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- All Subjects: Stress
- Creators: Department of Psychology
- Status: Published
This hypothesis is supported by previous studies demonstrating that stress-induced elevation of glucocorticoids increases the transcription of C4. I propose that activated glucocorticoid receptors directly increase C4 protein expression as a transcription factor activator. Additionally, I propose that activated glucocorticoid receptors inhibit the expression of the transcription factor nuclear factor-light-chain-enhancer of activated B cells (NF-κB), thereby leading to decreased expression of the C4 inhibitor CUB and Sushi multiple domains 1 (CSMD1).
Glucocorticoid receptors and C4 are richly expressed in the hippocampus, a region critical in memory consolidation, spatial, and declarative memory. I propose that stress-induced upregulation of C4 activity in the hippocampus promotes excessive synaptic pruning, contributing to specific deficits and hippocampal shrinkage seen in schizophrenia. Stress exposure during fetal development and adolescence likely acts through the proposed mechanisms to increase hippocampal C4 activity and subsequent schizophrenia risk. These mechanisms may reveal novel interactions between environmental and genetic risk factors in the etiology of schizophrenia through complement activation.
The COVID-19 pandemic has had an international impact since the novel coronavirus first surfaced in late 2019. Since then, different countries have taken different approaches to try and limit transmissions and deaths. While this is seemingly unprecedented in modern day times, many pandemics, or plagues, have happened relatively frequently in history. This paper examines three historical plagues through the lens of social psychologist Geert Hofstede’s six cultural dimensions to distinguish between cultures: power distance, individualism versus collectivism, masculinity versus femininity, uncertainty avoidance, long term orientation and indulgence versus restraint. This paper then applies these dimensions to the modern day U.S. and South Korea, two countries who have had different success in handling the COVID-19 pandemic. Through these dimensions, this paper aims to explain a factor in why South Korea has had better results than the U.S. It also recognizes that Hofstede’s cultural dimensions are not the only factor to affect the pandemic, and explores political influences in America through the lens of Henry David Thoreau and John Dewey. Overall, this paper argues that the U.S. has been unsuccessful in taming the pandemic because of certain cultural dimensions, such as more an individualist and indulgent culture, and its unstable and divisive political climate. Given this, the United States has a hopeful, yet arduous path moving forward with COVID-19 and future pandemics.