healthier lifestyles and enhance overall well-being.
ContributorsUnderhill, Jackson (Author) / Hrncir, Shawn (Thesis director) / Siegler, Jason (Committee member) / Barth, Christina (Committee member) / Barrett, The Honors College (Contributor) / School of Life Sciences (Contributor) / College of Health Solutions (Contributor)
Created2024-05
Description
Multiple sclerosis is currently deemed the most common autoimmune disease. By definition, multiple sclerosis, known more commonly as MS, involves an immune-mediated process in which an abnormal response of the body’s immune system is directed against the central nervous system (“Definition of MS,” n.d.). Common treatment protocols call for daily, monthly, or yearly disease-modifying medications. These drugs are taken indefinitely to stop the spread and appearance of new lesions, improve symptoms, and offer relief to the afflicted individuals. The necessity for patients to take these basic medical treatments is paramount, however, it should not be overlooked to make lifestyle changes as well. The purpose of this paper is to give a detailed understanding of multiple sclerosis, its etiology evolution, and medical advancements, while emphasizing the necessary transitions which must be made from a nutritional and lifestyle management standpoint. A brief focus will be placed on sleep, exercise, and stress management, with an emphasis on nutrition.
ContributorsDeets, Breanna L (Author) / Levinson, Simin (Thesis director) / Grant, Shauna (Committee member) / Department of Management and Entrepreneurship (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The purpose of this project is to present research within three main categories of treatment and care such as exercise, socialization and alternative therapies (art, pet, and reminiscent therapies) for Alzheimer’s Disease (AD). These categories will be examined in the following countries: United Kingdom, United States, Brazil, and China. Then, the synthesized material will be analyzed and placed into a comparison and contrast model showcasing what each country is currently using and the success of the particular resource within a heat map. According to the research found on the following categories of exercise, socialization and alternative therapies, I will conclude that a combination of aerobic and resistance training, routine support groups and art/pet therapies are the most effective treatment options against Alzheimer’s Disease.
ContributorsLew, Arianna Freedom (Author) / Lupone, Kathleen (Thesis director) / Holzapfel, Simon (Committee member) / School of Life Sciences (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05