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The tendency for psychopathology to aggregate within families is well-documented, though little is known regarding the level of specificity at which familial transmission of symptomology occurs. The current study first tested competing higher-order structures of psychopathology in adolescence, indexing general and more specific latent factors. Second, parent-offspring transmission was tested

The tendency for psychopathology to aggregate within families is well-documented, though little is known regarding the level of specificity at which familial transmission of symptomology occurs. The current study first tested competing higher-order structures of psychopathology in adolescence, indexing general and more specific latent factors. Second, parent-offspring transmission was tested for broadband domain specificity versus transmission of a general liability for psychopathology. Lastly, genetic and environmental mechanisms underlying the familial aggregation of psychopathology were examined using nuclear twin-family models. The sample was comprised of five hundred adolescent twin pairs (mean age 13.24 years) and their parents drawn from the Wisconsin Twin Project. Twins and parents completed independent diagnostic interviews. For aim 1, correlated factors, bifactor, and general-factor models were tested using adolescent symptom count data. For aim 2, structural equation modeling was used to determine whether broadband domain-specific transmission effects were necessary to capture parent-offspring resemblance in psychopathology above and beyond a general transmission effect indexed by the latent correlation between a parental internalizing factor and offspring P-factor. For aim 3, general factor models were fitted in both generations, and factor scores were subsequently extracted and used in nuclear twin-family model testing. Results indicated that the bifactor model exhibited the best fit to the adolescent data. Familial aggregation of psychopathology was sufficiently accounted for by the transmission of a general liability. Lastly, the best fitting reduced nuclear twin-family model indicated that additive genetic, sibling-specific shared environmental, and nonshared environmental influences contributed to general psychopathology. Parent-offspring transmission was accounted for by shared genetics only, whereas co-twin aggregation was additionally explained by sibling-specific shared environmental factors. Results provide novel insight into the specificity and etiology of the familial aggregation of psychopathology.
ContributorsOro, Veronica (Author) / Lemery-Chalfant, Kathryn (Thesis advisor) / Chassin, Laurie (Committee member) / Doane, Leah D (Committee member) / Arizona State University (Publisher)
Created2019
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Description
ADHD is a childhood neurobehavioral disorder characterized by inordinate levels of hyperactivity, inattention and impulsivity. The inability to withhold a reinforced response, or response inhibition capacity (RIC), is one aspect of impulsivity associated with ADHD. The first goal of this dissertation was to evaluate the fixed minimum interval (FMI) schedule

ADHD is a childhood neurobehavioral disorder characterized by inordinate levels of hyperactivity, inattention and impulsivity. The inability to withhold a reinforced response, or response inhibition capacity (RIC), is one aspect of impulsivity associated with ADHD. The first goal of this dissertation was to evaluate the fixed minimum interval (FMI) schedule as a method for assessing RIC. Chapter 2 showed that latencies were substantially more sensitive than FMI-derived estimates of RIC to the effects of pre-feeding and changes in rate and magnitude of reinforcement. Chapter 3 examined the ability of the FMI to discriminate between spontaneously hypertensive rats (SHR), an animal model of ADHD, and Wistar Kyoto (WKY) controls. Results from Chapter 3 showed that RIC was not substantially different between SHR and WKY rats. However, latencies were significantly shorter for SHRs than for WKYs suggesting incentive motivation differed between strains. The second goal of this dissertation was to examine the sensitivity of the SHR to nicotine. ADHD is a risk factor for tobacco dependence. The goal of Chapters 4 and 5 was to determine whether the SHR provided a model of ADHD-related tobacco sensitivity. Chapter 4 examined nicotine's locomotor and rewarding effects in adolescent SHRs using the conditioned place preference (CPP) procedure. SHRs developed CPP to the highest nicotine dose tested and were sensitive to nicotine's locomotor-enhancing properties. WKY controls did not develop CPP to any nicotine dose tested and were not sensitive to nicotine's locomotor properties. However, it is likely that nicotine effects were obscured by a pseudo-conditioning to saline in WKYs. Chapter 5 demonstrated that SHRs were more active than WKYs in the open-field but not in the Rotorat apparatus. Results also showed that SHRs and WKYs were both sensitive to nicotine's locomotor sensitizing effects. However, WKYs were more sensitive than SHRs to nicotine's locomotor suppressing effects. Collectively, results from Chapters 4 and 5 show that SHRs are sensitive to the rewarding and locomotor-enhancing properties of nicotine. However, more research is necessary to confirm that SHRs are a suitable model for studying ADHD-related tobacco use.
ContributorsWatterson, Elizabeth (Author) / Sanabria, Federico (Thesis advisor) / Olive, Foster (Thesis advisor) / Chassin, Laurie (Committee member) / Neisewander, Janet (Committee member) / Arizona State University (Publisher)
Created2015
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Description

Trauma is increasingly experienced by people in transit as border militarization increases migrants’ exposure to violence and forces them into more precarious situations. For queer migrants, this includes situations where they are more likely to experience persecution and sexual violence. This paper explores the availability of care for queer

Trauma is increasingly experienced by people in transit as border militarization increases migrants’ exposure to violence and forces them into more precarious situations. For queer migrants, this includes situations where they are more likely to experience persecution and sexual violence. This paper explores the availability of care for queer undocumented migrants in the United States after surviving a precarious and potentially deadly journey from their country of origin to the US, as well as forms of alternative care developed by the undocuqueer community. In particular, it focuses on access to care for LGBT migrants, who face stigmatization on multiple levels and as a result are more likely than their straight counterparts to experience extreme mental health consequences pre-, in-, and post-transit. Faced with a number of obstacles that prevent them from receiving appropriate mental health care, the undocuqueer community utilizes various strategies to ensure that the health and needs of the community are supported. I argue that in spite of facing traumatic experiences and being unable to fully access healthcare to alleviate these problems in the US, LGBT migrants demonstrate extreme resilience and resist the mechanisms that otherwise threaten their mental well-being.

ContributorsCordwell, Cailan Rose (Author) / Wheatley, Abby C. (Thesis director) / Ward, Mako Fitts (Committee member) / School of Human Evolution & Social Change (Contributor) / Department of Psychology (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Description

Adolescence is an important period of scaffolding for educational attainment, which is among the strongest predictors of outcomes in multiple domains. Parents who encourage academic success and promote self-regulation may enhance their offspring’s educational attainment. However, parents with externalizing disorders present a complex constellation of risk factors, including low educational

Adolescence is an important period of scaffolding for educational attainment, which is among the strongest predictors of outcomes in multiple domains. Parents who encourage academic success and promote self-regulation may enhance their offspring’s educational attainment. However, parents with externalizing disorders present a complex constellation of risk factors, including low educational attainment and poor parenting, and are more likely to have children with high levels of disinhibition. Previous research has identified low parental education, poor parenting and adolescent impulsivity as threats to educational attainment, but has not examined risk factors for discrepancies in educational attainment among siblings of the same family. Furthermore, studies have not examined the between- and within-family mechanisms that may explain why adolescents with externalizing parents have low educational attainment. The current study addressed these gaps by testing between- and within-family predictors of educational attainment using data from a longitudinal, multigenerational study that oversampled families at risk for alcohol use disorder. The sample consisted of 555 biological siblings within 240 families. We tested whether parental externalizing predicted lower educational attainment through parents’ own lower education, parents’ differential treatment of offspring, and impulsivity. Results suggested that between families, parents with externalizing disorders had lower educational attainment and more impulsive offspring, but did not exhibit increased differential parenting. Within families, siblings with greater impulsivity had lower educational attainment, whereas receiving more preferential maternal treatment than one’s siblings predicted higher educational attainment. Low parental educational attainment mediated the relation between parental externalizing disorders and low offspring educational attainment.

ContributorsPaxton, Lauren (Author) / Chassin, Laurie (Thesis director) / Corbin, William (Committee member) / Blake, Austin (Committee member) / Edwards, Michael (Committee member) / Barrett, The Honors College (Contributor) / School of Social Transformation (Contributor) / Department of Psychology (Contributor) / Economics Program in CLAS (Contributor)
Created2021-12
Description

Suicide is a significant public health problem, with incidence rates and lethality continuing to increase yearly. Given the large human and financial cost of suicide worldwide alongside the lack of progress in suicide prediction, more research is needed to inform suicide prevention and intervention efforts. This study approaches suicide from

Suicide is a significant public health problem, with incidence rates and lethality continuing to increase yearly. Given the large human and financial cost of suicide worldwide alongside the lack of progress in suicide prediction, more research is needed to inform suicide prevention and intervention efforts. This study approaches suicide from the lens of suicide note-leaving behavior, which can provide important information on predictors of suicide. Specifically, this study adds to the existing literature on note-leaving by examining history of suicidality, mental health problems, and their interaction in predicting suicide note-leaving, in addition to demographic predictors of note-leaving examined in previous research using data from the National Violent Death Reporting System (NVDRS, n = 98,515). We fit a logistic regression model predicting leaving a suicide note or not, the results of which indicated that those with mental health problems or a history of suicidality were more likely to leave a suicide note than those without such histories, and those with both mental health problems and a history of suicidality were most likely to leave a suicide note. These findings reinforce the need to tailor suicide prevention efforts toward identifying and targeting higher risk populations.

ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2022-05
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ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
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ContributorsCarnesi, Gregory (Author) / O'Rourke, Holly (Thesis director) / Brewer, Gene (Committee member) / Corbin, William (Committee member) / Chassin, Laurie (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
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Description

Accidents have been the leading cause of death in the United States military for the past two decades. The purpose of this research paper is to analyze the main causes of accidental deaths in the U.S. military, what has been done in an effort to stop these from occurring, and

Accidents have been the leading cause of death in the United States military for the past two decades. The purpose of this research paper is to analyze the main causes of accidental deaths in the U.S. military, what has been done in an effort to stop these from occurring, and any underlying factors that may have led to these preventable deaths. The information for this research paper was obtained via scientific articles, literature reviews, and government hearings. The results show that the majority of accidental deaths are due to factors such as inefficient training, neglected equipment, and lack of mental health. In conclusion, the U.S. military needs to invest more of its resources into promoting soldier health and safety.

ContributorsEsposito, Stephen (Author) / Niebuhr, Robert (Thesis director) / Cortese, Denis (Committee member) / School of Human Evolution & Social Change (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description

This study examined the differences in mental and behavioral treatment outcomes between use of Telehealth and in-person appointments in effort to mitigate discrepancies that may lessen treatment efficacy.

ContributorsStreiff, Abigail (Author) / Chia-Chen Chen, Angela (Thesis director) / Guthery, Ann (Committee member) / Barrett, The Honors College (Contributor) / School of Molecular Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-05
Description

Indian-American young adults are often caught between the cultures of their parents and their environment, and these two cultures can impact their views based on the cultures' views. In this project, I created an overview of personal accounts of Indian-American young adults on their experiences with mental health struggles, and

Indian-American young adults are often caught between the cultures of their parents and their environment, and these two cultures can impact their views based on the cultures' views. In this project, I created an overview of personal accounts of Indian-American young adults on their experiences with mental health struggles, and receiving counseling and treatment. This study analyzed a sample of accounts and testimonials previously collected through a qualitative review. I found that many of the Indian-American young adults were open to mental health counseling and treatment, but saw Indian cultural views as a barrier.

ContributorsMalladi, Dhanya (Author) / Jimenez Arista, Laura (Thesis director) / Prasad, Indulata (Committee member) / Barrett, The Honors College (Contributor) / School of International Letters and Cultures (Contributor) / School of Life Sciences (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-05