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Vitamin D-mediated Regulation of Anti-Aging Klotho and FOXO Signaling

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Vitamin D, Klotho, and FOXO3 have all been linked to have anti-aging and anti-cancerous effects as separate pathways. Specifically, mice with knockout Klotho in their genes have displayed signs of premature aging, humans who are vitamin D deficient have been shown to develop cardiovascular disease and cognitive impairments, and those…

Vitamin D, Klotho, and FOXO3 have all been linked to have anti-aging and anti-cancerous effects as separate pathways. Specifically, mice with knockout Klotho in their genes have displayed signs of premature aging, humans who are vitamin D deficient have been shown to develop cardiovascular disease and cognitive impairments, and those who have displayed overexpression of FOXO3 have shown to have a longer lifespan. Here we took each pathway and attempted to formulate a feedback mechanism loop linking all three separate pathways. We propose that vitamin D levels modulate klotho activity, including the expression of the s-klotho and m-klotho isoforms. Moreover, the anti-oxidation transcription factor FOXO3 is also thought to participate in crosstalk with VDR signaling. Through the connection between 1,25D and Klotho, we probed at their interactions with FOXO3 signaling in kidney and colon cells, and proposed that vitamin D and klotho may reduce oxidative stress and suppress the onset of epithelial cancers through it effects on FOXO3. Results showed a strong support for the cooperation between FOXO3 and 1,25D to stimulate both superoxide dismutase (a FOXO3 response element) and XDR3/ROC (vitamin D response elements). This cooperation was mostly seen in embryonic kidney cells (HEK293) and not in the colon cancer cells (HCT116), which has led to the conclusion that vitamin D and FOXO3 cooperation mainly occurs in kidney tissue and/or in tissue that is not yet been overtaken by cancer. Differences in the Klotho isoforms were seen when measuring FOXO3 and vitamin D activity, but experiments manipulating other components will need to be conducted to further understand the function of Klotho in maintaining reactive oxygenated species levels.
ContributorsSandoval, Ruby (Author) / Jurutka, Peter (Thesis director) / Sandrin, Todd R. (Committee member) / Heck, Michael (Committee member) / School of Social and Behavioral Sciences (Contributor) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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The Importance of Studying Interactions With Ovarian Hormones: Implications for Depressive Symptoms in Premenopausal and Menopausal Women

Description

The relevance of depression in the clinical realm is well known, as it is one of the most common mental disorders in the United States. Clinical depression is the leading cause of disease for women worldwide. The sex difference in depression and anxiety has guided the research of not just…

The relevance of depression in the clinical realm is well known, as it is one of the most common mental disorders in the United States. Clinical depression is the leading cause of disease for women worldwide. The sex difference in depression and anxiety has guided the research of not just recent studies but older studies as well, supporting the theory that gonadal hormones are associated with the mechanisms of emotional cognition. The scientific literature points towards a clear correlative relationship between gonadal hormones, especially estrogens, and emotion regulation. This thesis investigates the neural pathways that have been indicated to regulate mood and anxiety. Currently, the research points to the hypothalamic-pituitary-adrenal axis, which regulates the stress response through its ultimate secretion of cortisol through the adrenal cortex, and its modulated response when exposed to higher levels of estrogen. Another mechanism that has been investigated is the interaction of estrogen and the serotonergic system, which is noteworthy because the serotonergic system is known for its importance in mood regulation. However, it is important to note that the research seeking to determine the neurobiological underpinnings of estrogen and the serotonergic system is not expansive. Future research should focus on determining the direct relationship between cortisol hypersecretion and estrogens, the specific neurobiological effects of serotonergic receptor subtypes on the antidepressant actions of estrogens, and the simultaneous effects of the stress and serotonergic systems on depressive symptoms.
ContributorsArroyo, Mariana (Author) / Bimonte-Nelson, Heather (Thesis director) / Jurutka, Peter (Committee member) / School of International Letters and Cultures (Contributor) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The Benefits of Exercise in Treating Anxiety and Depression

Description
Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about…

Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about in modern forms of media. Finally, we apply the research to college students. At the end of the paper, you will find a brochure we made specifically for the college student struggling with anxiety or depression.
ContributorsCristante, Lilia (Author) / Ritter, Hailey (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05

The Benefits of Exercise in Treating Anxiety and Depression

Description

Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about…

Exercise has emerged as an effective way to treat anxiety and depression. This project first examines the early research on this topic so we can provide a historical context for the thesis. We then look into the contemporary context, where we can see how the topic is being talked about in modern forms of media. Finally, we apply the research to college students. At the end of the paper, you will find a brochure we made specifically for the college student struggling with anxiety or depression.
ContributorsRitter, Hailey (Author) / Cristante, Lilia (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / Sanford School of Social and Family Dynamics (Contributor)
Created2022-05
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The Effects of Physical Activity Prescriptions on Psychological Outcomes

Description
Research on the correlation between exercise and mental health outcomes has been a growing field for the past few decades. It is of specific interest to look at how physical activity affects psychological outcomes and it’s efficacy for treating mental health disorders. The current treatment options for depression and…

Research on the correlation between exercise and mental health outcomes has been a growing field for the past few decades. It is of specific interest to look at how physical activity affects psychological outcomes and it’s efficacy for treating mental health disorders. The current treatment options for depression and anxiety are not suitable for everyone and therefore there is a need for a more accessible and cost-effective form of treatment, like exercise. Furthermore, exercise as a treatment is also linked with many more health benefits. Indeed a wealth of studies have explored the relationships between exercise and depression as well as exercise and anxiety, showing exercise to be a positive predictor of mental health. The following paper will serve to: define depressive and anxiety disorders, explore the research on the effects of physical activity prescriptions on the outcomes of such disorders, create evidence-based applied recommendations for different disorders, and explore the mechanisms by which exercise mitigates symptoms to ultimately accredit the prescription of exercise as a form of treatment for mental health disorders.
ContributorsAddington, Rachel Anne (Author) / Hoffner, Kristin (Thesis director) / Broman, Tannah (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Ritter Thesis Brochure (Spring 2022)

ContributorsRitter, Hailey (Author) / Cristante, Lilia (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05
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Ritter Thesis (Spring 2022)

ContributorsRitter, Hailey (Author) / Cristante, Lilia (Co-author) / Sturgess, Jessica (Thesis director) / Hoffner, Kristin (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2022-05