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- All Subjects: Mental Health
- All Subjects: Organic Chemistry
- Creators: School of Molecular Sciences
- Resource Type: Text
Chapter 1 covers the research under Dr. Levitus. Four oligonucleotides were reacted for zero, five, and thirty minutes with uracil-DNA glycosylase and subsequent addition of piperidine. These oligonucleotides were chosen based on their torsional rigidities as predicted by past research and predictions. The objective was to better understand the relationship between the sequence of DNA surrounding the incorrect base and the enzyme’s ability to remove said base in order to prepare the DNA for the next step of the base excision repair pathway. The first pair of oligonucleotides showed no statistically significant difference in enzymatic efficiency with p values of 0.24 and 0.42, while the second pair had a p value of 0.01 at the five-minute reaction. The second pair is currently being researched at different reaction times to determine at what point the enzyme seems to equilibrate and react semi-equally with all sequences of DNA.
Chapter 2 covers the research conducted under Dr. Chaput. Along the TNA synthesis pathway, the nitrogenous base must be added to the threofuranose sugar. The objective was to optimize the original protocol of Vorbrüggen glycosylation and determine if there were better conditions for the synthesis of the preferred regioisomer. This research showed that toluene and ortho-xylene were more preferable as solvents than the original anhydrous acetonitrile, as the amount of preferred isomer product far outweighed the amount of side product formed, as well as improving total yield overall. The anhydrous acetonitrile reaction had a final yield of 60.61% while the ortho-xylene system had a final yield of 94.66%, an increase of approximately 32%. The crude ratio of preferred isomer to side product was also improved, as it went from 18% undesired in anhydrous acetonitrile to 4% undesired in ortho-xylene, both values normalized to the preferred regioisomer.
Majority of the CA young adults have perceived racial/ethnic discrimination in the community. Furthermore, perceived discrimination has been positively associated with their depressive and somatic symptoms, suggesting a need to address racial/ethnic discrimination issues to promote positive mental health in this population. It is important for school/work personnel and healthcare providers to assess CA young adults’ discrimination experiences, and have the sufficient resources (e.g., education, support groups) to prevent negative consequences associated with discrimination.
My research aims to determine the effectiveness of meditation and sleep applications (apps) on the reduction of anxiety and stress in college students, with a focus on sedative piano music. Results showed a significant reduction of stress and anxiety levels in college students when listening to sedative piano music versus non-sedative piano music. Music along with other therapy modalities in meditation and sleep apps show promise in reducing students’ anxiety and stress and promoting their successes.
U.S. border colonias, otherwise known as Disadvantaged Unincorporated Communities, are rural settlements along the U.S. Mexico border with substandard housing conditions. Colonia residents often face inadequate access to necessities such as appropriate shelter, septic and sewer systems, and potable water. Water insecurity in colonias poses a particularly difficult challenge for residents who require clean water not only for consumption, but also household use in sanitation and hygienic practices. As of 2015, an estimated 30% of over five million US colonia residents lack access to clean drinking water, resulting in health complications and unsanitary living conditions. Preliminary health data collected indicates that due to water insecurity, colonia residents are more likely to contract gastrointestinal disease, be exposed to carcinogenic compounds from contaminated water, and experience psychosocial distress. Yet more comprehensive research needs to be conducted to understand the full breadth of the public health issue. A scoping review on water insecurity in colonias has not been completed before and could be beneficial in informing policymakers and other stakeholders on the severity of the situation while advising possible solutions.
This study examined the differences in mental and behavioral treatment outcomes between use of Telehealth and in-person appointments in effort to mitigate discrepancies that may lessen treatment efficacy.
This research aimed to examine college students’ perceived racial discrimination, mental health, and differences of these variables by US citizenship to promote healthier mental health practices within Asian college students. Mental disorders are a leading cause of suicidal ideation, which is the fourth leading cause of death among teenagers and young adults, becoming a global phenomenon. The rate of mental health problems, including anxiety and depression, have steadily increased in a decade, with higher rates among racial and ethnic minorities. More than half of adults with serious mental illnesses haven't received treatments, with minorities being more likely to delay or fail seeking mental health treatments due to cultural and structural barriers such as cultural stigma, racial discrimination, acculturation, and language, making it more difficult to address the inaccessibility to high mental health care services, especially for Asians. The findings of this study suggest that, compared to international students, domestic students have greater mental health service seeking intention, received worse racial discrimination (subject to slurs and suspiciousness) and worse mental health since Covid-19, and determined language concordance between patient and healthcare provider is important. International students have more negative beliefs towards the difficulties of treatment and care of mental illnesses and determined ethnicity concordance between patient and healthcare provider is important. The findings provide preliminary insight to acknowledge the differences between domestic and international students in their perceived racial discrimination and mental health. Furthermore, based on findings the issue can be addressed by implementing a mixed-method approach on collecting disaggregated data among this population, removing language and stigmatic barriers to mental health services by education, and promoting cultural competency among mental health workers.