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- Creators: Barrett, The Honors College
- Creators: Edson College of Nursing and Health Innovation
- Creators: Aldana, Lauren Michelle
Description
Brief memory tasks for use with pet dogs were developed using radial arm maze performance as a standard comparison measurement of memory capacity. Healthy pet dogs were first tested in a radial arm maze, where more errors made in completing the maze indicated poorer memory. These dogs were later tested with five novel memory tests, three of which utilized a treat placed behind a box with an identical distracter nearby. The treat placement was shown to each dog, and a 35 second delay, a 15 second delay with occluder, or a 15 second delay with room exit was observed before the dog could approach and find the treat. It was found that errors on the delayed match to sample (35 second delay) and occluder/object permanence (15 second delay with occluder) tasks were significantly positively correlated with the average number of errors made in the 8th trial of the radial arm maze (r =.58, p<.01** and r =.49, p<.05*, respectively) indicating that these new brief tests can reliably be used to assess memory in pet dogs.
ContributorsBoileau, Rae Nicole (Author) / Wynne, Clive (Thesis director) / Knight, George (Committee member) / Bimonte-Nelson, Heather (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor)
Created2015-05
Description
Background: To determine the effect of sumac on vasodilation and oxidative stress in vascular tissue. This study hypothesized that sumac would increase vasodilation and reduce vascular damage in vascular tissue taken from rats to improve symptoms and risk of vascular dementia.
Methods: Male Sprague-Dawley rats were fed a chow diet or a high fat diet (HFD) for ten weeks. Endothelium-dependent vasodilation was measured in isolated mesenteric arterioles that were treated with or without 80 µg/ml sumac in the superfusate throughout the experiment.
Results: Sumac did not improve vasodilation or in ex vivo arteries from rats fed a high fat diet. There were trends of improved vasodilation in sumac treated vessels from high fat diet rats, but sumac did not significantly improve vasodilation. In rats fed a chow diet, sumac prevented phenylephrine (PE) constriction in the vascular tissue. The most likely cause for this is the presence of Gallic acid in sumac. Another possible explanation is the presence of nitrates in sumac which may have prevented PE vasoconstriction.
Conclusions: Sumac did not significantly improve vasodilation in isolated arteries from rats fed a high fat diet. The results are inconclusive for the improvement of symptoms or risk of vascular dementia. In vivo treatment with sumac should be tested as results may differ.
Methods: Male Sprague-Dawley rats were fed a chow diet or a high fat diet (HFD) for ten weeks. Endothelium-dependent vasodilation was measured in isolated mesenteric arterioles that were treated with or without 80 µg/ml sumac in the superfusate throughout the experiment.
Results: Sumac did not improve vasodilation or in ex vivo arteries from rats fed a high fat diet. There were trends of improved vasodilation in sumac treated vessels from high fat diet rats, but sumac did not significantly improve vasodilation. In rats fed a chow diet, sumac prevented phenylephrine (PE) constriction in the vascular tissue. The most likely cause for this is the presence of Gallic acid in sumac. Another possible explanation is the presence of nitrates in sumac which may have prevented PE vasoconstriction.
Conclusions: Sumac did not significantly improve vasodilation in isolated arteries from rats fed a high fat diet. The results are inconclusive for the improvement of symptoms or risk of vascular dementia. In vivo treatment with sumac should be tested as results may differ.
ContributorsLambries, Lorne Flores (Co-author) / Sweazea, Karen (Co-author, Thesis director) / Gonzales, Rayna (Co-author, Committee member) / Basile, Anthony (Co-author, Committee member) / Barbares, Julia (Co-author) / School of Nutrition and Health Promotion (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
BACKGROUND: Delirium is often not recognized by clinicians at hospice facilities, leading to the lack of beneficial interventions. The aim of this study is to find a baseline of how many patients show signs of delirium, dementia, or both, determine whether clinicians are recognizing these signs, and observe how dementia and delirium are being treated for these patients.
DESIGN: Patient charts were reviewed to obtain demographic information, medications, and patients' progress throughout stay including pharmacologic and non-pharmacologic interventions and results. Patients were then interviewed using the short portable mental status questionnaire.
SETTING: The prevalence and management of dementia and delirium was evaluated in 10 Hospice of the Valley inpatient settings.
RESULTS: Out of the 159 participants (mean age = 77.72 years), 93 (58.5%) presented with moderate to severe cognitive impairment, but only 38 participants (23.9%) had a formal diagnosis of dementia. Out of the 93 participants with significant cognitive impairment, 60 participants (65.6%) were treated with benzodiazepines and 82 (88.2%) were treated with opioids. Fifty-nine (63.4%) participants with cognitive impairment had documented non pharmacological interventions such as repositioning and reorientation, but only 22 (23.7%) participants received more meaningful non-pharmacological interventions such as hand massages, targeted videos, and favorite music.
CONCLUSIONS: The current study found a high prevalence of moderate to severe cognitive impairment without a diagnosis of dementia. A likely cause is the high frequency of opioids and benzodiazepines prescribed, causing drug-induced sedation and delirium which significantly impairs cognitive abilities. Safer alternatives, such as non-opioid pain medications, should be considered within the hospice population, especially given that age is a risk factor for delirium. A tool would be helpful to encourage staff to identify and document use of non-pharmacological interventions.
DESIGN: Patient charts were reviewed to obtain demographic information, medications, and patients' progress throughout stay including pharmacologic and non-pharmacologic interventions and results. Patients were then interviewed using the short portable mental status questionnaire.
SETTING: The prevalence and management of dementia and delirium was evaluated in 10 Hospice of the Valley inpatient settings.
RESULTS: Out of the 159 participants (mean age = 77.72 years), 93 (58.5%) presented with moderate to severe cognitive impairment, but only 38 participants (23.9%) had a formal diagnosis of dementia. Out of the 93 participants with significant cognitive impairment, 60 participants (65.6%) were treated with benzodiazepines and 82 (88.2%) were treated with opioids. Fifty-nine (63.4%) participants with cognitive impairment had documented non pharmacological interventions such as repositioning and reorientation, but only 22 (23.7%) participants received more meaningful non-pharmacological interventions such as hand massages, targeted videos, and favorite music.
CONCLUSIONS: The current study found a high prevalence of moderate to severe cognitive impairment without a diagnosis of dementia. A likely cause is the high frequency of opioids and benzodiazepines prescribed, causing drug-induced sedation and delirium which significantly impairs cognitive abilities. Safer alternatives, such as non-opioid pain medications, should be considered within the hospice population, especially given that age is a risk factor for delirium. A tool would be helpful to encourage staff to identify and document use of non-pharmacological interventions.
ContributorsDe Jesus, Sarah Spicer (Author) / Hamilton, Gillian (Thesis director) / Glenberg, Arthur (Committee member) / Volk-Craft, Barbara (Committee member) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2018-12
Description
Alzheimer's disease and related dementias are a growing issue in the United States. While medical experts try to develop treatments or a cure, what are we as a society to do in the meantime to help those living with Alzheimer's? The arts seem to be an answer. In this thesis, I highlight numerous programs already in place across the United States that utilize the visual, musical, and dramatic arts to give people with Alzheimer's an avenue for expression, a connection to the world around them, as well as a better quality of life. I address the largely positive impact these arts engagement programs have on caregivers and their perceptions of their loved ones. I discuss what it means to have narrative identity and personhood in the midst of a disease that appears to strip those things away. Finally, I share my own experiences creatively engaging with residents at a local memory care facility and what those experiences demonstrated with regard to narrative, being, and Self. The examination of material and experiences demonstrates that art taps into innate parts of human beings that science is unable to touch or treat; however, the reverse is also true for science. When faced with an issue as complex as Alzheimer's disease, art and science are strongest together, and I believe the cure to Alzheimer's lies in this unity. In the meantime, we must utilize the arts to validate the Selves of and improve the quality of life for our growing Alzheimer's population.
ContributorsSpeight, Gemma (Author) / Gruber, Diane (Thesis director) / Manninen, Bertha (Committee member) / School of Social and Behavioral Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
As the incidence of dementia continues to rise, the need for an effective and non-invasive method of intervention has become increasingly imperative. Music therapy has exhibited these qualities in addition to relatively low implementation costs, therefore establishing itself as a promising means of therapeutic intervention. In this review, current research was investigated in order to determine its effectiveness and uncover the neurochemical mechanisms that lead to positive manifestations such as improved memory recall, increased social affiliation, increased motivation, and decreased anxiety. Music therapy has been found to improve several aspects of memory recall. One proposed mechanism involves temporal entrainment, during which the melodic structures present in music provide a framework for chunking information. Although entrainment's role in the treatment of motor defects has been thoroughly studied, its role in treating cognitive disorders is still relatively new. Musicians have also been shown to demonstrate extensive plastic changes; therefore, it is hypothesized that non-musicians may also glean some benefits from engaging in music. Social affiliation has been found to increase due to increases in endogenous oxytocin. Oxytocin has also been shown to strengthen hippocampal spike transmission, a promising outcome for Alzheimer's patients. An increase in motivation has also been found to occur due to music's ability to tap into the reward center of the brain. Dopaminergic transmission between the VTA, NAc and higher functioning regions such as the OFC and hypothalamus has been revealed. Additionally, relaxing music decreases stress levels and modifies associated autonomic processes, i.e. heart rate, blood pressure, and respiratory rate. On the contrary, stimulating music has been found to initiate sympathetic nervous system activity. This is thought to occur by either a reflexive brainstem response or stimulus interpretation by the amygdala.
ContributorsFlores, Catalina Nicole (Author) / Redding, Kevin (Thesis director) / Hoffer, Julie (Committee member) / Neisewander, Janet (Committee member) / School of Molecular Sciences (Contributor) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Minority mental health patients face many health inequities and inequalities that may stem from implicit bias and a lack of cultural awareness from their healthcare providers. I analyzed the current literature evaluating implicit bias among healthcare providers and culturally specific life traumas that Latinos and African Americans face that can impact their mental health. Additionally, I researched a current mental health assessments tool, the Child and Adolescent Trauma Survey (CATS), and evaluated it for the use on Latino and African American patients. Face-to-face interviews with two healthcare providers were also used to analyze the CATS for its’ applicability to Latino and African American patients. Results showed that these assessments were not sufficient in capturing culturally specific life traumas of minority patients. Based on the literature review and analysis of the interviews with healthcare providers, a novel assessment tool, the Culturally Traumatic Events Questionnaire (CTEQ), was created to address the gaps that currently make up other mental health assessment tools used on minority patients.
ContributorsAldana, Lauren Michelle (Author) / Sullivan-Detheridge, Julie (Thesis director) / Allen, Angela (Committee member) / Edson College of Nursing and Health Innovation (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
For those living lives devoted to taking care of others, it can be difficult to remember to take care of themselves. This thesis project is a review of quantitative and qualitative literature pertaining to self-care for the caregivers of Alzheimer's and dementia patients. Three nursing diagnoses and related nursing interventions were created using data from the evidence-based literature. With the proper knowledge and assistance, caregivers can better prepare for the future and participate in health-promoting self-care activities which may improve their quality of life.
ContributorsSchmidt, Anna Claire (Author) / Fries, Kathleen (Thesis director) / Barnum, Leslie (Committee member) / Edson College of Nursing and Health Innovation (Contributor) / Watts College of Public Service & Community Solut (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
Description
Inflammatory genes are known to only show in African Americans and non-Hispanic Whites. The objective of this study was to observe the correlation from the obtained data of the prevalence of the APOE ε4 genotype. We examined cerebral free-water, a marker of neuroinflammation, hippocampal volume, and volume of white-matter hyperintensities in African Americans (AA) and non-Hispanic Whites who were categorized in groups based on whether they had APOE ε4 allele or not. AA had lower prevalence of APOE e4 genotype than non-Hispanic Whites. AA groups have a slightly higher hippocampal volume compared to the Non-Hispanic White (NHW) groups. African Americans also reported increased white-matter hyperintensities and cerebral free-water. Hippocampal atrophy is associated with Alzheimer's disease, this might suggest that the AA groups have a lower risk of Alzheimer's, although further research is needed to confirm this relationship. Lastly, our findings also suggest other potential socioeconomic factors that could contribute to increased incidence of dementia among AA and potential resilience factors early in the course of Alzheimer’s disease process.
ContributorsStephens, Sydney (Author) / Ofori, Edward (Thesis director) / Sklar, David (Committee member) / Barrett, The Honors College (Contributor)
Created2023-05
Description
Inflammatory genes are known to only show in African Americans and non-Hispanic Whites. The objective of this study was to observe the correlation from the obtained data of the prevalence of the APOE ε4 genotype. We examined cerebral free-water, a marker of neuroinflammation, hippocampal volume, and volume of white-matter hyperintensities in African Americans (AA) and non-Hispanic Whites who were categorized in groups based on whether they had APOE ε4 allele or not. AA had lower prevalence of APOE e4 genotype than non-Hispanic Whites. AA groups have a slightly higher hippocampal volume compared to the Non-Hispanic White (NHW) groups. African Americans also reported increased white-matter hyperintensities and cerebral free-water. Hippocampal atrophy is associated with Alzheimer's disease, this might suggest that the AA groups have a lower risk of Alzheimer's, although further research is needed to confirm this relationship. Lastly, our findings also suggest other potential socioeconomic factors that could contribute to increased incidence of dementia among AA and potential resilience factors early in the course of Alzheimer’s disease process.
ContributorsStephens, Sydney (Author) / Ofori, Edward (Thesis director) / Sklar, David (Committee member) / Barrett, The Honors College (Contributor)
Created2023-05
Description
Inflammatory genes are known to only show in African Americans and non-Hispanic Whites. The objective of this study was to observe the correlation from the obtained data of the prevalence of the APOE ε4 genotype. We examined cerebral free-water, a marker of neuroinflammation, hippocampal volume, and volume of white-matter hyperintensities in African Americans (AA) and non-Hispanic Whites who were categorized in groups based on whether they had APOE ε4 allele or not. AA had lower prevalence of APOE e4 genotype than non-Hispanic Whites. AA groups have a slightly higher hippocampal volume compared to the Non-Hispanic White (NHW) groups. African Americans also reported increased white-matter hyperintensities and cerebral free-water. Hippocampal atrophy is associated with Alzheimer's disease, this might suggest that the AA groups have a lower risk of Alzheimer's, although further research is needed to confirm this relationship. Lastly, our findings also suggest other potential socioeconomic factors that could contribute to increased incidence of dementia among AA and potential resilience factors early in the course of Alzheimer’s disease process.
ContributorsStephens, Sydney (Author) / Ofori, Edward (Thesis director) / Sklar, David (Committee member) / Barrett, The Honors College (Contributor)
Created2023-05