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Though schizophrenia was categorized as a mental illness over 100 years ago, there is a plethora of knowledge that continues to perplex the scientific and medical community alike. This tragic mental disorder affects approximately 1% of the general population, and many of these individuals are homeless if left untreated. Each

Though schizophrenia was categorized as a mental illness over 100 years ago, there is a plethora of knowledge that continues to perplex the scientific and medical community alike. This tragic mental disorder affects approximately 1% of the general population, and many of these individuals are homeless if left untreated. Each schizophrenia patient has a different set of symptoms, so all of these patients experience a variety of positive and negative symptoms. Negative symptoms are called so as they are in absence, and some examples include apathy, anhedonia, lack of motivation, reduced social drive, and reduced cognitive functioning. Positive behavior, on the other hand, is a change in behavior or thoughts such as visual or auditory hallucinations, delusions, confused thoughts, disorganized speech, and trouble concentrating. Because schizophrenia patients do not share the exact same set of symptoms, research in schizophrenia requires a tremendous amount of medical resources. Over the last few years, new studies have started in the field of schizophrenia involving proteomics, or the study of proteins and their function. This new frontier gives doctors and scientists alike a new opportunity to improve the quality of life of schizophrenia patients by providing a potential method through which patients would receive individualized treatment based on their specific symptoms.

ContributorsPeterson, Rozabel (Author) / Brian, Jennifer (Thesis director) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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My research aims to determine the effectiveness of meditation and sleep applications (apps) on the reduction of anxiety and stress in college students, with a focus on sedative piano music. Results showed a significant reduction of stress and anxiety levels in college students when listening to sedative piano music versus

My research aims to determine the effectiveness of meditation and sleep applications (apps) on the reduction of anxiety and stress in college students, with a focus on sedative piano music. Results showed a significant reduction of stress and anxiety levels in college students when listening to sedative piano music versus non-sedative piano music. Music along with other therapy modalities in meditation and sleep apps show promise in reducing students’ anxiety and stress and promoting their successes.

ContributorsPantha, Bidur (Author) / Brian, Jennifer (Thesis director) / Patten, Kristopher (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about

Health and Wealthness is a podcast where your hosts, Emily Weigel and Hanaa Khan discuss pressing and trending topics about health and wealth that everyone should know about. Our first four episodes focus on the opioid crisis. Both the science and healthcare sides. We then go on to talk about burnout and mental health in a conversational episode.

ContributorsKhan, Hanaa S (Co-author) / Weigel, Emily (Co-author) / Olive, Foster (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

U.S. border colonias, otherwise known as Disadvantaged Unincorporated Communities, are rural settlements along the U.S. Mexico border with substandard housing conditions. Colonia residents often face inadequate access to necessities such as appropriate shelter, septic and sewer systems, and potable water. Water insecurity in colonias poses a particularly difficult challenge for

U.S. border colonias, otherwise known as Disadvantaged Unincorporated Communities, are rural settlements along the U.S. Mexico border with substandard housing conditions. Colonia residents often face inadequate access to necessities such as appropriate shelter, septic and sewer systems, and potable water. Water insecurity in colonias poses a particularly difficult challenge for residents who require clean water not only for consumption, but also household use in sanitation and hygienic practices. As of 2015, an estimated 30% of over five million US colonia residents lack access to clean drinking water, resulting in health complications and unsanitary living conditions. Preliminary health data collected indicates that due to water insecurity, colonia residents are more likely to contract gastrointestinal disease, be exposed to carcinogenic compounds from contaminated water, and experience psychosocial distress. Yet more comprehensive research needs to be conducted to understand the full breadth of the public health issue. A scoping review on water insecurity in colonias has not been completed before and could be beneficial in informing policymakers and other stakeholders on the severity of the situation while advising possible solutions.

ContributorsZheng, Madeleine (Author) / Wutich, Amber (Thesis director) / Brewis, Alexandra (Committee member) / Kavouras, Stavros (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of International Letters and Cultures (Contributor)
Created2021-12
Description

This study examined the differences in mental and behavioral treatment outcomes between use of Telehealth and in-person appointments in effort to mitigate discrepancies that may lessen treatment efficacy.

ContributorsStreiff, Abigail (Author) / Chia-Chen Chen, Angela (Thesis director) / Guthery, Ann (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-05
Description

This research aimed to examine college students’ perceived racial discrimination, mental health, and differences of these variables by US citizenship to promote healthier mental health practices within Asian college students. Mental disorders are a leading cause of suicidal ideation, which is the fourth leading cause of death among teenagers and

This research aimed to examine college students’ perceived racial discrimination, mental health, and differences of these variables by US citizenship to promote healthier mental health practices within Asian college students. Mental disorders are a leading cause of suicidal ideation, which is the fourth leading cause of death among teenagers and young adults, becoming a global phenomenon. The rate of mental health problems, including anxiety and depression, have steadily increased in a decade, with higher rates among racial and ethnic minorities. More than half of adults with serious mental illnesses haven't received treatments, with minorities being more likely to delay or fail seeking mental health treatments due to cultural and structural barriers such as cultural stigma, racial discrimination, acculturation, and language, making it more difficult to address the inaccessibility to high mental health care services, especially for Asians. The findings of this study suggest that, compared to international students, domestic students have greater mental health service seeking intention, received worse racial discrimination (subject to slurs and suspiciousness) and worse mental health since Covid-19, and determined language concordance between patient and healthcare provider is important. International students have more negative beliefs towards the difficulties of treatment and care of mental illnesses and determined ethnicity concordance between patient and healthcare provider is important. The findings provide preliminary insight to acknowledge the differences between domestic and international students in their perceived racial discrimination and mental health. Furthermore, based on findings the issue can be addressed by implementing a mixed-method approach on collecting disaggregated data among this population, removing language and stigmatic barriers to mental health services by education, and promoting cultural competency among mental health workers.

ContributorsNguyen, Evie (Author) / Chen, Angela (Thesis director) / Han, SeungYong (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2023-05
Description
Cyclodextrins are known for their pharmaceutical applications in a range of pathologies. Beta(ꞵ)-cyclodextrins have been suggested to be effective scaffolds that can ligate to peptides when chemically modified, which has the potential to be cost-effective in comparison to other available treatments for antiviral therapeutics. It is hypothesized that a

Cyclodextrins are known for their pharmaceutical applications in a range of pathologies. Beta(ꞵ)-cyclodextrins have been suggested to be effective scaffolds that can ligate to peptides when chemically modified, which has the potential to be cost-effective in comparison to other available treatments for antiviral therapeutics. It is hypothesized that a ꞵ-cyclodextrin platform can be modified through a few-step reaction process to develop a ꞵ-cyclodextrin-DBCO-GFP nanobody. The findings of this few-step reaction support the general approach of conjugating the ꞵ-cyclodextrin derivative to GPF nanobody for developing a cyclodextrin antiviral scaffold.
ContributorsTaniguchi, Tohma (Author) / Hariadi, Rizal (Thesis director) / Stephanopoulos, Nicholas (Committee member) / Sasmal, Ranjan (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2023-05
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Description

Sulfur oxidation is a process that is seen a wide variety of places. One particular place is Yellowstone national park where an abundance of hot springs are present. These acidic and hot places are prime locations for sulfur oxidation to occur. At a very basic level this is thought of

Sulfur oxidation is a process that is seen a wide variety of places. One particular place is Yellowstone national park where an abundance of hot springs are present. These acidic and hot places are prime locations for sulfur oxidation to occur. At a very basic level this is thought of as Sulfur, oxygen, and water forming sulfate and hydrogen. Many other reactions occur when an organism performs these processes, and many enzymes are used for this. This paper aimed to create, balance, and analyze the reactions involved in the paper Sulfur Oxidation in the Acidophilic Autotrophic Acidithiobacillus spp. (Wang et al., 2019) Once these reactions were balanced thermodynamic properties were found to evaluate the Gibbs Free Energy of these reactions. This allowed for a unique energy-based view of how this web of reactions relate to each other.

ContributorsMolina, Johnathan (Author) / Shock, Everett (Thesis director) / Weeks, Katelyn (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor)
Created2021-12
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Description
Enzyme Replacement Therapy (ERT) is a treatment often used for patients with disorders that affect the production of various enzymes within the body, such as Cystic Fibrosis and Fabry Disease. ERT involves the use of artificially-produced enzymes, which can be derived from humans, pigs, and bacteria. Generally, enzymes derived from

Enzyme Replacement Therapy (ERT) is a treatment often used for patients with disorders that affect the production of various enzymes within the body, such as Cystic Fibrosis and Fabry Disease. ERT involves the use of artificially-produced enzymes, which can be derived from humans, pigs, and bacteria. Generally, enzymes derived from porcine and bacterial sources are much less expensive and more accessible than those derived from a human source. This, and the ethical implications that porcine enzymes carry, make the decision of choosing treatment simple to some and complex to others. Ethically, human-derived enzymes are often considered more ethical, while not conflicting with religious beliefs and practices as porcine-derived enzymes do.
In order to further compare porcine and human-derived enzymes, a determination of the enzyme effectiveness was done via digestion simulation. The digestion for both the human and porcine-derived enzymes consisted of three steps: oral, gastric, and intestinal. After the digestion, the absorbance for each enzyme class as well as a dilution curve of the formula used was read and recorded. Using the standard dilution curve and the absorbance values for each unknown, the formula and thus enzyme concentration that was lost through the reaction was able to be calculated.
The effectiveness of both the human and porcine enzymes, determined by the percent of formula lost, was 18.2% and 19.7%, respectively, with an error of 0.6% from the spectrophotometer, and an error of about 10% from the scale used for measuring the enzymes. This error was likely due to the small mass required of the enzymes and can be prevented in the future by performing the experiment at a larger scale.
ContributorsBlevins, Brianna R (Author) / Martin, Thomas (Thesis director) / McILwraith, Heide (Committee member) / College of Integrative Sciences and Arts (Contributor) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Description
Tempe Town Lake is the site of fifteen years’ worth of chemical data collection by ASU researchers. In 2018 the dataSONDE, an instrument capable of measuring different water quality parameters every thirty minutes for a month at a time was installed in the lake. The SONDE has the potential to

Tempe Town Lake is the site of fifteen years’ worth of chemical data collection by ASU researchers. In 2018 the dataSONDE, an instrument capable of measuring different water quality parameters every thirty minutes for a month at a time was installed in the lake. The SONDE has the potential to completely reduce the need for sampling by hand. Before the SONDE becomes the sole means of gathering data, it is important to verify its accuracy. In this study, the measurements gathered by the SONDE (pH, dissolved oxygen, temperature, conductivity and colored dissolved organic matter) were compared to measurements gathered using the verified methods from the past fifteen years.
ContributorsSauer, Elinor Rayne (Author) / Hartnett, Hilairy (Thesis director) / Glaser, Donald (Committee member) / Shock, Everett (Committee member) / Historical, Philosophical & Religious Studies (Contributor) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / School of Sustainability (Contributor) / Barrett, The Honors College (Contributor)
Created2020-12