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This thesis project is the result of close collaboration with the Arizona State University Biodesign Clinical Testing Laboratory (ABCTL) to document the characteristics of saliva as a test sample, preanalytical considerations, and how the ABCTL utilized saliva testing to develop swift COVID-19 diagnostic tests for the Arizona community. As of

This thesis project is the result of close collaboration with the Arizona State University Biodesign Clinical Testing Laboratory (ABCTL) to document the characteristics of saliva as a test sample, preanalytical considerations, and how the ABCTL utilized saliva testing to develop swift COVID-19 diagnostic tests for the Arizona community. As of April 2021, there have been over 130 million recorded cases of COVID-19 globally, with the United States taking the lead with approximately 31.5 million cases. Developing highly accurate and timely diagnostics has been an important need of our country that the ABCTL has had tremendous success in delivering. Near the start of the pandemic, the ABCTL utilized saliva as a testing sample rather than nasopharyngeal (NP) swabs that were limited in supply, required highly trained medical personnel, and were generally uncomfortable for participants. Results from literature across the globe showed how saliva performed just as well as the NP swabs (the golden standard) while being an easier test to collect and analyze. Going forward, the ABCTL will continue to develop high quality diagnostic tools and adapt to the ever-evolving needs our communities face regarding the COVID-19 pandemic.

ContributorsSmetanick, Jennifer (Author) / Compton, Carolyn (Thesis director) / Magee, Mitch (Committee member) / School of Life Sciences (Contributor) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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The main objective of this research is to develop and characterize a targeted contrast agent that will recognize acute neural injury pathology (i.e. fibrin) after traumatic brain injury (TBI). Single chain fragment variable antibodies (scFv) that bind specifically to fibrin have been produced and purified. DSPE-PEG micelles have been produced

The main objective of this research is to develop and characterize a targeted contrast agent that will recognize acute neural injury pathology (i.e. fibrin) after traumatic brain injury (TBI). Single chain fragment variable antibodies (scFv) that bind specifically to fibrin have been produced and purified. DSPE-PEG micelles have been produced and the scFv has been conjugated to the surface of the micelles; this nanoparticle system will be used to overcome limitations in diagnosing TBI. The binding and imaging properties will be analyzed in the future to determine functionality of the nanoparticle system in vivo.
ContributorsRumbo, Kailey Michelle (Author) / Stabenfeldt, Sarah (Thesis director) / Kodibagkar, Vikram (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2014-05
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Military personnel are affected by muscle fatigue during the various missions and training regimens for their work. Muscle fatigue is caused by the overuse and lack of nutrients to muscles. When a soldier is fatigued, they are unable to perform at their maximum potential and are also more susceptible to

Military personnel are affected by muscle fatigue during the various missions and training regimens for their work. Muscle fatigue is caused by the overuse and lack of nutrients to muscles. When a soldier is fatigued, they are unable to perform at their maximum potential and are also more susceptible to injury. For military personnel to save time and money as well as become more efficient within the missions they deploy soldiers, muscle fatigue should be predicted. Predicting fatigue will allow for a reduced rate of negative exercise-related impacts. This means that soldiers will be able to avoid potential life threatening situations they encounter due to the muscle fatigue. The newest technology in wearable devices includes clothing that incorporates heart rate monitors, breathing rate and breathing depth sensors, and a database that converts this information into the amount of calories burned during a workout. Fatigue can be tracked and predicted in the military using wearable clothing with activity sensors, preventing further injury to the soldiers and optimizing performance output at all times. For military personnel, the ability to predict fatigue using this technology would be beneficial to the soldiers and the military as a whole.
ContributorsFalk, Brady Thomas (Author) / Lockhart, Thurmon (Thesis director) / Williams, Deborah (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
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Description

For many, a long-distance hike on the 2,650+ mile Pacific Crest Trail (PCT) is the adventure of a lifetime. The federally designated National Scenic Trail passes through 48 Wilderness Areas in California, Washington, and Oregon on its way from Mexico to Canada. The trail experience on the PCT has been

For many, a long-distance hike on the 2,650+ mile Pacific Crest Trail (PCT) is the adventure of a lifetime. The federally designated National Scenic Trail passes through 48 Wilderness Areas in California, Washington, and Oregon on its way from Mexico to Canada. The trail experience on the PCT has been changing rapidly over the last 20 years due to two main factors: a four-fold increase in hikers attempting the whole trail each season; and hikers’ rapid adoption of digital technology like smartphones, GPS, and satellite messengers. Through a literature review and accompanying hiker survey, this study aimed to determine how these two factors have combined to alter the trail experience. Despite increased traffic on the trail, hikers appear to still be able to find ample solitude and a feeling of escape from society, and they reported being more likely to form lasting friendships as part of a “trail family”. However, increased traffic has altered many of the sensitive natural landscapes along the trail, contributed to the retirement of some iconic “trail angels” and led to increased conflict between subcultures within the community. Digital technology usage, particularly the use of smartphones and GPS-capable mapping apps, seems to be linked to decreased feelings of solitude, self-sufficiency, and escape. However, digital devices have helped democratize long-distance hiking by simplifying the logistics of long-distance hikes. Users of the devices also did not report reduced feelings of freedom or challenge from their hikes. Moreover, device users still felt that they were disconnecting with technology when hiking on the trail. Acknowledging both positive and negative effects of the changing trail experience, hikers can make more informed decisions about how to mitigate the negative impacts and maximize the positive impacts on the aspects of the trail experience they care the most about.

ContributorsDeSimone, Dante (Author) / Shaeffer, Duncan (Thesis director) / Schmidt, Peter (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2021-05
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Markov Chain Monte-Carlo methods are a Bayesian approach to predictive statistics, which takes advantage of prior beliefs and conditions as well as the existing data to produce posterior distributions of relevant parameters. This approach, implementable through the JAGS packaging in R, is promising for its impact on the diagnostics space,

Markov Chain Monte-Carlo methods are a Bayesian approach to predictive statistics, which takes advantage of prior beliefs and conditions as well as the existing data to produce posterior distributions of relevant parameters. This approach, implementable through the JAGS packaging in R, is promising for its impact on the diagnostics space, which is a critical bottleneck for pandemic planning and rapid response. Specifically, these methods provide the means to optimize diagnostic testing, for example, by determining whether it is best to test individuals in a certain locale once or multiple times. This study compares the expected accuracy of single and double testing under two specific conditions, a general and Icelandic test case, in order to ascertain the validity of MCMC methods in this space and inform decisionmakers and future research in the space. Models based on this platform may eventually be tailored to the priors of specific locales. Additionally, the ability to test multiple regimes of real or simulated data while maintaining uncertainty widens the pool of researchers that can impact the space. In future studies, ensemble methods investigating the full range of parameters and their combinations can be studied.
ContributorsSuresh, Tarun (Author) / Naufel, Mark (Thesis director) / Panchanathan, Sethuraman (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
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Smartphones have become an integral component of lifestyles worldwide, acting as mobile computers capable of life organization. They remain the most quickly cycled consumer electronic, owned for no more than 3 years on average. Individuals continue to upgrade their smartphones quickly, stemming from the desire for more power and better

Smartphones have become an integral component of lifestyles worldwide, acting as mobile computers capable of life organization. They remain the most quickly cycled consumer electronic, owned for no more than 3 years on average. Individuals continue to upgrade their smartphones quickly, stemming from the desire for more power and better features. In 2016, there were 1.15 billion smartphone upgrades, resulting in a growing used smartphone market valued at \$18 billion. Individuals continue to invest time and effort to sell their smartphone, receiving payment of less than market value. In regards to value-minded users with solidified schedules, I created Trusted Trade-in. This startup provides the bustling middle class with the ability to upgrade their smartphone in an efficient and valuable manner. Compared to current solutions, Trusted Trade-in offers an all-in-one upgrade system. The creation of this startup involved the complete creation of a business model in addition to the coding of a responsive website. An online-based business, customers will be able to visit the Trusted Trade-in website and be given the options to trade-in or trade-up. Competing against Craigslist, eBay and Verizon, Trusted Trade-in features a combined smartphone resale and upgrade process. If the decision is made to trade-in, the customer will be quoted for their current smartphone according to specific physical criteria. The trade-up option will request the same information from the customer and allow them to select a new model for their upgrade. This exciting and innovative marketplace will completely transform the way people upgrade their smartphones through financial and time-based savings.
ContributorsWoods, Quintin Delane (Author) / Sebold, Brent (Thesis director) / Lin, Elva S. Y. (Committee member) / Harrington Bioengineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
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The growth of the medical diagnostic industry in the past several decades has largely been due to the creation and iterative optimization of bio sensors. Recent pushes towards value added as well as preventative health care has made point of care devices more attractive to health care providers. Rapid detection

The growth of the medical diagnostic industry in the past several decades has largely been due to the creation and iterative optimization of bio sensors. Recent pushes towards value added as well as preventative health care has made point of care devices more attractive to health care providers. Rapid detection for diseases and cancers is done with a bio sensor, which a broad term used to describe an instrument which uses a bio chemical reaction to detect a chemical compound with the use of a bio recognition event in addition to a signal detection event. The bio sensors which are presented in this work are known as ion-sensitive field effects transistors (ISFETs) and are similar in function to a metal oxide field effect transistor (MOSFET). These ISFETs can be used to sense pH or the concentration of protons on the surface of the gate channel. These ISFETs can be used for certain bio recognition events and this work presents the application of these transistors for the quantification of tumor cell proliferation. This includes the development of a signal processing and acquisition system for the long term assessment of cellular metabolism and optimizing the system for use in an incubator. This thesis presents work done towards the optimization and implementation of complementary metal\u2014oxide\u2014semiconductor (CMOS) ISFETs as well as remote gate ISFETs for the continuous assessment of tumor cell extracellular pH. The work addresses the challenges faced with the fabrication and optimization of these sensors, which includes the mitigation of current drift with the use of pulse width modulation in addition to issues encountered with fabrication of electrodes on a quartz substrate. This work culminates in the testing of an autonomous system with mammary tumor cells as well as the assessment of cell viability in an incubator over extended periods. Future applications of this work include the creation of a remote gate ISFET array for multiplexed detection as well as the implementation of ISFETs for bio marker detection via an immunoassay.
ContributorsArafa, Hany Mohamed (Author) / Blain Christen, Jennifer (Thesis director) / LaBelle, Jeffrey (Committee member) / Harrington Bioengineering Program (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description

Phoenix Police officers are required to wear Body-Worn Cameras while out on patrol and must have the cameras turned on when interacting with the public. The Body-Worn Camera (BWC) Policy was initially established as a means of accruing evidence and increasing police accountability when in the presence of the public.

Phoenix Police officers are required to wear Body-Worn Cameras while out on patrol and must have the cameras turned on when interacting with the public. The Body-Worn Camera (BWC) Policy was initially established as a means of accruing evidence and increasing police accountability when in the presence of the public. However, BWC technology has the ability to perform many other useful functions. The information provided by the cameras could be used to reduce the paperwork done by police officers while on duty, thus allowing them to spend more time taking calls from dispatch. The versatility of the body-worn camera and its components also make it an ideal pairing for an electrocardiograph (ECG) device to aid in the health of officers and law enforcement retention.

ContributorsChacon, Elyana (Author) / Ross, Heather (Thesis director) / Scott, Michael (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2023-05
Description

This study investigates the impact of technology and social media on religious practices and beliefs concerning death and the afterlife. As the concept of a "Digital Afterlife" becomes more prevalent, questions surrounding its compatibility with religious belief systems and implications on privacy arise. The COVID-19 pandemic has intensified the issue,

This study investigates the impact of technology and social media on religious practices and beliefs concerning death and the afterlife. As the concept of a "Digital Afterlife" becomes more prevalent, questions surrounding its compatibility with religious belief systems and implications on privacy arise. The COVID-19 pandemic has intensified the issue, prompting social media platforms to develop digital wills, although their usage remains limited. This research seeks to explore how the Information Age is shaping the concept of the afterlife, its alignment with major religious belief systems, and perceptions of the digital afterlife across various societal groups. Furthermore, the study examines the role of social media in redefining religious values, norms, and boundaries, highlighting the importance of engaging in an ongoing conversation about the complex and evolving intersection of religion, technology, and death.

ContributorsAlsabah, Wid (Author) / Hussain, Faheem (Thesis director) / Mostafa, Mashiat (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2023-05
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My honors thesis focuses on the technological aspects and the legal impacts of prosthetics and advanced prosthetics. There is a lot of case law dealing with early prosthetics when it comes to worker’s compensation, airport security, prisons and sports. However, there has been little case law that has dealt with

My honors thesis focuses on the technological aspects and the legal impacts of prosthetics and advanced prosthetics. There is a lot of case law dealing with early prosthetics when it comes to worker’s compensation, airport security, prisons and sports. However, there has been little case law that has dealt with advanced prosthetics. As prosthetic limbs become more technologically advanced and intertwined with one’s identity, it is crucial that laws are made to draw a new line between person and property. The innovation of prosthetic limbs has just begun and will surely face setbacks along the way, but the benefits will be worth it once the law catches up with the rapidly advancing technology.

ContributorsRogers, Madison (Author) / Marchant, Gary (Thesis director) / Schaefer, Sydney (Committee member) / Barrett, The Honors College (Contributor) / Harrington Bioengineering Program (Contributor)
Created2022-05