Matching Items (31)
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- All Subjects: Depression
- Creators: Department of Psychology
- Creators: School of Life Sciences
- Resource Type: Text
Description
The current study investigated whether intermittent restraint stress (IRS) would impair fear extinction learning and lead to increased anxiety and depressive- like behaviors and then be attenuated when IRS ends and a post- stress rest period ensues for 6 weeks. Young adult, male Sprague Dawley rats underwent restraint stress using wire mesh (6hr/daily) for five days with two days off before restraint resumed for three weeks for a total of 23 restraint days. The groups consisted of control (CON) with no restraint other than food and water restriction yoked to the restrained groups, stress immediate (STR-IMM), which were restrained then fear conditioned soon after the end of the IRS paradigm, and stress given a rest for 6 weeks before fear conditioning commenced (STR-R6). Rats were fear conditioned by pairing a 20 second tone with a footshock, then given extinction training for two days (15 tone only on each day). On the first day of extinction, all groups discriminated well on the first trial, but then as trials progressed, STR-R6 discriminated between tone and context less than did CON. On the second day of extinction, STR- IMM froze more to context in the earlier trials than compared to STR-R6 and CON. As trials progressed STR-IMM and STR-R6 froze more to context than compared to CON. Together, CON discriminated between tone and context better than did STR-IMM and STR-R6. Sucrose preference, novelty suppressed feeding, and elevated plus maze was performed after fear extinction was completed. No statistical differences were observed among groups for sucrose preference or novelty suppressed feeding. For the elevated plus maze, STR-IMM entered the open arms and the sum of both open and closed arms fewer than did STR- R6 and CON. We interpret the findings to suggest that the stress groups displayed increased hypervigilance and anxiety with STR-R6 exhibiting a unique phenotype than that of STR-IMM and CON.
ContributorsShah, Vrishti Bimal (Author) / Conrad, Cheryl (Thesis director) / Newbern, Jason (Committee member) / Judd, Jessica (Committee member) / School of Life Sciences (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Monoamine neurotransmitters (e.g., serotonin, norepinephrine, and dopamine) are powerful modulators of mood and cognitive function in health and disease. We have been investigating the modulation of monoamine clearance in select brain regions via organic cation transporters (OCTs), a family of nonselective monoamine transporters. OCTs are thought to complement the actions of selective monoamine transporters in the brain by helping to clear monoamines from the extracellular space; thus, assisting to terminate the monoamine signal. Of particular interest, stress hormones (corticosterone; CORT) inhibit OCT3-mediated transport of monoamine, to putatively lead to prolonged monoamine signaling. It has been demonstrated that stress levels of CORT block OCT3 transport in the rat hypothalamus, an effect that likely underlies the rapid, stress-induced increase in local monoamines. We examined the effect of chronic variable stress (CVS) on the development of mood disorders and OCT3 expression in limbic and hypothalamic regions of the rat brain. Animals subjected to CVS (14-days with random stressor exposure two times/day) showed reduced body weight gain, indicating that CVS was perceived as stressful. However, behavioral tests of anxiety and depressive-like behaviors in rats showed no group differences. Although there were no behavioral effects of stress, molecular analysis revealed that there were stress-related changes in OCT3 protein expression. In situ hybridization data confirmed that OCT3 mRNA is expressed in the hippocampus, amygdala, and hypothalamus. Analysis of Western blot data by two-way ANOVA revealed a significant treatment effect on OCT3 protein levels, with a significant decrease in OCT3 protein in the amygdala and hippocampus in CVS rats, compared to controls. These data suggest an important role for CORT sensitive OCT3 in the reduction of monoamine clearance during stress.
ContributorsBoyll, Piper Savannah (Author) / Orchinik, Miles (Thesis director) / Conrad, Cheryl (Committee member) / Talboom, Joshua (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
The purpose of the study was to examine the effectiveness of two modes of exercise on depression in adolescents with Down syndrome (DS). Twelve participants randomly completed one of two exercise interventions. The interventions were: 1) Voluntary Cycling (VC), in which participants cycled at their self-selected pedaling rate 2) Assisted Cycling (AC), in which the participants' voluntary pedaling rates were augmented with a motor to ensure the maintenance of 80 rpms. In each intervention, the participant completed three cycling sessions each week for a total of eight weeks. Depression scores did decrease or improved after both AC and VC, but not significantly. There was a greater mean improvement for participants in the AC group than VC when analyzing total score and t-score. Future research will include a greater sample size and control group to reach significant results as well as try and reveal the mechanisms involved in these mental health improvements found after an acute bout of assisted cycling in adolescents with DS.
ContributorsTeslevich, Jennifer Lynn (Author) / Ringenbach, Shannon (Thesis director) / Kulinna, Pamela (Committee member) / Barrett, The Honors College (Contributor) / School of Nutrition and Health Promotion (Contributor) / Department of Psychology (Contributor)
Created2013-12
Description
Purpose: The purpose of this study was to determine the efficacy of a yoga intervention for adolescents suffering from depression. Secondary results regarding the viability of yoga as an intervention for increasing self-esteem and decreasing anxiety were also explored.
Methods: Using PubMed, Medline, and CINAHL the search terms adolescents, depression, and yoga were searched for related articles. Articles were then excluded or included based on certain criteria. Focus was placed on articles written within the last 10 years as well as studies done on children within 10-19 years of age. Final articles underwent extraction for relevant information and comparisons were drawn between the studies.
Results: Final exclusion lead to a total of 5 suitable studies. Studies varied in styles of yoga performed and measurement scales used to assess depression. Populations of adolescents varied significantly as well. The majority of these studies showed significant improvement in depression symptoms when measuring from pre to post intervention. Similar improvements were also noted in anxiety symptoms and low self-esteem.
Conclusion: Data gathered indicated that yoga serves a suitable intervention for decreasing depression symptoms in adolescents. Additionally, there seems to be promising results regarding the viability of yoga as an intervention for decreasing symptoms of anxiety and increasing self-esteem. Despite, current promising results, there is need for more research to affirm the findings found in these articles to determine the long term effects of yoga interventions.
Methods: Using PubMed, Medline, and CINAHL the search terms adolescents, depression, and yoga were searched for related articles. Articles were then excluded or included based on certain criteria. Focus was placed on articles written within the last 10 years as well as studies done on children within 10-19 years of age. Final articles underwent extraction for relevant information and comparisons were drawn between the studies.
Results: Final exclusion lead to a total of 5 suitable studies. Studies varied in styles of yoga performed and measurement scales used to assess depression. Populations of adolescents varied significantly as well. The majority of these studies showed significant improvement in depression symptoms when measuring from pre to post intervention. Similar improvements were also noted in anxiety symptoms and low self-esteem.
Conclusion: Data gathered indicated that yoga serves a suitable intervention for decreasing depression symptoms in adolescents. Additionally, there seems to be promising results regarding the viability of yoga as an intervention for decreasing symptoms of anxiety and increasing self-esteem. Despite, current promising results, there is need for more research to affirm the findings found in these articles to determine the long term effects of yoga interventions.
ContributorsMenon, Pranav (Co-author) / Giedraitis, Frances (Co-author) / Larkey, Linda (Thesis director) / Calvin, Samantha (Committee member) / W.P. Carey School of Business (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
In this creative thesis, I traveled to India and used my month long summer vacation back home to interview people about mental health in India. I talked to a therapist and four students about depression to find out what the situation is in India, contributing factors, experiences and stigma unique to depression among students in India, what the government is doing, and possible solutions or steps that can be taken to help students struggling with mental health problems. I also went to mainstream and special schools to meet special educators who work with differently abled children, occupational therapists, parents of differently abled children, and a student with Asperger’s in Chennai, Tamil Nadu to find out about the stigma surrounding differently abled children and their education path.
My efforts have culminated in the creation of the website mentalhealthinindia.com that can be used as a resource both by people in India as well as those abroad who are curious to learn about the stigma surrounding depression and differently abled children in India.
My efforts have culminated in the creation of the website mentalhealthinindia.com that can be used as a resource both by people in India as well as those abroad who are curious to learn about the stigma surrounding depression and differently abled children in India.
ContributorsVenkatakrishnan, Ranjani (Author) / Koester, Nicole (Thesis director) / Pruitt, Rhonda (Committee member) / Walter Cronkite School of Journalism & Mass Comm (Contributor) / School of International Letters and Cultures (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The ability to regulate emotions, attention, and behavior develops early in life and impacts future academic success, social competency, behavioral problems, and psychopathology. An impairment in regulation is known as dysregulation. Past research shows that children of mothers with postpartum depression are more likely to show impairment in regulatory abilities. There is an established link in the literature between family support and maternal depression, which in turn can impact child behavior. However, further research is needed to explore the impact of family support on early childhood dysregulation in the context of maternal depression. Using a sample of 322 Mexican-American, mother-child dyads, two models were examined. Model one hypothesized family support would buffer the effects of maternal depression on child dysregulation at 24 months. Model 2 hypothesized that family support is related to child dysregulation through its effect on maternal depression. Results showed that increased family support was related to more child dysregulation when there were high levels of maternal depression. There was no evidence to support the hypothesis that maternal depression mediated the relationship between family support and child dysregulation.
ContributorsRodrigues, Samantha Jean (Author) / Luecken, Linda (Thesis director) / Benitez, Viridiana (Committee member) / Davis, Mary (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Depression, anxiety, and suicidal thoughts or actions are on the rise in adolescents (National Institute of Mental Health, 2015; Bridge, Asti, & Horowitz, 2015). Parents, school administrators, and therapists are searching for resiliency factors with in at-risk groups to aid students in need. In previous work, Luthar and Zigler (1992) reported that intelligent youth are more resilient than less intelligent youth under low stress conditions but they lose their advantage under high stress conditions. This study examined whether intelligence (reflected in grade point average; GPA) and maladaptive (internalizing and externalizing symptoms) behaviors are negatively related in adolescents, and tested whether level of stress, reflected in emotion regulation and friendship quality, moderated that association. It also probed whether the relationships differ by gender. Sixth-graders (N=506) were recruited with active parental consent from three middle schools. Adolescents completed self-report questionnaires Regarding demo graphics, maladaptive behaviors, emotion regulation, and friendship quality, and GPA data were collected from the school. Regression analyses found that GPA was negatively related to externalizing symptoms. Girls with poor friendship communication report significantly higher maladaptive behaviors. This relation was more pronounced for girls with high GPAs, as predicted. Results support the theory that intelligent female adolescents are more reactive under adverse circumstances. Future efforts should follow students through middle school into high school to evaluate whether friendships remain important to adjustment, hold for boys as well as girls, and have implications for relationship interventions.
ContributorsGonzales, Ashlyn Carol (Author) / Luthar, Suniya (Thesis director) / Davis, Mary (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Barrett, The Honors College (Contributor)
Created2017-12
Description
Investment and interest in mental health on a global scale is increasing. This interest creates a need to gain an in depth understanding about how mental illness is conceptualized and treated in different cultures. This article aims to explore the views of maternal mental health in Kenya's sub-counties. Maternal mental health has a significant impact on child development outcomes, so the topic has cross-generational importance. Ten focus group discussions with a variety of participants were conducted to understand the health care system. The participants were from four Kenya sub-counties: Rachuonyo N., Wagwe, Okiki Amayo, Nyative and they were either members of either SCHMT (Sub-county health management team), CHEW (community health extension worker), facility/staff of the county hospital, HHCDO (Homa Hills Community Development Organization), THRIVE II staff (Catholic Relief Service's early childhood development program) or mothers and fathers with children under two years of age. The qualitative data were translated and transcribed on site and then retranslated and counterchecked. A secondary data analysis using Atlas.ti was performed to identify themes and trends in factors that contribute to maternal wellbeing. Four main categories were identified as having prevalent effects on the Kenyan mothers' mental health: cultural values, broken support system, limitations of resources, and knowledge, behavior and attitudes. The participants were broken up into administrative, clinical, social, maternal and paternal categories to determine specific influence in each of these areas. Further analysis defined participants' involvement in the categories as mediating, moderating and direct effects on maternal depression. Main contributors to depression were identified as a lack of paternal support, poor cultural values, and administrative resistance. Discussion focuses on consequences for the future.
ContributorsAugur, Haley Rose (Author) / Nelson, Elizabeth (Thesis director) / Glenberg, Arthur (Committee member) / Hagaman, Ashley (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Affluent children have been previously understudied and considerably neglected in developmental research due to the notion that they are "low risk." There is limited empirical research exploring the effects of parent involvement in affluent youth: specifically, the importance of the adolescent's perception that their mother/father do not spend as much time with them as they would like. The goals of the study were to explore the role of this dimension of perceived parental involvement in anxious-depressed symptoms, somatic symptoms, rule breaking behaviors and substance use with upper-class suburban youth. The sample was taken from the New England Study of Suburban Youth Cohort (NESSY) (Luthar & Latendresse, 2005b) consisting of 252 high school students in the 12th grade located in an affluent community in the Northeast. Results showed that the participants who indicated their fathers could have dinner with them more often if they tried presented significant group differences in anxious-depressed symptoms, somatic symptoms, and rule breaking behaviors while substance use trended towards significant. Thus, these data demonstrate that parent-child relationships are not only important for infant and child development, but are also an integral part of development of adaptive behaviors during adolescence. In addition, the data suggest the benefits from having strong, supportive, and stable relationships with not only mothers but with fathers as well. Results from post hoc analyses revealed perceived absence of fathers at dinnertime affects the adolescent more than the perceived absence of mothers at dinnertime. Finally, teens who indicated a need to spend more dinnertimes with their father may be suffering from a lack of open communication and opportunities to discuss social and emotional issues that are conducive to adolescent development and adjustment.
ContributorsOjeda, Johanna Alyssa Quiambao (Author) / Luthar, Suniya (Thesis director) / Glenberg, Arthur (Committee member) / Curlee, Alexandria (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Previous studies suggest an association between depression and anxiety in childhood and adolescence and increased risk for cardiovascular disease later in life. The aim of the present study was to test whether depression and anxiety symptoms in young adulthood were associated with retinal vessel diameter, a subclinical marker of cardiovascular disease. We further tested whether associations for depression were similar to associations for anxiety. Participants completed questionnaires about their depression and anxiety symptoms and underwent retinal imaging. Retinal vessel diameter was assessed using computer software. Results showed no association between depression or anxiety symptoms and retinal vessel diameter, suggesting that retinal vessel diameter may not signal subclinical cardiovascular risk in young adults with symptoms of depression and anxiety.
ContributorsGandee, Katherine Marie (Author) / Meier, Madeline (Thesis director) / Perez, Marisol (Committee member) / Infurna, Frank (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05