Matching Items (115)
Description
Described is a study investigating the feasibility and predictive value of the Teacher Feedback Coding System, a novel observational measure of teachers’ feedback provided to students in third grade classrooms. This measure assessed individual feedback events across three domains: feedback type, level of specificity and affect of the teacher. Exploratory and confirmatory factor analysis revealed five factors indicating separate types of feedback: positive and negative academic-informative feedback, positive and negative behavioral-informative feedback, and an overall factor representing supportive feedback. Multilevel models revealed direct relations between teachers’ negative academic-informative feedback and students’ spring math achievement, as well as between teachers’ negative behavioral-informative feedback and students’ behavior patterns. Additionally, a fall math-by-feedback interaction was detected in the case of teachers’ positive academic-informative feedback; students who began the year struggling in math benefitted from more of this type of feedback. Finally, teachers’ feedback was investigated as a potential mediator in a previously established relation between teachers’ self-reported depressive symptoms and the observed quality of the classroom environment. Partial mediation was detected in the case of teachers’ positive academic-informative feedback, such that this type of feedback was accountable for a portion of the variance observed in the relation between teachers’ depressive symptoms and the quality of the classroom environment.
ContributorsMcLean, Leigh Ellen (Author) / Connor, Carol M. (Thesis advisor) / Lemery, Kathryn (Committee member) / Doane, Leah (Committee member) / Grimm, Kevin (Committee member) / Arizona State University (Publisher)
Created2015
Description
Anxiety and depression are among the most prevalent disorders in youth, with prevalence rates ranging from 15% to 25% for anxiety and 5% to 14% for depression. Anxiety and depressive disorders cause significant impairment, fail to spontaneously remit, and have been prospectively linked to problematic substance use and legal problems in adulthood. These disorders often share a high-degree of comorbidity in both clinical and community samples, with anxiety disorders typically preceding the onset of depression. Given the nature and consequences of anxiety and depressive disorders, a plethora of treatment and preventative interventions have been developed and tested with data showing significant pre to post to follow-up reductions in anxiety and depressive symptoms. However, little is known about the mediators by which these interventions achieve their effects. To address this gap in the literature, the present thesis study combined meta-analytic methods and path analysis to evaluate the effects of youth anxiety and depression interventions on outcomes and four theory-driven mediators using data from 55 randomized controlled trials (N = 11,413). The mediators included: (1) information-processing biases, (2) coping strategies, (3) social competence, and (4) physiological hyperarousal. Meta-analytic results showed that treatment and preventative interventions reliably produced moderate effect sizes on outcomes and three of the four mediators (information-processing biases, coping strategies, social competence). Most importantly, findings from the path analysis showed that changes in information-processing biases and coping strategies consistently mediated changes in outcomes for anxiety and depression at both levels of intervention, whereas gains in social competence and reductions in physiological hyperarousal did not emerge as significant mediators. Knowledge of the mediators underlying intervention effects is important because they can refine testable models of treatment and prevention efforts and identify which anxiety and depression components need to be packaged or strengthened to maximize intervention effects. Allocating additional resources to significant mediators has the potential to reduce costs associated with adopting and implementing evidence-based interventions and improve dissemination and sustainability in real-world settings, thus setting the stage to be more readily integrated into clinical and non-clinical settings on a large scale.
ContributorsStoll, Ryan (Author) / Pina, Armando A (Thesis advisor) / MacKinnon, David (Committee member) / Knight, George (Committee member) / Arizona State University (Publisher)
Created2015
Description
Despite the strong link between pain and depressive symptoms, the mechanisms by which they are connected in the everyday lives of individuals with chronic pain are not well understood. In addition, previous investigations have tended to ignore biopsychosocial individual difference factors, assuming that all individuals respond to pain-related experiences and affect in the same manner. The present study tried to address these gaps in the existing literature. Two hundred twenty individuals with Fibromyalgia completed daily diaries during the morning, afternoon, and evening for 21 days. Findings were generally consistent with the hypotheses. Multilevel structural equation modeling revealed that morning pain and positive and negative affect are uniquely associated with morning negative pain appraisal, which in turn, is positively related to pain’s activity interference in the afternoon. Pain’s activity interference was the strongest predictor of evening depressive symptoms. Latent profile analysis using biopsychosocial measures identified three theoretically and clinically important subgroups (i.e., Low Functioning, Normative, and High Functioning groups). Although the daily pain-depressive symptoms link was not significantly moderated by these subgroups, individuals in the High Functioning group reported the lowest levels of average morning pain, negative affect, negative pain appraisal, afternoon pain’s activity interference, and evening depressive symptoms, and the highest levels of average morning positive affect across 21 days relative to the other two groups. The Normative group fared better on all measures than did the Low Functioning group. The findings of the present study suggest the importance of promoting morning positive affect and decreasing negative affect in disconnecting the within-day pain-depressive symptoms link, as well as the potential value of tailoring chronic pain interventions to those individuals who are in the greatest need.
ContributorsMun, Chung Jung (Author) / Karoly, Paul (Thesis advisor) / Davis, Mary C. (Thesis advisor) / Suk, Hye Won (Committee member) / Dishion, Thomas J (Committee member) / Arizona State University (Publisher)
Created2017
Description
This study investigated the relation between Sensory Processing Sensitivity (SPS) temperament and depression, and whether such a relation might be further influenced by the indirect effects of parenting environment and empathic personal distress. A moderated mediation model was proposed to explain the underlying relations among SPS, depression, parenting environment and empathic personal distress. That is, greater levels of SPS temperament might predict higher levels of empathic personal distress, which then leads to increasing likelihood of experiencing depression. Moreover, it was predicted that this mediation relation might be significantly stronger under a less positive parenting context. The present study recruited 661 participants from a U.S. university and implemented questionnaires in an online survey. There was a significant main effect of SPS temperament in predicting empathic personal distress and depression, such that the more sensitive individuals reported higher empathic personal distress and depression. There also was a significant main effect of parenting environment on depression, where more positive parenting was associated with less depression. Empathic personal distress was found to partially mediate the relation between SPS and depression. That is, the association between SPS and depression could be partially explained by empathic personal distress. However, parenting environment did not moderate the main effect of SPS temperament on depression, the main effect of SPS on empathic personal distress, or the mediation model.
ContributorsYang, Wenxi (Author) / Miller, Paul A. (Thesis advisor) / Hall, Deborah L. (Committee member) / Roberts, Nicole A. (Committee member) / Arizona State University (Publisher)
Created2019
Description
This study investigated the potential influences of a marital interaction involving affectionate touch and/or positive relationship-focused conversation on physiological reactivity to a subsequent laboratory stress task, and whether depressive symptoms moderated these relations. It was hypothesized that 1) the stress task would cause cardiac sympathetic activation and cardiac parasympathetic withdrawal; and that physical affection and/or positive conversation would 2) reduce sympathetic activation as indicated by cardiac interbeat interval (IBI), cardiac pre-ejection period (PEP), and finger pulse transit time (FPTT) and 3) reduce parasympathetic withdrawal (as indicated by respiratory sinus arrhythmia; RSA) in response to stress. Further, we expected that, compared to those lower in reported depressive symptoms, those higher in depressive symptoms 4) would show blunted cardiovascular activation in response to stress across experimental conditions; and after engaging in a positive marital exchange, 5) would demonstrate a smaller interaction-related reduction in stress-related sympathetic activation; but 6) show no difference in interaction-related reduction of stress-related parasympathetic withdrawal. Participants were 183 married couples who were at least moderately happy in their marriages and in generally good health. Participants completed a measure of depression (among other questionnaires) in an online survey, then attended a 3-hour laboratory session. After measuring baseline physiology with spouses in separate rooms, couples were then randomly assigned to either touch (while sitting quietly, then hug), talk (positive conversation, but no touch), both (touch while talking, then hug), or neither (sit quietly without touching or talking). Next, participants separately performed a stress-inducing speech task about their spouses’ strengths and weaknesses. Physiological indicators were recorded throughout the stress task. While positive conversation reduced husbands’ stress-related parasympathetic withdrawal, it predicted greater stress-related activation in wives’ PEP response. Stress reactivity (as indicated by FPTT) was reduced in husbands with lower depressive symptoms when the marital exchange included only touch or only talk, whereas for husbands with more depressive symptoms, there were no effects of the marital interaction. For wives, depressive symptoms predicted blunted cardiovascular activation regardless of positive interaction condition, as illustrated by smaller stress-related reduction in FPTT responses. Furthermore, higher self-reported depressive symptoms predicted larger interaction-related decreases in stress-related IBI responses in wives who experienced spousal touch. This study builds on previous work and is the first to explore how depressive symptoms may influence the relations between affectionate touch and stress reactivity.
ContributorsDuncan, Cayla Jessica (Author) / Burleson, Mary H (Thesis advisor) / Roberts, Nicole A. (Committee member) / Mickelson, Kristin (Committee member) / Arizona State University (Publisher)
Created2018
Description
Development of effective therapeutic interventions for the treatment of mental health disorders has been a significant driving force in the search to understand the human brain. Current treatments for mental health disorders rely on modulating neurotransmitter systems such as norepinephrine (NE), serotonin (5-HT), dopamine (DA) and γ-aminobutyric acid (GABA) to achieve clinically relevant relief of symptoms. While many medications are available to the clinician that individually target these neural systems, treatment often results in patients reporting unwanted side effects or experiencing incomplete relief. To counter this lack of treatment efficacy, further investigation of other avenues for achieving similar or better outcomes and potentially reach patients refractory to common therapies must be undertaken. One of these potential new target systems is the endogenous cannabinoid system (ECS), which is currently composed of cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). These metabotropic seven transmembrane (7-TM) loop G-protein coupled receptors (GPCR) are responsible for mediating the effects of acute Cannabis ingestion as well as modulating several core functions of the nervous system including emotion, memory, and learning behavior. Due ubiquitous expression of ECS proteins, there is broad overlap between brain regions that show high levels of receptor expression and those thought to be involved in the etiology of a range of mental health disorders including depression, anxiety and schizophrenia. Consequently, modulation of cannabinoid receptor function is a novel and potentially clinically relevant mechanism for influencing the levels of other neuromodulators and neurotransmitters, such as dopamine, that are known to play crucial roles in the progression of mental illness. In addition, characterization of endogenous cannabinoids and cannabinoid receptors with respect to their normal physiological function and possible roles in pathophysiology may provide insight for the development of future ECS-based therapies.
ContributorsStratton, Harrison (Author) / Shafer, Michael (Thesis advisor) / Olive, Micahel F (Thesis advisor) / Wu, Jie (Committee member) / Arizona State University (Publisher)
Created2019
Description
The purpose of this research was to determine if students who are enrolled in a professional flight program exhibit significantly higher rates of depression, stress, and anxiety. This study compared professional flight students to non-professional flight students to determine whether professional flight students have higher rates of depression and anxiety. In addition, this study sought to determine if there were higher depression, anxiety, and stress levels in upperclassmen (juniors and seniors) than in lowerclassmen (freshman and sophomore). Finally, upperclassmen and underclassmen within professional flight programs were compared to test if upperclassmen professional flight students exhibit higher rates for depression, anxiety and stress. These groups were compared to each other by using a survey that measures depression, anxiety, and stress. There were no statistically significant results. No singular group is more or less prone to depression, anxiety, or stress.
ContributorsJacobs, Destry (Author) / Niemczyk, Mary (Thesis advisor) / Cooke, Nancy J. (Thesis advisor) / Nullmeyer, Robert (Committee member) / Cline, Paul (Committee member) / Arizona State University (Publisher)
Created2019
Description
The present series of studies examined whether a novel implementation of an
intermittent restraint (IR) chronic stress paradigm could be used to investigate hippocampal-dependent spatial ability in both sexes. In experiments 1 and 2, Sprague- Dawley male rats were used to identify the optimal IR parameters to assess spatial ability. For IR, rats were restrained for 2 or 6hrs/day (IR2, IR6, respectively) for five days and then given two days off, a process that was repeated for three weeks and compared to rats restrained for 6hrs/d for each day (DR6) and non-stressed controls (CON). Spatial memory was tested on the radial arm water maze (RAWM), object placement (OP), novel object recognition (NOR) and Y-maze. The results for the first two experiments revealed that IR6, but not IR2, was effective in impairing spatial memory in male rats and that task order impacted performance. In experiment 3, an extended IR paradigm for six weeks was implemented before spatial memory testing commenced in male and female rats (IR- M, IR-F). Unexpectedly, an extended IR paradigm failed to impair spatial memory in either males or females, suggesting that when extended, the IR paradigm may have become predictable. In experiment 4, an unpredictable IR (UIR) paradigm was implemented, in which restraint duration (30 or 60-min) combined with orbital shaking, time of day, and the days off from UIR were varied. UIR impaired spatial memory in males, but not females. Together with other reports, these findings support the interpretation that chronic stress negatively impairs hippocampal-dependent function in males, but not females, and that females appear to be resilient to spatial memory deficits in the face of chronic stress.
intermittent restraint (IR) chronic stress paradigm could be used to investigate hippocampal-dependent spatial ability in both sexes. In experiments 1 and 2, Sprague- Dawley male rats were used to identify the optimal IR parameters to assess spatial ability. For IR, rats were restrained for 2 or 6hrs/day (IR2, IR6, respectively) for five days and then given two days off, a process that was repeated for three weeks and compared to rats restrained for 6hrs/d for each day (DR6) and non-stressed controls (CON). Spatial memory was tested on the radial arm water maze (RAWM), object placement (OP), novel object recognition (NOR) and Y-maze. The results for the first two experiments revealed that IR6, but not IR2, was effective in impairing spatial memory in male rats and that task order impacted performance. In experiment 3, an extended IR paradigm for six weeks was implemented before spatial memory testing commenced in male and female rats (IR- M, IR-F). Unexpectedly, an extended IR paradigm failed to impair spatial memory in either males or females, suggesting that when extended, the IR paradigm may have become predictable. In experiment 4, an unpredictable IR (UIR) paradigm was implemented, in which restraint duration (30 or 60-min) combined with orbital shaking, time of day, and the days off from UIR were varied. UIR impaired spatial memory in males, but not females. Together with other reports, these findings support the interpretation that chronic stress negatively impairs hippocampal-dependent function in males, but not females, and that females appear to be resilient to spatial memory deficits in the face of chronic stress.
ContributorsPeay, Dylan (Author) / Conrad, Cheryl D. (Thesis advisor) / Bimonte-Nelson, Heather A. (Committee member) / Wynne, Clive (Committee member) / Arizona State University (Publisher)
Created2019
Description
The current study investigated whether intermittent restraint stress (IRS) would impair fear extinction learning and lead to increased anxiety and depressive- like behaviors and then be attenuated when IRS ends and a post- stress rest period ensues for 6 weeks. Young adult, male Sprague Dawley rats underwent restraint stress using wire mesh (6hr/daily) for five days with two days off before restraint resumed for three weeks for a total of 23 restraint days. The groups consisted of control (CON) with no restraint other than food and water restriction yoked to the restrained groups, stress immediate (STR-IMM), which were restrained then fear conditioned soon after the end of the IRS paradigm, and stress given a rest for 6 weeks before fear conditioning commenced (STR-R6). Rats were fear conditioned by pairing a 20 second tone with a footshock, then given extinction training for two days (15 tone only on each day). On the first day of extinction, all groups discriminated well on the first trial, but then as trials progressed, STR-R6 discriminated between tone and context less than did CON. On the second day of extinction, STR- IMM froze more to context in the earlier trials than compared to STR-R6 and CON. As trials progressed STR-IMM and STR-R6 froze more to context than compared to CON. Together, CON discriminated between tone and context better than did STR-IMM and STR-R6. Sucrose preference, novelty suppressed feeding, and elevated plus maze was performed after fear extinction was completed. No statistical differences were observed among groups for sucrose preference or novelty suppressed feeding. For the elevated plus maze, STR-IMM entered the open arms and the sum of both open and closed arms fewer than did STR- R6 and CON. We interpret the findings to suggest that the stress groups displayed increased hypervigilance and anxiety with STR-R6 exhibiting a unique phenotype than that of STR-IMM and CON.
ContributorsShah, Vrishti Bimal (Author) / Conrad, Cheryl (Thesis director) / Newbern, Jason (Committee member) / Judd, Jessica (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions of selective monoamine transporters in the brain by helping to clear monoamines from the extracellular space; thus, assisting to terminate the monoamine signal. Of particular interest, stress hormones (corticosterone; CORT) inhibit OCT3-mediated transport of monoamine, to putatively lead to prolonged monoamine signaling. It has been demonstrated that stress levels of CORT block OCT3 transport in the rat hypothalamus, an effect that likely underlies the rapid, stress-induced increase in local monoamines. We examined the effect of chronic variable stress (CVS) on the development of mood disorders and OCT3 expression in limbic and hypothalamic regions of the rat brain. Animals subjected to CVS (14-days with random stressor exposure two times/day) showed reduced body weight gain, indicating that CVS was perceived as stressful. However, behavioral tests of anxiety and depressive-like behaviors in rats showed no group differences. Although there were no behavioral effects of stress, molecular analysis revealed that there were stress-related changes in OCT3 protein expression. In situ hybridization data confirmed that OCT3 mRNA is expressed in the hippocampus, amygdala, and hypothalamus. Analysis of Western blot data by two-way ANOVA revealed a significant treatment effect on OCT3 protein levels, with a significant decrease in OCT3 protein in the amygdala and hippocampus in CVS rats, compared to controls. These data suggest an important role for CORT sensitive OCT3 in the reduction of monoamine clearance during stress.
ContributorsBoyll, Piper Savannah (Author) / Orchinik, Miles (Thesis director) / Conrad, Cheryl (Committee member) / Talboom, Joshua (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05